Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 6149-6155

  Bandgar, Babasaheb P ^a,b   Totre, Jalinder V ^c   Gawande, Shrikant S ^b,c   Khobragade, C N ^b   Warangkar, Suchita C ^b   Kadam, Prasad D ^a  

^a SOLAPUR UNIVERSITY   (India)

^b SWAMI RAMANAND TEERTH MARATHWADA UNIVERSITY   (India)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

3,5 Diaryl pyrazole derivatives; Anti inflammatory activity; Anticancer activity; Diphenolase inhibitors; Polyphenol oxidase; Rohitukine; Tyrosinase

Indexed keywords

2 (2 HYDROXYMETHYL 1 METHYL PYRROLIDIN 3 YL) 3,5 DIMETHOXY 6 [5 (2 METHOXYPHENYL) 1H PYRAZOL 3 YL]PHENOL; 2 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXY 6 (5 O TOLYL 1H PYRAZOL 3 YL)PHENOL; 2 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXY 6 (5 P TOLYL 1H PYRAZOL 3 YL)PHENOL; 2 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXY 6 [5 (4 METHOXYPHENYL) 1H PYRAZOL 3 YL]PHENOL; 2 [5 (2 BROMOPHENYL) 1H PYRAZOL 3 YL] 6 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL] 3,5 DIMETHOXYPHENOL; 2 [5 (2 CHLORO 4 NITROPHENYL) 1H PYRAZOL 3 YL] 6 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXYPHENOL; 2 [5 (2 CHLOROPHENYL) 1H PYRAZOL 3 YL] 6 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXYPHENOL; 2 [5 (2 FLUOROPHENYL) 1H PYRAZOL 3 YL] 6 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXYPHENOL; 2 [5 (2,4 DICHLOROPHENYL) 1H PYRAZOL 3 YL] 6 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXYPHENOL; 2 [5 (2,4 DIMETHOXYPHENYL) 1H PYRAZOL 3 YL] 6 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXYPHENOL; 2 [5 (3 BROMOPHENYL) 1H PYRAZOL 3 YL] 6 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXYPHENOL; 2 [5 (3 CHLOROPHENYL) 1H PYRAZOL 3 YL] 6 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXYPHENOL; 2 [5 (4 BROMOPHENYL) 1H PYRAZOL 3 YL] 6 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXYPHENOL; 2 [5 (4 CHLOROPHENYL) 1H PYRAZOL 3 YL] 6 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXYPHENOL; 2 [5 (4 FLUOROPHENYL) 1H PYRAZOL 3 YL] 6 (2 HYDROXYMETHYL 1 METHYLPYRROLIDIN 3 YL) 3,5 DIMETHOXYPHENOL; 8 [2 (HYDROXYMETHYL) 1 METHYLPYRROLIDIN 3 YL] 5,7 DIMETHOXY 2 PHENYL 4H CHROMEN 4 ONE; ALCOHOL; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; DEXAMETHASONE; FLAVOPIRIDOL; HYDRAZINE; INTERLEUKIN 6; OXYGENASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRROLIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; COLON CANCER; COMBINATORIAL CHEMISTRY; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; LEUKEMIA CELL LINE; LUNG CANCER; MASS SPECTROMETRY; PROMYELOCYTIC LEUKEMIA; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

AGARICALES; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYTOKINES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MONOPHENOL MONOOXYGENASE; NEOPLASMS; PYRAZOLES;

EID: 77955470505     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.046     Document Type: Article

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