Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus

Organic Letters

Volumn 11, Issue 6, 2009, Pages 1241-1244

  Lodeiro, Silvia ^a   Xiong, Quanbo ^a   Wilson, William K ^a   Ivanova, Yulia ^a   Smith, Mckenzie L ^a   May, Gregory S ^b   Matsuda, Seiichi P T ^a  

^a RICE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DRUG DERIVATIVE; FUSIDIC ACID; HELVOLIC ACID; LANOSTEROL SYNTHASE; MUTASE; PROTOSTA 13(17),24 DIEN 3BETA OL; PROTOSTA-13(17),24-DIEN-3BETA-OL; TRITERPENE;

ARTICLE; ASPERGILLUS FUMIGATUS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; STEREOISOMERISM;

ANTI-BACTERIAL AGENTS; ASPERGILLUS FUMIGATUS; FUSIDIC ACID; INTRAMOLECULAR TRANSFERASES; MOLECULAR STRUCTURE; STEREOISOMERISM; TRITERPENES;

EID: 64049095850     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol802696a     Document Type: Article

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44. Also, barring HGT of an unknown bacterial PDS, H2 requires several recent instances of convergent evolution of fungal cyclases. Cycloartenol synthase of Stigmatella aurantiaca is a plausible HGT candidate (Figure 3B), although its GC content (68%) is elevated relative to PDSs (55-62%) ; see Table S10 (Supporting Information). Penicillin synthesis and likely recent HGTs of squalene cyclases in aspergilli provide precedent for H2.
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