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Volumn 34, Issue 12, 2013, Pages 676-688

Illuminating somatostatin analog action at neuroendocrine tumor receptors

Author keywords

lanreotide; octreotide; pasireotide; sst receptors

Indexed keywords

ANGIOPEPTIN; BIM 23A760; DG 3173; DOPASTATIN; G PROTEIN COUPLED RECEPTOR; KE 108; OCTREOTIDE; PASIREOTIDE; PENTETREOTIDE; PLACEBO; PTR 3173; SOMATOSTATIN; SOMATOSTATIN 14; SOMATOSTATIN 28; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR 1; SOMATOSTATIN RECEPTOR 2; SOMATOSTATIN RECEPTOR 3; SOMATOSTATIN RECEPTOR 4; SOMATOSTATIN RECEPTOR 5; UNCLASSIFIED DRUG;

EID: 84889084502     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2013.10.001     Document Type: Review
Times cited : (76)

References (160)
  • 1
    • 0015914428 scopus 로고
    • Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone
    • P. Brazeau Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone Science 179 1973 77 79
    • (1973) Science , vol.179 , pp. 77-79
    • Brazeau, P.1
  • 2
    • 13444303891 scopus 로고    scopus 로고
    • Hypothalamic hormones A.K.A hypothalamic releasing factors
    • R. Guillemin Hypothalamic hormones a.k.a. hypothalamic releasing factors J. Endocrinol. 184 2005 11 28
    • (2005) J. Endocrinol. , vol.184 , pp. 11-28
    • Guillemin, R.1
  • 4
    • 43549112903 scopus 로고    scopus 로고
    • Somatostatinergic systems in brain: Networks and functions
    • C. Viollet Somatostatinergic systems in brain: networks and functions Mol. Cell. Endocrinol. 286 2008 75 87
    • (2008) Mol. Cell. Endocrinol. , vol.286 , pp. 75-87
    • Viollet, C.1
  • 5
    • 84873958606 scopus 로고    scopus 로고
    • Central actions of somatostatin-28 and oligosomatostatin agonists to prevent components of the endocrine, autonomic and visceral responses to stress through interaction with different somatostatin receptor subtypes
    • A. Stengel Central actions of somatostatin-28 and oligosomatostatin agonists to prevent components of the endocrine, autonomic and visceral responses to stress through interaction with different somatostatin receptor subtypes Curr. Pharm. Des. 19 2013 98 105
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 98-105
    • Stengel, A.1
  • 6
    • 67449168131 scopus 로고    scopus 로고
    • The role(s) of somatostatin, structurally related peptides and somatostatin receptors in the gastrointestinal tract: A review
    • J. Van Op den Bosch The role(s) of somatostatin, structurally related peptides and somatostatin receptors in the gastrointestinal tract: a review Regul. Pept. 156 2009 1 8
    • (2009) Regul. Pept. , vol.156 , pp. 1-8
    • Van Op Den Bosch, J.1
  • 7
    • 33744985589 scopus 로고    scopus 로고
    • Cortistatin: A natural somatostatin analog
    • L. de Lecea Cortistatin: a natural somatostatin analog J. Endocrinol. Invest. 28 Suppl. Int. 2005 10 14
    • (2005) J. Endocrinol. Invest. , vol.28 , Issue.SUPPL. INT. , pp. 10-14
    • De Lecea, L.1
  • 8
    • 43549087397 scopus 로고    scopus 로고
    • Pharmacological profile of somatostatin and cortistatin receptors
    • S. Siehler Pharmacological profile of somatostatin and cortistatin receptors Mol. Cell. Endocrinol. 286 2008 26 34
    • (2008) Mol. Cell. Endocrinol. , vol.286 , pp. 26-34
    • Siehler, S.1
  • 9
    • 0242666360 scopus 로고    scopus 로고
    • MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion
    • N. Robas MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion J. Biol. Chem. 278 2003 44400 44404
    • (2003) J. Biol. Chem. , vol.278 , pp. 44400-44404
    • Robas, N.1
  • 10
    • 79955577752 scopus 로고    scopus 로고
    • Resistance to somatostatin analogs in acromegaly
    • A. Colao Resistance to somatostatin analogs in acromegaly Endocr. Rev. 32 2011 247 271
    • (2011) Endocr. Rev. , vol.32 , pp. 247-271
    • Colao, A.1
  • 11
    • 70350504344 scopus 로고    scopus 로고
    • Medical therapy of acromegaly: Efficacy and safety of somatostatin analogues
    • R.A. Feelders Medical therapy of acromegaly: efficacy and safety of somatostatin analogues Drugs 69 2009 2207 2226
    • (2009) Drugs , vol.69 , pp. 2207-2226
    • Feelders, R.A.1
  • 12
    • 0024598967 scopus 로고
    • Resistance of metastatic pancreatic endocrine tumours after long-term treatment with the somatostatin analogue octreotide (SMS 201-995)
    • D. Wynick Resistance of metastatic pancreatic endocrine tumours after long-term treatment with the somatostatin analogue octreotide (SMS 201-995) Clin. Endocrinol. (Oxf.) 30 1989 385 388
    • (1989) Clin. Endocrinol. (Oxf.) , vol.30 , pp. 385-388
    • Wynick, D.1
  • 13
    • 0018073907 scopus 로고
    • Characterization of functional receptors for somatostatin in rat pituitary cells in culture
    • A.H. Schonbrunn, and A.H. Tashijan Jr Characterization of functional receptors for somatostatin in rat pituitary cells in culture J. Biol. Chem. 253 1978 6473 6483
    • (1978) J. Biol. Chem. , vol.253 , pp. 6473-6483
    • Schonbrunn, A.H.1    Tashijan, Jr.A.H.2
  • 14
    • 0019884587 scopus 로고
    • Receptor binding of somatostatin-28 is tissue specific
    • C.B. Srikant, and Y.C. Patel Receptor binding of somatostatin-28 is tissue specific Nature 294 1981 259 260
    • (1981) Nature , vol.294 , pp. 259-260
    • Srikant, C.B.1    Patel, Y.C.2
  • 15
    • 0019870385 scopus 로고
    • High affinity binding sites for a somatostatin-28 analog in rat brain
    • J.C. Reubi High affinity binding sites for a somatostatin-28 analog in rat brain Life Sci. 28 1981 2191 2198
    • (1981) Life Sci. , vol.28 , pp. 2191-2198
    • Reubi, J.C.1
  • 16
    • 0022548218 scopus 로고
    • Distribution of somatostatin receptors in the human brain: An autoradiographic study
    • J.C. Reubi Distribution of somatostatin receptors in the human brain: an autoradiographic study Neuroscience 18 1986 329 346
    • (1986) Neuroscience , vol.18 , pp. 329-346
    • Reubi, J.C.1
  • 17
    • 0028955742 scopus 로고
    • Classification and nomenclature of somatostatin receptors
    • D. Hoyer Classification and nomenclature of somatostatin receptors Trends Pharmacol. Sci. 16 1995 86 88
    • (1995) Trends Pharmacol. Sci. , vol.16 , pp. 86-88
    • Hoyer, D.1
  • 18
    • 0026673028 scopus 로고
    • Cloning and expression of a novel mouse somatostatin receptor (SSTR2B)
    • M. Vanetti Cloning and expression of a novel mouse somatostatin receptor (SSTR2B) FEBS Lett. 311 1992 290 294
