Monoclonal antibody disulfide reduction during manufacturing Untangling process effects from product effects

mAbs

Volumn 5, Issue 4, 2013, Pages 608-613

  Hutterer, Katariina M ^a   Hong, Robert W ^a   Lull, Jonathon ^a   Zhao, Xiaoyang ^a   Wang, Tian ^a   Pei, Rex ^a   Le, M Eleanor ^a   Borisov, Oleg ^a   Piper, Rob ^b   Liu, Yaoqing Diana ^a   Petty, Krista ^a   Apostol, Izydor ^a   Flynn, Gregory C ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

Antibody disulfide reduction; Capillary electrophoresis; CE SDS; Free cysteine; Harvest

Indexed keywords

DISULFIDE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; THIOREDOXIN; THIOREDOXIN REDUCTASE;

ANTIBODY TITER; ARTICLE; CELL CLONE; CELL CULTURE; CELL DENSITY; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; PROCESS MODEL; QUALITY CONTROL; REDUCTION;

ANTIBODY DISULFIDE REDUCTION; CAPILLARY ELECTROPHORESIS; CE-SDS; FREE CYSTEINE; HARVEST;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; CRICETULUS; DISULFIDES; DITHIOTHREITOL; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; OXIDATION-REDUCTION; OXYGEN; RECOMBINANT PROTEINS;

EID: 84880086575     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.24725     Document Type: Article

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