Fabrication of carvedilol nanosuspensions through the anti-solvent precipitation-ultrasonication method for the improvement of dissolution rate and oral bioavailability

AAPS PharmSciTech

Volumn 13, Issue 1, 2012, Pages 295-304

  Liu, Dandan ^a   Xu, Heming ^a   Tian, Baocheng ^a   Yuan, Kun ^a   Pan, Hao ^a   Ma, Shilin ^a   Yang, Xinggang ^a   Pan, Weisan ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Alpha tocopherol succinate; Anti solvent precipitation; Carvedilol; Nanosuspensions; Oral bioavailability

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; CARVEDILOL; DODECYL SULFATE SODIUM; NANOPARTICLE;

ANTISOLVENT PRECIPITATION ULTRASONICATION TECHNIQUE; AREA UNDER THE CURVE; ARTICLE; CHEMICAL INTERACTION; COMPOSITE MATERIAL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; HYDROGEN BOND; IN VIVO STUDY; INFRARED SPECTROSCOPY; MAXIMUM PLASMA CONCENTRATION; NANOFABRICATION; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; PROCESS TECHNOLOGY; RESPONSE SURFACE METHOD; SCANNING ELECTRON MICROSCOPY; SUSPENSION; TABLET; TEMPERATURE; TIME; X RAY POWDER DIFFRACTION; ZETA POTENTIAL;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CARBAZOLES; CHEMICAL PRECIPITATION; CHEMISTRY, PHARMACEUTICAL; MALE; NANOPARTICLES; PARTICLE SIZE; PROPANOLAMINES; RANDOM ALLOCATION; RATS; RATS, WISTAR; SOLUBILITY; SOLVENTS; SUSPENSIONS; ULTRASONICS; X-RAY DIFFRACTION;

EID: 84862808110     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9750-7     Document Type: Article

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