-
1
-
-
34547696982
-
Monoclonal antibody "gold rush."
-
Maggon, K. (2007) Monoclonal antibody "gold rush." Curr. Med. Chem. 14, 1978-1987
-
(2007)
Curr. Med. Chem
, vol.14
, pp. 1978-1987
-
-
Maggon, K.1
-
2
-
-
77951614830
-
Monoclonal antibodies: Versatile platforms for cancer immunotherapy
-
Weiner, L. M., Surana, R., and Wang, S. (2010) Monoclonal antibodies: versatile platforms for cancer immunotherapy. Nat. Rev. Immunol. 10, 317-327
-
(2010)
Nat. Rev. Immunol
, vol.10
, pp. 317-327
-
-
Weiner, L.M.1
Surana, R.2
Wang, S.3
-
3
-
-
52449112071
-
Heterogeneity of monoclonal antibodies
-
Liu, H., Gaza-Bulseco, G., Faldu, D., Chumsae, C., and Sun, J. (2008) Heterogeneity of monoclonal antibodies. J. Pharm. Sci. 97, 2426-2447
-
(2008)
J. Pharm. Sci
, vol.97
, pp. 2426-2447
-
-
Liu, H.1
Gaza-Bulseco, G.2
Faldu, D.3
Chumsae, C.4
Sun, J.5
-
4
-
-
34250182367
-
β-elimination and peptide bond hydrolysis: Two distinct mechanisms of human IgG1 hinge fragmentation upon storage
-
Cohen, S. L., Price, C., and Vlasak, J. (2007) β-elimination and peptide bond hydrolysis: two distinct mechanisms of human IgG1 hinge fragmentation upon storage. J. Am. Chem. Soc. 129, 6976-6977
-
(2007)
J. Am. Chem. Soc
, vol.129
, pp. 6976-6977
-
-
Cohen, S.L.1
Price, C.2
Vlasak, J.3
-
5
-
-
20944441421
-
Characterization of a novel modification to monoclonal antibodies: Thioether crosslink of heavy and light chains
-
Tous, G. I., Wei, Z., Feng, J., Bilbulian, S., Bowen, S., Smith, J., Strouse, R., McGeehan, P., Casas-Finet, J., and Schenerman, M. A. (2005) Characterization of a novel modification to monoclonal antibodies: thioether crosslink of heavy and light chains. Anal. Chem. 77, 2675-2682
-
(2005)
Anal. Chem
, vol.77
, pp. 2675-2682
-
-
Tous, G.I.1
Wei, Z.2
Feng, J.3
Bilbulian, S.4
Bowen, S.5
Smith, J.6
Strouse, R.7
McGeehan, P.8
Casas-Finet, J.9
Schenerman, M.A.10
-
6
-
-
77955676995
-
Exposure of a monoclonal antibody, IgG1, to UV-light leads to protein dithiohemiacetal and thioether cross-links: A role for thiyl radicals?
-
Mozziconacci, O., Kerwin, B. A., and Schöneich, C. (2010) Exposure of a monoclonal antibody, IgG1, to UV-light leads to protein dithiohemiacetal and thioether cross-links: a role for thiyl radicals? Chem. Res. Toxicol. 23, 1310-1312
-
(2010)
Chem Res. Toxicol
, vol.23
, pp. 1310-1312
-
-
Mozziconacci, O.1
Kerwin, B.A.2
Schöneich, C.3
-
7
-
-
72149086122
-
Human IgG1 hinge fragmentation as the results of H2O2-mediated radical cleavage
-
Yan, B., Yates, Z., Balland, A., and Kleemann, G. R. (2009) Human IgG1 Hinge Fragmentation as the Results of H2O2-mediated Radical Cleavage. J. Biol. Chem. 284, 35390-35402
-
(2009)
J. Biol. Chem
, vol.284
, pp. 35390-35402
-
-
Yan, B.1
Yates, Z.2
Balland, A.3
Kleemann, G.R.4
-
8
-
-
79956148004
-
Specific racemization of heavy-chain cysteine-220 in the hinge region of immunoglobulin γ1 as a possible cause of degradation during storage
-
Amano, M., Hasegawa, J., Kobayashi, N., Kishi, N., Nakazawa, T., Uchiyama, S., and Fukui, K. (2011) Specific racemization of heavy-chain cysteine-220 in the hinge region of immunoglobulin γ1 as a possible cause of degradation during storage. Anal. Chem. 83, 3857-3864
-
(2011)
Anal. Chem
, vol.83
, pp. 3857-3864
-
-
Amano, M.1
Hasegawa, J.2
