-
2
-
-
67649687039
-
An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease
-
Moreira PI, Duarte AI, Santos MS, Rego AC, Oliveira CR (2009) An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease. J Alzheimers Dis 16, 741-761.
-
(2009)
J Alzheimers Dis
, vol.16
, pp. 741-761
-
-
Moreira, P.I.1
Duarte, A.I.2
Santos, M.S.3
Rego, A.C.4
Oliveira, C.R.5
-
3
-
-
66249141245
-
Age, neuropathology, and dementia
-
Medical Research Council Cognitive F
-
Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C, Medical Research Council Cognitive F, Ageing S (2009) Age, neuropathology, and dementia. N Engl J Med 360, 2302-2309.
-
(2009)
N Engl J Med
, vol.360
, pp. 2302-2309
-
-
Savva, G.M.1
Wharton, S.B.2
Ince, P.G.3
Forster, G.4
Matthews, F.E.5
Brayne, C.6
Ageing, S.7
-
4
-
-
84863337843
-
Alzheimer mechanisms and therapeutic strategies
-
Huang Y, Mucke L (2012) Alzheimer mechanisms and therapeutic strategies. Cell 148, 1204-1222.
-
(2012)
Cell
, vol.148
, pp. 1204-1222
-
-
Huang, Y.1
Mucke, L.2
-
5
-
-
79960896430
-
Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
-
Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2011) Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. J Pathol 225, 54-62.
-
(2011)
J Pathol
, vol.225
, pp. 54-62
-
-
Liu, Y.1
Liu, F.2
Grundke-Iqbal, I.3
Iqbal, K.4
Gong, C.X.5
-
6
-
-
77956183989
-
Current challenges for the early detection of Alzheimer's disease: Brain imaging and CSF studies
-
Mistur R, Mosconi L, Santi SD, Guzman M, Li Y, TsuiW, de Leon MJ (2009) Current challenges for the early detection of Alzheimer's disease: Brain imaging and CSF studies. J Clin Neurol 5, 153-166.
-
(2009)
J Clin Neurol
, vol.5
, pp. 153-166
-
-
Mistur, R.1
Mosconi, L.2
Santi, S.D.3
Guzman, M.4
Li, Y.5
Tsui, W.6
De Leon, M.J.7
-
7
-
-
15244350991
-
Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer's disease
-
de la Monte SM, Wands JR (2005) Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer's disease. J Alzheimers Dis 7, 45-61. (Pubitemid 40387184)
-
(2005)
Journal of Alzheimer's Disease
, vol.7
, Issue.1
, pp. 45-61
-
-
De La Monte, S.M.1
Wands, J.R.2
-
8
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - Is this type 3 diabetes?
-
Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM (2005) Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes J Alzheimers Dis 7, 63-80. (Pubitemid 40387185)
-
(2005)
Journal of Alzheimer's Disease
, vol.7
, Issue.1
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
Cannon, J.L.4
Neely, T.R.5
Tavares, R.6
Xu, X.J.7
Wands, J.R.8
De La Monte, S.M.9
-
9
-
-
79952449386
-
Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease
-
Correia SC, Santos RX, Perry G, Zhu X, Moreira PI, Smith MA (2011) Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease Ageing Res Rev 10, 264-273.
-
(2011)
Ageing Res Rev
, vol.10
, pp. 264-273
-
-
Correia, S.C.1
Santos, R.X.2
Perry, G.3
Zhu, X.4
Moreira, P.I.5
Ma, S.6
-
10
-
-
33645960672
-
Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer's disease
-
Lester-Coll N, Rivera EJ, Soscia SJ, Doiron K, Wands JR, de la Monte SM (2006) Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer's disease. J Alzheimers Dis 9, 13-33.
-
(2006)
J Alzheimers Dis
, vol.9
, pp. 13-33
-
-
Lester-Coll, N.1
Rivera, E.J.2
Soscia, S.J.3
Doiron, K.4
Wands, J.R.5
De La Monte, S.M.6
-
11
-
-
0027391758
-
The cellular and physiological actions of insulin in the central nervous system
-
Wozniak M, Rydzewski B, Baker SP, Raizada MK (1993) The cellular and physiological actions of insulin in the central nervous system. Neurochem Int 22, 1-10.
