Aurora isoform selectivity: Design and synthesis of imidazo[4,5- B ]pyridine derivatives as highly selective inhibitors of aurora-A kinase in cells

Journal of Medicinal Chemistry

Volumn 56, Issue 22, 2013, Pages 9122-9135

  Bavetsias, Vassilios ^a   Faisal, Amir ^a   Crumpler, Simon ^a   Brown, Nathan ^a   Kosmopoulou, Magda ^a   Joshi, Amar ^b   Atrash, Butrus ^a   Pérez Fuertes, Yolanda ^a   Schmitt, Jessica A ^a   Boxall, Katherine J ^a   Burke, Rosemary ^a   Sun, Chongbo ^a   Avery, Sian ^a   Bush, Katherine ^a   Henley, Alan ^a   Raynaud, Florence I ^a   Workman, Paul ^a   Bayliss, Richard ^a,b   Linardopoulos, Spiros ^a   Blagg, Julian ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [[6 CHLORO 2 (1,3 DIMETHYL 1H PYRAZOL 4 YL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY] N CYCLOBUTYLBENZAMIDE; 4 [[6 CHLORO 2 (1,3 DIMETHYL 1H PYRAZOL 4 YL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY] N PHENYLBENZAMIDE; 4 [[6 CHLORO 2 (1,3 DIMETHYL 1H PYRAZOL 4 YL) 3H IMIDAZOL[4,5 B]PYRIDIN 7YL]AMINOI] N PHENYLBENZAMIDE; ACETAMIDE DERIVATIVE; ANTINEOPLASTIC AGENT; AURORA A KINASE; AURORA B KINASE; AURORA C KINASE; AURORA KINASE INHIBITOR; IMIDAZO[4,5 B]PYRIDINE DERIVATIVE; INDOLE DERIVATIVE; N [1 [6 CHLORO 2 (1,3 DIMETHYL 1H PYRAZOL 4 YL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]PYRROLIDIN 3 YL]ACETAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER INHIBITION; CELL STRAIN HCT116; COLON CARCINOMA; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DERIVATIZATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PROTEIN INTERACTION; SUBSTITUTION REACTION; WILD TYPE;

ANIMALS; AURORA KINASE A; AURORA KINASE B; CATALYTIC DOMAIN; DRUG DESIGN; DRUG STABILITY; HCT116 CELLS; HUMANS; IMIDAZOLES; INDOLES; ISOENZYMES; MALE; MICE; MOLECULAR DOCKING SIMULATION; PROTEIN KINASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 84889260007     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401115g     Document Type: Article

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