    • (1992) FEBS Lett. , vol.311 , pp. 290-294
    • Vanetti, M.1
  • 19
    • 79952456492 scopus 로고    scopus 로고
    • Truncated somatostatin receptors as new players in somatostatin- cortistatin pathophysiology
    • J. Cordoba-Chacon Truncated somatostatin receptors as new players in somatostatin-cortistatin pathophysiology Ann. N. Y. Acad. Sci. 1220 2011 6 15
    • (2011) Ann. N. Y. Acad. Sci. , vol.1220 , pp. 6-15
    • Cordoba-Chacon, J.1
  • 20
    • 67650245551 scopus 로고    scopus 로고
    • Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors
    • M. Duran-Prado Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors J. Clin. Endocrinol. Metab. 94 2009 2634 2643
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 2634-2643
    • Duran-Prado, M.1
  • 21
    • 84876986891 scopus 로고    scopus 로고
    • Novel pathway for somatostatin analogs in patients with acromegaly
    • M.R. Gadelha Novel pathway for somatostatin analogs in patients with acromegaly Trends Endocrinol. Metab. 24 2013 238 246
    • (2013) Trends Endocrinol. Metab. , vol.24 , pp. 238-246
    • Gadelha, M.R.1
  • 22
    • 33644803255 scopus 로고    scopus 로고
    • 2A antibodies with somatostatin receptor autoradiography
    • 2A antibodies with somatostatin receptor autoradiography Am. J. Surg. Pathol. 29 2005 1642 1651
    • (2005) Am. J. Surg. Pathol. , vol.29 , pp. 1642-1651
    • Korner, M.1
  • 23
    • 84869210746 scopus 로고    scopus 로고
    • Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release
    • S. Park Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release Proc. Natl. Acad. Sci. U.S.A. 109 2012 19003 19008
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 19003-19008
    • Park, S.1
  • 24
    • 84861553696 scopus 로고    scopus 로고
    • Pathophysiology of GPCR homo- and heterodimerization: Special emphasis on somatostatin receptors
    • R.K. Somvanshi, and U. Kumar Pathophysiology of GPCR homo- and heterodimerization: special emphasis on somatostatin receptors Pharmaceuticals 5 2012 417 446
    • (2012) Pharmaceuticals , vol.5 , pp. 417-446
    • Somvanshi, R.K.1    Kumar, U.2
  • 25
    • 0021746861 scopus 로고
    • High density of somatostatin receptors in pituitary tumors from acromegalic patients
    • J.C. Reubi, and A.M. Landolt High density of somatostatin receptors in pituitary tumors from acromegalic patients J. Clin. Endocrinol. Metab. 59 1984 1148 1151
    • (1984) J. Clin. Endocrinol. Metab. , vol.59 , pp. 1148-1151
    • Reubi, J.C.1    Landolt, A.M.2
  • 26
    • 0042854927 scopus 로고    scopus 로고
    • Peptide receptors as molecular targets for cancer diagnosis and therapy
    • J.C. Reubi Peptide receptors as molecular targets for cancer diagnosis and therapy Endocr. Rev. 24 2003 389 427
    • (2003) Endocr. Rev. , vol.24 , pp. 389-427
    • Reubi, J.C.1
  • 27
    • 0029979951 scopus 로고    scopus 로고
    • Local upregulation of neuropeptide receptors in host blood vessels around human colorectal cancers
    • J.C. Reubi Local upregulation of neuropeptide receptors in host blood vessels around human colorectal cancers Gastroenterology 110 1996 1719 1726
    • (1996) Gastroenterology , vol.110 , pp. 1719-1726
    • Reubi, J.C.1
  • 28
    • 0032126640 scopus 로고    scopus 로고
    • Localization of receptors for vasoactive intestinal peptide, somatostatin, and substance P in distinct compartments of human lymphoid organs
    • J.C. Reubi Localization of receptors for vasoactive intestinal peptide, somatostatin, and substance P in distinct compartments of human lymphoid organs Blood 92 1998 191 197
    • (1998) Blood , vol.92 , pp. 191-197
    • Reubi, J.C.1
  • 29
    • 0033329860 scopus 로고    scopus 로고
    • 2a receptors in the lymphatic, smooth muscular, and peripheral nervous systems of the human gastrointestinal tract: Facts and artifacts
    • 2a receptors in the lymphatic, smooth muscular, and peripheral nervous systems of the human gastrointestinal tract: facts and artifacts J. Clin. Endocrinol. Metab. 84 1999 2942 2950
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 2942-2950
    • Reubi, J.C.1
  • 30
    • 4644295622 scopus 로고    scopus 로고
    • 2A receptors in human gastrointestinal tissue
    • 2A receptors in human gastrointestinal tissue Gut 53 2004 1431 1436
    • (2004) Gut , vol.53 , pp. 1431-1436
    • Gugger, M.1
  • 31
    • 35348933794 scopus 로고    scopus 로고
    • Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: A proposal of scoring system correlated with somatostatin receptor scintigraphy
    • M. Volante Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy Mod. Pathol. 20 2007 1172 1182
    • (2007) Mod. Pathol. , vol.20 , pp. 1172-1182
    • Volante, M.1
  • 32
    • 57349142534 scopus 로고    scopus 로고
    • 2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1
    • 2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1 J. Clin. Endocrinol. Metab. 93 2008 4519 4524
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 4519-4524
    • Fischer, T.1
  • 33
    • 84857715394 scopus 로고    scopus 로고
    • Somatostatin receptors subtype 2A immunohistochemistry using a new monoclonal antibody selects tumors suitable for in vivo somatostatin receptor targeting
    • M. Korner Somatostatin receptors subtype 2A immunohistochemistry using a new monoclonal antibody selects tumors suitable for in vivo somatostatin receptor targeting Am. J. Surg. Pathol. 36 2012 242 252
    • (2012) Am. J. Surg. Pathol. , vol.36 , pp. 242-252
    • Korner, M.1
  • 34
    • 0031869490 scopus 로고    scopus 로고
    • 2A in human tumors
    • 2A in human tumors Am. J. Pathol. 153 1998 233 245
    • (1998) Am. J. Pathol. , vol.153 , pp. 233-245
    • Reubi, J.C.1
  • 35
    • 81355123315 scopus 로고    scopus 로고
    • 5 somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4
    • 5 somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4 Neuroendocrinology 94 2011 255 264
    • (2011) Neuroendocrinology , vol.94 , pp. 255-264
    • Lupp, A.1
  • 36
    • 84871675071 scopus 로고    scopus 로고
    • The glucagon-like peptide-1 receptor - Or not?
    • C. Pyke, and L.B. Knudsen The glucagon-like peptide-1 receptor - or not? Endocrinology 154 2013 4 8
    • (2013) Endocrinology , vol.154 , pp. 4-8
    • Pyke, C.1    Knudsen, L.B.2
  • 37
    • 60849130682 scopus 로고    scopus 로고
    • How reliable are G-protein-coupled receptor antibodies?
