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Volumn , Issue , 2007, Pages 71-88

Drug nanocrystals-the universal formulation approach for poorly soluble drugs

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EID: 85055809757     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (37)

References (78)
  • 2
    • 0036742053 scopus 로고    scopus 로고
    • Poor aqueous solubility-an industry wide problem in drug delivery
    • Lipinski C. Poor aqueous solubility-an industry wide problem in drug delivery. Am Pharm Rev 2002; 5:82-85.
    • (2002) Am Pharm Rev , vol.5 , pp. 82-85
    • Lipinski, C.1
  • 4
    • 0036240009 scopus 로고    scopus 로고
    • Report on the international workshop on the biopharmaceutics classification system (BCS): Scientific and regulatory aspects in practice
    • Kanfer I. Report on the international workshop on the biopharmaceutics classification system (BCS): scientific and regulatory aspects in practice. J Pharm Pharm Sci 2002; 5(1):1-4.
    • (2002) J Pharm Pharm Sci , vol.5 , Issue.1 , pp. 1-4
    • Kanfer, I.1
  • 5
    • 0028286401 scopus 로고
    • Evaluation of pain and irritation following local administration of parenteral formulations using the rat paw lick model
    • Gupta PK, Patel JP, Hahn KR. Evaluation of pain and irritation following local administration of parenteral formulations using the rat paw lick model. J Pharm Sci Technol 1994; 48(3):159-166.
    • (1994) J Pharm Sci Technol , vol.48 , Issue.3 , pp. 159-166
    • Gupta, P.K.1    Patel, J.P.2    Hahn, K.R.3
  • 6
    • 0037139411 scopus 로고    scopus 로고
    • Paclitaxel and its formulations
    • Singla AK, Garg A, Aggarwal D. Paclitaxel and its formulations. Int J Pharm 2002; 235(1-2):179-192.
    • (2002) Int J Pharm , vol.235 , Issue.1-2 , pp. 179-192
    • Singla, A.K.1    Garg, A.2    Aggarwal, D.3
  • 7
    • 0021591223 scopus 로고
    • Intravenous premedication with diazepam: A comparison between two vehicles
    • Mattila MA, Suistomaa M. Intravenous premedication with diazepam: a comparison between two vehicles. Anaesthesia 1984; 39(9):879-882.
    • (1984) Anaesthesia , vol.39 , Issue.9 , pp. 879-882
    • Mattila, M.A.1    Suistomaa, M.2
  • 8
    • 16344364096 scopus 로고    scopus 로고
    • Design and evaluation of cyclodextrin-based drug formulation
    • Uekama K. Design and evaluation of cyclodextrin-based drug formulation. Chem Pharm Bull (Tokyo) 2004; 52(8):900-915.
    • (2004) Chem Pharm Bull (Tokyo) , vol.52 , Issue.8 , pp. 900-915
    • Uekama, K.1
  • 11
    • 5344234787 scopus 로고    scopus 로고
    • The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs
    • Kipp JE. The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs. Int J Pharm 2004; 284(1-2):109-122.
    • (2004) Int J Pharm , vol.284 , Issue.1-2 , pp. 109-122
    • Kipp, J.E.1
  • 15
    • 4644309307 scopus 로고    scopus 로고
    • Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology
    • Möschwitzer J, Achleitner G, Pomper H, Muller RH. Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology. Eur J Pharm Biopharm 2004; 58(3):615-619.
    • (2004) Eur J Pharm Biopharm , vol.58 , Issue.3 , pp. 615-619
    • Möschwitzer, J.1    Achleitner, G.2    Pomper, H.3    Muller, R.H.4
  • 16
    • 4544275025 scopus 로고    scopus 로고
    • Challenges and solutions for the delivery of biotech drugs-a review of drug nanocrystal technology and lipid nanoparticles
    • Müller RH, Keck CM. Challenges and solutions for the delivery of biotech drugs-a review of drug nanocrystal technology and lipid nanoparticles. J Biotechnol 2004; 113(1-3):151-170.
    • (2004) J Biotechnol , vol.113 , Issue.1-3 , pp. 151-170
    • Müller, R.H.1    Keck, C.M.2
  • 17
    • 0029080002 scopus 로고
    • Particle size reduction for improvement of oral bioavailability of hydrophobic drugs. I Absolute oral bioavailability of nanocrystalline danazol in beagle dogs
    • Liversidge GG, Cundy KC. Particle size reduction for improvement of oral bioavailability of hydrophobic drugs. I Absolute oral bioavailability of nanocrystalline danazol in beagle dogs. Int J Pharm 1995; 125:91-97.
