Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells

Human Gene Therapy

Volumn 24, Issue 1, 2013, Pages 78-96

  Pelascini, Laetitia P L ^a   Janssen, Josephine M ^a   Gonçalves, Manuel A F V ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; HISTONE DEACETYLASE; INTEGRATION DEFECTIVE LENTIVIRAL VECTOR; LENTIVIRUS VECTOR; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL DIVISION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; ENZYME INHIBITION; EPIGENETICS; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSDUCTION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MESENCHYMAL STEM CELL; MYOTUBE; NONHUMAN; POLYMERASE CHAIN REACTION; TRANSGENE;

BROMODEOXYURIDINE; BUTYRATES; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; GENETIC THERAPY; GENETIC VECTORS; HEK293 CELLS; HELA CELLS; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; INTEGRASES; LENTIVIRUS; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSGENES; VIRUS INTEGRATION;

EID: 84872776482     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2012.069     Document Type: Article

References (55)

1. Agalioti, T., Chen, G., and Thanos, D. (2002). Deciphering the transcriptional histone acetylation code for a human gene. Cell 111, 381-392.
2. Apolonia, L., Waddington, S.N., Fernandes, C., et al. (2007). Stable gene transfer to muscle using non-integrating lentiviral vectors. Mol. Ther. 15, 1947-1954.
3. Askar, S.F., Bingen, B.O., Swildens, J., et al. (2012). Connexin43 silencing in myofibroblasts prevents arrhythmias in myocardial cultures: role of maximal diastolic potential. Cardiovasc. Res. 93, 434-444.
4. Banasik,M.B., andMcCray Jr, P.B. (2010). Integrase-defective lentiviral vectors: progress and applications. Gene Ther. 17, 150-157.
5. Bannister, A.J., and Kouzarides, T. (2011). Regulation of chromatin by histone modifications. Cell Res. 21, 381-395.
6. Bannister, A.J., Schneider, R., Myers, F.A., et al. (2005). Spatial distribution of di-and tri-methyl lysine 36 of histone H3 at active genes. J. Biol. Chem. 280, 17732-17736.
7. Barkess, G., and West, A.G. (2012). Chromatin insulator elements: establishing barriers to set heterochromatin boundaries. Epigenomics 4, 67-80.
8. Barski, A., Cuddapah, S., Cui, K., et al. (2007). High-resolution profiling of histone methylations in the human genome. Cell 129, 823-837.
9. Bishop, C.L., Ramalho, M., Nadkarni, N., et al. (2006). Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA. Mol. Cell. Biol. 26, 2583-2594. Erratum in: Mol. Cell. Biol. (2006). 26, 3997.
10. Bolden, J.E., Peart, M.J., and Johnstone, R.W. (2006). Anticancer activities of histone deacetylase inhibitors. Nat. Rev. Drug Discov. 5, 769-784.
11. Cedar, H., and Bergman, Y. (2009). Linking DNA methylation and histone modification: patterns and paradigms. Nat. Rev. Genet. 10, 295-304.
12. Charrier, S., Stockholm, D., Seye, K., et al. (2005). A lentiviral vector encoding the human Wiskott-Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice. Gene Ther. 12, 597-606.
13. Cornu, T., and Cathomen, T. (2007). Targeted genome modifications using integrase-deficient lentiviral vectors. Mol. Ther. 15, 2107-2113.
14. Cudré-Mauroux, C., Occhiodoro, T., König, S., et al. (2003). Lentivector-mediated transfer of Bmi-1 and telomerase in muscle satellite cells yields a Duchenne myoblast cell line with long-term genotypic and phenotypic stability. Hum. Gene. Ther. 14, 1525-1533.
15. Deyle, D.R., Li, Y., Olson, E.M., et al. (2010). Nonintegrating foamy virus vectors. J. Virol. 84, 9341-9349.
16. Downes, M., Ordentlich, P., Kao, H.Y., et al. (2000). Identification of a nuclear domain with deacetylase activity. Proc. Natl. Acad. Sci. USA 97, 10330-10335.
17. Dropulić, B. (2011). Lentiviral vectors: their molecular design, safety, and use in laboratory and preclinical research. Hum. Gene Ther. 22, 649-657.
18. Dull, T., Zufferey, R., Kelly, M., et al. (1998). A third-generation lentivirus vector with a conditional packaging system. J. Virol. 72, 8463-8471.
19. Finlan, L.E., Sproul, D., Thomson, I., et al. (2008). Recruitment to the nuclear periphery can alter expression of genes in human cells. PLoS Genet. 21, e1000039.
20. Gonçalves, M.A.F.V., Swildens, J., Holkers, M., et al. (2008). Genetic complementation of human muscle cells via directed stem cell fusion. Mol. Ther. 16, 741-748.
21. Gonçalves, M.A.F.V., Janssen, J.M., Nguyen, Q.G., et al. (2011). Transcription factor rational design improves directed differentiation of human mesenchymal stem cells into skeletal myocytes. Mol. Ther. 19, 1331-1341.
22. Kantor, B., Ma, H., Webster-Cyriaque, J., et al. (2009). Epigenetic activation of HIV-1 genomes by gut-associated short chain fatty acids and its implications for HIV infection. Proc. Natl. Acad. Sci. USA 106, 18786-18791.
23. Katz, R.A., Jack-Scott, E., Narezkina, A., et al. (2007). Highfrequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. J. Virol. 81, 2592-2604.
