Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 2, 2013, Pages 636-641

  Fitzmaurice, Arthur G ^a,b,c   Rhodes, Shannon L ^d   Lulla, Aaron ^c   Murphy, Niall P ^e   Lam, Hoa A ^e   O'Donnell, Kelley C ^c   Barnhill, Lisa ^c   Casida, John E ^f   Cockburn, Myles ^g   Sagasti, Alvaro ^c   Stahl, Mark C ^a   Maidment, Nigel T ^e   Ritz, Beate ^c,d   Bronstein, Jeff M ^a,c,h  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^h VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROXYPHENYLACETALDEHYDE; ALDEHYDE DEHYDROGENASE; BENOMYL; DOPAMINE DERIVATIVE; S METHYL N THIOCARBAMATE SULFOXIDE; THIOCARBAMATE SULFOXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; FEMALE; HOMEOSTASIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MESENCEPHALON; MOUSE; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; ZEBRA FISH;

3,4-DIHYDROXYPHENYLACETIC ACID; ALDEHYDE DEHYDROGENASE; ANIMALS; BENOMYL; DOPAMINERGIC NEURONS; FLOW CYTOMETRY; FUNGICIDES, INDUSTRIAL; HUMANS; LOGISTIC MODELS; MESENCEPHALON; MITOCHONDRIA; NERVE DEGENERATION; ODDS RATIO; PARKINSON DISEASE; RATS; ZEBRAFISH;

DANIO RERIO; MUS;

EID: 84872171338     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220399110     Document Type: Article

References (50)