    • (1995) Int J Pharm , vol.125 , pp. 91-97
    • Liversidge, G.G.1    Cundy, K.C.2
  • 18
    • 0037312695 scopus 로고    scopus 로고
    • Nanosizing: A formulation approach for poorly water-soluble compounds
    • Merisko-Liversidge E, Liversidge GG, Cooper ER. Nanosizing: a formulation approach for poorly water-soluble compounds. Eur J Pharm Sci 2003; 18(2):113-120.
    • (2003) Eur J Pharm Sci , vol.18 , Issue.2 , pp. 113-120
    • Merisko-Liversidge, E.1    Liversidge, G.G.2    Cooper, E.R.3
  • 19
    • 0028824401 scopus 로고
    • Conzentino, Phil. Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rats
    • Liversidge GG, Conzentino, Phil. Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rats. Int J Pharm 1995; 125:309-313.
    • (1995) Int J Pharm , vol.125 , pp. 309-313
    • Liversidge, G.G.1
  • 21
    • 0035910873 scopus 로고    scopus 로고
    • Production and characterisation of mucoadhesive nanosuspensions for the formulation of bupravaquone
    • Jacobs C, Kayser O, Müller RH. Production and characterisation of mucoadhesive nanosuspensions for the formulation of bupravaquone. Int J Pharm 2001; 214(1-2):3-7.
    • (2001) Int J Pharm , vol.214 , Issue.1-2 , pp. 3-7
    • Jacobs, C.1    Kayser, O.2    Müller, R.H.3
  • 22
    • 0037177516 scopus 로고    scopus 로고
    • Buparvaquone mucoadhesive nanosuspension: Preparation, optimisation and long-term stability
    • Müller RH, Jacobs C. Buparvaquone mucoadhesive nanosuspension: preparation, optimisation and long-term stability. Int J Pharm 2002; 237(1-2):151-161.
    • (2002) Int J Pharm , vol.237 , Issue.1-2 , pp. 151-161
    • Müller, R.H.1    Jacobs, C.2
  • 23
    • 0034756945 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease
    • Lamprecht A, Ubrich N, Yamamoto H, et al. Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease. J Pharmacol Exp Ther 2001; 299(2):775-781.
    • (2001) J Pharmacol Exp Ther , vol.299 , Issue.2 , pp. 775-781
    • Lamprecht, A.1    Ubrich, N.2    Yamamoto, H.3
  • 24
    • 0035940059 scopus 로고    scopus 로고
    • Recent advances in the understanding of uptake of microp-articulates across the gastrointestinal lymphatics
    • Hussain N, Jaitley V, Florence AT. Recent advances in the understanding of uptake of microp-articulates across the gastrointestinal lymphatics. Adv Drug Deliv Rev 2001; 50(1-2):107-142.
    • (2001) Adv Drug Deliv Rev , vol.50 , Issue.1-2 , pp. 107-142
    • Hussain, N.1    Jaitley, V.2    Florence, A.T.3
  • 25
    • 0032950123 scopus 로고    scopus 로고
    • Physical stability of ethyl diatrizoate nanocrystalline suspension in steam sterilization
    • Na GC, Stevens Jr J, Yuan BO, Rajagopalan N. Physical stability of ethyl diatrizoate nanocrystalline suspension in steam sterilization. Pharm Res 1999; 16(4):569-574.
    • (1999) Pharm Res , vol.16 , Issue.4 , pp. 569-574
    • Na, G.C.1    Stevens, J.2    Yuan, B.O.3    Rajagopalan, N.4
  • 26
    • 0002819692 scopus 로고    scopus 로고
    • Nanosuspensions for the formulation of poorly soluble drugs
    • In: Nielloud F, Marti-Mestres G, eds. New York: Marcel Dekker
    • Müller RH, Jacobs C, Kayser O. Nanosuspensions for the formulation of poorly soluble drugs. In: Nielloud F, Marti-Mestres G, eds. Pharmaceutical Emulsions and Suspensions. New York: Marcel Dekker, 2000:383-407.
    • (2000) Pharmaceutical Emulsions and Suspensions , pp. 383-407
    • Müller, R.H.1    Jacobs, C.2    Kayser, O.3
  • 27
    • 77953384960 scopus 로고    scopus 로고
    • Production and characterisation of nanosuspensions as novel delivery system for drugs with low bioavailability
    • In: Berlin: Free University of Berlin
    • Böhm B. Production and characterisation of nanosuspensions as novel delivery system for drugs with low bioavailability. In: Pharmaceutical Technology. Berlin: Free University of Berlin, 1999.
