Identification of inhibitors for UDP-galactopyranose mutase

Journal of the American Chemical Society

Volumn 126, Issue 34, 2004, Pages 10532-10533

  Soltero Higgin, Michelle ^a   Carlson, Erin E ^a   Phillips, John H ^a   Kiessling, Laura L ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL POLYSACCHARIDE; ENZYME INHIBITOR; FLAVOPROTEIN; FLUORESCENT DYE; FURAN DERIVATIVE; GALACTOFURANOSE; GALACTOFURANOSYL TRANSFERASE; LIPOPHOSPHOGLYCAN; MUTASE; TRANSFERASE; UNCLASSIFIED DRUG; URIDINE 5' DIPHOSPHATE GALACTOPYRANOSE MUTASE; URIDINE 5' DIPHOSPHATE GALACTOPYRANOSE MUTASE INHIBITOR;

ARTICLE; BACTERIAL METABOLISM; BACTERIAL VIRULENCE; CONCENTRATION RESPONSE; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG IDENTIFICATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; FLUORESCENCE POLARIZATION; HIGH THROUGHPUT SCREENING; ISOMERIZATION; KLEBSIELLA PNEUMONIAE; LEISHMANIA; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STEREOCHEMISTRY; TECHNIQUE; X RAY CRYSTALLOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; FLUORESCENCE POLARIZATION; INHIBITORY CONCENTRATION 50; INTRAMOLECULAR TRANSFERASES; KINETICS; MYCOBACTERIUM TUBERCULOSIS; SUBSTRATE SPECIFICITY;

EID: 4344593011     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja048017v     Document Type: Article

References (20)

1. Besra, G. S.; Brennan, P. J. J. Pharm. Pharmacol. 1997, 49, 25-30.
2. Crick, D.; Mahapatra, S.; Brennan, P. Glycobiology 2001, 11, 107R-18R.
3. Turco, S.; Orlandi, P. J. Biol. Chem. 1989, 264, 6711-6715.
4. Koplin, R.; Brisson, J. R.; Whitfield, C. J. J. Biol. Chem. 1997, 272, 4121-4128.
5. Nassau, P. M.; Martin, S. L.; Brown, R. E.; Weston, A.; Monsey, D.; McNeil, M.; Duncan, K. J. Bacteriol. 1996, 178, 1047-1052.
6. Pederson, L. L.; Turco, S. J. Cell. Mol. Life Sci. 2003, 60, 259-266.
7. Sanders, D.; Staines, A.; McMahon, S.; McNeil, M.; Whitfield, C.; Naismith, J. Nat. Struct. Biol. 2001, 8, 858-863.
8. Scherman, M. S.; Winans, K. A.; Stern, R. J.; Jones, V.; Bertozzi, C. R.; McNeil, M. R. Antimicrob. Agents Chemother. 2003, 47, 378-382.
9. Helm, J. S.; Hu, Y.; Chen, L.; Gross, B.; Walker, S. J. Am. Chem. Soc. 2003, 125, 11168-11169.
10. Weatherman, R. V.; Kiessling, L. L. J. Org. Chem. 1996, 61, 534-538.
11. Wong, S. S.; Frey, P. A. Biochemistry 1977, 16, 298-305.
12. Kang, U. G.; Nolan, L. D.; Frey, P. A. J. Biol. Chem. 1975, 250, 7099-7105.
13. Wong, C. H.; Halcomb, R. L.; Ichikawa, Y.; Kajimoto, T. Angew. Chem., Int. Ed. Engl. 1995, 34, 521-546.
14. Thogersen, H.; Lemieux, R. U.; Bock, K.; Meyer, B. Can. J. Chem. 1982, 60, 44-57.
15. Soltero-Higgin, M.; Kiessling, L. L. University of Wisconsin-Madison. Unpublished results, 2004.
16. Kiessling, L. L.; Soltero-Higgin, M.; Phillips, J. H.; Carlson, E. E. Presented at the ACS Meeting, New York City, September 7-11, 2003.
17. Sim, M. M.; Ng, S. B.; Buss, A. D.; Crasta, S. C.; Goh, K. L.; Lee, S. K. Bioorg. Med. Chem. Lett. 2002, 12, 697-699.
18. Andres, C. J.; Bronson, J. J.; D'Andrea, S. V.; Deshpande, M. S.; Falk, P. J.; Grant-Young, K. A.; Harte, W. E.; Ho, H. T.; Misco, P. F.; Robertson, J. G.; Stock, D.; Sun, Y.; Walsh, A. W. Bioorg. Med. Chem. Lett. 2000, 10, 715-717.
19. Fang, J.; Li, J.; Chen, X.; Zhang, Y.; Wang, J.; Guo, Z.; Zhang, W.; Yu, L.; Brew, K.; Wang, P. G. J. Am. Chem. Soc. 1998, 120, 6635-6638.
20. Meyer, E. A.; Castellano, R. K.; Diederich, F. Angew. Chem., Int. Ed. 2003, 42, 1210-1250.