Histone deacetylase inhibition rescues gene knockout levels achieved with integrase-defective lentiviral vectors encoding zinc-finger nucleases

Human Gene Therapy Methods

Volumn 24, Issue 6, 2013, Pages 399-411

  Pelascini, Laetitia P L ^a   Maggio, Ignazio ^a   Liu, Jin ^a   Holkers, Maarten ^a   Cathomen, Toni ^b   Gonçalves, Manuel A F V ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; HISTONE DEACETYLASE; INTEGRASE; LENTIVIRUS VECTOR; RECOMBINANT DNA; TRICHOSTATIN A; VORINOSTAT; ZINC FINGER NUCLEASE;

APOPTOSIS; ARTICLE; CELL CULTURE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DNA END JOINING REPAIR; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE DISRUPTION; GENE DOSAGE; GENE EXPRESSION; GENE SEQUENCE; GENOTYPE; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; KNOCKOUT GENE; MUTAGENESIS; MYOBLAST; OPEN READING FRAME; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SITE DIRECTED MUTAGENESIS; VIRAL GENE DELIVERY SYSTEM;

DNA BREAKS, DOUBLE-STRANDED; ENDODEOXYRIBONUCLEASES; GENE KNOCKOUT TECHNIQUES; GENETIC VECTORS; HEK293 CELLS; HELA CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INTEGRASES; LENTIVIRUS; MESENCHYMAL STROMAL CELLS; MYOBLASTS; ZINC FINGERS;

EID: 84890362377     PISSN: 19466536     EISSN: 19466544     Source Type: Journal    
DOI: 10.1089/hgtb.2013.107     Document Type: Article

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