Identification of active-site inhibitors of MurG using a generalizable, high-throughput glycosyltransferase screen

Journal of the American Chemical Society

Volumn 125, Issue 37, 2003, Pages 11168-11169

  Helm, Jeremiah S ^a   Hu, Yanan ^a   Chen, Lan ^a   Gross, Ben ^a   Walker, Suzanne ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; GLYCOSYLTRANSFERASE; PEPTIDOGLYCAN; PROTEIN MURG; UNCLASSIFIED DRUG;

ANISOTROPY; ARTICLE; BACTERIAL MEMBRANE; BINDING AFFINITY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG TARGETING; ENZYME ACTIVE SITE; FLUORESCENCE POLARIZATION; REACTION ANALYSIS;

ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; BINDING SITES; ENZYME INHIBITORS; GLYCOSYLTRANSFERASES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; N-ACETYLGLUCOSAMINYLTRANSFERASES; PROTEIN CONFORMATION;

EID: 0041692300     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja036494s     Document Type: Article

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26. Similar functionalized cores have been reported for inhibitors of other enzymes that utilize UDP-sugars. See: (a) Andres, C. J.; Bronson, J. J.; D'Andrea, S. V.; Deshpande, M. S.; Falk, P. J.; Grant-Young, K. A.; Harte, W. E.; Ho, H. T.; Misco, P. F.; Robertson, J. G.; Stock, D.; Sun, Y.; Walsh, A. W. Bioorg. Med. Chem. Lett. 2000, 10, 715-717. (b) Ma, Y.; Stern, R. J.; Scherman, M. S.; Vissa, V. D.; Yan, W.; Jones, V. C.; Zhang, F.; Franzblau, S. G.; Lewis, W. H.; McNeil, M. R. Antimicrob. Agents Chemother. 2001, 45, 1407-1416. (c) Sim, M. M.; Ng, S. B.; Buss, A. D.; Crasta, S. C.; Goh, K. L.; Lee, S. K. Bioorg. Med. Chem. Lett. 2002, 12, 697-699.
27. Similar functionalized cores have been reported for inhibitors of other enzymes that utilize UDP-sugars. See: (a) Andres, C. J.; Bronson, J. J.; D'Andrea, S. V.; Deshpande, M. S.; Falk, P. J.; Grant-Young, K. A.; Harte, W. E.; Ho, H. T.; Misco, P. F.; Robertson, J. G.; Stock, D.; Sun, Y.; Walsh, A. W. Bioorg. Med. Chem. Lett. 2000, 10, 715-717. (b) Ma, Y.; Stern, R. J.; Scherman, M. S.; Vissa, V. D.; Yan, W.; Jones, V. C.; Zhang, F.; Franzblau, S. G.; Lewis, W. H.; McNeil, M. R. Antimicrob. Agents Chemother. 2001, 45, 1407-1416. (c) Sim, M. M.; Ng, S. B.; Buss, A. D.; Crasta, S. C.; Goh, K. L.; Lee, S. K. Bioorg. Med. Chem. Lett. 2002, 12, 697-699.