Kobayashi, N.3
Kishi, N.4
Nakazawa, T.5
Uchiyama, S.6
Fukui, K.7
-
9
-
-
14744289246
-
Nonenzymatic hinge region fragmentation of antibodies in solution
-
Cordoba, A. J., Shyong, B. J., Breen, D., and Harris, R. J. (2005) Nonenzymatic hinge region fragmentation of antibodies in solution. J. Chromatog. B 818, 115-121
-
(2005)
J. Chromatog. B
, vol.818
, pp. 115-121
-
-
Cordoba, A.J.1
Shyong, B.J.2
Breen, D.3
Harris, R.J.4
-
10
-
-
84878752552
-
IgG1 thioether bond formation in vivo
-
Zhang, Q., Schenauer, M. R., McCarter, J. D., and Flynn, G. C. (2013) IgG1 thioether bond formation in vivo. J. Biol. Chem. 288, 16371-16382
-
(2013)
J Biol Chem
, vol.288
, pp. 16371-16382
-
-
Zhang, Q.1
Schenauer, M.R.2
McCarter, J.D.3
Flynn, G.C.4
-
11
-
-
69649088633
-
Human antibody Fc deamidation in vivo
-
Liu, Y. D., van Enk, J. Z., and Flynn, G. C. (2009) Human antibody Fc deamidation in vivo. Biologicals 37, 313-322
-
(2009)
Biologicals
, vol.37
, pp. 313-322
-
-
Liu, Y.D.1
Van Enk, J.Z.2
Flynn, G.C.3
-
12
-
-
77953618368
-
Naturally occurring glycan forms of human immunoglobulins G1 and G2
-
Flynn, G. C., Chen, X., Liu, Y. D., Shah, B., and Zhang, Z. (2010) Naturally occurring glycan forms of human immunoglobulins G1 and G2. Mol. Immunol. 47, 2074-2082
-
(2010)
Mol. Immunol
, vol.47
, pp. 2074-2082
-
-
Flynn, G.C.1
Chen, X.2
Liu, Y.D.3
Shah, B.4
Zhang, Z.5
-
13
-
-
64249156466
-
Quantitation of soluble aggregates in recombinant monoclonal antibody cell culture by pH-gradient protein A chromatography
-
Pan, H., Chen, K., Pulisic, M., Apostol, I., and Huang, G. (2009) Quantitation of soluble aggregates in recombinant monoclonal antibody cell culture by pH-gradient protein A chromatography. Anal. Biochem. 388, 273-278
-
(2009)
Anal. Biochem
, vol.388
, pp. 273-278
-
-
Pan, H.1
Chen, K.2
Pulisic, M.3
Apostol, I.4
Huang, G.5
-
14
-
-
47049097120
-
Human IgG2 antibodies display disulfide- mediated structural isoforms
-
Wypych, J., Li, M., Guo, A., Zhang, Z., Martinez, T., Allen, M. J., Fodor, S., Kelner, D. N., Flynn, G. C., Liu, Y. D., Bondarenko, P. V., Ricci, M. S., Dillon, T. M., and Balland, A. (2008) Human IgG2 antibodies display disulfide- mediated structural isoforms. J. Biol. Chem. 283, 16194-16205
-
(2008)
J. Biol. Chem
, vol.283
, pp. 16194-16205
-
-
Wypych, J.1
Li, M.2
Guo, A.3
Zhang, Z.4
Martinez, T.5
Allen, M.J.6
Fodor, S.7
Kelner, D.N.8
Flynn, G.C.9
Liu, Y.D.10
Bondarenko, P.V.11
Ricci, M.S.12
Dillon, T.M.13
Balland, A.14
-
15
-
-
47049114087
-
Structural and functional characterization of disulfide isoforms of the human IgG2 subclass
-
Dillon, T. M., Ricci, M. S., Vezina, C., Flynn, G. C., Liu, Y. D., Rehder, D. S., Plant, M., Henkle, B., Li, Y., Deechongkit, S., Varnum, B., Wypych, J., Balland, A., and Bondarenko, P. V. (2008) Structural and functional characterization of disulfide isoforms of the human IgG2 subclass. J. Biol. Chem. 283, 16206-16215
-
(2008)
J. Biol. Chem
, vol.283
, pp. 16206-16215
-
-
Dillon, T.M.1
Ricci, M.S.2
Vezina, C.3
Flynn, G.C.4
Liu, Y.D.5
Rehder, D.S.6
Plant, M.7
Henkle, B.8
Li, Y.9
Deechongkit, S.10
Varnum, B.11
Wypych, J.12
Balland, A.13
Bondarenko, P.V.14
-
16
-
-
0023177775
-
Lanthionine, a protein cross-link in cataractous human lenses
-
