Specific racemization of heavy-chain cysteine-220 in the hinge region of immunoglobulin gamma 1 as a possible cause of degradation during storage

Analytical Chemistry

Volumn 83, Issue 10, 2011, Pages 3857-3864

  Amano, Masato ^a   Hasegawa, Jun ^a   Kobayashi, Naoki ^a   Kishi, Naoyuki ^a   Nakazawa, Takashi ^b   Uchiyama, Susumu ^c   Fukui, Kiichi ^c  

^a DAIICHI SANKYO CO   (Japan)

^b NARA WOMEN'S UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BASE CATALYST; CARBONYL CARBON; CYSTEINE RESIDUES; D-AMINO ACID; HEAVY CHAIN; HINGE SEQUENCES; IMIDAZOLINES; REACTION MECHANISM; SUCCINIMIDE; TANDEM MASS SPECTROMETRY; THERAPEUTIC ANTIBODIES; TRYPTIC DIGESTS; TRYPTIC PEPTIDES;

AMIDES; DEGRADATION; ION CHROMATOGRAPHY; ISOMERS; MASS SPECTROMETRY;

AMINO ACIDS;

CYSTEINE; DEUTERIUM; IMMUNOGLOBULIN G;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; HUMAN; HYDROLYSIS; METABOLISM; METHODOLOGY; PEPTIDE MAPPING; PH; TANDEM MASS SPECTROMETRY; TEMPERATURE; TIME;

AMINO ACID SEQUENCE; CYSTEINE; DEUTERIUM; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IMMUNOGLOBULIN G; PEPTIDE MAPPING; TANDEM MASS SPECTROMETRY; TEMPERATURE; TIME FACTORS;

EID: 79956148004     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac200321v     Document Type: Article

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