메뉴 건너뛰기




Volumn 8, Issue 2, 2012, Pages 426-434

Highly Efficient Zinc-Finger Nuclease-Mediated Disruption of an eGFP Transgene in Keratinocyte Stem Cells without Impairment of Stem Cell Properties

Author keywords

Cytotoxicity; EGFP protein; Gene targeting; Gene therapy; Keratinocytes; Mice; Stem cells

Indexed keywords

ENDONUCLEASE; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; ZINC FINGER PROTEIN;

EID: 84861702128     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-011-9313-z     Document Type: Article
Times cited : (11)

References (35)
  • 1
    • 78649810923 scopus 로고    scopus 로고
    • Gene therapy, gene targeting and induced pluripotent stem cells: applications in monogenic disease treatment
    • Wong, G. K., & Chiu, A. T. (2011). Gene therapy, gene targeting and induced pluripotent stem cells: applications in monogenic disease treatment. Biotechnology Advances, 29(1), 1-10.
    • (2011) Biotechnology Advances , vol.29 , Issue.1 , pp. 1-10
    • Wong, G.K.1    Chiu, A.T.2
  • 3
    • 0016729431 scopus 로고
    • Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells
    • Rheinwald, J. G., & Green, H. (1975). Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell, 6(3), 331-343.
    • (1975) Cell , vol.6 , Issue.3 , pp. 331-343
    • Rheinwald, J.G.1    Green, H.2
  • 4
    • 33845524625 scopus 로고    scopus 로고
    • Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells
    • Mavilio, F., Pellegrini, G., Ferrari, S., et al. (2006). Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nature Medicine, 12(12), 1397-1402.
    • (2006) Nature Medicine , vol.12 , Issue.12 , pp. 1397-1402
    • Mavilio, F.1    Pellegrini, G.2    Ferrari, S.3
  • 5
    • 51349158298 scopus 로고    scopus 로고
    • Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
    • Howe, S. J., Mansour, M. R., Schwarzwaelder, K., et al. (2008). Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. The Journal of Clinical Investigation, 118(9), 3143-3150.
    • (2008) The Journal of Clinical Investigation , vol.118 , Issue.9 , pp. 3143-3150
    • Howe, S.J.1    Mansour, M.R.2    Schwarzwaelder, K.3
  • 6
    • 79960110370 scopus 로고    scopus 로고
    • Risk assessment in skin gene therapy: Viral-cellular fusion transcripts generated by proviral transcriptional read-through in keratinocytes transduced with self-inactivating lentiviral vectors
    • [Epub ahead of print]
    • Almarza D, Bussadori G, Navarro M, Mavilio F, Larcher F, Murillas R. (2011). Risk assessment in skin gene therapy: viral-cellular fusion transcripts generated by proviral transcriptional read-through in keratinocytes transduced with self-inactivating lentiviral vectors. Gene Ther, [Epub ahead of print].
    • (2011) Gene Ther
    • Almarza, D.1    Bussadori, G.2    Navarro, M.3    Mavilio, F.4    Larcher, F.5    Murillas, R.6
  • 8
    • 39149111247 scopus 로고    scopus 로고
    • Single-nucleotide-specific siRNA targeting in a dominant-negative skin model
    • Hickerson, R. P., Smith, F. J., Reeves, R. E., et al. (2008). Single-nucleotide-specific siRNA targeting in a dominant-negative skin model. The Journal of Investigative Dermatology, 128(3), 594-605.
    • (2008) The Journal of Investigative Dermatology , vol.128 , Issue.3 , pp. 594-605
    • Hickerson, R.P.1    Smith, F.J.2    Reeves, R.E.3
  • 9
    • 45749145124 scopus 로고    scopus 로고
    • Zinc-finger nucleases: the next generation emerges
    • Cathomen, T., & Joung, J. K. (2008). Zinc-finger nucleases: the next generation emerges. Molecular Therapy, 16(7), 1200-1207.
    • (2008) Molecular Therapy , vol.16 , Issue.7 , pp. 1200-1207
    • Cathomen, T.1    Joung, J.K.2
  • 10
    • 78650735673 scopus 로고    scopus 로고
    • Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
    • Holt, N., Wang, J., Kim, K., et al. (2010). Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nature Biotechnology, 28(8), 839-847.
    • (2010) Nature Biotechnology , vol.28 , Issue.8 , pp. 839-847
    • Holt, N.1    Wang, J.2    Kim, K.3
  • 11
    • 79953123523 scopus 로고    scopus 로고
    • Chemokine receptor 5 knockout strategies
    • Cannon, P., & June, C. (2011). Chemokine receptor 5 knockout strategies. Current Opinion in HIV and AIDS, 6(1), 74-79.
    • (2011) Current Opinion in HIV and AIDS , vol.6 , Issue.1 , pp. 74-79
    • Cannon, P.1    June, C.2
  • 12
    • 47349097567 scopus 로고    scopus 로고
    • Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification
    • Maeder, M. L., Thibodeau-Beganny, S., Osiak, A., et al. (2008). Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Molecular Cell, 31(2), 294-301.