    • M.C. Michel How reliable are G-protein-coupled receptor antibodies? Naunyn Schmiedebergs Arch. Pharmacol. 379 2009 385 388
    • (2009) Naunyn Schmiedebergs Arch. Pharmacol. , vol.379 , pp. 385-388
    • Michel, M.C.1
  • 38
    • 0034924612 scopus 로고    scopus 로고
    • 5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands
    • 5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands Eur. J. Nucl. Med. 28 2001 836 846
    • (2001) Eur. J. Nucl. Med. , vol.28 , pp. 836-846
    • Reubi, J.C.1
  • 39
    • 0037907532 scopus 로고    scopus 로고
    • Concomitant expression of several peptide receptors in neuroendocrine tumors as molecular basis for in vivo multireceptor tumor targeting
    • J.C. Reubi, and B. Waser Concomitant expression of several peptide receptors in neuroendocrine tumors as molecular basis for in vivo multireceptor tumor targeting Eur. J. Nucl. Med. 30 2003 781 793
    • (2003) Eur. J. Nucl. Med. , vol.30 , pp. 781-793
    • Reubi, J.C.1    Waser, B.2
  • 40
    • 0025028868 scopus 로고
    • Detection of somatostatin receptors in surgical and percutaneous needle biopsy samples of carcinoids and islet cell carcinomas
    • J.C. Reubi Detection of somatostatin receptors in surgical and percutaneous needle biopsy samples of carcinoids and islet cell carcinomas Cancer Res. 50 1990 5969 5977
    • (1990) Cancer Res. , vol.50 , pp. 5969-5977
    • Reubi, J.C.1
  • 41
    • 0024518194 scopus 로고
    • The growth hormone responses to octreotide in acromegaly correlate with adenoma somatostatin receptor status
    • J.C. Reubi, and A.M. Landolt The growth hormone responses to octreotide in acromegaly correlate with adenoma somatostatin receptor status J. Clin. Endocrinol. Metab. 68 1989 844 850
    • (1989) J. Clin. Endocrinol. Metab. , vol.68 , pp. 844-850
    • Reubi, J.C.1    Landolt, A.M.2
  • 42
    • 0035062749 scopus 로고    scopus 로고
    • Somatostatin receptor subtype 2 and 5 in human GH-secreting pituitary adenomas: Analysis of gene sequence and mRNA expression
    • S. Corbetta Somatostatin receptor subtype 2 and 5 in human GH-secreting pituitary adenomas: analysis of gene sequence and mRNA expression Eur. J. Clin. Invest. 31 2001 208 214
    • (2001) Eur. J. Clin. Invest. , vol.31 , pp. 208-214
    • Corbetta, S.1
  • 43
    • 84872070630 scopus 로고    scopus 로고
    • 2A receptor monoclonal antibody strongly predicts the biochemical response to adjuvant treatment with somatostatin analogs in acromegaly
    • 2A receptor monoclonal antibody strongly predicts the biochemical response to adjuvant treatment with somatostatin analogs in acromegaly J. Clin. Endocrinol. Metab. 98 2013 E66 E71
    • (2013) J. Clin. Endocrinol. Metab. , vol.98
    • Gatto, F.1
  • 44
    • 66849135261 scopus 로고    scopus 로고
    • Analyses of factors influencing the acute effect of octreotide in growth hormone-secreting adenomas
    • M. Nakashima Analyses of factors influencing the acute effect of octreotide in growth hormone-secreting adenomas Endocr. J. 56 2009 295 304
    • (2009) Endocr. J. , vol.56 , pp. 295-304
    • Nakashima, M.1
  • 45
    • 39149098829 scopus 로고    scopus 로고
    • The clinical response to somatostatin analogues in acromegaly correlates to the somatostatin receptor subtype 2a protein expression of the adenoma
    • S.L. Fougner The clinical response to somatostatin analogues in acromegaly correlates to the somatostatin receptor subtype 2a protein expression of the adenoma Clin. Endocrinol. (Oxf.) 68 2008 458 465
    • (2008) Clin. Endocrinol. (Oxf.) , vol.68 , pp. 458-465
    • Fougner, S.L.1
  • 46
    • 57749094817 scopus 로고    scopus 로고
    • 2 decreases cell viability and hormonal hypersecretion and reverses octreotide resistance of human pituitary adenomas
    • 2 decreases cell viability and hormonal hypersecretion and reverses octreotide resistance of human pituitary adenomas Cancer Res. 68 2008 10163 10170
    • (2008) Cancer Res. , vol.68 , pp. 10163-10170
    • Acunzo, J.1
  • 47
    • 43549106356 scopus 로고    scopus 로고
    • Somatostatin and somatostatin receptors in Cushing's disease
    • L.J. Hofland Somatostatin and somatostatin receptors in Cushing's disease Mol. Cell. Endocrinol. 286 2008 199 205
    • (2008) Mol. Cell. Endocrinol. , vol.286 , pp. 199-205
    • Hofland, L.J.1
  • 48
    • 0344394952 scopus 로고    scopus 로고
    • Somatostatin receptors 2 and 5 are the major somatostatin receptors in insulinomas: An in vivo and in vitro study
    • J. Bertherat Somatostatin receptors 2 and 5 are the major somatostatin receptors in insulinomas: an in vivo and in vitro study J. Clin. Endocrinol. Metab. 88 2003 5353 5360
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 5353-5360
    • Bertherat, J.1
  • 49
    • 70349900717 scopus 로고    scopus 로고
    • Effects of initial therapy for five years with somatostatin analogs for acromegaly on growth hormone and insulin-like growth factor-I levels, tumor shrinkage, and cardiovascular disease: A prospective study
    • A. Colao Effects of initial therapy for five years with somatostatin analogs for acromegaly on growth hormone and insulin-like growth factor-I levels, tumor shrinkage, and cardiovascular disease: a prospective study J. Clin. Endocrinol. Metab. 94 2009 3746 3756
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 3746-3756
    • Colao, A.1
  • 50
    • 0025046240 scopus 로고
    • Somatostatin secretion and action in the regulation of growth hormone secretion
    • L.A. Frohman Somatostatin secretion and action in the regulation of growth hormone secretion Metabolism 39 Suppl. 2 1990 43 45
    • (1990) Metabolism , vol.39 , Issue.SUPPL. 2 , pp. 43-45
    • Frohman, L.A.1
  • 51
    • 0027324394 scopus 로고
    • Metastatic carcinoid tumors and the malignant carcinoid syndrome
    • L.K. Kvols, and J.C. Reubi Metastatic carcinoid tumors and the malignant carcinoid syndrome Acta Oncol. 32 1993 197 201
    • (1993) Acta Oncol. , vol.32 , pp. 197-201
    • Kvols, L.K.1    Reubi, J.C.2
  • 52
    • 79958120505 scopus 로고    scopus 로고
    • Somatostatin receptors as targets for nuclear medicine imaging and radionuclide treatment
    • H.R. Maecke, and J.C. Reubi Somatostatin receptors as targets for nuclear medicine imaging and radionuclide treatment J. Nucl. Med. 52 2011 841 844
    • (2011) J. Nucl. Med. , vol.52 , pp. 841-844
    • Maecke, H.R.1    Reubi, J.C.2
  • 53
    • 43549108138 scopus 로고    scopus 로고
    • Antitumor effects of somatostatin
    • S. Pyronnet Antitumor effects of somatostatin Mol. Cell. Endocrinol. 286 2008 230 237
    • (2008) Mol. Cell. Endocrinol. , vol.286 , pp. 230-237
    • Pyronnet, S.1
  • 54
    • 0041836171 scopus 로고    scopus 로고
    • Development of targeted somatostatin-based antiangiogenic therapy: A review and future perspectives
    • E.A. Woltering Development of targeted somatostatin-based antiangiogenic therapy: a review and future perspectives Cancer Biother. Radiopharm. 18 2003 601 609
    • (2003) Cancer Biother. Radiopharm. , vol.18 , pp. 601-609
    • Woltering, E.A.1
  • 55
    • 0032513507 scopus 로고    scopus 로고
    • Induction of wild-type p53, Bax, and acidic endonuclease during somatostatin-signaled apoptosis in MCF-7 human breast cancer cells
