SCOPUS 정보 검색 플랫폼

Volumn 12, Issue 3, 2014, Pages 486-494

Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility

(6) Fisher, Martin a Basak, Ramkrishna a Kalverda, Arnout P a Fishwick, Colin W G a Bruce Turnbull, W a Nelson, Adam a

a UNIVERSITY OF LEEDS (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ASSAYS; CHEMICAL SPACE; LIGAND DESIGN; SMALL MOLECULES; STRUCTURE-BASED; STRUCTURE-BASED DESIGNS; SYNTHETIC APPROACH; TARGET PROTEINS;

LIGANDS; PROTEINS;

DESIGN;

ACYLTRANSFERASE; ADAMANTANE; AMINOBENZOIC ACID DERIVATIVE; ANILIDE; ENZYME INHIBITOR; ESCHERICHIA COLI PROTEIN; FABF PROTEIN, E COLI; FATTY ACID SYNTHASE; LIGAND; PLATENSIMYCIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DEVELOPMENT; GENETICS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETYLTRANSFERASES; ADAMANTANE; AMINOBENZOATES; ANILIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; FATTY ACID SYNTHASE, TYPE II; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84890280733 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/c3ob41975d Document Type: Article

Times cited : (9)

References (54)

1
- 61649114657
- I. Akritopoulou-Zanze P. J. Hajduk Drug Discovery Today 2009 14 291
- (2009) Drug Discovery Today , vol.14 , pp. 291
- Akritopoulou-Zanze, I.¹ Hajduk, P.J.²

2
- 84862795414
- T. Cheng Q. Li Z. Zhou Y. Wang S. H. Bryant AAPS J. 2012 14 133
- (2012) AAPS J. , vol.14 , pp. 133
- Cheng, T.¹ Li, Q.² Zhou, Z.³ Wang, Y.⁴ Bryant, S.H.⁵

3
- 33749245117
- A. R. Leach B. K. Shoichet C. E. Peishoff J. Med. Chem. 2006 49 5851
- (2006) J. Med. Chem. , vol.49 , pp. 5851
- Leach, A.R.¹ Shoichet, B.K.² Peishoff, C.E.³

4
- 23844449940
- G. Schneider U. Fechner Nat. Rev. Drug Discovery 2005 4 649
- (2005) Nat. Rev. Drug Discovery , vol.4 , pp. 649
- Schneider, G.¹ Fechner, U.²

5
- 0034680641
- G. Schneider O. Clément-Chomienne L. Hilfiger P. Schneider S. Kirsch H. J. Böhm W. Neidhart Angew. Chem., Int. Ed. 2000 39 4130
- (2000) Angew. Chem., Int. Ed. , vol.39 , pp. 4130
- Schneider, G.¹ Clément-Chomienne, O.² Hilfiger, L.³ Schneider, P.⁴ Kirsch, S.⁵ Böhm, H.J.⁶ Neidhart, W.⁷

6
- 77953605369
- K. J. Simmons I. Chopra C. W. G. Fishwick Nat. Rev. Microbiol. 2010 8 501
- (2010) Nat. Rev. Microbiol. , vol.8 , pp. 501
- Simmons, K.J.¹ Chopra, I.² Fishwick, C.W.G.³

7
- 14444281534
- S. W. Kaldor V. J. Kalish J. F. Davies B. V. Shetty J. E. Fritz K. Appelt J. A. Burgess K. M. Campanale N. Y. Chirgadze D. K. Clawson B. A. Dressman S. D. Hatch D. A. Khalil M. B. Kosa P. P. Lubbehusen M. A. Muesing A. K. Patick S. H. Reich K. S. Su J. H. Tatlock J. Med. Chem. 1997 40 3979
- (1997) J. Med. Chem. , vol.40 , pp. 3979
- Kaldor, S.W.¹ Kalish, V.J.² Davies, J.F.³ Shetty, B.V.⁴ Fritz, J.E.⁵ Appelt, K.⁶ Burgess, J.A.⁷ Campanale, K.M.⁸ Chirgadze, N.Y.⁹ Clawson, D.K.¹⁰ Dressman, B.A.¹¹ Hatch, S.D.¹² Khalil, D.A.¹³ Kosa, M.B.¹⁴ Lubbehusen, P.P.¹⁵ Muesing, M.A.¹⁶ Patick, A.K.¹⁷ Reich, S.H.¹⁸ Su, K.S.¹⁹ Tatlock, J.H.²⁰ more..