    • (2008) Molecular Cell , vol.31 , Issue.2 , pp. 294-301
    • Maeder, M.L.1    Thibodeau-Beganny, S.2    Osiak, A.3
  • 13
    • 25144501447 scopus 로고    scopus 로고
    • Custom zinc-finger nucleases for use in human cells
    • Alwin, S., Gere, M. B., Guhl, E., et al. (2005). Custom zinc-finger nucleases for use in human cells. Molecular Therapy, 12(4), 610-617.
    • (2005) Molecular Therapy , vol.12 , Issue.4 , pp. 610-617
    • Alwin, S.1    Gere, M.B.2    Guhl, E.3
  • 14
    • 34447323568 scopus 로고    scopus 로고
    • Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
    • Szczepek, M., Brondani, V., Buchel, J., Serrano, L., Segal, D. J., & Cathomen, T. (2007). Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nature Biotechnology, 25(7), 786-793.
    • (2007) Nature Biotechnology , vol.25 , Issue.7 , pp. 786-793
    • Szczepek, M.1    Brondani, V.2    Buchel, J.3    Serrano, L.4    Segal, D.J.5    Cathomen, T.6
  • 15
    • 75549091564 scopus 로고    scopus 로고
    • Establishment of spontaneously immortalized keratinocyte lines from wild-type and mutant mice
    • Reichelt, J., & Haase, I. (2010). Establishment of spontaneously immortalized keratinocyte lines from wild-type and mutant mice. Methods in Molecular Biology, 585, 59-69.
    • (2010) Methods in Molecular Biology , vol.585 , pp. 59-69
    • Reichelt, J.1    Haase, I.2
  • 16
    • 80053039555 scopus 로고    scopus 로고
    • A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
    • [Epub ahead of print]
    • Mussolino C, Morbitzer R, Lutge F, Dannemann N, Lahaye T, Cathomen T. (2011). A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity. Nucleic Acids Res, [Epub ahead of print].
    • (2011) Nucleic Acids Res
    • Mussolino, C.1    Morbitzer, R.2    Lutge, F.3    Dannemann, N.4    Lahaye, T.5    Cathomen, T.6
  • 17
    • 0032835593 scopus 로고    scopus 로고
    • Normal ultrastructure, but altered stratum corneum lipid and protein composition in a mouse model for epidermolytic hyperkeratosis
    • Reichelt, J., Doering, T., Schnetz, E., Fartasch, M., Sandhoff, K., & Magin, A. M. (1999). Normal ultrastructure, but altered stratum corneum lipid and protein composition in a mouse model for epidermolytic hyperkeratosis. The Journal of Investigative Dermatology, 113(3), 329-334.
    • (1999) The Journal of Investigative Dermatology , vol.113 , Issue.3 , pp. 329-334
    • Reichelt, J.1    Doering, T.2    Schnetz, E.3    Fartasch, M.4    Sandhoff, K.5    Magin, A.M.6
  • 18
    • 0035015769 scopus 로고    scopus 로고
    • Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line
    • Constien, R., Forde, A., Liliensiek, B., et al. (2001). Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line. Genesis, 30(1), 36-44.
    • (2001) Genesis , vol.30 , Issue.1 , pp. 36-44
    • Constien, R.1    Forde, A.2    Liliensiek, B.3
  • 19
    • 44849130087 scopus 로고    scopus 로고
    • Genotoxicity in gene therapy: an account of vector integration and designer nucleases
    • Bohne, J., & Cathomen, T. (2008). Genotoxicity in gene therapy: an account of vector integration and designer nucleases. Current Opinion in Molecular Therapeutics, 10(3), 214-223.
    • (2008) Current Opinion in Molecular Therapeutics , vol.10 , Issue.3 , pp. 214-223
    • Bohne, J.1    Cathomen, T.2
  • 20
    • 84861679782 scopus 로고    scopus 로고
    • Two- and three-dimensional culture of keratinocyte stem and precursor cells derived from primary murine epidermal cultures
    • doi: 10. 1007/s12015-011-9314-y
    • Vollmers, A., Wallace, L., Fullard, N., et al. (2011). Two- and three-dimensional culture of keratinocyte stem and precursor cells derived from primary murine epidermal cultures. Stem Cell Reviews and Reports. doi: 10. 1007/s12015-011-9314-y.
    • (2011) Stem Cell Reviews and Reports
    • Vollmers, A.1    Wallace, L.2    Fullard, N.3
  • 21
    • 0347634454 scopus 로고    scopus 로고
    • Defining the epithelial stem cell niche in skin
    • Tumbar, T., Guasch, G., Greco, V., et al. (2004). Defining the epithelial stem cell niche in skin. Science, 303(5656), 359-363.
    • (2004) Science , vol.303 , Issue.5656 , pp. 359-363
    • Tumbar, T.1    Guasch, G.2    Greco, V.3
  • 22
    • 35948946526 scopus 로고    scopus 로고
    • Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
    • Lombardo, A., Genovese, P., Beausejour, C. M., et al. (2007). Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nature Biotechnology, 25(11), 1298-1306.
    • (2007) Nature Biotechnology , vol.25 , Issue.11 , pp. 1298-1306