1. Fearnley JM, Lees AJ (1991) Ageing and Parkinson's disease: Substantia nigra regional selectivity. Brain 114(Pt 5):2283-2301.
2. Nalls MA, et al.; International Parkinson Disease Genomics Consortium (2011) Imputation of sequence variants for identification of genetic risks for Parkinson's disease: A meta-analysis of genome-wide association studies. Lancet 377(9766):641-649.
3. Priyadarshi A, Khuder SA, Schaub EA, Priyadarshi SS (2001) Environmental risk factors and Parkinson's disease: A metaanalysis. Environ Res 86(2):122- 127.
4. Ascherio A, et al. (2006) Pesticide exposure and risk for Parkinson' s disease. Ann Neurol 60(2):197-203.
5. Firestone JA, et al. (2005) Pesticides and risk of Parkinson disease: A population-based case-control study. Arch Neurol 62(1):91-95.
6. Moisan F, et al. (2011) The relation between type of farming and prevalence of Parkinson's disease among agricultural workers in five French districts. Mov Disord 26(2):271-279.
7. Petrovitch H, et al. (2002) Plantation work and risk of Parkinson disease in a population- based longitudinal study. Arch Neurol 59(11):1787-1792.
8. Kamel F, et al. (2007) Pesticide exposure and self-reported Parkinson's disease in the agricultural health study. Am J Epidemiol 165(4):364-374.
9. Tanner CM, et al. (2011) Rotenone, paraquat, and Parkinson's disease. Environ Health Perspect 119(6):866-872.
10. Dhillon AS, et al. (2008) Pesticide/environmental exposures and Parkinson's disease in East Texas. J Agromed 13(1):37-48.
11. Hancock DB, Martin ER, Vance JM, Scott WK (2008) Nitric oxide synthase genes and their interactionswith environmental factors in Parkinson's disease. Neurogenetics 9(4):249-262.
12. Elbaz A, et al. (2004) CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease. Ann Neurol 55(3):430-434.
13. Hatcher JM, Pennell KD, Miller GW (2008) Parkinson's disease and pesticides: a toxicological perspective. Trends Pharmacol Sci 29(6):322-329.
14. Environmental Protection Agency (2001) Benomyl's cancellation order. Fed Regist 66: 41589-41591.
15. Gupta K, et al. (2004) Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin. Biochemistry 43(21):6645-6655.
16. Ren Y, Liu W, Jiang H, Jiang Q, Feng J (2005) Selective vulnerability of dopaminergic neurons to microtubule depolymerization. J Biol Chem 280(40):34105-34112.
17. Chou AP, Li S, Fitzmaurice AG, Bronstein JM (2010) Mechanisms of rotenone-induced proteasome inhibition. Neurotoxicology 31(4):367-372.
18. Staub RE, Quistad GB, Casida JE (1998) Mechanism for benomyl action as a mitochondrial aldehyde dehydrogenase inhibitor in mice. Chem Res Toxicol 11(5):535-543.
19. Leiphon LJ, Picklo MJ, Sr. (2007) Inhibition of aldehyde detoxification in CNS mitochondria by fungicides. Neurotoxicology 28(1):143-149.
20. Marchitti SA, Deitrich RA, Vasiliou V (2007) Neurotoxicity and metabolism of the catecholamine- derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: The role of aldehyde dehydrogenase. Pharmacol Rev 59(2):125-150.
21. Burke WJ, et al. (2004) Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: Role in neurodegenerative diseases. Neurotoxicology 25(1-2):101-115.
22. Burke WJ, Li SW, Williams EA, Nonneman R, Zahm DS (2003) 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo : Implications for Parkinson's disease pathogenesis. Brain Res 989(2):205-213.
23. Panneton WM, Kumar VB, Gan Q, Burke WJ, Galvin JE (2010) The neurotoxicity of DOPAL: Behavioral and stereological evidence for its role in Parkinson disease pathogenesis. PLoS ONE 5(12):e15251.
24. Wang XF, Li S, Chou AP, Bronstein JM (2006) Inhibitory effects of pesticides on proteasome activity: Implication in Parkinson' s disease. Neurobiol Dis 23(1):198-205.
25. Levin ED, Tanguay RL (2011) Introduction to zebrafish: Current discoveries and emerging technologies for neurobehavioral toxicology and teratology. Neurotoxicol Teratol 33(6):607.
26. Wen L, et al. (2008) Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish. Dev Biol 314(1):84-92.
27. Holzschuh J, Ryu S, Aberger F, Driever W (2001) Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Mech Dev 101(1-2):237-243.
28. Sagasti A, Guido MR, Raible DW, Schier AF (2005) Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arbors. Curr Biol 15(9):804-814.
29. Morpurgo G, Bellincampi D, Gualandi G, Baldinelli L, Crescenzi OS (1979) Analysis of mitotic nondisjunction with Aspergillus nidulans. Environ Health Perspect 31(1):81-95.
30. Oakley BR, Morris NR (1980) Nuclear movement is beta-tubulin-dependent in Aspergillus nidulans. Cell 19(1):255 -262.
31. Boubaker H, Saadi B, Boudyach EH, Benaoumar AA (2008) Resistance of Verticillium theobromae to benzimidazole fungicides in Morocco. J Appl Sci 8(21):3903-3909.
32. Potocnik I, et al. (2009) In vitro toxicity of selected fungicides from the groups of benzimidazoles and demethylation inhibitors to Cladobotryum dendroides and Agaricus bisporus. J Environ Sci Health B 44(4):365-370.
33. Kataria HR, Grover RK (1976) Effect of benomyl and thiophanate-methyl on metabolic activities of Rhizoctonia solani Kühn. Ann Microbiol (Paris) 127A(2):297-306.
34. Wey MC, et al. (2012) Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease. PLoS ONE 7(2):e31522.
35. Chou AP, et al. (2008) Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome. J Biol Chem 283(50):34696-34703.
36. Goldstein DS, et al. (2011) Catechols in post-mortem brain of patients with Parkinson disease. Eur J Neurol 18(5):703-710.
37. Goldstein DS, Holmes C, Kopin IJ, Sharabi Y (2011) Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases. J Clin Invest 121(8):3320-3330.
38. Anderson DG, Mariappan SV, Buettner GR, Doorn JA (2011) Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone. J Biol Chem 286(30):26978-26986.
39. Gatto NM, Cockburn M, Bronstein J, Manthripragada AD, Ritz B (2009) Well-water consumption and Parkinson's disease in rural California. Environ Health Perspect 117(12):1912-1918.
40. Goldman SM, et al. (2012) Solvent exposures and Parkinson disease risk in twins. Ann Neurol 71(6):776-784.
41. Tanaka K, et al. (2011) Occupational risk factors for Parkinson's disease: A case-control study in Japan. BMC Neurol 11(83):1-6.
42. Costello S, Cockburn M, Bronstein J, Zhang X, Ritz B (2009) Parkinson' s disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California. Am J Epidemiol 169(8):919-926.
43. Wang A, et al. (2011) Parkinson's disease risk from ambient exposure to pesticides. Eur J Epidemiol 26(7):547-555.
44. Quistad GB, Sparks SE, Casida JE (1994) Aldehyde dehydrogenase of mice inhibited by thiocarbamate herbicides. Life Sci 55(20):1537-1544.
45. Tottmar SO, Pettersson H, Kiessling KH (1973) The subcellular distribution and properties of aldehyde dehydrogenases in rat liver. Biochem J 135(4):577-586.
46. Bence NF, Sampat RM, Kopito RR (2001) Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292(5521):1552-1555.
47. Rayport S, et al. (1992) Identified postnatal mesolimbic dopamine neurons in culture: Morphology and electrophysiology. J Neurosci 12(11):4264-4280.
48. Ritz BR, et al. (2009) Dopamine transporter genetic variants and pesticides in Parkinson's disease. Environ Health Perspect 117(6):964-969.
49. Goldberg DW, Wilson JP, Knoblock CA, Ritz B, Cockburn MG (2008) An effective and efficient approach formanually improving geocoded data. Int J Health Geogr 7(60):1-20.
50. Rull RP, Ritz B (2003) Historical pesticide exposure in California using pesticide use reports and land-use surveys: An assessment of misclassification error and bias. Environ Health Perspect 111(13):1582-1589.