8
- 0031804609
- A. Wlodawer J. Vondrasek Annu. Rev. Biophys. Biomol. Struct. 1998 27 249
- (1998) Annu. Rev. Biophys. Biomol. Struct. , vol.27 , pp. 249
- Wlodawer, A.¹ Vondrasek, J.²

9
- 74049165055
- D. Cowen P. Bedingfield G. A. McConkey C. W. G. Fishwick A. P. Johnson Bioorg. Med. Chem. Lett. 2010 20 1284
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 1284
- Cowen, D.¹ Bedingfield, P.² McConkey, G.A.³ Fishwick, C.W.G.⁴ Johnson, A.P.⁵

10
- 3042799070
- M. D. Burke S. L. Schreiber Angew. Chem., Int. Ed. 2004 43 46
- (2004) Angew. Chem., Int. Ed. , vol.43 , pp. 46
- Burke, M.D.¹ Schreiber, S.L.²

11
- 84890262167
- A. H. Lipkus Q. Yuan K. A. Lucas S. A. Funk W. F. Bartelt R. J. Schenck A. J. Trippe J. Org. Chem. 2008 73 444
- (2008) J. Org. Chem. , vol.73 , pp. 444
- Lipkus, A.H.¹ Yuan, Q.² Lucas, K.A.³ Funk, S.A.⁴ Bartelt, W.F.⁵ Schenck, R.J.⁶ Trippe, A.J.⁷

12
- 48149108752
- C. Cordier D. Morton S. Murrison A. Nelson C. O'Leary-Steele Nat. Prod. Rep. 2008 25 719
- (2008) Nat. Prod. Rep. , vol.25 , pp. 719
- Cordier, C.¹ Morton, D.² Murrison, S.³ Nelson, A.⁴ O'Leary-Steele, C.⁵

13
- 82955213501
- M. Dow M. Fisher T. James F. Marchetti A. Nelson Org. Biomol. Chem. 2012 10 17
- (2012) Org. Biomol. Chem. , vol.10 , pp. 17
- Dow, M.¹ Fisher, M.² James, T.³ Marchetti, F.⁴ Nelson, A.⁵

14
- 33644839988
- D. S. Tan Nat. Chem. Biol. 2005 1 74
- (2005) Nat. Chem. Biol. , vol.1 , pp. 74
- Tan, D.S.¹

15
- 20444410443
- S. Shang D. S. Tan Curr. Opin. Chem. Biol. 2005 9 248
- (2005) Curr. Opin. Chem. Biol. , vol.9 , pp. 248
- Shang, S.¹ Tan, D.S.²

16
- 84880296641
- W. R. J. D. Galloway A. Isidro-Llobet D. R. Spring Nat. Commun. 2010 1 80
- (2010) Nat. Commun. , vol.1 , pp. 80
- Galloway, W.R.J.D.¹ Isidro-Llobet, A.² Spring, D.R.³

17
- 58149346448
- D. Morton S. Leach C. Cordier S. Warriner A. Nelson Angew. Chem., Int. Ed. 2009 48 104
- (2009) Angew. Chem., Int. Ed. , vol.48 , pp. 104
- Morton, D.¹ Leach, S.² Cordier, C.³ Warriner, S.⁴ Nelson, A.⁵

