메뉴 건너뛰기




Volumn 73, Issue 23, 2013, Pages 7111-7121

Neuropilin-2 is upregulated in lung cancer cells during TGF-β1-induced epithelial-mesenchymal transition

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPILIN 2; PROTEIN KINASE B; SEMAPHORIN 3F; SHORT HAIRPIN RNA; SMAD PROTEIN; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN;

EID: 84890262516     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-1755     Document Type: Article
Times cited : (67)

References (60)
  • 1
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer 2013;13:97-110.
    • (2013) Nat Rev Cancer , vol.13 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 3
    • 57049132745 scopus 로고    scopus 로고
    • Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy
    • Thomson S, Petti F, Sujka-Kwok I, Epstein D, Haley JD. Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy. Clin Exp Metastasis 2008;25:843-54.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 843-854
    • Thomson, S.1    Petti, F.2    Sujka-Kwok, I.3    Epstein, D.4    Haley, J.D.5
  • 5
    • 77957273623 scopus 로고    scopus 로고
    • TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
    • Yao Z, Fenoglio S, Gao DC, Camiolo M, Stiles B, Lindsted T, et al. TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proc Natl Acad Sci U S A 2010;107:15535-40.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15535-15540
    • Yao, Z.1    Fenoglio, S.2    Gao, D.C.3    Camiolo, M.4    Stiles, B.5    Lindsted, T.6
  • 6
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 2003;3:807-21.
    • (2003) Nat Rev Cancer , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 8
    • 58149213801 scopus 로고    scopus 로고
    • Non-Smad pathways in TGF-beta signaling
    • Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res 2009;19:128-39.
    • (2009) Cell Res , vol.19 , pp. 128-139
    • Zhang, Y.E.1
  • 9
    • 84857037901 scopus 로고    scopus 로고
    • High transforming growth factor beta expression represents an important prognostic parameter for surgically resected non-small cell lung cancer
    • Sterlacci W, Wolf D, Savic S, Hilbe W, Schmid T, Jamnig H, et al. High transforming growth factor beta expression represents an important prognostic parameter for surgically resected non-small cell lung cancer. Hum Pathol 2012;43:339-49.
    • (2012) Hum Pathol , vol.43 , pp. 339-349
    • Sterlacci, W.1    Wolf, D.2    Savic, S.3    Hilbe, W.4    Schmid, T.5    Jamnig, H.6
  • 11
    • 80054829319 scopus 로고    scopus 로고
    • Elucidating the mechanism of regulation of transforming growth factor beta Type II receptor expression in human lung cancer cell lines
    • Halder SK, Cho YJ, Datta A, Anumanthan G, Ham AJ, Carbone DP, et al. Elucidating the mechanism of regulation of transforming growth factor beta Type II receptor expression in human lung cancer cell lines. Neoplasia 2011;13:912-22.
    • (2011) Neoplasia , vol.13 , pp. 912-922
    • Halder, S.K.1    Cho, Y.J.2    Datta, A.3    Anumanthan, G.4    Ham, A.J.5    Carbone, D.P.6
  • 12
    • 84859862408 scopus 로고    scopus 로고
    • Loss of transforming growth factor beta type II receptor increases aggressive tumor behavior and reduces survival in lung adenocarcinoma and squamous cell carcinoma
    • Malkoski SP, Haeger SM, Cleaver TG, Rodriguez KJ, Li H, Lu SL, et al. Loss of transforming growth factor beta type II receptor increases aggressive tumor behavior and reduces survival in lung adenocarcinoma and squamous cell carcinoma. Clin Cancer Res 2012;18:2173-83.
    • (2012) Clin Cancer Res , vol.18 , pp. 2173-2183
    • Malkoski, S.P.1    Haeger, S.M.2    Cleaver, T.G.3    Rodriguez, K.J.4    Li, H.5    Lu, S.L.6
  • 13
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 2012;22:725-36.
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 14
    • 84873811988 scopus 로고    scopus 로고
    • Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition
    • Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, et al. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science 2013;339:580-4.
    • (2013) Science , vol.339 , pp. 580-584
    • Yu, M.1    Bardia, A.2    Wittner, B.S.3    Stott, S.L.4    Smas, M.E.5    Ting, D.T.6
  • 15
    • 9244251007 scopus 로고    scopus 로고
    • Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin
    • Roche J, Boldog F, Robinson M, Robinson L, Varella-Garcia M, Swanton M, et al. Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin. Oncogene 1996;12:1289-97.
