Systematic investigation of the cavi-precipitation process for the production of ibuprofen nanocrystals

International Journal of Pharmaceutics

Volumn 458, Issue 2, 2013, Pages 315-323

  Sinha, Biswadip ^a   Müller, Rainer H ^a   Möschwitzer, Jan P ^b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b ABBVIE INC   (United States)

Author keywords

Bottom up process; Combination process; High pressure homogenization; NANOEDGE ; Nanosuspension; Solvent anti solvent precipitation; Ternary diagram

Indexed keywords

2 PROPANOL; DODECYL SULFATE SODIUM; HYDROXYPROPYLMETHYLCELLULOSE; IBUPROFEN; NANOCRYSTAL; WATER;

ARTICLE; CAVI PRECIPITATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG MANUFACTURE; DRUG MIXTURE; DRUG SOLUBILITY; HIGH PRESSURE HOMOGENIZATION; INTERMETHOD COMPARISON; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SOLID STATE; STANDARD;

BOTTOM-UP PROCESS; COMBINATION PROCESS; HIGH PRESSURE HOMOGENIZATION; NANOEDGE™; NANOSUSPENSION; SOLVENT-ANTI-SOLVENT PRECIPITATION; TERNARY DIAGRAM;

2-PROPANOL; BIOLOGICAL AVAILABILITY; CHEMICAL PRECIPITATION; IBUPROFEN; METHYLCELLULOSE; NANOPARTICLES; PARTICLE SIZE; PRESSURE; SODIUM DODECYL SULFATE; SOLUBILITY; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84889095814     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.10.025     Document Type: Article

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