Targeting monocarboxylate transporter by α-cyano-4-hydroxycinnamate modulates apoptosis and cisplatin resistance of Colo205 cells: Implication of altered cell survival regulation

Apoptosis

Volumn 18, Issue 12, 2013, Pages 1574-1585

  Kumar, Ajay ^a   Kant, Shiva ^a   Singh, Sukh Mahendra ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Cyano 4 hydroxycinnamate ( CHC); Apoptosis; Cisplatin; Monocarboxylate transporter (MCT); Multidrug resistance

Indexed keywords

ALPHA CYANO 4 HYDROXYCINNAMIC ACID; CASPASE 3; CISPLATIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER; MULTIDRUG RESISTANCE PROTEIN 1; NITRIC OXIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL PH; CELL SURVIVAL; CHEMOSENSITIZATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG TARGETING; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MODULATION; MOLECULAR EVOLUTION; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOCARCINOMA; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; COLONIC NEOPLASMS; COUMARIC ACIDS; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS;

EID: 84889080194     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0894-7     Document Type: Article

References (67)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 6:69-90
2. Galon J, Fridman WH, Pagès F (2007) The adaptive immunologic microenvironment in colorectal cancer: a novel perspective. Cancer Res 67:1883-1886
3. Cammarota R, Bertolini V, Pennesi G et al (2010) The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker. J Transl Med 8:112
4. Peddareddigari VG, Wang D, Dubois RN (2010) The tumor microenvironment in colorectal carcinogenesis. Cancer Microenviron 3:149-166
5. Ogino S, Giovannucci E (2012) Commentary: lifestyle factors and colorectal cancer microsatellite instability-molecular pathological epidemiology science, based on unique tumour principle. Int J Epidemiol 41:1072-1074
6. Yamakuchi M, Yagi S, Ito T, Lowenstein CJ (2011) MicroRNA-22 regulates hypoxia signaling in colon cancer cells. PLoS One 6:e20291
7. Yeung TM, Gandhi SC, Bodmer WF (2011) Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells. Proc Natl Acad Sci USA 108:4382-4387
8. Xue X, Taylor M, Anderson E et al (2012) Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res 72:2285-2293
9. Ehrmann-Jósko A, Siemińska J, Górnicka B, Ziarkiewicz-Wróblewska B, Ziółkowski B, Muszyński J (2006) Impaired glucose metabolism in colorectal cancer. Scand J Gastroenterol 41:1079-1086
10. Ehrmann-Jósko A, Siemińska J, Górnicka B, Ziarkiewicz-Wróblewska B, Ziółkowski B, Muszyński J (2011) Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival. PLoS One 6:e24411
11. Koukourakis MI, Giatromanolaki A, Harris AL, Sivridis E (2006) Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res 66:632-637
12. Le Floch R, Chiche J, Marchiq I et al (2011) CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci USA 108:16663-16668
13. Baba M, Inoue M, Itoh K, Nishizawa Y (2008) Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism. Biochem Biophys Res Commun 374:111-116
14. Sonveaux P, Végran F, Schroeder T et al (2008) Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 118:3930-3942
15. Espinoza AM, Venook AP (2011) Lactic acidosis and colon cancer: oncologic emergency? Clin Colorectal Cancer 10:194-197
16. Végran F, Boidot R, Michiels C, Sonveaux P, Feron O (2011) Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis. Cancer Res 71:2550-2560
17. Pinheiro C, Reis RM, Ricardo S, Longatto-Filho A, Schmitt F, Baltazar F (2010) Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. J Biomed Biotechnol 2010:427694
18. Halestrap AP, Meredith D (2004) The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 447:619-628
19. Halestrap AP (2012) The monocarboxylate transporter family-structure and functional characterization. IUBMB Life 64:1-9
20. Kennedy KM, Dewhirst MW (2010) Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. Future Oncol 6:127-148