    • (1996) Oncogene , vol.12 , pp. 1289-1297
    • Roche, J.1    Boldog, F.2    Robinson, M.3    Robinson, L.4    Varella-Garcia, M.5    Swanton, M.6
  • 17
    • 84875626156 scopus 로고    scopus 로고
    • Semaphorins in cancer: Biological mechanisms and therapeutic approaches
    • Rehman M, Tamagnone L. Semaphorins in cancer: biological mechanisms and therapeutic approaches. Semin Cell Dev Biol 2013;24:179-89.
    • (2013) Semin Cell Dev Biol , vol.24 , pp. 179-189
    • Rehman, M.1    Tamagnone, L.2
  • 19
    • 0342872023 scopus 로고    scopus 로고
    • Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III
    • Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron 1997;19:547-59.
    • (1997) Neuron , vol.19 , pp. 547-559
    • Chen, H.1    Chedotal, A.2    He, Z.3    Goodman, C.S.4    Tessier-Lavigne, M.5
  • 20
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998;92:735-45.
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 21
    • 0032215144 scopus 로고    scopus 로고
    • Neuropilin-2 is a receptor for semaphorin IV: Insight into the structural basis of receptor function and specificity
    • Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. Neuron 1998;21:1079-92.
    • (1998) Neuron , vol.21 , pp. 1079-1092
    • Giger, R.J.1    Urquhart, E.R.2    Gillespie, S.K.3    Levengood, D.V.4    Ginty, D.D.5    Kolodkin, A.L.6
  • 22
    • 56349094235 scopus 로고    scopus 로고
    • Semaphorins and their receptors in lung cancer
    • Potiron VA, Roche J, Drabkin HA. Semaphorins and their receptors in lung cancer. Cancer Lett 2009;273:1-14.
    • (2009) Cancer Lett , vol.273 , pp. 1-14
    • Potiron, V.A.1    Roche, J.2    Drabkin, H.A.3
  • 24
    • 0031790633 scopus 로고    scopus 로고
    • Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites
    • Johannes G, Sarnow P. Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites. RNA 1998;4:1500-13.
    • (1998) RNA , vol.4 , pp. 1500-1513
    • Johannes, G.1    Sarnow, P.2
  • 25
    • 80054729670 scopus 로고    scopus 로고
    • Inducible expression of TGFbeta, snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model
    • Argast GM, Krueger JS, Thomson S, Sujka-Kwok I, Carey K, Silva S, et al. Inducible expression of TGFbeta, snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model. Clin Exp Metastasis 2011;28:593-614.
    • (2011) Clin Exp Metastasis , vol.28 , pp. 593-614
    • Argast, G.M.1    Krueger, J.S.2    Thomson, S.3    Sujka-Kwok, I.4    Carey, K.5    Silva, S.6
  • 26
    • 79953325707 scopus 로고    scopus 로고
    • Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition
    • Dave N, Guaita-Esteruelas S, Gutarra S, Frias A, Beltran M, Peiro S, et al. Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J Biol Chem 2011;286:12024-32.
    • (2011) J Biol Chem , vol.286 , pp. 12024-12032
    • Dave, N.1    Guaita-Esteruelas, S.2    Gutarra, S.3    Frias, A.4    Beltran, M.5    Peiro, S.6
  • 27
    • 77957787219 scopus 로고    scopus 로고
    • Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype
    • Cao Y, Szabolcs A, Dutta SK, Yaqoob U, Jagavelu K, Wang L, et al. Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype. J Biol Chem 2010;285:31840-8.
    • (2010) J Biol Chem , vol.285 , pp. 31840-31848
    • Cao, Y.1    Szabolcs, A.2    Dutta, S.K.3    Yaqoob, U.4    Jagavelu, K.5    Wang, L.6
  • 28
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague J. TGFbeta in cancer. Cell 2008;134:215-30.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 29
    • 0037093230 scopus 로고    scopus 로고
    • High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer
    • Bremnes RM, Veve R, Gabrielson E, Hirsch FR, Baron A, Bemis L, et al. High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. J Clin Oncol 2002;20:2417-28.
    • (2002) J Clin Oncol , vol.20 , pp. 2417-2428
    • Bremnes, R.M.1    Veve, R.2    Gabrielson, E.3    Hirsch, F.R.4    Baron, A.5    Bemis, L.6
  • 30
    • 0038010147 scopus 로고    scopus 로고
    • Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines
    • Lantuejoul S, Constantin B, Drabkin H, Brambilla C, Roche J, Brambilla E. Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines. J Pathol 2003;200:336-47.
    • (2003) J Pathol , vol.200 , pp. 336-347
    • Lantuejoul, S.1    Constantin, B.2    Drabkin, H.3    Brambilla, C.4    Roche, J.5    Brambilla, E.6
  • 32
    • 78650073575 scopus 로고    scopus 로고
    • Prediction of human targets for viral-encoded microRNAs by thermodynamics and empirical constraints
    • Lagana A, Forte S, Russo F, Giugno R, Pulvirenti A, Ferro A. Prediction of human targets for viral-encoded microRNAs by thermodynamics and empirical constraints. J RNAi Gene Silencing 2010;6:379-85.
    • (2010) J RNAi Gene Silencing , vol.6 , pp. 379-385
    • Lagana, A.1    Forte, S.2    Russo, F.3    Giugno, R.4    Pulvirenti, A.5    Ferro, A.6
  • 33
    • 77649261101 scopus 로고    scopus 로고
    • TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI
    • Chaudhury A, Hussey GS, Ray PS, Jin G, Fox PL, Howe PH. TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat Cell Biol 2010;12:286-93.
    • (2010) Nat Cell Biol , vol.12 , pp. 286-293
    • Chaudhury, A.1    Hussey, G.S.2    Ray, P.S.3    Jin, G.4    Fox, P.L.5    Howe, P.H.6
  • 34
    • 34548386720 scopus 로고    scopus 로고
    • TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA
    • Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, et al. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J 2007;26:3957-67.
    • (2007) EMBO J , vol.26 , pp. 3957-3967
    • Lee, M.K.1    Pardoux, C.2    Hall, M.C.3    Lee, P.S.4    Warburton, D.5    Qing, J.6
  • 35
    • 26444560222 scopus 로고    scopus 로고
    • Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways
    • Davies M, Robinson M, Smith E, Huntley S, Prime S, Paterson I. Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways. J Cell Biochem 2005;95:918-31.
    • (2005) J Cell Biochem , vol.95 , pp. 918-931
    • Davies, M.1    Robinson, M.2    Smith, E.3    Huntley, S.4    Prime, S.5    Paterson, I.6
  • 36
    • 77955924885 scopus 로고    scopus 로고
    • Heterodimerization with Fra-1 cooperates with the ERK pathway to stabilize c-Jun in response to the RAS oncoprotein
    • Talotta F, Mega T, Bossis G, Casalino L, Basbous J, Jariel-Encontre I, et al. Heterodimerization with Fra-1 cooperates with the ERK pathway to stabilize c-Jun in response to the RAS oncoprotein. Oncogene 2010;29:4732-40.
    • (2010) Oncogene , vol.29 , pp. 4732-4740
    • Talotta, F.1    Mega, T.2    Bossis, G.3    Casalino, L.4    Basbous, J.5    Jariel-Encontre, I.6
  • 37
    • 0031756337 scopus 로고    scopus 로고
    • Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells
    • Kustikova O, Kramerov D, Grigorian M, Berezin V, Bock E, Lukanidin E, et al. Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells. Mol Cell Biol 1998;18:7095-105.
    • (1998) Mol Cell Biol , vol.18 , pp. 7095-7105
    • Kustikova, O.1    Kramerov, D.2    Grigorian, M.3    Berezin, V.4    Bock, E.5    Lukanidin, E.6
  • 38
    • 77950353276 scopus 로고    scopus 로고
    • ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events
    • Shin S, Dimitri CA, Yoon SO, Dowdle W, Blenis J. ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Mol Cell 2010;38:114-27.
    • (2010) Mol Cell , vol.38 , pp. 114-127
    • Shin, S.1    Dimitri, C.A.2    Yoon, S.O.3    Dowdle, W.4    Blenis, J.5
  • 39
    • 78651102047 scopus 로고    scopus 로고
    • TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression
    • Bandyopadhyay B, Han A, Dai J, Fan J, Li Y, Chen M, et al. TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression. J Cell Sci 2011;124:19-24.
    • (2011) J Cell Sci , vol.124 , pp. 19-24
    • Bandyopadhyay, B.1    Han, A.2    Dai, J.3    Fan, J.4    Li, Y.5    Chen, M.6
  • 40
    • 15444372825 scopus 로고    scopus 로고
    • Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase
    • Yi JY, Shin I, Arteaga CL. Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem 2005;280:10870-6.
