-
1
-
-
0030962953
-
A putative serine/threonine kinase encoding gene BTAK on chromosome 20g13 is amplified and overexpressed in human breast cancer cell lines
-
Sen, S.; Zhou, H.; White, R. A. A putative serine/threonine kinase encoding gene BTAK on chromosome 20g13 is amplified and overexpressed in human breast cancer cell lines Oncogene 1997, 14, 2195-2200
-
(1997)
Oncogene
, vol.14
, pp. 2195-2200
-
-
Sen, S.1
Zhou, H.2
White, R.A.3
-
2
-
-
10344236486
-
Aurora-kinase inhibitors as anticancer agents
-
Keen, N.; Taylor, S. Aurora-kinase inhibitors as anticancer agents Nat. Rev. Cancer 2004, 4, 927-936
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 927-936
-
-
Keen, N.1
Taylor, S.2
-
3
-
-
33746508429
-
Mitotic kinases: The key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis
-
Li, J. J.; Li, S. A. Mitotic kinases: the key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis Pharmacol. Ther. 2006, 111, 974-984
-
(2006)
Pharmacol. Ther.
, vol.111
, pp. 974-984
-
-
Li, J.J.1
Li, S.A.2
-
4
-
-
0028938482
-
Mutations in Aurora prevent centrosome separation leading to the formation of monpolar spindles
-
Glover, D. M.; Leibowitz, M. H.; McLean, D. A.; Parry, H. Mutations in Aurora prevent centrosome separation leading to the formation of monpolar spindles Cell 1995, 81, 95-105
-
(1995)
Cell
, vol.81
, pp. 95-105
-
-
Glover, D.M.1
Leibowitz, M.H.2
McLean, D.A.3
Parry, H.4
-
5
-
-
0037048279
-
On the role of Aurora-A in centrosome function
-
Dutertre, S.; Descamps, S.; Prigent, C. On the role of Aurora-A in centrosome function Oncogene 2002, 21, 6175-6183
-
(2002)
Oncogene
, vol.21
, pp. 6175-6183
-
-
Dutertre, S.1
Descamps, S.2
Prigent, C.3
-
6
-
-
18644380150
-
Roles of Aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells
-
Marumoto, T.; Hirota, T.; Morisaki, T.; Kunitoku, N.; Zhang, D.; Ichikawa, Y.; Sasayama, T.; Kuninaka, S.; Mimori, T.; Tamaki, N.; Kimura, M.; Okano, Y.; Saya, H. Roles of Aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells Genes Cells 2002, 7, 1173-1182
-
(2002)
Genes Cells
, vol.7
, pp. 1173-1182
-
-
Marumoto, T.1
Hirota, T.2
Morisaki, T.3
Kunitoku, N.4
Zhang, D.5
Ichikawa, Y.6
Sasayama, T.7
Kuninaka, S.8
Mimori, T.9
Tamaki, N.10
Kimura, M.11
Okano, Y.12
Saya, H.13
-
7
-
-
34948901399
-
Aurora-A: The maker and breaker of spindle poles
-
Barr, A. R.; Gergely, F. Aurora-A: the maker and breaker of spindle poles J. Cell Sci. 2007, 120, 2987-2996
-
(2007)
J. Cell Sci.
, vol.120
, pp. 2987-2996
-
-
Barr, A.R.1
Gergely, F.2
-
8
-
-
4444239881
-
The mitotic serine threonine kinase, Aurora-2 is a potential target for drug development in human pancreatic cancer
-
Rojanala, S.; Han, H.; Munoz, R. M.; Browne, W.; Nagle, R.; Von Hoff, D. D.; Bearss, D. J. The mitotic serine threonine kinase, Aurora-2 is a potential target for drug development in human pancreatic cancer Mol. Cancer Ther. 2004, 3, 451-457
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 451-457
-
-
Rojanala, S.1
Han, H.2
Munoz, R.M.3
Browne, W.4
Nagle, R.5
Von Hoff, D.D.6
Bearss, D.J.7
-
9
-
-
39749106551
-
Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells
-
Evans, R.; Naber, C.; Steffler, T.; Checkland, T.; Keats, J.; Maxwell, C.; Perry, T.; Chau, H.; Belch, A.; Pilarski, L.; Reiman, T. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells Leuk. Lymphoma 2008, 49, 559-569
-
(2008)
Leuk. Lymphoma
, vol.49
, pp. 559-569
-
-
Evans, R.1
Naber, C.2
Steffler, T.3
Checkland, T.4
Keats, J.5
Maxwell, C.6
Perry, T.7
Chau, H.8
Belch, A.9
Pilarski, L.10
Reiman, T.11
-
10
-
-
0013057087
-
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2 and Cenp-E to kinetochores
-
Ditchfield, C.; Johnson, V. L.; Tighe, A.; Ellston, R.; Haworth, C.; Johnson, T.; Mortlock, A.; Keen, N.; Taylor, S. S. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2 and Cenp-E to kinetochores J. Cell Biol. 2003, 161, 267-280
-
(2003)
