Down-regulation of P-glycoprotein expression by sustained intracellular acidification in K562/Dox cells

Biochemical and Biophysical Research Communications

Volumn 377, Issue 2, 2008, Pages 441-446

  Lu, Ying ^a   Pang, Tianxiang ^a   Wang, Jianxiang ^a   Xiong, Dongsheng ^a   Ma, Li ^a   Li, Bin ^a   Li, Qinghua ^a   Wakabayashi, Shigeo ^b  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Intracellular pH; Multidrug resistance; Na+ H+ exchanger1; P glycoprotein

Indexed keywords

CARIPORIDE; DOXORUBICIN; GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN;

ACIDIFICATION; ARTICLE; CELL PH; CELL STRAIN K 562; CONTROLLED STUDY; DOWN REGULATION; DRUG ACCUMULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

ACIDS; ANTIBIOTICS, ANTINEOPLASTIC; CATION TRANSPORT PROTEINS; CELL LINE; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GUANIDINES; HUMANS; HYDROGEN-ION CONCENTRATION; K562 CELLS; P-GLYCOPROTEIN; RHODAMINE 123; SODIUM-HYDROGEN ANTIPORTER; SULFONES; VERAPAMIL;

EID: 55649115290     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.10.005     Document Type: Article

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