    • K. Sharma, and C.B. Srikant Induction of wild-type p53, Bax, and acidic endonuclease during somatostatin-signaled apoptosis in MCF-7 human breast cancer cells Int. J. Cancer 76 1998 259 266
    • (1998) Int. J. Cancer , vol.76 , pp. 259-266
    • Sharma, K.1    Srikant, C.B.2
  • 56
    • 0034771199 scopus 로고    scopus 로고
    • Hypothalamic hormones and cancer
    • A.V. Schally Hypothalamic hormones and cancer Front. Neuroendocrinol. 22 2001 248 291
    • (2001) Front. Neuroendocrinol. , vol.22 , pp. 248-291
    • Schally, A.V.1
  • 57
    • 0021341542 scopus 로고
    • The somatostatin receptor is directly coupled to adenylate cyclase in GH4C1 pituitary cell membranes
    • B.D. Koch, and A. Schonbrunn The somatostatin receptor is directly coupled to adenylate cyclase in GH4C1 pituitary cell membranes Endocrinology 114 1984 1784 1790
    • (1984) Endocrinology , vol.114 , pp. 1784-1790
    • Koch, B.D.1    Schonbrunn, A.2
  • 58
    • 0029609149 scopus 로고
    • Development and use of a receptor antibody to characterize the interaction between somatostatin receptor sst1 and G proteins
    • Y-Z. Gu Development and use of a receptor antibody to characterize the interaction between somatostatin receptor sst1 and G proteins Mol. Pharmacol. 48 1995 1004 1014
    • (1995) Mol. Pharmacol. , vol.48 , pp. 1004-1014
    • Gu, Y.-Z.1
  • 59
    • 0030896442 scopus 로고    scopus 로고
    • 2A and G proteins: Isolation of the receptor-G protein complex with a receptor antibody
    • 2A and G proteins: isolation of the receptor-G protein complex with a receptor antibody Mol. Endocrinol. 11 1997 527 537
    • (1997) Mol. Endocrinol. , vol.11 , pp. 527-537
    • Gu, Y.-Z.1    Schonbrunn, A.2
  • 60
    • 84876081315 scopus 로고    scopus 로고
    • i protein family members revealed by dissecting SST5 coupling in human pituitary cells
    • i protein family members revealed by dissecting SST5 coupling in human pituitary cells J. Cell Sci. 126 2013 638 644
    • (2013) J. Cell Sci. , vol.126 , pp. 638-644
    • Peverelli, E.1
  • 61
    • 0011994865 scopus 로고
    • Mechanism by which somatostatin inhibits pituitary hormone release
    • S. Reichlin, Plenum Press
    • A. Schonbrunn, and B.D. Koch Mechanism by which somatostatin inhibits pituitary hormone release S. Reichlin, Somatostatin: Basic and Clinical Status 1987 Plenum Press 121 135
    • (1987) Somatostatin: Basic and Clinical Status , pp. 121-135
    • Schonbrunn, A.1    Koch, B.D.2
  • 62
    • 0025829064 scopus 로고
    • + channels through protein dephosphorylation
    • + channels through protein dephosphorylation Nature 351 1991 570 573
    • (1991) Nature , vol.351 , pp. 570-573
    • White, R.E.1
  • 63
    • 0023818534 scopus 로고
    • Characterization of the cyclic AMP-independent actions of somatostatin in GH cells. I. An increase in potassium conductance is responsible for both the hyperpolarization and the decrease in intracellular free calcium produced by somatostatin
    • B.D. Koch Characterization of the cyclic AMP-independent actions of somatostatin in GH cells. I. An increase in potassium conductance is responsible for both the hyperpolarization and the decrease in intracellular free calcium produced by somatostatin J. Biol. Chem. 263 1988 216 225
    • (1988) J. Biol. Chem. , vol.263 , pp. 216-225
    • Koch, B.D.1
  • 64
    • 0022348092 scopus 로고
    • Pertussis toxin blocks both cyclic AMP-mediated and cyclic AMP-independent actions of somatostatin. Evidence for coupling of Ni to decreases in intracellular free calcium
    • B.D. Koch Pertussis toxin blocks both cyclic AMP-mediated and cyclic AMP-independent actions of somatostatin. Evidence for coupling of Ni to decreases in intracellular free calcium J. Biol. Chem. 260 1985 13138 13145
    • (1985) J. Biol. Chem. , vol.260 , pp. 13138-13145
    • Koch, B.D.1
  • 65
    • 0023879290 scopus 로고
    • Characterization of the cyclic AMP-independent actions of somatostatin in GH cells. II. An increase in potassium conductance initiates somatostatin-induced inhibition of prolactin secretion
    • B.D. Koch, and A. Schonbrunn Characterization of the cyclic AMP-independent actions of somatostatin in GH cells. II. An increase in potassium conductance initiates somatostatin-induced inhibition of prolactin secretion J. Biol. Chem. 263 1988 226 234
    • (1988) J. Biol. Chem. , vol.263 , pp. 226-234
    • Koch, B.D.1    Schonbrunn, A.2
  • 66
    • 0025117441 scopus 로고
    • Evidence that receptor-linked G protein inhibits exocytosis by a post-second-messenger mechanism in AtT-20 cells
    • A. Luini, and M.A. De Matteis Evidence that receptor-linked G protein inhibits exocytosis by a post-second-messenger mechanism in AtT-20 cells J. Neurochem. 54 1990 30 38
    • (1990) J. Neurochem. , vol.54 , pp. 30-38
    • Luini, A.1    De Matteis, M.A.2
  • 67
    • 0025193752 scopus 로고
    • 2+-induced insulin secretion in permeabilized HIT-T15 cells
    • 2+-induced insulin secretion in permeabilized HIT-T15 cells Biochem. J. 270 1990 273 276
    • (1990) Biochem. J. , vol.270 , pp. 273-276
    • Ullrich, S.1
  • 68
    • 84857019757 scopus 로고    scopus 로고
    • GPCR mediated regulation of synaptic transmission
    • K.M. Betke GPCR mediated regulation of synaptic transmission Prog. Neurobiol. 96 2012 304 321
    • (2012) Prog. Neurobiol. , vol.96 , pp. 304-321
    • Betke, K.M.1
  • 69
    • 84895944357 scopus 로고    scopus 로고
    • Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma
    • 10.1016/j.mce.2013.09.006
    • Y. Zhou Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma Mol. Cell. Endocrinol. 2013 10.1016/j.mce.2013.09.006
    • (2013) Mol. Cell. Endocrinol.
    • Zhou, Y.1
  • 70
    • 84877935267 scopus 로고    scopus 로고
    • Genetics of pituitary adenomas
    • M.R. Gadelha Genetics of pituitary adenomas Front. Horm. Res. 41 2013 111 140
    • (2013) Front. Horm. Res. , vol.41 , pp. 111-140
    • Gadelha, M.R.1
  • 71
    • 77955314342 scopus 로고    scopus 로고
    • GNAS imprinting and pituitary tumors
    • G. Mantovani GNAS imprinting and pituitary tumors Mol. Cell. Endocrinol. 326 2010 15 18
    • (2010) Mol. Cell. Endocrinol. , vol.326 , pp. 15-18
    • Mantovani, G.1
  • 72
    • 34249856993 scopus 로고    scopus 로고
    • Rapid pituitary tumor shrinkage with dissociation between antiproliferative and antisecretory effects of a long-acting octreotide in an acromegalic patient
    • E. Resmini Rapid pituitary tumor shrinkage with dissociation between antiproliferative and antisecretory effects of a long-acting octreotide in an acromegalic patient J. Clin. Endocrinol. Metab. 92 2007 1592 1599
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 1592-1599
    • Resmini, E.1
  • 73
    • 33845342901 scopus 로고    scopus 로고
    • Dissociation between tumor shrinkage and hormonal response during somatostatin analog treatment in an acromegalic patient: Preferential expression of somatostatin receptor subtype 3
    • A.P. Casarini Dissociation between tumor shrinkage and hormonal response during somatostatin analog treatment in an acromegalic patient: preferential expression of somatostatin receptor subtype 3 J. Endocrinol. Invest. 29 2006 826 830