18
- 58149358949
- S. L. Schreiber Nature 2009 457 153
- (2009) Nature , vol.457 , pp. 153
- Schreiber, S.L.¹

19
- 58249110426
- H. Waldmann Nature 2009 5 76
- (2009) Nature , vol.5 , pp. 76
- Waldmann, H.¹

20
- 0035085234
- J. G. Olsen A. Kadziola P. von Wettstein-Knowles M. Siggaard-Andersen S. Larsen Structure 2001 9 233
- (2001) Structure , vol.9 , pp. 233
- Olsen, J.G.¹ Kadziola, A.² Von Wettstein-Knowles, P.³ Siggaard-Andersen, M.⁴ Larsen, S.⁵

21
- 0032473567
- W. Huang J. Jia P. Edwards K. Dehesh G. Schneider Y. Lindqvist EMBO J. 1998 17 1183
- (1998) EMBO J. , vol.17 , pp. 1183
- Huang, W.¹ Jia, J.² Edwards, P.³ Dehesh, K.⁴ Schneider, G.⁵ Lindqvist, Y.⁶

22
- 0036783668
- D. J. Payne W. H. Miller V. Berry J. Brosky W. J. Burgess E. Chen W. E. Dewolf A. P. Fosberry R. Greenwood M. S. Head D. A. Heerding C. A. Janson D. D. Jaworski P. M. Keller P. J. Manley T. D. Moore K. A. Newlander S. Pearson B. J. Polizzi X. Qiu S. F. Rittenhouse C. Slater-radosti K. L. Salyers M. A. Seefeld M. G. Smyth D. T. Takata I. N. Uzinskas K. Vaidya N. G. Wallis S. B. Winram C. C. K. Yuan W. F. Huffman Antimicrob. Agents Chemother. 2002 46 3118
- (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3118
- Payne, D.J.¹ Miller, W.H.² Berry, V.³ Brosky, J.⁴ Burgess, W.J.⁵ Chen, E.⁶ Dewolf, W.E.⁷ Fosberry, A.P.⁸ Greenwood, R.⁹ Head, M.S.¹⁰ Heerding, D.A.¹¹ Janson, C.A.¹² Jaworski, D.D.¹³ Keller, P.M.¹⁴ Manley, P.J.¹⁵ Moore, T.D.¹⁶ Newlander, K.A.¹⁷ Pearson, S.¹⁸ Polizzi, B.J.¹⁹ Qiu, X.²⁰ more..

23
- 33745817391
- Y. M. Zhang S. W. White C. O. Rock J. Biol. Chem. 2006 281 17541
- (2006) J. Biol. Chem. , vol.281 , pp. 17541
- Zhang, Y.M.¹ White, S.W.² Rock, C.O.³

24
- 33744994317
- J. Wang S. M. Soisson K. Young W. Shoop S. Kodali A. Galgoci R. Painter G. Parthasarathy Y. S. Tang R. Cummings S. Ha K. Dorso M. Motyl H. Jayasuriya J. Ondeyka K. Herath C. Zhang L. Hernandez J. Allocco A. Basilio J. R. Tormo O. Genilloud F. Vicente F. Pelaez L. Colwell S. H. Lee B. Michael T. Felcetto C. Gill L. L. Silver J. D. Hermes K. Bartizal J. Barrett D. Schmatz J. W. Becker D. Cully S. B. Singh Nature 2006 441 358
- (2006) Nature , vol.441 , pp. 358
- Wang, J.¹ Soisson, S.M.² Young, K.³ Shoop, W.⁴ Kodali, S.⁵ Galgoci, A.⁶ Painter, R.⁷ Parthasarathy, G.⁸ Tang, Y.S.⁹ Cummings, R.¹⁰ Ha, S.¹¹ Dorso, K.¹² Motyl, M.¹³ Jayasuriya, H.¹⁴ Ondeyka, J.¹⁵ Herath, K.¹⁶ Zhang, C.¹⁷ Hernandez, L.¹⁸ Allocco, J.¹⁹ Basilio, A.²⁰ more..