    • (2005) J Biol Chem , vol.280 , pp. 10870-10876
    • Yi, J.Y.1    Shin, I.2    Arteaga, C.L.3
  • 41
    • 78650510746 scopus 로고    scopus 로고
    • Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-beta-induced epithelial-mesenchymal transition
    • Lamouille S, Derynck R. Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-beta-induced epithelial-mesenchymal transition. Cells Tissues Organs 2011;193:8-22.
    • (2011) Cells Tissues Organs , vol.193 , pp. 8-22
    • Lamouille, S.1    Derynck, R.2
  • 42
    • 22244476115 scopus 로고    scopus 로고
    • The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
    • Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG Jr. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell 2005;8:25-33.
    • (2005) Cancer Cell , vol.8 , pp. 25-33
    • Wei, W.1    Jin, J.2    Schlisio, S.3    Harper, J.W.4    Kaelin Jr., W.G.5
  • 43
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007;7:415-28.
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 44
    • 31544452076 scopus 로고    scopus 로고
    • Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
    • Witta SE, Gemmill RM, Hirsch FR, Coldren CD, Hedman K, Ravdel L, et al. Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res 2006;66:944-50.
    • (2006) Cancer Res , vol.66 , pp. 944-950
    • Witta, S.E.1    Gemmill, R.M.2    Hirsch, F.R.3    Coldren, C.D.4    Hedman, K.5    Ravdel, L.6
  • 45
    • 84876432144 scopus 로고    scopus 로고
    • Global decrease of histone H3K27 acetylation in ZEB1-induced epithelial to mesenchymal transition in lung cancer cells
    • Roche J, Nasarre P, Gemmill R, Baldys A, Pontis J, Korch C, et al. Global decrease of histone H3K27 acetylation in ZEB1-induced epithelial to mesenchymal transition in lung cancer cells. Cancers 2013;5:334-56.
    • (2013) Cancers , vol.5 , pp. 334-356
    • Roche, J.1    Nasarre, P.2    Gemmill, R.3    Baldys, A.4    Pontis, J.5    Korch, C.6
  • 46
    • 79955954699 scopus 로고    scopus 로고
    • An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
    • Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, et al. An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell 2011;22:1686-98.
    • (2011) Mol Biol Cell , vol.22 , pp. 1686-1698
    • Gregory, P.A.1    Bracken, C.P.2    Smith, E.3    Bert, A.G.4    Wright, J.A.5    Roslan, S.6
  • 47
    • 0033575194 scopus 로고    scopus 로고
    • SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5′-CACCT sequences in candidate target genes
    • Verschueren K, Remacle JE, Collart C, Kraft H, Baker BS, Tylzanowski P, et al. SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5′-CACCT sequences in candidate target genes. J Biol Chem 1999;274:20489-98.
    • (1999) J Biol Chem , vol.274 , pp. 20489-20498
    • Verschueren, K.1    Remacle, J.E.2    Collart, C.3    Kraft, H.4    Baker, B.S.5    Tylzanowski, P.6
  • 48
    • 0033568198 scopus 로고    scopus 로고
    • New mode of DNA binding of multi-zinc finger transcription factors: DeltaEF1 family members bind with two hands to two target sites
    • Remacle JE, Kraft H, Lerchner W, Wuytens G, Collart C, Verschueren K, et al. New mode of DNA binding of multi-zinc finger transcription factors: deltaEF1 family members bind with two hands to two target sites. EMBO J 1999;18:5073-84.
    • (1999) EMBO J , vol.18 , pp. 5073-5084
    • Remacle, J.E.1    Kraft, H.2    Lerchner, W.3    Wuytens, G.4    Collart, C.5    Verschueren, K.6
  • 49
    • 0038324070 scopus 로고    scopus 로고
    • Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
    • Postigo AA, Depp JL, Taylor JJ, Kroll KL. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J 2003;22:2453-62.
    • (2003) EMBO J , vol.22 , pp. 2453-2462
    • Postigo, A.A.1    Depp, J.L.2    Taylor, J.J.3    Kroll, K.L.4
  • 51
    • 85047693077 scopus 로고    scopus 로고
    • Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype
    • Bielenberg DR, Hida Y, Shimizu A, Kaipainen A, Kreuter M, Kim CC, et al. Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. J Clin Invest 2004;114:1260-71.