    • (2006) J. Endocrinol. Invest. , vol.29 , pp. 826-830
    • Casarini, A.P.1
  • 74
    • 0030659656 scopus 로고    scopus 로고
    • S49 cells endogenously express subtype 2 somatostatin receptors which couple to increase protein tyrosine phosphatase activity in membranes and down-regulate Raf-1 activity in situ
    • P. Dent S49 cells endogenously express subtype 2 somatostatin receptors which couple to increase protein tyrosine phosphatase activity in membranes and down-regulate Raf-1 activity in situ Cell. Signal. 9 1997 539 549
    • (1997) Cell. Signal. , vol.9 , pp. 539-549
    • Dent, P.1
  • 75
    • 0030949012 scopus 로고    scopus 로고
    • Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected Ras-transformed NIH 3T3 cells: Coexpression with catalytically inactive SHP-2 blocks responsiveness
    • D.B. Reardon Activation in vitro of somatostatin receptor subtypes 2, 3, or 4 stimulates protein tyrosine phosphatase activity in membranes from transfected Ras-transformed NIH 3T3 cells: coexpression with catalytically inactive SHP-2 blocks responsiveness Mol. Endocrinol. 11 1997 1062 1069
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1062-1069
    • Reardon, D.B.1
  • 76
    • 43549097557 scopus 로고    scopus 로고
    • Somatostatin/somatostatin receptor signalling: Phosphotyrosine phosphatases
    • T. Florio Somatostatin/somatostatin receptor signalling: phosphotyrosine phosphatases Mol. Cell. Endocrinol. 286 2008 40 48
    • (2008) Mol. Cell. Endocrinol. , vol.286 , pp. 40-48
    • Florio, T.1
  • 77
    • 38449109564 scopus 로고    scopus 로고
    • Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors
    • T. Florio Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors Front. Biosci. 13 2008 822 840
    • (2008) Front. Biosci. , vol.13 , pp. 822-840
    • Florio, T.1
  • 78
    • 0031005019 scopus 로고    scopus 로고
    • Somatostatin acts by inhibiting the cyclic 3′,5′-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency
    • J.J. Tentler Somatostatin acts by inhibiting the cyclic 3′,5′-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency Mol. Endocrinol. 11 1997 859 866
    • (1997) Mol. Endocrinol. , vol.11 , pp. 859-866
    • Tentler, J.J.1
  • 79
    • 80051619308 scopus 로고    scopus 로고
    • Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia
    • I. Drozdov Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia PLoS ONE 6 2011 e22457
    • (2011) PLoS ONE , vol.6 , pp. 22457
    • Drozdov, I.1
  • 80
    • 84879611898 scopus 로고    scopus 로고
    • Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells
    • A.C. Emery Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells Sci. Signal. 6 2013 ra51
    • (2013) Sci. Signal. , vol.6 , pp. 51
    • Emery, A.C.1
  • 81
    • 84861013765 scopus 로고    scopus 로고
    • 2B receptor expression in neuroendocrine tumours: Potential targets for therapy
    • 2B receptor expression in neuroendocrine tumours: potential targets for therapy Purinergic Signal. 8 2012 265 274
    • (2012) Purinergic Signal. , vol.8 , pp. 265-274
    • Kalhan, A.1
  • 82
    • 73849117889 scopus 로고    scopus 로고
    • PACAP induces signaling and stimulation of 5-hydroxytryptamine release and growth in neuroendocrine tumor cells
    • P.M. Germano PACAP induces signaling and stimulation of 5-hydroxytryptamine release and growth in neuroendocrine tumor cells J. Mol. Neurosci. 39 2009 391 401
    • (2009) J. Mol. Neurosci. , vol.39 , pp. 391-401
    • Germano, P.M.1
  • 83
    • 79952467943 scopus 로고    scopus 로고
    • Physiopathology of somatolactotroph cells: From transduction mechanisms to cotargeting therapy
    • T. Cuny Physiopathology of somatolactotroph cells: from transduction mechanisms to cotargeting therapy Ann. N. Y. Acad. Sci. 1220 2011 60 70
    • (2011) Ann. N. Y. Acad. Sci. , vol.1220 , pp. 60-70
    • Cuny, T.1
  • 84
    • 0029811177 scopus 로고    scopus 로고
    • Somatostatin receptor-mediated signaling in smooth muscle. Activation of phospholipase C-β3 by Gβγ and inhibition of adenylyl cyclase by Gαi1 and Gαo
    • K.S. Murthy Somatostatin receptor-mediated signaling in smooth muscle. Activation of phospholipase C-β3 by Gβγ and inhibition of adenylyl cyclase by Gαi1 and Gαo J. Biol. Chem. 271 1996 23458 23463
    • (1996) J. Biol. Chem. , vol.271 , pp. 23458-23463
    • Murthy, K.S.1
  • 85
    • 0029125086 scopus 로고
    • 2+ mobilization in rat AR42J pancreas cells
    • 2+ mobilization in rat AR42J pancreas cells Biochem. Biophys. Res. Commun. 214 1995 81 85
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 81-85
    • Taylor, J.E.1
  • 86
    • 73549093367 scopus 로고    scopus 로고
    • 2A receptor: The pan-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways
    • 2A receptor: the pan-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways Mol. Endocrinol. 24 2010 240 249
    • (2010) Mol. Endocrinol. , vol.24 , pp. 240-249
    • Cescato, R.1
  • 87
    • 18844395883 scopus 로고    scopus 로고
    • SRC homology-2-containing protein tyrosine phosphatase-1 restrains cell proliferation in human medullary thyroid carcinoma
    • M.C. Zatelli SRC homology-2-containing protein tyrosine phosphatase-1 restrains cell proliferation in human medullary thyroid carcinoma Endocrinology 146 2005 2692 2698
    • (2005) Endocrinology , vol.146 , pp. 2692-2698
    • Zatelli, M.C.1
  • 88
    • 33747635920 scopus 로고    scopus 로고
    • Somatostatin analogues stimulate p27 expression and inhibit the MAP kinase pathway in pituitary tumours
    • E. Hubina Somatostatin analogues stimulate p27 expression and inhibit the MAP kinase pathway in pituitary tumours Eur. J. Endocrinol. 155 2006 371 379
    • (2006) Eur. J. Endocrinol. , vol.155 , pp. 371-379
    • Hubina, E.1
  • 89
    • 34548291341 scopus 로고    scopus 로고
    • Differential signaling of dopamine-D2S and -D2L receptors to inhibit ERK1/2 phosphorylation
    • I.I. Van-Ham Differential signaling of dopamine-D2S and -D2L receptors to inhibit ERK1/2 phosphorylation J. Neurochem. 102 2007 1796 1804
    • (2007) J. Neurochem. , vol.102 , pp. 1796-1804
    • Van-Ham, I.I.1
  • 90
    • 50249160709 scopus 로고    scopus 로고
    • Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines
    • M. Kidd Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines Cancer 113 2008 690 700
    • (2008) Cancer , vol.113 , pp. 690-700
    • Kidd, M.1
  • 91
    • 34548835206 scopus 로고    scopus 로고
    • An update on somatostatin receptor signaling in native systems and new insights on their pathophysiology
    • D. Cervia, and P. Bagnoli An update on somatostatin receptor signaling in native systems and new insights on their pathophysiology Pharmacol. Ther. 116 2007 322 341
    • (2007) Pharmacol. Ther. , vol.116 , pp. 322-341
    • Cervia, D.1    Bagnoli, P.2
  • 92
  • 93
    • 78649719156 scopus 로고    scopus 로고
    • Somatostatin receptor biology in neuroendocrine and pituitary tumours: Part 1 - Molecular pathways
    • M. Cakir Somatostatin receptor biology in neuroendocrine and pituitary tumours: part 1 - molecular pathways J. Cell. Mol. Med. 14 2010 2570 2584
    • (2010) J. Cell. Mol. Med. , vol.14 , pp. 2570-2584
    • Cakir, M.1
  • 94