J. Cell Biol.
, vol.161
, pp. 267-280
-
-
Ditchfield, C.1
Johnson, V.L.2
Tighe, A.3
Ellston, R.4
Haworth, C.5
Johnson, T.6
Mortlock, A.7
Keen, N.8
Taylor, S.S.9
-
11
-
-
0038746733
-
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
-
Hauf, S.; Cole, R. W.; LaTerra, S.; Zimmer, C.; Schnapp, G.; Walter, R.; Heckel, A.; van.Meel, J.; Rieder, C.; Peters, J. M. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint J. Cell Biol. 2003, 161, 281-294
-
(2003)
J. Cell Biol.
, vol.161
, pp. 281-294
-
-
Hauf, S.1
Cole, R.W.2
Laterra, S.3
Zimmer, C.4
Schnapp, G.5
Walter, R.6
Heckel, A.7
Van Meel, J.8
Rieder, C.9
Peters, J.M.10
-
12
-
-
0032517860
-
AIR-2: An Aurora/Ip11-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos
-
Schumacher, J. M.; Golden, A.; Donovan, P. J. AIR-2: an Aurora/Ip11-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos J. Cell Biol. 1998, 143, 1635-1646
-
(1998)
J. Cell Biol.
, vol.143
, pp. 1635-1646
-
-
Schumacher, J.M.1
Golden, A.2
Donovan, P.J.3
-
13
-
-
0033548619
-
Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ip11-related protein kinase, AIK3
-
Kimura, M.; Matsuda, Y.; Yoshika, T.; Okano, Y. Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ip11-related protein kinase, AIK3 J. Biol. Chem. 1999, 274, 7334-7340
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7334-7340
-
-
Kimura, M.1
Matsuda, Y.2
Yoshika, T.3
Okano, Y.4
-
14
-
-
19944394833
-
Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells
-
Sasai, K.; Katayama, H.; Stenoien, D. L.; Fujii, S.; Honda, R.; Kimura, M.; Okano, Y.; Tatsuka, M.; Suzuki, F.; Nigg, E. A.; Earnshaw, W. C.; Brinkley, W. R.; Sen, S. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells Cell Motil. Cytoskeleton 2004, 59, 249-263
-
(2004)
Cell Motil. Cytoskeleton
, vol.59
, pp. 249-263
-
-
Sasai, K.1
Katayama, H.2
Stenoien, D.L.3
Fujii, S.4
Honda, R.5
Kimura, M.6
Okano, Y.7
Tatsuka, M.8
Suzuki, F.9
Nigg, E.A.10
Earnshaw, W.C.11
Brinkley, W.R.12
Sen, S.13
-
15
-
-
2342639645
-
VX-680, a potent and selective small molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
-
Harrington, E. A.; Bebbington, D.; Moore, J.; Rasmussen, R. K.; Ajose-Adeogun, A. O.; Nakayama, T.; Graham, J. A.; Demur, C.; Hercend, T.; Diu-Hercend, A.; Su, M.; Golec, J. M. C.; Miller, K. M. VX-680, a potent and selective small molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo Nat. Med. 2004, 10, 262-267
-
(2004)
Nat. Med.
