Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 6, 2011, Pages 2725-2733

  Chiou, Yi Siou ^a,b   Tsai, Mei Ling ^a   Nagabhushanam, Kalyanam ^c   Wang, Yin Jen ^b   Wu, Chih Hsiung ^d   Ho, Chi Tang ^e   Pan, Min Hsiung ^a  

^a NATIONAL KAOHSIUNG UNIVERSITY OF APPLIED SCIENCES   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c SABINSA CORPORATION   (United States)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e RUTGERS UNIVERSITY   (United States)

Author keywords

aldose reductase; azoxymethane; heme oxygenase 1; Nrf2; Pterostilbene

Indexed keywords

ALDOSE REDUCTASE; AZOXYMETHANE; HEME OXYGENASE-1; NRF2; PTEROSTILBENE;

DISEASES; ENZYMES; GENE EXPRESSION; NITRIC OXIDE; OXYGEN; PHOSPHORYLATION; PORPHYRINS; SIGNALING;

PATHOLOGY;

ANTIOXIDANT; AZOXYMETHANE; PTEROSTILBENE; RESVERATROL; STILBENE DERIVATIVE; TRANSCRIPTION FACTOR NRF2;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; COLON TUMOR; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; AZOXYMETHANE; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; MICE, INBRED BALB C; NF-E2-RELATED FACTOR 2; SIGNAL TRANSDUCTION; STILBENES;

MUS;

EID: 79952756381     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf2000103     Document Type: Article

References (35)

1. Jemal, A.; Siegel, R.; Ward, E.; Hao, Y.; Xu, J.; Thun, M. J. Cancer statistics, 2009 CA-Cancer J. Clin. 2009, 59, 225-249
2. Fearon, E. R.; Vogelstein, B. A genetic model for colorectal tumorigenesis Cell 1990, 61, 759-767
3. Davis, C. D.; Hord, N. G. Nutritional "omics" technologies for elucidating the role(s) of bioactive food components in colon cancer prevention J. Nutr. 2005, 135, 2694-2697 (Pubitemid 43156615)
4. Wogan, G. N.; Hecht, S. S.; Felton, J. S.; Conney, A. H.; Loeb, L. A. Environmental and chemical carcinogenesis Semin. Cancer Biol. 2004, 14, 473-486 (Pubitemid 39360995)
5. Poullis, A.; Foster, R.; Shetty, A.; Fagerhol, M. K.; Mendall, M. A. Bowel inflammation as measured by fecal calprotectin: A link between lifestyle factors and colorectal cancer risk Cancer Epidemiol., Biomarkers Prev. 2004, 13, 279-284 (Pubitemid 38222561)
6. Kundu, J. K.; Surh, Y. J. Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis Pharm. Res. 2010, 27, 999-1013
7. Volate, S. R.; Davenport, D. M.; Muga, S. J.; Wargovich, M. J. Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin) Carcinogenesis 2005, 26, 1450-1456 (Pubitemid 41417889)
8. Aoi, W.; Naito, Y.; Takagi, T.; Kokura, S.; Mizushima, K.; Takanami, Y.; Kawai, Y.; Tanimura, Y.; Hung, L. P.; Koyama, R.; Ichikawa, H.; Yoshikawa, T. Regular exercise reduces colon tumorigenesis associated with suppression of iNOS Biochem. Biophys. Res. Commun. 2010, 399, 14-19
9. Skrzydlewska, E.; Sulkowski, S.; Koda, M.; Zalewski, B.; Kanczuga-Koda, L.; Sulkowska, M. Lipid peroxidation and antioxidant status in colorectal cancer World J. Gastroenterol. 2005, 11, 403-406 (Pubitemid 40125250)
10. Leung, E. Y.; Crozier, J. E.; Talwar, D.; O'Reilly, D. S.; McKee, R. F.; Horgan, P. G.; McMillan, D. C. Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer Int. J. Cancer 2008, 123, 2460-2464
11. Tammali, R.; Ramana, K. V.; Srivastava, S. K. Aldose reductase regulates TNF-α-induced PGE2 production in human colon cancer cells Cancer Lett. 2007, 252, 299-306 (Pubitemid 46823949)
12. Tammali, R.; Ramana, K. V.; Singhal, S. S.; Awasthi, S.; Srivastava, S. K. Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells Cancer Res. 2006, 66, 9705-9713 (Pubitemid 44623671)
13. Kundu, J. K.; Surh, Y. J. Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives Cancer Lett. 2008, 269, 243-261
14. Mikstacka, R.; Ignatowicz, E. Chemopreventive and chemotherapeutic effect of trans -resveratrol and its analogues in cancer Pol. Merkuriusz Lek. 2010, 28, 496-500
15. Chiou, Y. S.; Tsai, M. L.; Wang, Y. J.; