Exposure of a monoclonal antibody, IgG1, to UV-light leads to protein dithiohemiacetal and thioether cross-links: A role for thiyl radicals?

Chemical Research in Toxicology

Volumn 23, Issue 8, 2010, Pages 1310-1312

  Mozziconacci, Olivier ^a   Kerwin, Bruce A ^b   Schöneich, Christian ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAL; DITHIOHEMIACETAL; IMMUNOGLOBULIN G1; SULFIDE; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; DISULFIDE BOND; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RADIATION EXPOSURE; ULTRAVIOLET RADIATION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FREE RADICALS; IMMUNOGLOBULIN G; PHOTOCHEMISTRY; SULFHYDRYL COMPOUNDS; SULFIDES; TANDEM MASS SPECTROMETRY; ULTRAVIOLET RAYS;

EID: 77955676995     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100193b     Document Type: Article

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