    • Lombardo, A.1    Genovese, P.2    Beausejour, C.M.3
  • 23
    • 77950572073 scopus 로고    scopus 로고
    • Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform
    • Benabdallah, B. F., Allard, E., Yao, S., et al. (2010). Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform. Cytotherapy, 12, 394-399.
    • (2010) Cytotherapy , vol.12 , pp. 394-399
    • Benabdallah, B.F.1    Allard, E.2    Yao, S.3
  • 24
  • 25
    • 38849103093 scopus 로고    scopus 로고
    • DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases
    • Cornu, T. I., Thibodeau-Beganny, S., Guhl, E., et al. (2008). DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases. Molecular Therapy, 16(2), 352-358.
    • (2008) Molecular Therapy , vol.16 , Issue.2 , pp. 352-358
    • Cornu, T.I.1    Thibodeau-Beganny, S.2    Guhl, E.3
  • 26
    • 79951699566 scopus 로고    scopus 로고
    • Zinc-finger nuclease based genome surgery: it's all about specificity
    • Handel, E. M., & Cathomen, T. (2011). Zinc-finger nuclease based genome surgery: it's all about specificity. Current Gene Therapy, 11(1), 28-37.
    • (2011) Current Gene Therapy , vol.11 , Issue.1 , pp. 28-37
    • Handel, E.M.1    Cathomen, T.2
  • 27
    • 70249114821 scopus 로고    scopus 로고
    • Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases
    • Hockemeyer, D., Soldner, F., Beard, C., et al. (2009). Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nature Biotechnology, 27(9), 851-857.
    • (2009) Nature Biotechnology , vol.27 , Issue.9 , pp. 851-857
    • Hockemeyer, D.1    Soldner, F.2    Beard, C.3
  • 28
    • 67649170378 scopus 로고    scopus 로고
    • Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells
    • Zou, J., Maeder, M. L., Mali, P., et al. (2009). Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell, 5(1), 97-110.
    • (2009) Cell Stem Cell , vol.5 , Issue.1 , pp. 97-110
    • Zou, J.1    Maeder, M.L.2    Mali, P.3
  • 29
    • 77956260872 scopus 로고    scopus 로고
    • Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells
    • Guenther, M. G., Frampton, G. M., Soldner, F., et al. (2010). Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell, 7(2), 249-257.
    • (2010) Cell Stem Cell , vol.7 , Issue.2 , pp. 249-257
    • Guenther, M.G.1    Frampton, G.M.2    Soldner, F.3
  • 30
    • 77953159822 scopus 로고    scopus 로고
    • Human iPS cell-based therapy: considerations before clinical applications
    • Sun, N., Longaker, M. T., & Wu, J. C. (2010). Human iPS cell-based therapy: considerations before clinical applications. Cell Cycle, 9(5), 880-885.
    • (2010) Cell Cycle , vol.9 , Issue.5 , pp. 880-885
    • Sun, N.1    Longaker, M.T.2    Wu, J.C.3
  • 31
    • 77953466536 scopus 로고    scopus 로고
    • Nuclear reprogramming to a pluripotent state by three approaches
    • Yamanaka, S., & Blau, H. M. (2010). Nuclear reprogramming to a pluripotent state by three approaches. Nature, 465(7299), 704-712.
    • (2010) Nature , vol.465 , Issue.7299 , pp. 704-712
    • Yamanaka, S.1    Blau, H.M.2
  • 32
    • 77953121698 scopus 로고    scopus 로고
    • Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death
    • Sotiropoulou, P. A., Candi, A., Mascre, G., et al. (2010). Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nature Cell Biology, 12(6), 572-582.
    • (2010) Nature Cell Biology , vol.12 , Issue.6 , pp. 572-582
    • Sotiropoulou, P.A.1    Candi, A.2    Mascre, G.3
  • 33
    • 77956251480 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
    • Mohrin, M., Bourke, E., Alexander, D., et al. (2010). Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell, 7(2), 174-185.
    • (2010) Cell Stem Cell , vol.7 , Issue.2 , pp. 174-185
    • Mohrin, M.1    Bourke, E.2    Alexander, D.3
  • 34
    • 77956233247 scopus 로고    scopus 로고
    • A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal
    • Milyavsky, M., Gan, O. I., Trottier, M., et al. (2010). A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell, 7(2), 186-197.
    • (2010) Cell Stem Cell , vol.7 , Issue.2 , pp. 186-197
    • Milyavsky, M.1    Gan, O.I.2    Trottier, M.3
  • 35
    • 79952003900 scopus 로고    scopus 로고
    • DNA damage response in adult stem cells: pathways and consequences
    • Mandal, P. K., Blanpain, C., & Rossi, D. J. (2011). DNA damage response in adult stem cells: pathways and consequences. Nature Reviews. Molecular Cell Biology, 12(3), 198-202.
    • (2011) Nature Reviews. Molecular Cell Biology , vol.12 , Issue.3 , pp. 198-202
    • Mandal, P.K.1    Blanpain, C.2    Rossi, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.