-
(1993)
Neurochem Int
, vol.22
, pp. 1-10
-
-
Wozniak, M.1
Rydzewski, B.2
Baker, S.P.3
Raizada, M.K.4
-
12
-
-
1842633872
-
Insulin and the insulin receptor in experimental models of learning and memory
-
DOI 10.1016/j.ejphar.2004.02.045, PII S001429990400202X
-
Zhao WQ, Chen H, Quon MJ, Alkon DL (2004) Insulin and the insulin receptor in experimental models of learning and memory. Eur J Pharmacol 490, 71-81. (Pubitemid 38482161)
-
(2004)
European Journal of Pharmacology
, vol.490
, Issue.1-3
, pp. 71-81
-
-
Zhao, W.-Q.1
Chen, H.2
Quon, M.J.3
Alkon, D.L.4
-
13
-
-
75249106915
-
Insulin is a two-edged knife on the brain
-
Cardoso S, Correia S, Santos RX, Carvalho C, Santos MS, Oliveira CR, Perry G, Smith MA, Zhu X, Moreira PI (2009) Insulin is a two-edged knife on the brain. J Alzheimers Dis 18, 483-507.
-
(2009)
J Alzheimers Dis
, vol.18
, pp. 483-507
-
-
Cardoso, S.1
Correia, S.2
Santos, R.X.3
Carvalho, C.4
Santos, M.S.5
Oliveira, C.R.6
Perry, G.7
Smith, M.A.8
Zhu, X.9
Moreira, P.I.10
-
14
-
-
38449088511
-
Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: An experimental approach
-
Salkovic-Petrisic M, Hoyer S (2007) Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: An experimental approach. J Neural Transm Suppl, 217-233.
-
(2007)
J Neural Transm Suppl
, pp. 217-233
-
-
Salkovic-Petrisic, M.1
Hoyer, S.2
-
15
-
-
74949100388
-
Modeling sporadic Alzheimer's disease: The insulin resistant brain state generates multiple long-term morphobiological abnormalities including hyperphosphorylated tau protein and amyloid-beta
-
Salkovic-Petrisic M, Osmanovic J, Grunblatt E, Riederer P, Hoyer S (2009) Modeling sporadic Alzheimer's disease: The insulin resistant brain state generates multiple long-term morphobiological abnormalities including hyperphosphorylated tau protein and amyloid-beta. J Alzheimers Dis 18, 729-750.
-
(2009)
J Alzheimers Dis
, vol.18
, pp. 729-750
-
-
Salkovic-Petrisic, M.1
Osmanovic, J.2
Grunblatt, E.3
Riederer, P.4
Hoyer, S.5
-
16
-
-
79960787962
-
Spatial distribution of glucose hypometabolism induced by intracerebroventricular streptozotocin in monkeys
-
Heo JH, Lee SR, Lee ST, Lee KM, Oh JH, Jang DP, Chang KT, Cho ZH (2011) Spatial distribution of glucose hypometabolism induced by intracerebroventricular streptozotocin in monkeys. J Alzheimers Dis 25, 517-523.
-
(2011)
J Alzheimers Dis
, vol.25
, pp. 517-523
-
-
Heo, J.H.1
Lee, S.R.2
Lee, S.T.3
Lee, K.M.4
Oh, J.H.5
Jang, D.P.6
Chang, K.T.7
Zh, C.8
-
17
-
-
0033990048
-
Primer3 on the WWW for general users and for biologist programmers
-
Rozen S, Skaletsky H (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132, 365-386.
-
(2000)
Methods Mol Biol
, vol.132
, pp. 365-386
-
-
Rozen, S.1
Skaletsky, H.2
-
18
-
-
84860508679
-
Large-scale transcriptome sequencing and gene analyses in the crab-eating macaque (Macaca fascicularis) for biomedical research
-
Huh JW, Kim YH, Park SJ, Kim DS, Lee SR, Kim KM, Jeong KJ, Kim JS, Song BS, Sim BW, Kim SU, Kim SH, Chang KT (2012) Large-scale transcriptome sequencing and gene analyses in the crab-eating macaque (Macaca fascicularis) for biomedical research. BMC Genomics 13, 163.