    • 0029791822 scopus 로고    scopus 로고
    • Agonist-dependent regulation of cloned human somatostatin receptor types 1-5 (hSSTR1-5): Subtype selective internalization or upregulation
    • N. Hukovic Agonist-dependent regulation of cloned human somatostatin receptor types 1-5 (hSSTR1-5): subtype selective internalization or upregulation Endocrinology 137 1996 4046 4049
    • (1996) Endocrinology , vol.137 , pp. 4046-4049
    • Hukovic, N.1
  • 95
    • 2442705543 scopus 로고    scopus 로고
    • Differential β-arrestin trafficking and endosomal sorting of somatostatin receptor subtypes
    • G. Tulipano Differential β-arrestin trafficking and endosomal sorting of somatostatin receptor subtypes J. Biol. Chem. 279 2004 21374 21382
    • (2004) J. Biol. Chem. , vol.279 , pp. 21374-21382
    • Tulipano, G.1
  • 96
    • 43549108318 scopus 로고    scopus 로고
    • Selective agonism in somatostatin receptor signaling and regulation
    • A. Schonbrunn Selective agonism in somatostatin receptor signaling and regulation Mol. Cell. Endocrinol. 286 2008 35 39
    • (2008) Mol. Cell. Endocrinol. , vol.286 , pp. 35-39
    • Schonbrunn, A.1
  • 97
    • 84857019641 scopus 로고    scopus 로고
    • Molecular mechanisms of somatostatin receptor trafficking
    • Z. Csaba Molecular mechanisms of somatostatin receptor trafficking J. Mol. Endocrinol. 48 2012 R1 R12
    • (2012) J. Mol. Endocrinol. , vol.48
    • Csaba, Z.1
  • 98
    • 0030946790 scopus 로고    scopus 로고
    • 2A somatostatin receptor
    • 2A somatostatin receptor J. Biol. Chem. 272 1997 13869 13876
    • (1997) J. Biol. Chem. , vol.272 , pp. 13869-13876
    • Hipkin, R.W.1
  • 99
    • 0036843753 scopus 로고    scopus 로고
    • Homologous and heterologous regulation of somatostatin receptor 2
    • G. Elberg Homologous and heterologous regulation of somatostatin receptor 2 Mol. Endocrinol. 16 2002 2502 2514
    • (2002) Mol. Endocrinol. , vol.16 , pp. 2502-2514
    • Elberg, G.1
  • 100
    • 66649130802 scopus 로고    scopus 로고
    • 2 receptors in somatostatin target tissues
    • 2 receptors in somatostatin target tissues J. Nucl. Med. 50 2009 936 941
    • (2009) J. Nucl. Med. , vol.50 , pp. 936-941
    • Waser, B.1
  • 101
    • 77952756362 scopus 로고    scopus 로고
    • 2 receptors in neuroendocrine tumors of octreotide-treated patients
    • 2 receptors in neuroendocrine tumors of octreotide-treated patients J. Clin. Endocrinol. Metab. 95 2010 2343 2350
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 2343-2350
    • Reubi, J.C.1
  • 102
    • 0034006943 scopus 로고    scopus 로고
    • 2A somatostatin receptor
    • 2A somatostatin receptor J. Biol. Chem. 275 2000 5591 5599
    • (2000) J. Biol. Chem. , vol.275 , pp. 5591-5599
    • Hipkin, R.W.1
  • 103
    • 67649884461 scopus 로고    scopus 로고
    • 2A) phosphorylation
    • 2A) phosphorylation Mol. Pharmacol. 76 2009 68 80
    • (2009) Mol. Pharmacol. , vol.76 , pp. 68-80
    • Liu, Q.1
  • 104
    • 75149175187 scopus 로고    scopus 로고
    • 2A somatostatin receptor phosphorylation
    • 2A somatostatin receptor phosphorylation Mol. Endocrinol. 24 2010 436 446
    • (2010) Mol. Endocrinol. , vol.24 , pp. 436-446
    • Poll, F.1
  • 105
    • 79953902541 scopus 로고    scopus 로고
    • Differential temporal and spatial regulation of somatostatin receptor phosphorylation and dephosphorylation
    • M. Ghosh, and A. Schonbrunn Differential temporal and spatial regulation of somatostatin receptor phosphorylation and dephosphorylation J. Biol. Chem. 286 2011 13561 13573
    • (2011) J. Biol. Chem. , vol.286 , pp. 13561-13573
    • Ghosh, M.1    Schonbrunn, A.2
  • 106
    • 38549090808 scopus 로고    scopus 로고
    • 2A somatostatin receptor control internalization, desensitization, and arrestin binding
    • 2A somatostatin receptor control internalization, desensitization, and arrestin binding Mol. Pharmacol. 73 2008 292 304
    • (2008) Mol. Pharmacol. , vol.73 , pp. 292-304
    • Liu, Q.1
  • 107
    • 49049108953 scopus 로고    scopus 로고
    • Arrestins as multi-functional signaling adaptors
    • V.V. Gurevich Arrestins as multi-functional signaling adaptors Handb. Exp. Pharmacol. 186 2008 15 37
    • (2008) Handb. Exp. Pharmacol. , vol.186 , pp. 15-37
    • Gurevich, V.V.1
  • 108
    • 79957663678 scopus 로고    scopus 로고
    • 2A receptor trafficking: Role of site-specific phosphorylation and receptor activation in the actions of biased somatostatin agonists
    • 2A receptor trafficking: role of site-specific phosphorylation and receptor activation in the actions of biased somatostatin agonists Mol. Endocrinol. 25 2011 1040 1054
    • (2011) Mol. Endocrinol. , vol.25 , pp. 1040-1054
    • Kao, Y.J.1
  • 109
    • 80053039967 scopus 로고    scopus 로고
    • Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling
    • F. Poll Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling J. Biol. Chem. 286 2011 32931 32936
    • (2011) J. Biol. Chem. , vol.286 , pp. 32931-32936
    • Poll, F.1
  • 110
    • 0347362837 scopus 로고    scopus 로고
    • In vivo phosphorylation of the somatostatin 2A receptor in human tumors
    • Q. Liu In vivo phosphorylation of the somatostatin 2A receptor in human tumors J. Clin. Endocrinol. Metab. 88 2003 6073 6079
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 6073-6079
    • Liu, Q.1
  • 111
    • 84860231357 scopus 로고    scopus 로고
    • 2 receptors in neuroendocrine tumors after octreotide treatment of patients
    • 2 receptors in neuroendocrine tumors after octreotide treatment of patients Am. J. Pathol. 180 2012 1942 1949
    • (2012) Am. J. Pathol. , vol.180 , pp. 1942-1949
    • Waser, B.1
  • 112
    • 40849098704 scopus 로고    scopus 로고
    • The third intracellular loop of the human somatostatin receptor 5 is crucial for arrestin binding and receptor internalization after somatostatin stimulation
    • E. Peverelli The third intracellular loop of the human somatostatin receptor 5 is crucial for arrestin binding and receptor internalization after somatostatin stimulation Mol. Endocrinol. 22 2008 676 688
    • (2008) Mol. Endocrinol. , vol.22 , pp. 676-688
    • Peverelli, E.1
  • 113
    • 84875541584 scopus 로고    scopus 로고
    • 5 somatostatin receptor
    • 5 somatostatin receptor Mol. Endocrinol. 27 2013 671 682
    • (2013) Mol. Endocrinol. , vol.27 , pp. 671-682
    • Petrich, A.1
  • 114
    • 0030816392 scopus 로고    scopus 로고
    • Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization
    • A. Roth Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization J. Biol. Chem. 272 1997 23769 23774
    • (1997) J. Biol. Chem. , vol.272 , pp. 23769-23774
    • Roth, A.1
  • 115
    • 0031032344 scopus 로고    scopus 로고
    • 2 receptor subtypes: A confocal microscopic study using novel fluorescent somatostatin derivatives
    • 2 receptor subtypes: a confocal microscopic study using novel fluorescent somatostatin derivatives Endocrinology 138 1997 296 306
    • (1997) Endocrinology , vol.138 , pp. 296-306
    • Nouel, D.1
  • 116
    • 0035793625 scopus 로고    scopus 로고
    • 1). Relationship to desensitization and internalization
    • 1). Relationship to desensitization and internalization J. Biol. Chem. 276 2001 3709 3717