    • (1999) Pharmaceutical Technology
    • Böhm, B.1
  • 28
    • 0033965872 scopus 로고    scopus 로고
    • Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection
    • Peters K et al. Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection. J Antimicrob Chemother 2000; 45(1):77-83.
    • (2000) J Antimicrob Chemother , vol.45 , Issue.1 , pp. 77-83
    • Peters, K.1
  • 29
    • 0343831483 scopus 로고    scopus 로고
    • Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis
    • Scholer N et al. Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis. Antimicrob Agents Chemother 2001; 45(6):1771-1779.
    • (2001) Antimicrob Agents Chemother , vol.45 , Issue.6 , pp. 1771-1779
    • Scholer, N.1
  • 30
    • 0032711216 scopus 로고    scopus 로고
    • An in vitro assessment of a NanoCrystal beclomethasone dipropionate colloidal dispersion via ultrasonic nebulization
    • Ostrander KD, Bosch HW, Bondanza DM. An in vitro assessment of a NanoCrystal beclomethasone dipropionate colloidal dispersion via ultrasonic nebulization. Eur J Pharm Biopharm 1999; 48(3): 207-215.
    • (1999) Eur J Pharm Biopharm , vol.48 , Issue.3 , pp. 207-215
    • Ostrander, K.D.1    Bosch, H.W.2    Bondanza, D.M.3
  • 31
    • 0036176196 scopus 로고    scopus 로고
    • Production and characterization of a budesonide nanosuspension for pulmonary administration
    • Jacobs C, Müller RH. Production and characterization of a budesonide nanosuspension for pulmonary administration. Pharm Res 2002; 19(2):189-194.
    • (2002) Pharm Res , vol.19 , Issue.2 , pp. 189-194
    • Jacobs, C.1    Müller, R.H.2
  • 32
    • 0030614519 scopus 로고    scopus 로고
    • Nebulization of NanoCrystals: Production of a respirable solid-in-liquid-in-air colloidal dispersion
    • Wiedmann TS, DeCastro L, Wood RW. Nebulization of NanoCrystals: production of a respirable solid-in-liquid-in-air colloidal dispersion. Pharm Res 1997; 14(1):112-116.
    • (1997) Pharm Res , vol.14 , Issue.1 , pp. 112-116
    • Wiedmann, T.S.1    DeCastro, L.2    Wood, R.W.3
  • 33
    • 0347625573 scopus 로고    scopus 로고
    • The pharmacokinetics of nebulized nanocrystal budesonide suspension in healthy volunteers
    • Kraft WK et al. The pharmacokinetics of nebulized nanocrystal budesonide suspension in healthy volunteers. J Clin Pharmacol 2004; 44(1):67-72.
    • (2004) J Clin Pharmacol , vol.44 , Issue.1 , pp. 67-72
    • Kraft, W.K.1
  • 34
    • 18744409539 scopus 로고    scopus 로고
    • Colloidal carriers for ophthalmic drug delivery
    • Mainardes RM et al. Colloidal carriers for ophthalmic drug delivery. Curr Drug Targets 2005; 6(3):363-371.
    • (2005) Curr Drug Targets , vol.6 , Issue.3 , pp. 363-371
    • Mainardes, R.M.1
  • 35
    • 85132515661 scopus 로고    scopus 로고
    • Ophtalmika: Etablierte Arzneiformen und neue Konzepte
    • In: Müller RH, Hildebrand GE, eds. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH
    • Keipert S. Ophtalmika: etablierte Arzneiformen und neue Konzepte. In: Müller RH, Hildebrand GE, eds. Pharmazeutische Technologie: Moderne Arzneiformen. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH, 1998:77-98.
    • (1998) Pharmazeutische Technologie: Moderne Arzneiformen , pp. 77-98
    • Keipert, S.1
  • 36
    • 6744240226 scopus 로고
    • Praxiswissen Verfahrenstechnik. Köln: TÜV Rheinland GmbH
    • Pahl MH. Zerkleinerungstechnik. Praxiswissen Verfahrenstechnik. Köln: TÜV Rheinland GmbH, 1991.
    • (1991) Zerkleinerungstechnik
    • Pahl, M.H.1
  • 40
    • 85132521227 scopus 로고    scopus 로고
    • Pharmaceutical Technology
    • Ph.D. Thesis. Berlin, Free University of Berlin. In preparation
    • Möschwitzer J. Pharmaceutical Technology. Ph.D. Thesis. Berlin, Free University of Berlin. In preparation.
