P38MAPK-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling

Free Radical Biology and Medicine

Volumn 67, Issue , 2014, Pages 292-303

  Rubio, Noemí ^a,b   Verrax, Julien ^a   Dewaele, Michael ^a   Verfaillie, Tom ^a   Johansen, Terje ^c   Piette, Jacques ^b   Agostinis, Patrizia ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Autophagy; ER stress; Free radicals; NBR1; p62; PDT; Photodynamic stress; Proteotoxicity; ROS

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; HYPERICIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NEIGHBOR OF BRCA1 PROTEIN 1; PHOSPHOPROTEIN; PROTEIN P62; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UBIQUITIN; UNCLASSIFIED DRUG; NBR1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; P62 PROTEIN, HUMAN; PERYLENE; PROTEIN; PROTEIN AGGREGATE; PROTEIN KINASE INHIBITOR; RADIOSENSITIZING AGENT; RNA BINDING PROTEIN;

ARTICLE; AUTOPHAGY; CANCER CELL; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; HELA CELL LINE; LIGHT; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; PROTEIN DEGRADATION; RADIATION RESPONSE;

ANIMALS; AUTOPHAGY; CELL LINE; FIBROBLASTS; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; HELA CELLS; HUMANS; LIGHT; MICE; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PERYLENE; PROTEIN AGGREGATES; PROTEIN KINASE INHIBITORS; PROTEINS; PROTEOLYSIS; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 84889968303     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.11.010     Document Type: Article

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