Bessems, G. J., Rennen, H. J., and Hoenders, H. J. (1987) Lanthionine, a protein cross-link in cataractous human lenses. Exp. eye res. 44, 691-695
-
(1987)
Exp. Eye Res
, vol.44
, pp. 691-695
-
-
Bessems, G.J.1
Rennen, H.J.2
Hoenders, H.J.3
-
17
-
-
4544350320
-
Dehydroalanine crosslinks in human lens
-
Linetsky, M., Hill, J. M., LeGrand, R. D., and Hu, F. (2004) Dehydroalanine crosslinks in human lens. Exp. Eye Res. 79, 499-512
-
(2004)
Exp. Eye Res
, vol.79
, pp. 499-512
-
-
Linetsky, M.1
Hill, J.M.2
Legrand, R.D.3
Hu, F.4
-
18
-
-
84880086575
-
Monoclonal antibody disulfide reduction during manufacturing Untangling process effects from product effects
-
Hutterer, K. M., Hong, R. W., Lull, J., Zhao, X., Wang, T., Pei, R., Le, M. E., Borisov, O., Piper, R., Liu, Y. D., Petty, K., Apostol, I., and Flynn, G. C. (2013) Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from product effects. MAbs. 5, 608-613
-
(2013)
MAbs
, vol.5
, pp. 608-613
-
-
Hutterer, K.M.1
Hong, R.W.2
Lull, J.3
Zhao, X.4
Wang, T.5
Pei, R.6
Le, M.E.7
Borisov, O.8
Piper, R.9
Liu, Y.D.10
Petty, K.11
Apostol, I.12
Flynn, G.C.13
-
19
-
-
0028020624
-
Nephelometric measurements of human IgG subclasses and their reference ranges
-
Vlug, A., Nieuwenhuys, E. J., van Eijk, R. V., Geertzen, H. G., and van Houte, A. J. (1994) Nephelometric measurements of human IgG subclasses and their reference ranges. Annales de Biologie Clinique 52, 561-567
-
(1994)
Annales de Biologie Clinique
, vol.52
, pp. 561-567
-
-
Vlug, A.1
Nieuwenhuys, E.J.2
Van Eijk, R.V.3
Geertzen, H.G.4
Van Houte, A.J.5
-
20
-
-
0242585330
-
Pharmacokinetics of total immunoglobulin G and immunoglobulin G subclasses in patients undergoing replacement therapy for primary immunodeficiency syndromes
-
Alyanakian, M. A., Bernatowska, E., Scherrmann, J. M., Aucouturier, P., and Poplavsky, J. L. (2003) Pharmacokinetics of total immunoglobulin G and immunoglobulin G subclasses in patients undergoing replacement therapy for primary immunodeficiency syndromes. Vox Sang. 84, 188-192
-
(2003)
Vox Sang
, vol.84
, pp. 188-192
-
-
Alyanakian, M.A.1
Bernatowska, E.2
Scherrmann, J.M.3
Aucouturier, P.4
Poplavsky, J.L.5
-
21
-
-
0021722276
-
The effect of reduction of IgM on the quantitative determination of IgM by radial immunodiffusion and turbidimetry
-
Out, T. A., McDonald, J. R., Woldhuis-Kant, J., and Nieuwenhuys, E. J. (1984) The effect of reduction of IgM on the quantitative determination of IgM by radial immunodiffusion and turbidimetry. Clin. Chim. Acta 144, 115-126
-
(1984)
Clin. Chim. Acta
, vol.144
, pp. 115-126
-
-
Out, T.A.1
McDonald, J.R.2
Woldhuis-Kant, J.3
Nieuwenhuys, E.J.4
-
22
-
-
84862212634
-
Quality attributes of therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach
-
Eon-Duval, A., Broly, H., and Gleixner, R. (2012) Quality Attributes of Therapeutic Proteins: An Assessment of Impact on Safety and Efficacy as Part of a Quality by Design Development Approach. Biotechnol. Prog. 28, 608-622
-
(2012)
Biotechnol. Prog
, vol.28
, pp. 608-622
-
-
Eon-Duval, A.1
Broly, H.2
Gleixner, R.3
-
23
-
-
84863045993
-
Disulfide bond structures of IgG molecules
-
Liu, H., and May, K. (2012) Disulfide bond structures of IgG molecules. Mabs 4, 17-23
-
(2012)
Mabs
, vol.4
, pp. 17-23
-
-
Liu, H.1
May, K.2
|