-
(2012)
BMC Genomics
, vol.13
, pp. 163
-
-
Huh, J.W.1
Kim, Y.H.2
Park, S.J.3
Kim, D.S.4
Lee, S.R.5
Kim, K.M.6
Jeong, K.J.7
Kim, J.S.8
Song, B.S.9
Sim, B.W.10
Kim, S.U.11
Kim, S.H.12
Chang, K.T.13
-
19
-
-
84874009086
-
Selection of appropriate reference genes for RT-qPCR analysis in a streptozotocin-induced Alzheimer's disease model of cynomolgus monkeys (Macaca fascicularis)
-
Park SJ, Kim YH, Lee Y, Kim KM, Kim HS, Lee SR, Kim SU, Kim SH, Kim JS, Jeong KJ, Lee KM, Huh JW, Chang KT (2013) Selection of appropriate reference genes for RT-qPCR analysis in a streptozotocin-induced Alzheimer's disease model of cynomolgus monkeys (Macaca fascicularis). PLoS One 8, e56034.
-
(2013)
PLoS One
, vol.8
-
-
Park, S.J.1
Kim, Y.H.2
Lee, Y.3
Kim, K.M.4
Kim, H.S.5
Lee, S.R.6
Kim, S.U.7
Kim, S.H.8
Kim, J.S.9
Jeong, K.J.10
Lee, K.M.11
Huh, J.W.12
Chang, K.T.13
-
20
-
-
84857651914
-
Dorsal root ganglia isolated from Nf1+/-mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels
-
Hodgdon KE, Hingtgen CM, Nicol GD (2012) Dorsal root ganglia isolated from Nf1+/-mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels. Neuroscience 206, 237-244.
-
(2012)
Neuroscience
, vol.206
, pp. 237-244
-
-
Hodgdon, K.E.1
Hingtgen, C.M.2
Nicol, G.D.3
-
21
-
-
0036581160
-
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
-
Pfaffl MW, Horgan GW, Dempfle L (2002) Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30, e36.
-
(2002)
Nucleic Acids Res
, vol.30
-
-
Pfaffl, M.W.1
Horgan, G.W.2
Dempfle, L.3
-
22
-
-
44949231424
-
T method
-
DOI 10.1038/nprot.2008.73, PII NPROT.2008.73
-
Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3, 1101-1108. (Pubitemid 351818697)
-
(2008)
Nature Protocols
, vol.3
, Issue.6
, pp. 1101-1108
-
-
Schmittgen, T.D.1
Livak, K.J.2
-
23
-
-
33644591150
-
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine
-
Rivera EJ, Goldin A, Fulmer N, Tavares R, Wands JR, de la Monte SM (2005) Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: Link to brain reductions in acetylcholine. J Alzheimers Dis 8, 247-268.
-
(2005)
J Alzheimers Dis
, vol.8
, pp. 247-268
-
-
Rivera, E.J.1
Goldin, A.2
Fulmer, N.3
Tavares, R.4
Wands, J.R.5
De La Monte, S.M.6
-
24
-
-
0026094583
-
HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to elav and sex-lethal
-
Szabo A, Dalmau J, ManleyG, Rosenfeld M,Wong E, Henson J, Posner JB, Furneaux HM (1991) HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. Cell 67, 325-333. (Pubitemid 121001448)
-
(1991)
Cell
, vol.67
, Issue.2
, pp. 325-333
-
-
Szabo, A.1
Dalmau, J.2
Manley, G.3
Rosenfeld, M.4
Wong, E.5
Henson, J.6
Posner, J.B.7
Furneaux, H.M.8
-
25
-
-
17344392308
-
A new mathematical model for relative quantification in real-time RT-PCR
-
Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29, e45.
-
(2001)
Nucleic Acids Res
, vol.29
-
-
Pfaffl, M.W.1
-
26
-
-
79251578040
-
A critical role for IGF-II in memory consolidation and enhancement
-
Chen DY, Stern SA, Garcia-Osta A, Saunier-Rebori B, Pollonini G, Bambah-Mukku D, Blitzer RD, AlberiniCM(2011) A critical role for IGF-II in memory consolidation and enhancement. Nature 469, 491-497.
