Synthesis of novel N-(3-chloro-4-flurophenyl)-2-(5-((3-(4-hydroxy-2, 2-dimethyl-2, 3-dihydrobenzofuran-5-yl)-1-phenyl-1H-pyrazol-4-yl) methylene)-4-oxo-2-thioxothiazolidin-3-yl) acetamides having anti-inflammatory activity

Drug Invention Today

Volumn 5, Issue 4, 2013, Pages 288-295

  Shyam Sunder, K ^a   Maleraju, Jayapal ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b INSTITUTE OF AERONAUTICAL ENGINEERING   (India)

Author keywords

1H NMR; IR; Mass spectra and anti inflammatory activity; Rhodanine acetamides

Indexed keywords

ANTIINFLAMMATORY AGENT; IBUPROFEN; N (3 CHLORO 4 FLUOROPHENYL) 2 [5 [[3 (4 HYDROXY 2,2 DIMETHYL 2,3 DIHYDROBENZOFURAN 5 YL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 2 PHENYLACETAMIDE; N (3 CHLORO 4 FLUOROPHENYL) 2 [5 [[3 (4 HYDROXY 2,2 DIMETHYL 2,3 DIHYDROBENZOFURAN 5 YL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 METHYLBUTANAMIDE; N (3 CHLORO 4 FLUOROPHENYL) 2 [5 [[3 (4 HYDROXY 2,2 DIMETHYL 2,3 DIHYDROBENZOFURAN 5 YL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLACETAMIDE; N (3 CHLORO 4 FLUOROPHENYL) 2 [5 [[3 (4 HYDROXY 2,2 DIMETHYL 2,3 DIHYDROBENZOFURAN 5 YL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETAMIDE; N (3 CHLORO 4 FLUOROPHENYL) 2 [5 [[3 (4 HYDROXY 2,2 DIMETHYL 2,3 DIHYDROBENZOFURAN 5 YL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MASS SPECTROMETRY; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 84889023023     PISSN: 09757619     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dit.2013.07.004     Document Type: Article

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