21. Pinheiro C, Longatto-Filho A, Azevedo-Silva J, Casal M, Schmitt FC, Baltazar F (2012) Role of monocarboxylate transporters in human cancers: state of the art. J Bioenerg Biomembr 44:127-139
22. Webb BA, Chimenti M, Jacobson MP, Barber DL (2011) Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer 11:671-677
23. Izumi H, Torigoe T, Ishiguchi H et al (2003) Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy. Cancer Treat Rev 29:541-549
24. Mathupala SP, Colen CB, Parajuli P, Sloan AE (2007) Lactate and malignant tumors: a therapeutic target at the end stage of glycolysis. J Bioenerg Biomembr 39:73-77
25. Kumar A, Kant S, Singh SM (2013) α-Cyano-4-hydroxycinnamate induces apoptosis in Dalton's lymphoma cells: role of altered cell survival-regulatory mechanisms. Anticancer Drugs 24:158-171
26. Colen CB, Seraji-Bozorgzad N, Marples B, Galloway MP, Sloan AE, Mathupala SP (2006) Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study. Neurosurgery 59:1313-1323
27. Colen CB, Shen Y, Ghoddoussi F et al (2011) Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study. Neoplasia 13:620-632
28. Fang J, Quinones QJ, Holman TL et al (2006) The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol Pharmacol 70:2108-2115
29. Simchowitz L, Davis AO (1991) Internal alkalinization by reversal of anion exchange in human neutrophils: regulation of transport by pH. Am J Physiol 260:132-142
30. Brivet M, Garcia-Cazorla A, Lyonnet S et al (2003) Impaired mitochondrial pyruvate importation in a patient and a fetus at risk. Mol Genet Metab 78:186-192
31. Szakács G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM (2006) Targeting multidrug resistance in cancer. Nat Rev Drug Discov 5:219-234
32. Pérez-Tomás R (2006) Multidrug resistance: retrospect and prospects in anti-cancer drug treatment. Curr Med Chem 13:1859-1876
33. Wahl ML, Owen JA, Burd R et al (2002) Regulation of intracellular pH in human melanoma: potential therapeutic implications. Mol Cancer Ther 1:617-628
34. Franck P, Petitipain N, Cherlet M et al (1996) Measurement of intracellular pH in cultured cells by flow cytometry with BCECF-AM. J Biotechnol 46:187-195
35. Kumar A, Singh SM (2012) Priming effect of aspirin for tumor cells to augment cytotoxic action of cisplatin against tumor cells: implication of altered constitution of tumor microenvironment, expression of cell cycle, apoptosis, and survival regulatory molecules. Mol Cell Biochem 371:43-54
36. Vishvakarma NK, Kumar A, Kumar A, Kant S, Bharti AC, Singh SM (2012) Myelopotentiating effect of curcumin in tumor-bearing host: role of bone marrow resident macrophages. Toxicol Appl Pharmacol 263:111-121
37. Vishvakarma NK, Kumar A, Singh SM (2011) Role of curcumin-dependent modulation of tumor microenvironment of a murine T cell lymphoma in altered regulation of tumor cell survival. Toxicol Appl Pharmacol 252:298-306
38. Kant S, Kumar A, Singh SM (2012) Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: role of cell survival regulatory molecules. Biochim Biophys Acta 1820:1764-1773
39. Kumar A, Kant S, Singh SM (2012) Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: implication of altered glucose metabolism, pH homeostasis and cell survival regulation. Chem Biol Interact 199:29-37
40. Ding AH, Nathan CF, Stuehr DJ (1988) Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages Comparison of activating cytokines and evidence for independent production. J Immunol 141:2407-2412
41. Somoza B, Guzman R, Cano V et al (2007) Induction of cardiac uncoupling protein-2 expression and adenosine 5′-monophosphate- activated protein kinase phosphorylation during early states of diet-induced obesity in mice. Endocrinology 148:924-931
42. Chaudhuri RK, Mukherjee M, Sengupta D, Mazumder S (2006) Limitation of glucose oxidase method of glucose estimation in jaundiced neonates. Indian J Exp Biol 44:254-255
43. Chen M, Huang SL, Zhang XQ, Zhang B, Zhu H, Yang VW, Zou XP (2012) Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1α/P-gp and MRP1 signaling pathway in vitro and in vivo. J Cell Biochem 113:2474-2487