-
(2011)
Nature
, vol.469
, pp. 491-497
-
-
Chen, D.Y.1
Stern, S.A.2
Garcia-Osta, A.3
Saunier-Rebori, B.4
Pollonini, G.5
Bambah-Mukku, D.6
Blitzer, R.D.7
Alberini, C.M.8
-
27
-
-
0027269766
-
Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice
-
DOI 10.1016/0896-6273(93)90173-O
-
Carson MJ, Behringer RR, Brinster RL, McMorris FA (1993) Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice. Neuron 10, 729-740. (Pubitemid 23127975)
-
(1993)
Neuron
, vol.10
, Issue.4
, pp. 729-740
-
-
Carson, M.J.1
Behringer, R.R.2
Brinster, R.L.3
McMorris, F.A.4
-
28
-
-
0028936950
-
Insulin-like growth factor-1 mRNA is increased in deafferented hippocampus: Spatiotemporal correspondence of a trophic event with axon sprouting
-
Guthrie KM, Nguyen T, Gall CM (1995) Insulin-like growth factor-1 mRNA is increased in deafferented hippocampus: Spatiotemporal correspondence of a trophic event with axon sprouting. J Comp Neurol 352, 147-160.
-
(1995)
J Comp Neurol
, vol.352
, pp. 147-160
-
-
Guthrie, K.M.1
Nguyen, T.2
Gall, C.M.3
-
30
-
-
0035967193
-
Neuronal synthesized insulin roles on neural differentiation within fetal rat neuron cell cultures
-
DOI 10.1016/S0165-3806(01)00110-9, PII S0165380601001109
-
Schechter R, AbboudM(2001) Neuronal synthesized insulin roles on neural differentiation within fetal rat neuron cell cultures. Brain Res Dev Brain Res 127, 41-49. (Pubitemid 32245736)
-
(2001)
Developmental Brain Research
, vol.127
, Issue.1
, pp. 41-49
-
-
Schechter, R.1
Abboud, M.2
-
31
-
-
0030583645
-
Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system
-
DOI 10.1016/0006-8993(96)00664-6, PII S0006899396006646
-
Schechter R, Beju D, GaffneyT, Schaefer F, WhetsellL(1996) Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system. Brain Res 736, 16-27. (Pubitemid 26356458)
-
(1996)
Brain Research
, vol.736
, Issue.1-2
, pp. 16-27
-
-
Schechter, R.1
Beju, D.2
Gaffney, T.3
Schaefer, F.4
Whetsell, L.5
-
32
-
-
0028310417
-
Insulin gene expression and insulin synthesis in mammalian neuronal cells
-
Devaskar SU, Giddings SJ, Rajakumar PA, Carnaghi LR, Menon RK, Zahm DS (1994) Insulin gene expression and insulin synthesis in mammalian neuronal cells. J Biol Chem 269, 8445-8454. (Pubitemid 24200266)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.11
, pp. 8445-8454
-
-
Devaskar, S.U.1
Giddings, S.J.2
Rajakumar, P.A.3
Carnaghi, L.R.4
Menon, R.K.5
Zahm, D.S.6
-
33
-
-
0022976762
-
Periventricular hypothalamic cells in the rat brain contain insulin mRNA
-
Young WS, 3rd (1986) Periventricular hypothalamic cells in the rat brain contain insulin mRNA. Neuropeptides 8, 93-97.
-
(1986)
Neuropeptides
, vol.8
, pp. 93-97
-
-
Young Iii., W.S.1
-
34
-
-
34247324303
-
Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein
-
DOI 10.1111/j.1471-4159.2006.04368.x
-
Grunblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S (2007) Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J Neurochem 101, 757-770. (Pubitemid 46633313)
-
(2007)
Journal of Neurochemistry
, vol.101
, Issue.3
, pp. 757-770
-
-
Grunblatt, E.1
Salkovic-Petrisic, M.2
Osmanovic, J.3
Riederer, P.4
Hoyer, S.5
-
35
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14, 837-842.
-
(2008)
Nat Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
Regan, C.M.11
Walsh, D.M.12
Sabatini, B.L.13
Selkoe, D.J.14
-
36
-
-
38049110692
-
Amyloid beta oligomers induce impairment of neuronal insulin receptors
-
Zhao WQ, De Felice FG, Fernandez S, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL (2008) Amyloid beta oligomers induce impairment of neuronal insulin receptors. FASEB J 22, 246-260.
