Effect of cation-π interactions and steric bulk on the catalytic action of oxidosqualene cyclase: A case study of phe728 of β-amyrin synthase from euphorbia tirucalli L

Chemistry - A European Journal

Volumn 19, Issue 50, 2013, Pages 17150-17158

  Ito, Ryousuke ^a   Hashimoto, Ippei ^a   Masukawa, Yukari ^a   Hoshino, Tsutomu ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

alkenes; cyclization; enzyme catalysis; polycycles; terpenoids

Indexed keywords

CATIONIC INTERMEDIATES; ENZYMATIC ACTIVITIES; ENZYME CATALYSIS; EXPERIMENTAL EVIDENCE; OXIDOSQUALENE CYCLASES; POLYCYCLES; PRODUCT DISTRIBUTIONS; TERPENOIDS;

CYCLIZATION; ENZYME ACTIVITY; OLEFINS;

POSITIVE IONS;

2,3 OXIDOSQUALENE; 2,3 OXIDOSQUALENE BETA AMYRIN CYCLASE; 2,3-OXIDOSQUALENE; 2,3-OXIDOSQUALENE-BETA-AMYRIN-CYCLASE; ALKENE; AMINO ACID; CATION; DRUG DERIVATIVE; MUTASE; OXIDOSQUALENE; SQUALENE; TRITERPENE;

ARTICLE; CATALYSIS; CHEMISTRY; CYCLIZATION; ENZYME CATALYSIS; ENZYMOLOGY; EUPHORBIA; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYCYCLES; TERPENOIDS;

ALKENES; CYCLIZATION; ENZYME CATALYSIS; POLYCYCLES; TERPENOIDS;

ALKENES; AMINO ACIDS; CATALYSIS; CATIONS; CYCLIZATION; EUPHORBIA; INTRAMOLECULAR TRANSFERASES; MAGNETIC RESONANCE SPECTROSCOPY; SQUALENE; TRITERPENES;

EID: 84889561459     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201301917     Document Type: Article

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