    • (2001) J. Biol. Chem. , vol.276 , pp. 3709-3717
    • Liu, Q.1    Schonbrunn, A.2
  • 117
    • 33847077694 scopus 로고    scopus 로고
    • Agonist-induced endocytosis of rat somatostatin receptor 1
    • D. Roosterman Agonist-induced endocytosis of rat somatostatin receptor 1 Endocrinology 148 2007 1050 1058
    • (2007) Endocrinology , vol.148 , pp. 1050-1058
    • Roosterman, D.1
  • 119
    • 0031793402 scopus 로고    scopus 로고
    • Rat somatostatin receptor subtype 4 can be made sensitive to agonist-induced internalization by mutation of a single threonine (residue 331)
    • H.J. Kreienkamp Rat somatostatin receptor subtype 4 can be made sensitive to agonist-induced internalization by mutation of a single threonine (residue 331) DNA Cell Biol. 17 1998 869 878
    • (1998) DNA Cell Biol. , vol.17 , pp. 869-878
    • Kreienkamp, H.J.1
  • 120
    • 84856652508 scopus 로고    scopus 로고
    • Physiological role of G-protein coupled receptor phosphorylation
    • A.J. Butcher Physiological role of G-protein coupled receptor phosphorylation Handb. Exp. Pharmacol. 208 2012 79 94
    • (2012) Handb. Exp. Pharmacol. , vol.208 , pp. 79-94
    • Butcher, A.J.1
  • 121
    • 79953192547 scopus 로고    scopus 로고
    • Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code
    • A.J. Butcher Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code J. Biol. Chem. 286 2011 11506 11518
    • (2011) J. Biol. Chem. , vol.286 , pp. 11506-11518
    • Butcher, A.J.1
  • 122
    • 0346328229 scopus 로고    scopus 로고
    • Opportunities in somatostatin research: Biological, chemical and therapeutic aspects
    • G. Weckbecker Opportunities in somatostatin research: biological, chemical and therapeutic aspects Nat. Rev. Drug Discov. 2 2003 999 1017
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 999-1017
    • Weckbecker, G.1
  • 123
    • 0020363575 scopus 로고
    • SMS 201-995: A very potent and selective octapeptide analogue of somatostatin with prolonged action
    • W. Bauer SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action Life Sci. 31 1982 1133 1141
    • (1982) Life Sci. , vol.31 , pp. 1133-1141
    • Bauer, W.1
  • 124
    • 0022479691 scopus 로고
    • Chemistry and pharmacology of SMS 201-995, a long-acting octapeptide analogue of somatostatin
    • J. Pless Chemistry and pharmacology of SMS 201-995, a long-acting octapeptide analogue of somatostatin Scand. J. Gastroenterol. 21 Suppl. 119 1986 54 64
    • (1986) Scand. J. Gastroenterol. , vol.21 , Issue.SUPPL. 119 , pp. 54-64
    • Pless, J.1
  • 125
    • 0021213939 scopus 로고
    • Evidence for two somatostatin-14 receptor types in rat brain cortex
    • J.C. Reubi Evidence for two somatostatin-14 receptor types in rat brain cortex Neurosci. Lett. 49 1984 259 263
    • (1984) Neurosci. Lett. , vol.49 , pp. 259-263
    • Reubi, J.C.1
  • 126
    • 0021804166 scopus 로고
    • New specific radioligand for one subpopulation of brain somatostatin receptors
    • J.C. Reubi New specific radioligand for one subpopulation of brain somatostatin receptors Life Sci. 36 1985 1829 1836
    • (1985) Life Sci. , vol.36 , pp. 1829-1836
    • Reubi, J.C.1
  • 127
    • 0021959356 scopus 로고
    • Brain somatostatin receptor subpopulation visualized by autoradiography
    • R. Maurer, and J.C. Reubi Brain somatostatin receptor subpopulation visualized by autoradiography Brain Res. 333 1985 178 181
    • (1985) Brain Res. , vol.333 , pp. 178-181
    • Maurer, R.1    Reubi, J.C.2
  • 128
    • 84925581799 scopus 로고    scopus 로고
    • Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy
    • K.E. Oberg Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy Gastroenterology 139 2010 742 753
    • (2010) Gastroenterology , vol.139 , pp. 742-753
    • Oberg, K.E.1
  • 129
    • 70350442637 scopus 로고    scopus 로고
    • Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID study group
    • A. Rinke Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID study group J. Clin. Oncol. 27 2009 4656 4663
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4656-4663
    • Rinke, A.1
  • 130
    • 15944427116 scopus 로고    scopus 로고
    • Clinical review: The antitumoral effects of somatostatin analog therapy in acromegaly
    • J.S. Bevan Clinical review: the antitumoral effects of somatostatin analog therapy in acromegaly J. Clin. Endocrinol. Metab. 90 2005 1856 1863
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 1856-1863
    • Bevan, J.S.1
  • 131
    • 77954556448 scopus 로고    scopus 로고
    • Antiproliferative effect of somatostatin analogs in gastroenteropancreatic neuroendocrine tumors
    • J. Strosberg, and L. Kvols Antiproliferative effect of somatostatin analogs in gastroenteropancreatic neuroendocrine tumors World J. Gastroenterol. 16 2010 2963 2970
    • (2010) World J. Gastroenterol. , vol.16 , pp. 2963-2970
    • Strosberg, J.1    Kvols, L.2
  • 132
    • 0035985284 scopus 로고    scopus 로고
    • The clinical role of somatostatin analogues as antineoplastic agents: Much ado about nothing?
    • M. Hejna The clinical role of somatostatin analogues as antineoplastic agents: much ado about nothing? Ann. Oncol. 13 2002 653 668
    • (2002) Ann. Oncol. , vol.13 , pp. 653-668
    • Hejna, M.1
  • 133
    • 0037027926 scopus 로고    scopus 로고
    • A new peptidic somatostatin agonist with high affinity to all five somatostatin receptors
    • J.C. Reubi A new peptidic somatostatin agonist with high affinity to all five somatostatin receptors Eur. J. Pharmacol. 456 2002 45 49
    • (2002) Eur. J. Pharmacol. , vol.456 , pp. 45-49
    • Reubi, J.C.1
  • 134
    • 84867411913 scopus 로고    scopus 로고
    • Pasireotide (SOM230) shows efficacy and tolerability in the treatment of patients with advanced neuroendocrine tumors refractory or resistant to octreotide LAR: Results from a phase II study
    • L.K. Kvols Pasireotide (SOM230) shows efficacy and tolerability in the treatment of patients with advanced neuroendocrine tumors refractory or resistant to octreotide LAR: results from a phase II study Endocr. Relat. Cancer 19 2012 657 666
    • (2012) Endocr. Relat. Cancer , vol.19 , pp. 657-666
    • Kvols, L.K.1
  • 135
    • 84857826594 scopus 로고    scopus 로고
    • A 12-month phase 3 study of pasireotide in Cushing's disease
    • A. Colao A 12-month phase 3 study of pasireotide in Cushing's disease N. Engl. J. Med. 366 2012 914 924
    • (2012) N. Engl. J. Med. , vol.366 , pp. 914-924
    • Colao, A.1
  • 136
    • 17744364678 scopus 로고    scopus 로고
    • Novel long-acting somatostatin analog with endocrine selectivity: Potent suppression of growth hormone but not of insulin
    • M. Afargan Novel long-acting somatostatin analog with endocrine selectivity: potent suppression of growth hormone but not of insulin Endocrinology 142 2001 477 486
    • (2001) Endocrinology , vol.142 , pp. 477-486
    • Afargan, M.1
  • 137
    • 84856094615 scopus 로고    scopus 로고
    • DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours
    • U. Plockinger DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours Eur. J. Endocrinol. 166 2012 223 234
    • (2012) Eur. J. Endocrinol. , vol.166 , pp. 223-234
    • Plockinger, U.1
  • 138
    • 82155172862 scopus 로고    scopus 로고