-
(2008)
FASEB J
, vol.22
, pp. 246-260
-
-
Zhao, W.Q.1
De Felice, F.G.2
Fernandez, S.3
Chen, H.4
Lambert, M.P.5
Quon, M.J.6
Krafft, G.A.7
Klein, W.L.8
-
37
-
-
60549084867
-
Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Abeta oligomers
-
De Felice FG, Vieira MN, Bomfim TR, Decker H, Velasco PT, Lambert MP, Viola KL, Zhao WQ, Ferreira ST, Klein WL(2009) Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci USA 106, 1971-1976.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 1971-1976
-
-
De Felice, F.G.1
Vieira, M.N.2
Bomfim, T.R.3
Decker, H.4
Velasco, P.T.5
Lambert, M.P.6
Viola, K.L.7
Zhao, W.Q.8
Ferreira, S.T.9
Klein, W.L.10
-
38
-
-
0028348778
-
Insulin receptor substrate-1 (IRS-1) expression in rat brain
-
DOI 10.1210/en.134.4.1952
-
Baskin DG, Schwartz MW, Sipols AJ, D'Alessio DA, Goldstein BJ, White MF (1994) Insulin receptor substrate-1 (IRS-1) expression in rat brain. Endocrinology 134, 1952-1955. (Pubitemid 24110760)
-
(1994)
Endocrinology
, vol.134
, Issue.4
, pp. 1952-1955
-
-
Baskin, D.G.1
Schwartz, M.W.2
Sipols, A.J.3
D'Alessio, D.A.4
Goldstein, B.J.5
White, M.F.6
-
39
-
-
0025813375
-
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
-
Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E,Wilden PA, Cahill DA, Goldstein BJ, White MF (1991) Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352, 73-77. (Pubitemid 21896701)
-
(1991)
Nature
, vol.352
, Issue.6330
, pp. 73-77
-
-
Sun, X.J.1
Rothenberg, P.2
Kahn, C.R.3
Backer, J.M.4
Araki, E.5
Wilden, P.A.6
Cahill, D.A.7
Goldstein, B.J.8
White, M.F.9
-
40
-
-
0034513781
-
Insulin receptor substrate (IRS) transduction system: Distinct and overlapping signaling potential
-
DOI 10.1002/1520-7560(2000) 9999:9999<::AID-DMRR159>3.0.CO;2-8
-
Giovannone B, Scaldaferri ML, Federici M, Porzio O, Lauro D, Fusco A, Sbraccia P, Borboni P, Lauro R, Sesti G (2000) Insulin receptor substrate (IRS) transduction system: Distinct and overlapping signaling potential. Diabetes Metab Res Rev 16, 434-441. (Pubitemid 32066549)
-
(2000)
Diabetes/Metabolism Research and Reviews
, vol.16
, Issue.6
, pp. 434-441
-
-
Giovannone, B.1
Scaldaferri, M.L.2
Federici, M.3
Porzio, O.4
Lauro, D.5
Fusco, A.6
Sbraccia, P.7
Borboni, P.8
Lauro, R.9
Sesti, G.10
-
41
-
-
0037773543
-
Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling
-
DOI 10.1016/S0014-5793(03)00438-1
-
Johnston AM, Pirola L, Van Obberghen E (2003) Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling. FEBS Lett 546, 32-36. (Pubitemid 36789763)
-
(2003)
FEBS Letters
, vol.546
, Issue.1
, pp. 32-36
-
-
Johnston, A.M.1
Pirola, L.2
Van Obberghen, E.3
-
42
-
-
84859718265
-
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
-
Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, Fuino RL, Kawaguchi KR, Samoyedny AJ, Wilson RS, Arvanitakis Z, Schneider JA, Wolf BA, Bennett DA, Trojanowski JQ, Arnold SE (2012) Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 122, 1316-1338.
-
(2012)
J Clin Invest
, vol.122
, pp. 1316-1338
-
-
Talbot, K.1
Wang, H.Y.2
Kazi, H.3
Han, L.Y.4
Bakshi, K.P.5
Stucky, A.6
Fuino, R.L.7
Kawaguchi, K.R.8
Samoyedny, A.J.9
Wilson, R.S.10
Arvanitakis, Z.11
Schneider, J.A.12
Wolf, B.A.13
Bennett, D.A.14
Trojanowski, J.Q.15
Arnold, S.E.16
-
43
-
-
0032762661
-
Insulin signaling and action in fat cells: Associations with insulin resistance and type 2 diabetes
-
Smith U, Axelsen M, Carvalho E, Eliasson B, Jansson PA, Wesslau C (1999) Insulin signaling and action in fat cells: Associations with insulin resistance and type 2 diabetes. Ann N Y Acad Sci 892, 119-126.