, vol.10
, pp. 262-267
-
-
Harrington, E.A.1
Bebbington, D.2
Moore, J.3
Rasmussen, R.K.4
Ajose-Adeogun, A.O.5
Nakayama, T.6
Graham, J.A.7
Demur, C.8
Hercend, T.9
Diu-Hercend, A.10
Su, M.11
Golec, J.M.C.12
Miller, K.M.13
-
16
-
-
34247603906
-
Discovery, synthesis and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of Aurora B kinase
-
Mortlock, A. A.; Foote, K. M.; Heron, N. M.; Jung, F. H.; Pasquet, G.; Lohmann, J. J.; Warin, N.; Renaud, F.; Savi, C. D.; Roberts, N. J.; Johnson, T.; Dousson, C. B.; Hill, G. B.; Perkins, D.; Hatter, G.; Wilkinson, R. W.; Wedge, S. R.; Heaton, S. P.; Odera, R.; Keen, N. J.; Crafter, C.; Brown, E.; Thompson, K.; Brightwell, S.; Khatri, L.; Brady, M. C.; Kearney, S.; Mckillop, D.; Rhead, S.; Parry, T.; Green, S. Discovery, synthesis and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of Aurora B kinase J. Med. Chem. 2007, 50, 2213-2224
-
(2007)
J. Med. Chem.
, vol.50
, pp. 2213-2224
-
-
Mortlock, A.A.1
Foote, K.M.2
Heron, N.M.3
Jung, F.H.4
Pasquet, G.5
Lohmann, J.J.6
Warin, N.7
Renaud, F.8
Savi, C.D.9
Roberts, N.J.10
Johnson, T.11
Dousson, C.B.12
Hill, G.B.13
Perkins, D.14
Hatter, G.15
Wilkinson, R.W.16
Wedge, S.R.17
Heaton, S.P.18
Odera, R.19
Keen, N.J.20
Crafter, C.21
Brown, E.22
Thompson, K.23
Brightwell, S.24
Khatri, L.25
Brady, M.C.26
Kearney, S.27
McKillop, D.28
Rhead, S.29
Parry, T.30
Green, S.31
more..
-
17
-
-
77952684936
-
Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase
-
Adams, N. D.; Adams, J. L.; Burgess, J. L.; Chaudhari, A. M.; Copeland, R. A.; Donatelli, C. A.; Drewry, D. H.; Fisher, K. E.; Hamajima, T.; Hardwicke, M. A.; Huffman, W. F.; Koretke-Brown, A. K.; Lai, Z, V.; McDonald, O. B.; Nakamura, H.; Newlander, K. A.; Oleykowski, C. A.; Parrish, C. A.; Patrick, D. R.; Plant, R.; Sarpong, M. A.; Sasaki, K.; Wang, J. C.; Xiang, H.; Yang, J.; Dhanak, D. Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase J. Med. Chem. 2010, 53, 3973-4001
-
(2010)
J. Med. Chem.
, vol.53
, pp. 3973-4001
-
-
Adams, N.D.1
Adams, J.L.2
Burgess, J.L.3
Chaudhari, A.M.4
Copeland, R.A.5
Donatelli, C.A.6
Drewry, D.H.7
Fisher, K.E.8
Hamajima, T.9
Hardwicke, M.A.10
Huffman, W.F.11
Koretke-Brown, A.K.12
Lai, Z.V.13
McDonald, O.B.14
Nakamura, H.15
Newlander, K.A.16
Oleykowski, C.A.17
Parrish, C.A.18
Patrick, D.R.19
Plant, R.20
Sarpong, M.A.21
Sasaki, K.22
Wang, J.C.23
Xiang, H.24
Yang, J.25
Dhanak, D.26
more..
-
18
-
-
65649152925
-
Discovery and development of Aurora kinase inhibitors as anticancer agents
-
Pollard, J. R.; Mortimore, M. Discovery and development of Aurora kinase inhibitors as anticancer agents J. Med. Chem. 2009, 52, 2629-2651
-
(2009)
J. Med. Chem.
, vol.52
, pp. 2629-2651
-
-
Pollard, J.R.1
Mortimore, M.2
-
19
-
-
34247259822
-
Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase
-
Manfredi, M. G.; Ecsedy, J. A.; Meetze, K. A.; Balani, S. K.; Burenkova, O.; Chen, W.; Galvin, K. M.; Hoar, K. M.; Huck, J. J.; Leroy, P. J.; Ray, E. T.; Sells, T. B.; Stringer, B.; Stroud, S. G.; Vos, T. J.; Weatherhead, G. S.; Wysong, D. R.; Zhang, M.; Bolen, J. B.; Claiborne, C. F. Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 4106-4111
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 4106-4111
-
-
Manfredi, M.G.1
Ecsedy, J.A.2
Meetze, K.A.3
Balani, S.K.4
Burenkova, O.5
Chen, W.6
Galvin, K.M.7
Hoar, K.M.8
Huck, J.J.9
Leroy, P.J.10
Ray, E.T.11
Sells, T.B.12
Stringer, B.13
Stroud, S.G.14
Vos, T.J.15
Weatherhead, G.S.16
Wysong, D.R.17
Zhang, M.18
Bolen, J.B.19
Claiborne, C.F.20
more..