44. Kim MY, Trudel LJ, Wogan GN (2009) Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. Anticancer Res 29:3733-3740
45. Gao J, Liu X, Rigas B (2005) Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress. Proc Natl Acad Sci USA 102:17207-17212
46. Chau Q, Stewart DJ (1999) Cisplatin efflux, binding and intracellular pH in the HTB56 human lung adenocarcinoma cell line and the E-8/0.7 cisplatin-resistant variant. Cancer Chemother Pharmacol 44:193-202
47. Epand RF, Epand RM, Gupta RS, Cragoe EJ Jr (1991) Reversal of intrinsic multidrug resistance in Chinese hamster ovary cells by amiloride analogs. Br J Cancer 63:247-251
48. Simon S, Roy D, Schindler M (1994) Intracellular pH and the control of multidrug resistance. Proc Natl Acad Sci USA 91:1128-1132
49. Wong P, Lee C, Tannock IF (2005) Reduction of intracellular pH as a strategy to enhance the pH-dependent cytotoxic effects of melphalan for human breast cancer cells. Clin Cancer Res 11:3553-3557
50. Lu Y, Pang T, Wang J, Xiong D, Ma L et al (2008) Down-regulation of P-glycoprotein expression by sustained intracellular acidification in K562/Dox cells. Biochem Biophys Res Commun 377:441-446
51. Zhu H, Chen XP, Luo SF et al (2005) Involvement of hypoxia-inducible factor-1-alpha in multidrug resistance induced by hypoxia in HepG2 cells. J Exp Clin Cancer Res 24:565-574
52. Milane L, Duan Z, Amiji M (2011) Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning. Cancer Cell Int 11:3
53. Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L et al (2005) Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res 65:613-621
54. Ullah MS, Davies AJ, Halestrap AP (2006) The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 281:9030-9037
55. Comerford KM, Wallace TJ, Karhausen J, Louis NA, Montalto MC et al (2002) Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res 62:3387-3394
56. Zhou M, Zhao Y, Ding Y et al (2010) Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol. Mol Cancer 9:33
57. Basu A, Haldar S (1998) The relationship between BcI2, Bax and p53: consequences for cell cycle progression and cell death. Mol Hum Reprod 4:1099-1109
58. Suzuki A, Shiraki K (2001) Tumor cell "dead or alive": caspase and survivin regulate cell death, cell cycle and cell survival. Histol Histopathol 16:583-593
59. Suárez L, Vidriales B, García-Laraña J et al (2001) Multiparametric analysis of apoptotic and multi-drug resistance phenotypes according to the blast cell maturation stage in elderly patients with acute myeloid leukemia. Haematologica 86:1287-1295
60. Chauhan PS, Bhushan B, Singh LC et al (2012) Expression of genes related to multiple drug resistance and apoptosis in acute leukemia: response to induction chemotherapy. Exp Mol Pathol 92:44-49
61. Guenova ML, Balatzenko GN, Nikolova VR, Spassov BV, Konstantinov SM (2010) An anti-apoptotic pattern correlates with multidrug resistance in acute myeloid leukemia patients: a comparative study of active caspase-3, cleaved PARPs, Bcl-2, Survivin and MDR1 gene. Hematology 15:135-143
62. Xu W, Liu LZ, Loizidou M, Ahmed M, Charles IG (2002) The role of nitric oxide in cancer. Cell Res 12:311-320
63. Wink DA, Vodovotz Y, Laval J, Laval F, Dewhirst MW, Mitchell JB (1998) The multifaceted roles of nitric oxide in cancer. Carcinogenesis 19:711-721
64. Matthews NE, Adams MA, Maxwell LR, Gofton TE, Graham CH (2001) Nitric oxide-mediated regulation of chemosensitivity in cancer cells. J Natl Cancer Inst 93:1879-1885
65. Riganti C, Miraglia E, Viarisio D, Costamagna C, Pescarmona G, Ghigo D, Bosia A (2005) Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux. Cancer Res 65:516-525
66. Nagata J, Kijima H, Hatanaka H et al (2001) Reversal of cisplatin and multidrug resistance by ribozyme-mediated glutathione suppression. Biochem Biophys Res Commun 286:406-413
67. McWhinney SR, Goldberg RM, McLeod HL (2009) Platinum neurotoxicity pharmacogenetics. Mol Cancer Ther 8:10-16 Science and Technology and Technology