-
(1999)
Ann N y Acad Sci
, vol.892
, pp. 119-126
-
-
Smith, U.1
Axelsen, M.2
Carvalho, E.3
Eliasson, B.4
Jansson, P.A.5
Wesslau, C.6
-
44
-
-
0029148591
-
Role of IRS-2 in insulin and cytokine signalling
-
Sun XJ, Wang LM, Zhang Y, Yenush L, Myers MG Jr, Glasheen E, Lane WS, Pierce JH, White MF (1995) Role of IRS-2 in insulin and cytokine signalling. Nature 377, 173-177.
-
(1995)
Nature
, vol.377
, pp. 173-177
-
-
Sun, X.J.1
Wang, L.M.2
Zhang, Y.3
Yenush, L.4
Myers Jr., M.G.5
Glasheen, E.6
Lane, W.S.7
Pierce, J.H.8
White, M.F.9
-
45
-
-
0030995946
-
The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family
-
DOI 10.1074/jbc.272.17.11439
-
Lavan BE, Lane WS, Lienhard GE (1997) The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family. J Biol Chem 272, 11439-11443. (Pubitemid 27184151)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.17
, pp. 11439-11443
-
-
Lavan, B.E.1
Lane, W.S.2
Lienhard, G.E.3
-
46
-
-
0036460322
-
Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans
-
DOI 10.1007/s00125-002-0945-z
-
Bjornholm M, He AR, Attersand A, Lake S, Liu SC, Lienhard GE, Taylor S, Arner P, Zierath JR (2002) Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans. Diabetologia 45, 1697-1702. (Pubitemid 35478139)
-
(2002)
Diabetologia
, vol.45
, Issue.12
, pp. 1697-1702
-
-
Bjornholm, M.1
He, A.R.2
Attersand, A.3
Lake, S.4
Liu, S.C.H.5
Lienhard, G.E.6
Taylor, S.7
Arner, P.8
Zierath, J.R.9
-
47
-
-
79951707099
-
Astrocytes: Implications for neuroinflammatory pathogenesis of Alzheimer's disease
-
Li C, Zhao R, Gao K,Wei Z, YinMY, Lau LT, Chui D, Hoi Yu AC (2011) Astrocytes: Implications for neuroinflammatory pathogenesis of Alzheimer's disease. Curr Alzheimer Res 8, 67-80.
-
(2011)
Curr Alzheimer Res
, vol.8
, pp. 67-80
-
-
Li, C.1
Zhao, R.2
Gao, K.3
Wei, Z.4
Yin, M.Y.5
Lau, L.T.6
Chui, D.7
Hoi Yu, A.C.8
-
48
-
-
78649903759
-
Recent insights into a new hydrodynamics of the cerebrospinal fluid
-
Bulat M, Klarica M (2011) Recent insights into a new hydrodynamics of the cerebrospinal fluid. Brain Res Rev 65, 99-112.
-
(2011)
Brain Res Rev
, vol.65
, pp. 99-112
-
-
Bulat, M.1
Klarica, M.2
-
49
-
-
0027321678
-
Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system
-
DOI 10.1006/bbrc.1993.1557
-
BrantAM,Jess TJ, Milligan G, Brown CM, GouldGW(1993) Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system. Biochem Biophys Res Commun 192, 1297-1302. (Pubitemid 23218553)
-
(1993)
Biochemical and Biophysical Research Communications
, vol.192
, Issue.3
, pp. 1297-1302
-
-
Brant, A.M.1
Jess, T.J.2
Milligan, G.3
Brown, C.M.4
Gould, G.W.5
-
50
-
-
5044231048
-
Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain - An immunohistochemical study
-
DOI 10.1016/j.jchemneu.2004.05.009, PII S0891061804000742
-
Arluison M, Quignon M, Nguyen P, Thorens B, Leloup C, Penicaud L (2004) Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain-an immunohistochemical study. J Chem Neuroanat 28, 117-136. (Pubitemid 39336524)
-
(2004)
Journal of Chemical Neuroanatomy
, vol.28
, Issue.3
, pp. 117-136
-
-
Arluison, M.1
Quignon, M.2
Nguyen, P.3
Thorens, B.4
Leloup, C.5
Penicaud, L.6
-
51
-
-
33645100144
-
Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway
-
Salkovic-Petrisic M, Tribl F, Schmidt M, Hoyer S, Riederer P (2006) Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway. J Neurochem 96, 1005-1015.