25
- 33745211232
- Y. M. Zhang J. Hurlbert S. W. White C. O. Rock J. Biol. Chem. 2006 281 17390
- (2006) J. Biol. Chem. , vol.281 , pp. 17390
- Zhang, Y.M.¹ Hurlbert, J.² White, S.W.³ Rock, C.O.⁴

26
- 33750574927
- S. Huang X. Zou J. Comput. Chem. 2006 27 1876
- (2006) J. Comput. Chem. , vol.27 , pp. 1876
- Huang, S.¹ Zou, X.²

27
- 34248329634
- Y. Zou C.-H. Chen C. D. Taylor B. M. Foxman B. B. Snider Org. Lett. 2007 9 1825
- (2007) Org. Lett. , vol.9 , pp. 1825
- Zou, Y.¹ Chen, C.-H.² Taylor, C.D.³ Foxman, B.M.⁴ Snider, B.B.⁵

28
- 33750629319
- K. C. Nicolaou A. Li D. J. Edmonds Angew. Chem., Int. Ed. 2006 45 7086
- (2006) Angew. Chem., Int. Ed. , vol.45 , pp. 7086
- Nicolaou, K.C.¹ Li, A.² Edmonds, D.J.³

29
- 64549097262
- A. K. Ghosh K. Xi J. Org. Chem. 2009 74 1163
- (2009) J. Org. Chem. , vol.74 , pp. 1163
- Ghosh, A.K.¹ Xi, K.²

30
- 70349934314
- Arun K. Ghosh Kai Xi Angew. Chem., Int. Ed. 2012 48 5372
- (2012) Angew. Chem., Int. Ed. , vol.48 , pp. 5372
- Ghosh, A.K.¹ Xi, K.²

31
- 82355175618
- E. Martens A. L. Demain J. Antibiot. 2011 64 705
- (2011) J. Antibiot. , vol.64 , pp. 705
- Martens, E.¹ Demain, A.L.²

32
- 84857251103
- D. Krsta C. K. Ku I. T. Crosby B. Capuano D. T. Manallack MedChemComm 2012 3 244
- (2012) MedChemComm , vol.3 , pp. 244
- Krsta, D.¹ Ku, C.K.² Crosby, I.T.³ Capuano, B.⁴ Manallack, D.T.⁵

33
- 62349119695
- J. Wang V. Lee H. O. Sintim Chem.-Eur. J. 2009 15 2747
- (2009) Chem.-Eur. J. , vol.15 , pp. 2747
- Wang, J.¹ Lee, V.² Sintim, H.O.³

34
- 58149148291
- K. C. Nicolaou A. F. Stepan T. Lister A. Li A. Montero G. S. Tria C. I. Turner Y. Tang J. Wang R. M. Denton D. J. Edmonds J. Am. Chem. Soc. 2008 130 13110
- (2008) J. Am. Chem. Soc. , vol.130 , pp. 13110
- Nicolaou, K.C.¹ Stepan, A.F.² Lister, T.³ Li, A.⁴ Montero, A.⁵ Tria, G.S.⁶ Turner, C.I.⁷ Tang, Y.⁸ Wang, J.⁹ Denton, R.M.¹⁰ Edmonds, D.J.¹¹

35
- 61349159407
- H. C. Shen F.-X. Ding S. B. Singh G. Parthasarathy S. M. Soisson S. N. Ha X. Chen S. Kodali J. Wang K. Dorso J. R. Tata M. L. Hammond M. Maccoss S. L. Colletti Bioorg. Med. Chem. Lett. 2009 19 1623
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 1623
- Shen, H.C.¹ Ding, F.-X.² Singh, S.B.³ Parthasarathy, G.⁴ Soisson, S.M.⁵ Ha, S.N.⁶ Chen, X.⁷ Kodali, S.⁸ Wang, J.⁹ Dorso, K.¹⁰ Tata, J.R.¹¹ Hammond, M.L.¹² MacCoss, M.¹³ Colletti, S.L.¹⁴