    • (2004) J Clin Invest , vol.114 , pp. 1260-1271
    • Bielenberg, D.R.1    Hida, Y.2    Shimizu, A.3    Kaipainen, A.4    Kreuter, M.5    Kim, C.C.6
  • 52
    • 84857119664 scopus 로고    scopus 로고
    • Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer progression
    • Wendt MK, Tian M, Schiemann WP. Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer progression. Cell Tissue Res 2012;347:85-101.
    • (2012) Cell Tissue Res , vol.347 , pp. 85-101
    • Wendt, M.K.1    Tian, M.2    Schiemann, W.P.3
  • 53
    • 1842479071 scopus 로고    scopus 로고
    • Defective expression of transforming growth factor beta receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer
    • Zhang HT, Chen XF, Wang MH, Wang JC, Qi QY, Zhang RM, et al. Defective expression of transforming growth factor beta receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer. Clin Cancer Res 2004;10:2359-67.
    • (2004) Clin Cancer Res , vol.10 , pp. 2359-2367
    • Zhang, H.T.1    Chen, X.F.2    Wang, M.H.3    Wang, J.C.4    Qi, Q.Y.5    Zhang, R.M.6
  • 54
    • 84870020040 scopus 로고    scopus 로고
    • MED12 controls the response to multiple cancer drugs through regulation of TGF-beta receptor signaling
    • Huang S, Holzel M, Knijnenburg T, Schlicker A, Roepman P, McDermott U, et al. MED12 controls the response to multiple cancer drugs through regulation of TGF-beta receptor signaling. Cell 2012;151:937-50.
    • (2012) Cell , vol.151 , pp. 937-950
    • Huang, S.1    Holzel, M.2    Knijnenburg, T.3    Schlicker, A.4    Roepman, P.5    McDermott, U.6
  • 55
    • 84870816403 scopus 로고    scopus 로고
    • Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
    • Ocana OH, Corcoles R, Fabra A, Moreno-Bueno G, Acloque H, Vega S, et al. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 2012;22:709-24.
    • (2012) Cancer Cell , vol.22 , pp. 709-724
    • Ocana, O.H.1    Corcoles, R.2    Fabra, A.3    Moreno-Bueno, G.4    Acloque, H.5    Vega, S.6
  • 56
    • 79959806137 scopus 로고    scopus 로고
    • Neuropilin-2 expression promotes TGF-beta1-mediated epithelial to mesenchymal transition in colorectal cancer cells
    • Grandclement C, Pallandre JR, Valmary Degano S, Viel E, Bouard A, Balland J, et al. Neuropilin-2 expression promotes TGF-beta1-mediated epithelial to mesenchymal transition in colorectal cancer cells. PLoS OONE 2011;6:e20444.
    • (2011) PLoS OONE , vol.6
    • Grandclement, C.1    Pallandre, J.R.2    Valmary Degano, S.3    Viel, E.4    Bouard, A.5    Balland, J.6
  • 57
    • 38449095310 scopus 로고    scopus 로고
    • Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver
    • Gray MJ, Van Buren G, Dallas NA, Xia L, Wang X, Yang AD, et al. Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver. J Natl Cancer Inst 2008;100:109-20.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 109-120
    • Gray, M.J.1    Van Buren, G.2    Dallas, N.A.3    Xia, L.4    Wang, X.5    Yang, A.D.6
  • 58
    • 58149356250 scopus 로고    scopus 로고
    • Neuropilin-2-mediated tumor growth and angiogenesis in pancreatic adenocarcinoma
    • Dallas NA, Gray MJ, Xia L, Fan F, van Buren G II, Gaur P, et al. Neuropilin-2-mediated tumor growth and angiogenesis in pancreatic adenocarcinoma. Clin Cancer Res 2008;14:8052-60.
    • (2008) Clin Cancer Res , vol.14 , pp. 8052-8060
    • Dallas, N.A.1    Gray, M.J.2    Xia, L.3    Fan, F.4    Van Buren II, G.5    Gaur, P.6
  • 59
    • 80054792520 scopus 로고    scopus 로고
    • Neuropilin-2 mediated beta-catenin signaling and survival in human gastro-intestinal cancer cell lines
    • Samuel S, Gaur P, Fan F, Xia L, Gray MJ, Dallas NA, et al. Neuropilin-2 mediated beta-catenin signaling and survival in human gastro-intestinal cancer cell lines. PLoS ONE 2011;6:e23208.
    • (2011) PLoS ONE , vol.6
    • Samuel, S.1    Gaur, P.2    Fan, F.3    Xia, L.4    Gray, M.J.5    Dallas, N.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.