24. Keedy, K.S.,Archin, N.M.,Gates,A.T., et al. (2009).Alimited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression. J. Virol. 83, 4749-4756.
25. Knaän-Shanzer, S., van de Watering, M.J.M., van der Velde, I., et al. (2005). Endowing human adenovirus serotype 5 vectors with fiber domains of species B greatly enhances gene transfer into human mesenchymal stem cells. Stem Cells 23, 93-102.
26. Kutner, R.H., Zhang, X.Y., and Reiser, J. (2009). Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors. Nat Protoc. 4, 495-505.
27. Lane, A.A., and Chabner, B.A. (2009). Histone deacetylase inhibitors in cancer therapy. J. Clin. Oncol. 27, 5459-5468.
28. Levrero, M., Pollicino, T., Petersen, J., et al. (2009). Control of cccDNA function in hepatitis B virus infection. J. Hepatol. 51, 581-592.
29. Liang, G., Lin, J.C., Wei, V., et al. (2004). Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proc. Natl. Acad. Sci. USA 101, 7357-7362.
30. Loewen, N., Leske, D.A., Chen, Y., et al. (2003). Comparison of wild-type and class I integrase mutant-FIV vectors in retina demonstrates sustained expression of integrated transgenes in retinal pigment epithelium. J. Gene Med. 5, 1009-1017.
31. Lois, C., Hong, E.J., Pease, S., et al. (2002). Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295, 868-872.
32. Lombardo, A., Genovese, P., Beausejour, C.M., et al. (2007). Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat. Biotechnol. 25, 1298-1306.
33. Mali, P., Ye, Z., Hommond, H.H., et al. (2008). Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells 26, 1998-2005.
34. Mateescu, B., England, P., Halgand, F., et al. (2004). Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3. EMBO Rep. 5, 490-496.
35. Mátrai, J., Cantore, A., Bartholomae, C.C., et al. (2011). Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. Hepatology 53, 1696-1707.
36. Moltó, E., Fernández, A., and Montoliu, L. (2009). Boundaries in vertebrate genomes: different solutions to adequately insulate gene expression domains. Brief. Funct. Genomic. Proteomic. 8, 283-296.
37. Negri, D.R., Michelini, Z., and Cara, A. (2010). Toward integrase defective lentiviral vectors for genetic immunization. Curr. HIV Res. 8, 274-281.
38. Nevels, M., Nitzsche, A., and Paulus, C. (2011). How to control an infectious bead string: nucleosome-based regulation and targeting of herpesvirus chromatin. Rev. Med. Virol. 21, 154-180.
39. Philippe, S., Sarkis, C., Barkats, M., et al. (2006). Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo. Proc. Natl. Acad. Sci. USA 103, 17684-17689.
40. Philpott, N.J., and Thrasher, A.J. (2007). Use of nonintegrating lentiviral vectors for gene therapy. Hum. Gene Ther. 18, 483-489.
41. Rando, O.J. (2012). Combinatorial complexity in chromatin structure and function: revisiting the histone code. Curr. Opin. Genet. Dev. 22: 148-155.
42. Riu, E., Chen, Z.-Y., Xu, Z., et al. (2007). Histone modifications are associated with the persistence or silencing of vectormediated transgene expression in vivo. Mol. Ther. 15, 1348-1355.
43. Ross, P.J., Kennedy, M.A., and Parks, R.J. (2009). Host cell detection of noncoding stuffer DNA contained in helperdependent adenovirus vectors leads to epigenetic repression of transgene expression. J. Virol. 83, 8409-8417.
44. Ross, P.J., Kennedy, M.A., Christou, C., et al. (2011). Assembly of helper-dependent adenovirus DNA into chromatin promotes efficient gene expression. J. Virol. 85, 3950-3958.
45. Schröder, A.R., Shinn, P., Chen, H., et al. (2002). HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110, 521-529.
46. Seppen, J., Rijnberg, M., Cooreman, M.P., et al. (2002). Lentiviral vectors for efficient transduction of isolated primary quiescent hepatocytes. J. Hepatol. 36, 459-465.
47. Staunstrup, N.H., Moldt, B., Mátés, L., et al. (2009). Hybrid lentivirus-transposon vectors with a random integration profile in human cells. Mol. Ther. 17, 1205-1214.
48. van Tuyn, J., Knaän-Shanzer, S., van de Watering, M.J., et al. (2005). Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin. Cardiovasc. Res. 67, 245-255.
49. Walsh, K., and Perlman, H. (1997). Cell cycle exit upon myogenic differentiation. Curr. Opin. Genet. Dev. 7, 597-602.
50. Wang, Z., Zang, C., Rosenfeld, J.A., et al. (2008). Combinatorial patterns of histone acetylations and methylations in the human genome. Nat. Genet. 40, 897-903.
51. Wanisch, K., and Yáñez-Muñoz, R. (2009). Integration-deficient lentiviral vectors: a slow coming of age. Mol. Ther. 17, 1316-1332.
52. Wu, X., Li, Y., Crise, B., et al. (2003). Transcription start regions in the human genome are favored targets for MLV integration. Science 300, 1749-1751.
53. Yahi, H., Philipot, O., Guasconi, V., et al. (2006). Chromatin modification and muscle differentiation. Expert. Opin. Ther. Targets 10, 923-934.
54. Yáñez-Muñoz, R.J., Balaggan, K.S., MacNeil, A., et al. (2006). Effective gene therapy with nonintegrating lentiviral vectors. Nat. Med. 12, 348-353.
55. You, J. (2010). Papillomavirus interaction with cellular chromatin. Biochim. Biophys. Acta 1799, 192-209.