36
- 61349158580
- C. Zhang J. Ondeyka D. L. Zink B. Burgess J. Wang S. B. Singh Chem. Commun. 2008 5034
- (2008) Chem. Commun. , pp. 5034
- Zhang, C.¹ Ondeyka, J.² Zink, D.L.³ Burgess, B.⁴ Wang, J.⁵ Singh, S.B.⁶

37
- 36849044252
- K. C. Nicolaou Y. Tang J. Wang A. F. Stepan A. Li A. Montero J. Am. Chem. Soc. 2007 129 14850
- (2007) J. Am. Chem. Soc. , vol.129 , pp. 14850
- Nicolaou, K.C.¹ Tang, Y.² Wang, J.³ Stepan, A.F.⁴ Li, A.⁵ Montero, A.⁶

38
- 84890256808
- S. B. Singh H. Jayasuriya K. B. Herath C. Zhang G. Ondeyka D. L. Zink S. Ha G. Parthasarathy J. W. Becker J. Wang S. M. Soisson Tetrahedron Lett. 2009 50 1
- (2009) Tetrahedron Lett. , vol.50 , pp. 1
- Singh, S.B.¹ Jayasuriya, H.² Herath, K.B.³ Zhang, C.⁴ Ondeyka, G.⁵ Zink, D.L.⁶ Ha, S.⁷ Parthasarathy, G.⁸ Becker, J.W.⁹ Wang, J.¹⁰ Soisson, S.M.¹¹

39
- 34347267633
- K. C. Nicolaou T. Lister R. M. Denton A. Montero D. J. Edmonds Angew. Chem., Int. Ed. 2007 46 4712
- (2007) Angew. Chem., Int. Ed. , vol.46 , pp. 4712
- Nicolaou, K.C.¹ Lister, T.² Denton, R.M.³ Montero, A.⁴ Edmonds, D.J.⁵

40
- 1642559332
- J. M. S. Law D. Y. K. Fung Z. Zsoldos A. Simon Z. Szabo I. G. Csizmadia A. P. Johnson J. Mol. Struct. 2003 666-667 651
- (2003) J. Mol. Struct. , vol.666-667 , pp. 651
- Law, J.M.S.¹ Fung, D.Y.K.² Zsoldos, Z.³ Simon, A.⁴ Szabo, Z.⁵ Csizmadia, I.G.⁶ Johnson, A.P.⁷

41
- 0028167547
- V. J. Gillet W. Newell P. Mata G. Myatt S. Sike Z. Zsoldos A. P. Johnson J. Chem. Inf. Comput. Sci. 1994 34 207
- (1994) J. Chem. Inf. Comput. Sci. , vol.34 , pp. 207
- Gillet, V.J.¹ Newell, W.² Mata, P.³ Myatt, G.⁴ Sike, S.⁵ Zsoldos, Z.⁶ Johnson, A.P.⁷

42
- 1642574323
- Z. Zsoldos I. Szabo Z. Szabo A. P. Johnson J. Mol. Struct. 2003 666-667 659
- (2003) J. Mol. Struct. , vol.666-667 , pp. 659
- Zsoldos, Z.¹ Szabo, I.² Szabo, Z.³ Johnson, A.P.⁴

43
- 12144289984
- R. A. Friesner J. L. Banks R. B. Murphy T. A. Halgren J. J. Klicic D. T. Mainz M. P. Repasky E. H. Knoll M. Shelley J. K. Perry D. E. Shaw P. Francis P. S. Shenkin J. Med. Chem. 2004 47 1739
- (2004) J. Med. Chem. , vol.47 , pp. 1739
- Friesner, R.A.¹ Banks, J.L.² Murphy, R.B.³ Halgren, T.A.⁴ Klicic, J.J.⁵ Mainz, D.T.⁶ Repasky, M.P.⁷ Knoll, E.H.⁸ Shelley, M.⁹ Perry, J.K.¹⁰ Shaw, D.E.¹¹ Francis, P.¹² Shenkin, P.S.¹³