    • Möschwitzer, J.1
  • 45
    • 0001909840 scopus 로고    scopus 로고
    • Hydrosole, eine Alternative für die parenterale Anwendung von schwer wasserlöslichen Wirkstoffen
    • In: Müller RH, Hildebrand GE, eds. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH
    • Sucker H. Hydrosole, eine Alternative für die parenterale Anwendung von schwer wasserlöslichen Wirkstoffen. In: Müller RH, Hildebrand GE, eds. Pharmazeutische Technologie: Moderne Arzneiformen. Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH, 1998:383-391.
    • (1998) Pharmazeutische Technologie: Moderne Arzneiformen , pp. 383-391
    • Sucker, H.1
  • 48
    • 0037467170 scopus 로고    scopus 로고
    • Microcrystals for dissolution rate enhancement of poorly water-soluble drugs
    • Rasenack N, Hartenhauer H, Müller BW. Microcrystals for dissolution rate enhancement of poorly water-soluble drugs. Int J Pharm 2003; 254(2):137-145.
    • (2003) Int J Pharm , vol.254 , Issue.2 , pp. 137-145
    • Rasenack, N.1    Hartenhauer, H.2    Müller, B.W.3
  • 53
    • 0002819692 scopus 로고    scopus 로고
    • DissoCubes-a novel formulation for poorly soluble and poorly bioavailable drugs
    • New York: Marcel Dekker, In: Roberts MJRJHMS, ed
    • Müller RHJCK O. DissoCubes-a novel formulation for poorly soluble and poorly bioavailable drugs, In: Roberts MJRJHMS, ed. Modified-Release Drug Delivery Technology. New York: Marcel Dekker, 2003:135-149.
    • (2003) Modified-Release Drug Delivery Technology , pp. 135-149
    • Müller, R.H.J.C.K.O.1
  • 54
    • 33751163286 scopus 로고    scopus 로고
    • Manufacturing of nanoparticles by milling and homogenisation techniques
    • In: Kompella G, ed. New York: Marcel Dekker. Submitted
    • Müller RH, Möschwitzer J, Bushrab FN. Manufacturing of nanoparticles by milling and homogenisation techniques. In: Kompella G, ed. Nanoparticle Technology for Drug Delivery. New York: Marcel Dekker. Submitted.
    • Nanoparticle Technology for Drug Delivery
    • Müller, R.H.1    Möschwitzer, J.2    Bushrab, F.N.3
  • 55
    • 0035937599 scopus 로고    scopus 로고
    • Nanosuspensions as particulate drug formulations in therapy: Rationale for development and what we can expect for the future
    • Müller RH, Jacobs C, Kayser O. Nanosuspensions as particulate drug formulations in therapy: rationale for development and what we can expect for the future. Adv Drug Deliv Rev 2001; 47(1):3-19.
    • (2001) Adv Drug Deliv Rev , vol.47 , Issue.1 , pp. 3-19
    • Müller, R.H.1    Jacobs, C.2    Kayser, O.3
  • 56
    • 0033964139 scopus 로고    scopus 로고
    • Nanosuspensions of poorly soluble drugs-reproducibility of small scale production
    • Grau MJ, Kayser O, Müller RH. Nanosuspensions of poorly soluble drugs-reproducibility of small scale production. Int J Pharm 2000; 196(2):155-159.
    • (2000) Int J Pharm , vol.196 , Issue.2 , pp. 155-159
    • Grau, M.J.1    Kayser, O.2    Müller, R.H.3
  • 57
    • 0342897023 scopus 로고    scopus 로고
    • Nanosuspensions for the formulation of poorly soluble drugs. I. Preparation by a size-reduction technique
    • Müller RH, Peters K. Nanosuspensions for the formulation of poorly soluble drugs. I. Preparation by a size-reduction technique. Int J Pharm 1998; 160(2):229-237.
    • (1998) Int J Pharm , vol.160 , Issue.2 , pp. 229-237
    • Müller, R.H.1    Peters, K.2
  • 58
    • 0000595701 scopus 로고    scopus 로고
    • Nanosuspensions-a formulation approach for poorly soluble and poorly bioavailable drugs
    • In: Wise DL, ed. New York: Marcel Dekker
    • Müller RH, Böhm BHL, Grau MJ. Nanosuspensions-a formulation approach for poorly soluble and poorly bioavailable drugs. In: Wise DL, ed. Handbook of Pharmaceutical Controlled Release. New York: Marcel Dekker, 2000:345-357.