-
(2006)
J Neurochem
, vol.96
, pp. 1005-1015
-
-
Salkovic-Petrisic, M.1
Tribl, F.2
Schmidt, M.3
Hoyer, S.4
Riederer, P.5
-
52
-
-
0028598190
-
Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats
-
Duelli R, Schrock H, Kuschinsky W, Hoyer S (1994) Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats. Int J Dev Neurosci 12, 737-743.
-
(1994)
Int J Dev Neurosci
, vol.12
, pp. 737-743
-
-
Duelli, R.1
Schrock, H.2
Kuschinsky, W.3
Hoyer, S.4
-
53
-
-
0037249257
-
Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes
-
Salkovic-Petrisic M, Lackovic Z (2003) Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes. J Neural Transm 110, 15-29. (Pubitemid 36135552)
-
(2003)
Journal of Neural Transmission
, vol.110
, Issue.1
, pp. 15-29
-
-
Salkovic-Petrisic, M.1
Lackovic, Z.2
-
54
-
-
45749151056
-
Animal models of Alzheimer's disease and frontotemporal dementia
-
DOI 10.1038/nrn2420, PII NRN2420
-
Gotz J, Ittner LM (2008) Animal models of Alzheimer's disease and frontotemporal dementia. Nat Rev Neurosci 9, 532-544. (Pubitemid 351873467)
-
(2008)
Nature Reviews Neuroscience
, vol.9
, Issue.7
, pp. 532-544
-
-
Gotz, J.1
Ittner, L.M.2
-
55
-
-
33646126924
-
A decade of modeling Alzheimer's disease in transgenic mice
-
McGowan E, Eriksen J, Hutton M (2006) A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet 22, 281-289.
-
(2006)
Trends Genet
, vol.22
, pp. 281-289
-
-
McGowan, E.1
Eriksen, J.2
Hutton, M.3
-
56
-
-
75349095224
-
Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition
-
Oikawa N, Kimura N, Yanagisawa K (2010) Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition. Brain Res 1315, 137-149.
-
(2010)
Brain Res
, vol.1315
, pp. 137-149
-
-
Oikawa, N.1
Kimura, N.2
Yanagisawa, K.3
-
57
-
-
0141570702
-
Age-related changes of Alzheimer's disease-associated proteins in cynomolgus monkey brains
-
DOI 10.1016/j.bbrc.2003.09.012
-
Kimura N, Tanemura K, Nakamura S, Takashima A, Ono F, Sakakibara I, Ishii Y, Kyuwa S, Yoshikawa Y (2003) Agerelated changes of Alzheimer's disease-associated proteins in cynomolgus monkey brains. Biochem Biophys Res Commun 310, 303-311. (Pubitemid 37163664)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.310
, Issue.2
, pp. 303-311
-
-
Kimura, N.1
Tanemura, K.2
Nakamura, S.-I.3
Takashima, A.4
Ono, F.5
Sakakibara, I.6
Ishii, Y.7
Kyuwa, S.8
Yoshikawa, Y.9
-
58
-
-
0032176674
-
Histopathological studies of senile plaques and cerebral amyloidosis in cynomolgus monkeys
-
Nakamura S, Nakayama H, Goto N, Ono F, Sakakibara I, Yoshikawa Y (1998) Histopathological studies of senile plaques and cerebral amyloidosis in cynomolgus monkeys. J Med Primatol 27, 244-252. (Pubitemid 128521592)
-
(1998)
Journal of Medical Primatology
, vol.27
, Issue.5
, pp. 244-252
-
-
Nakamura, S.1
Nakayama, H.2
Goto, N.3
One, F.4
Sakakibara, I.5
Yoshikawa, Y.6
-
59
-
-
0033854926
-
Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys
-
DOI 10.1002/1531-8249(200008) 48:2<250::AID-ANA16>3.0.CO;2-1
-
Grondin R, Zhang Z, Gerhardt GA, Gash DM (2000) Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys. Ann Neurol 48, 250-253. (Pubitemid 30617045)
-
(2000)
Annals of Neurology
, vol.48
, Issue.2
, pp. 250-253
-
-
Grondin, R.1
Zhang, Z.2
Gerhardt, G.A.3
Gash, D.M.4
|