-
20
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman, M. W.; Herrgard, S.; Treiber, D. K.; Gallant, P.; Atteridge, C. E.; Campbell, B. T.; Chan, K. W.; Ciceri, P.; Davis, M. I.; Edeen, P. T.; Faraoni, R.; Floyd, M.; Hunt, J. P.; Lochart, D. J.; Milanov, Z. V.; Morrison, M. J.; Pallares, G.; Patel, H. K.; Pritchard, S.; Wodicka, L. M.; Zarrinkar, P. P. A quantitative analysis of kinase inhibitor selectivity Nat. Biotechnol. 2008, 26, 127-132
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
Gallant, P.4
Atteridge, C.E.5
Campbell, B.T.6
Chan, K.W.7
Ciceri, P.8
Davis, M.I.9
Edeen, P.T.10
Faraoni, R.11
Floyd, M.12
Hunt, J.P.13
Lochart, D.J.14
Milanov, Z.V.15
Morrison, M.J.16
Pallares, G.17
Patel, H.K.18
Pritchard, S.19
Wodicka, L.M.20
Zarrinkar, P.P.21
more..
-
21
-
-
0029044538
-
Palladium-catalysed synthesis of arylamines from aryl halides. Mechanistic studies lead to coupling in the absence of tin reagents
-
Louie, J.; Hartwig, J. F. Palladium-catalysed synthesis of arylamines from aryl halides. Mechanistic studies lead to coupling in the absence of tin reagents Tetrahedron Lett. 1995, 36, 3609-3612
-
(1995)
Tetrahedron Lett.
, vol.36
, pp. 3609-3612
-
-
Louie, J.1
Hartwig, J.F.2
-
22
-
-
44849085422
-
Palladium-catalysed amination of aryl halides and aryl triflates
-
Wolfe, J. P.; Buchwald, S. L. Palladium-catalysed amination of aryl halides and aryl triflates Org. Synth. 2004, 423
-
(2004)
Org. Synth.
, pp. 423
-
-
Wolfe, J.P.1
Buchwald, S.L.2
-
23
-
-
0242330123
-
Structural basis of Aurora-A activation by TPX2 at the mitotic spindle
-
Bayliss, R.; Sardon, T.; Vernos, I.; Conti, E. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle Mol. Cell 2003, 12, 851-862
-
(2003)
Mol. Cell
, vol.12
, pp. 851-862
-
-
Bayliss, R.1
Sardon, T.2
Vernos, I.3
Conti, E.4
-
24
-
-
49449091410
-
A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability
-
Rawson, T. E.; Rueth, M.; Blackwood, E.; Burdick, D.; Corson, L.; Dotson, J.; Drummond, J.; Fields, C.; Georges, G. J.; Goller, B.; Halladay, J.; Hunsaker, T.; Kleinheinz, T.; Krell, H.-W.; Li, J.; Liang, J.; Limberg, A.; McNutt, A.; Moffat, J.; Phillips, G.; Ran, Y.; Safina, B.; Ultsch, M.; Walker, L.; Wiesmann, C.; Zhang, B.; Zhou, A.; Zhu, B.-Y.; Rueger, P.; Cochran, A. G. A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability J. Med. Chem. 2008, 51, 4465-4475
-
(2008)
J. Med. Chem.
, vol.51
, pp. 4465-4475
-
-
Rawson, T.E.1
Rueth, M.2
Blackwood, E.3
Burdick, D.4
Corson, L.5
Dotson, J.6
Drummond, J.7
Fields, C.8
Georges, G.J.9
Goller, B.10
Halladay, J.11
Hunsaker, T.12
Kleinheinz, T.13
Krell, H.-W.14
Li, J.15
Liang, J.16
Limberg, A.17
McNutt, A.18
Moffat, J.19
Phillips, G.20
Ran, Y.21
Safina, B.22
Ultsch, M.23
Walker, L.24
Wiesmann, C.25
Zhang, B.26
Zhou, A.27
Zhu, B.-Y.28
Rueger, P.29
Cochran, A.G.30
more..
|