    • (2000) Handbook of Pharmaceutical Controlled Release , pp. 345-357
    • Müller, R.H.1    Böhm, B.H.L.2    Grau, M.J.3
  • 61
    • 0033982674 scopus 로고    scopus 로고
    • Influence of high pressure homogenisation equipment on nanodispersions characteristics
    • Liedtke S et al. Influence of high pressure homogenisation equipment on nanodispersions characteristics. Int J Pharm 2000; 196(2):183-185.
    • (2000) Int J Pharm , vol.196 , Issue.2 , pp. 183-185
    • Liedtke, S.1
  • 62
    • 0033982671 scopus 로고    scopus 로고
    • Heavy metal contamination of nanosuspensions produced by high-pressure homogenisation
    • Krause KP et al. Heavy metal contamination of nanosuspensions produced by high-pressure homogenisation. Int J Pharm 2000; 196(2):169-172.
    • (2000) Int J Pharm , vol.196 , Issue.2 , pp. 169-172
    • Krause, K.P.1
  • 63
    • 0035910878 scopus 로고    scopus 로고
    • Production and characterisation of highly concentrated nanosus-pensions by high pressure homogenisation
    • Krause KP, Müller RH. Production and characterisation of highly concentrated nanosus-pensions by high pressure homogenisation. Int J Pharm 2001; 214(1-2):21-24.
    • (2001) Int J Pharm , vol.214 , Issue.1-2 , pp. 21-24
    • Krause, K.P.1    Müller, R.H.2
  • 68
    • 0242334090 scopus 로고    scopus 로고
    • Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: Organic solvent versus organic/aqueous co-solvent systems
    • Hu J, Johnston KP, Williams RO III. Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous co-solvent systems. Eur J Pharm Sci 2003; 20(3):295-303.
    • (2003) Eur J Pharm Sci , vol.20 , Issue.3 , pp. 295-303
    • Hu, J.1    Johnston, K.P.2    Williams, R.O.3
  • 69
    • 0037151556 scopus 로고    scopus 로고
    • Preparation of cyclosporine as nanoparticles by evaporative precipitation into aqueous solution
    • Chen X et al. Preparation of cyclosporine as nanoparticles by evaporative precipitation into aqueous solution. Int J Pharm 2002; 242(1-2):3-14.
    • (2002) Int J Pharm , vol.242 , Issue.1-2 , pp. 3-14
    • Chen, X.1
  • 70
    • 77953435944 scopus 로고    scopus 로고
    • Investigation of dissolution velocity, saturation solubility and stability of ultrafine drug suspensions
    • Dissertation. Berlin: Free University of Berlin
    • Grau M. Investigation of dissolution velocity, saturation solubility and stability of ultrafine drug suspensions. Dissertation. Pharmazeutische Technologie. Berlin: Free University of Berlin, 2000.
    • (2000) Pharmazeutische Technologie
    • Grau, M.1
  • 71
    • 12344327354 scopus 로고    scopus 로고
    • Understanding agglomeration of indomethacin during the dissolution of micronised indomethacin mixtures through dissolution and de-agglomeration modeling approaches
    • Stewart PJ, Zhao FY. Understanding agglomeration of indomethacin during the dissolution of micronised indomethacin mixtures through dissolution and de-agglomeration modeling approaches. Eur J Pharm Biopharm 2005; 59(2):315-323.
    • (2005) Eur J Pharm Biopharm , vol.59 , Issue.2 , pp. 315-323
    • Stewart, P.J.1    Zhao, F.Y.2
  • 72
    • 85132503420 scopus 로고    scopus 로고
    • In: 32nd annual meeting and exposition of the Controlled Release Society, Miami
    • Kirkof N. Creation and characterization of Nanoparticles. In: 32nd annual meeting and exposition of the Controlled Release Society, Miami, 2005.
    • (2005) Creation and characterization of Nanoparticles
    • Kirkof, N.1
  • 74
    • 85132507067 scopus 로고    scopus 로고
    • Spray coated pellets as carrier system for mucoadhesive drug nanocrystals
    • Submitted
    • Möschwitzer J, Müller RH. Spray coated pellets as carrier system for mucoadhesive drug nanocrystals. Eur J Pharm Biopharm. Submitted.
    • Eur J Pharm Biopharm
    • Möschwitzer, J.1    Müller, R.H.2
  • 76
    • 28444441941 scopus 로고    scopus 로고
    • Nanocrystals of poorly soluble drugs for oral administration
    • Bushrab NF, Müller RH. Nanocrystals of poorly soluble drugs for oral administration. NewDrugs 2003; 5:20-22.
    • (2003) NewDrugs , vol.5 , pp. 20-22
    • Bushrab, N.F.1    Müller, R.H.2


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