44
- 34548672579
- P. Heretsch A. Giannis Synthesis 2007 2614
- (2007) Synthesis , pp. 2614
- Heretsch, P.¹ Giannis, A.²

45
- 20344373155
- O. Tamura T. Shiro M. Ogasawara A. Toyao H. Ishibashi J. Org. Chem. 2005 70 4569
- (2005) J. Org. Chem. , vol.70 , pp. 4569
- Tamura, O.¹ Shiro, T.² Ogasawara, M.³ Toyao, A.⁴ Ishibashi, H.⁵

46
- 0029119899
- T. Fukuyama M. Cheung Tetrahedron Lett. 1995 36 6373
- (1995) Tetrahedron Lett. , vol.36 , pp. 6373
- Fukuyama, T.¹ Cheung, M.²

47
- 21644459359
- D. K. Mohapatra K. A. Durugkar ARKIVOC 2005 20
- (2005) ARKIVOC , pp. 20
- Mohapatra, D.K.¹ Durugkar, K.A.²

48
- 84890299960
- M. Ito Y. Kobayashi Synlett 2002 1508
- (2002) Synlett , pp. 1508
- Ito, M.¹ Kobayashi, Y.²

49
- 0033789206
- C. Dalvit P. Pevarello M. Tatò M. Veronesi A. Vulpetti M. Sundström J. Biomol. NMR 2000 18 65
- (2000) J. Biomol. NMR , vol.18 , pp. 65
- Dalvit, C.¹ Pevarello, P.² Tatò, M.³ Veronesi, M.⁴ Vulpetti, A.⁵ Sundström, M.⁶

50
- 85052723050
- Wiley-VCH, Weinheim
- J. Gladysz, D. P. Curran and I. Horvath, Handbook of Fluorous Chemistry, Wiley-VCH, Weinheim, 2005
- (2005) Handbook of Fluorous Chemistry
- Gladysz, J.¹ Curran, D.P.² Horvath, I.³

51
- 0035692794
- C. Dalvit G. Fogliatto A. Stewart M. Veronesi B. Stockman J. Biomol. NMR 2001 21 349
- (2001) J. Biomol. NMR , vol.21 , pp. 349
- Dalvit, C.¹ Fogliatto, G.² Stewart, A.³ Veronesi, M.⁴ Stockman, B.⁵

52
- 0037030693
- C. Dalvit M. Fasolini M. Flocco S. Knapp P. Pevarello M. Veronesi J. Med. Chem. 2002 45 2610
- (2002) J. Med. Chem. , vol.45 , pp. 2610
- Dalvit, C.¹ Fasolini, M.² Flocco, M.³ Knapp, S.⁴ Pevarello, P.⁵ Veronesi, M.⁶

53
- 84862027743
- T. Scior A. Bender G. Tresadern J. L. Medina-Franco K. Martínez-Mayorga T. Langer K. Cuanalo-Contreras D. K. Agrafiotis J. Chem. Inf. Model. 2012 52 867
- (2012) J. Chem. Inf. Model. , vol.52 , pp. 867
- Scior, T.¹ Bender, A.² Tresadern, G.³ Medina-Franco, J.L.⁴ Martínez- Mayorga, K.⁵ Langer, T.⁶ Cuanalo-Contreras, K.⁷ Agrafiotis, D.K.⁸

54
- 84856372411
- Wiley-VCH, Weinheim
- C. Sotriffer, Virtual Screening: Principles, Challenges, and Practical Guidelines, Wiley-VCH, Weinheim, 2011
- (2011) Virtual Screening: Principles, Challenges, and Practical Guidelines
- Sotriffer, C.¹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.