    • Somatostatin-dopamine chimeras: A novel approach to treatment of neuroendocrine tumors
    • M.D. Culler Somatostatin-dopamine chimeras: a novel approach to treatment of neuroendocrine tumors Horm. Metab. Res. 43 2011 854 857
    • (2011) Horm. Metab. Res. , vol.43 , pp. 854-857
    • Culler, M.D.1
  • 140
    • 84889099420 scopus 로고    scopus 로고
    • Ipsen 15 December
    • Ipsen (2010) Ipsen Closes its BIM 23A760 Trials, 15 December (http://www.ipsen.com/wp-content/uploads/2013/03/PR-Ipsen-BIM-23A760-EN-FINAL. pdf)
    • (2010) Ipsen Closes Its BIM 23A760 Trials
  • 141
    • 77952354490 scopus 로고    scopus 로고
    • Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery
    • T. Kenakin, and L.J. Miller Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery Pharmacol. Rev. 62 2010 265 304
    • (2010) Pharmacol. Rev. , vol.62 , pp. 265-304
    • Kenakin, T.1    Miller, L.J.2
  • 142
    • 22344439021 scopus 로고    scopus 로고
    • Receptor signaling and endocytosis are differentially regulated by somatostatin analogs
    • Q. Liu Receptor signaling and endocytosis are differentially regulated by somatostatin analogs Mol. Pharmacol. 68 2005 90 101
    • (2005) Mol. Pharmacol. , vol.68 , pp. 90-101
    • Liu, Q.1
  • 143
    • 59749083610 scopus 로고    scopus 로고
    • Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro
    • S. Lesche Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro J. Clin. Endocrinol. Metab. 94 2009 654 661
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 654-661
    • Lesche, S.1
  • 144
    • 84874738532 scopus 로고    scopus 로고
    • Pasireotide, a multi-somatostatin receptor ligand with potential efficacy for treatment of pituitary and neuroendocrine tumors
    • R.A. Feelders Pasireotide, a multi-somatostatin receptor ligand with potential efficacy for treatment of pituitary and neuroendocrine tumors Drugs Today (Barc.) 49 2013 89 103
    • (2013) Drugs Today (Barc.) , vol.49 , pp. 89-103
    • Feelders, R.A.1
  • 145
    • 84881316265 scopus 로고    scopus 로고
    • Hyperglycemia associated with pasireotide: Results from a mechanistic study in healthy volunteers
    • R.R. Henry Hyperglycemia associated with pasireotide: results from a mechanistic study in healthy volunteers J. Clin. Endocrinol. Metab. 98 2013 3446 3453
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. 3446-3453
    • Henry, R.R.1
  • 147
    • 84868312359 scopus 로고    scopus 로고
    • SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- And α-cells
    • B. Kailey SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells Am. J. Physiol. Endocrinol. Metab. 303 2012 E1107 E1116
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.303
    • Kailey, B.1
  • 148
    • 43749091955 scopus 로고    scopus 로고
    • Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3]octreotate: Toxicity, efficacy, and survival
    • D.J. Kwekkeboom Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3]octreotate: toxicity, efficacy, and survival J. Clin. Oncol. 26 2008 2124 2130
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2124-2130
    • Kwekkeboom, D.J.1
  • 149
    • 57349195981 scopus 로고    scopus 로고
    • Peptide-based probes for cancer imaging
    • J.C. Reubi, and H.R. Maecke Peptide-based probes for cancer imaging J. Nucl. Med. 49 2008 1735 1738
    • (2008) J. Nucl. Med. , vol.49 , pp. 1735-1738
    • Reubi, J.C.1    Maecke, H.R.2
  • 150
    • 21244490346 scopus 로고    scopus 로고
    • 68Ga-DOTANOC: A first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5
    • 68Ga-DOTANOC: a first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5 Eur. J. Nucl. Med. Mol. Imaging 32 2005 724
    • (2005) Eur. J. Nucl. Med. Mol. Imaging , vol.32 , pp. 724
    • Wild, D.1
  • 151
    • 0141996533 scopus 로고    scopus 로고
    • DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals
    • D. Wild DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals Eur. J. Nucl. Med. Mol. Imaging 30 2003 1338 1347
    • (2003) Eur. J. Nucl. Med. Mol. Imaging , vol.30 , pp. 1338-1347
    • Wild, D.1
  • 152
    • 84874875874 scopus 로고    scopus 로고
    • Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT within patients with gastroenteropancreatic neuroendocrine tumors
    • D. Wild Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT within patients with gastroenteropancreatic neuroendocrine tumors J. Nucl. Med. 54 2013 364 372
    • (2013) J. Nucl. Med. , vol.54 , pp. 364-372
    • Wild, D.1
  • 153
    • 42249083915 scopus 로고    scopus 로고
    • New pansomatostatin ligands and their chelated versions: Affinity profile, agonist activity, internalization, and tumor targeting
    • M. Ginj New pansomatostatin ligands and their chelated versions: affinity profile, agonist activity, internalization, and tumor targeting Clin. Cancer Res. 14 2008 2019 2027
    • (2008) Clin. Cancer Res. , vol.14 , pp. 2019-2027
    • Ginj, M.1
  • 154
    • 84889089988 scopus 로고    scopus 로고
    • Biodistribution and dosimetry of [68Ga]-DOTASOM targeting somatostatin receptors in a pig model
    • U. Eberlein Biodistribution and dosimetry of [68Ga]-DOTASOM targeting somatostatin receptors in a pig model Eur. J. Nucl. Med. Mol. Imaging 39 Suppl. 2 2012 S325
    • (2012) Eur. J. Nucl. Med. Mol. Imaging , vol.39 , Issue.SUPPL. 2 , pp. 325
    • Eberlein, U.1
  • 155
    • 84889086100 scopus 로고    scopus 로고
    • 0LTT-SS28
    • 0]LTT-SS28 Eur. J. Nucl. Med. 37 Suppl. 2 2010 S299
    • (2010) Eur. J. Nucl. Med. , vol.37 , Issue.SUPPL. 2 , pp. 299
    • Tatsi, A.1
  • 156
    • 84875912117 scopus 로고    scopus 로고
    • 111In-DOTA]Somatostatin-14 analogs as potential pansomatostatin-like radiotracers - First results of a preclinical study
    • 111In-DOTA]Somatostatin-14 analogs as potential pansomatostatin-like radiotracers - first results of a preclinical study EJNMMI Res. 2 2012 25
    • (2012) EJNMMI Res. , vol.2 , pp. 25
    • Tatsi, A.1
  • 157
    • 33646005541 scopus 로고    scopus 로고
    • 5 receptors: Effects of somatostatin agonists and antagonists
    • 5 receptors: effects of somatostatin agonists and antagonists J. Nucl. Med. 47 2006 502 511
    • (2006) J. Nucl. Med. , vol.47 , pp. 502-511
    • Cescato, R.1
  • 158
    • 33750823665 scopus 로고    scopus 로고
    • Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors
    • M. Ginj Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors Proc. Natl. Acad. Sci. U.S.A. 103 2006 16436 16441
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 16436-16441
    • Ginj, M.1
  • 159
    • 79958169382 scopus 로고    scopus 로고
    • First clinical evaluation of somatostatin receptor antagonist imaging
    • D. Wild First clinical evaluation of somatostatin receptor antagonist imaging J. Nucl. Med. 51 Suppl. 2 2010 483
    • (2010) J. Nucl. Med. , vol.51 , Issue.SUPPL. 2 , pp. 483
    • Wild, D.1
  • 160
    • 46849089935 scopus 로고    scopus 로고
    • 2-selective somatostatin antagonists suitable for radiotargeting
    • 2-selective somatostatin antagonists suitable for radiotargeting J. Med. Chem. 51 2008 4030 4037
    • (2008) J. Med. Chem. , vol.51 , pp. 4030-4037
    • Cescato, R.1


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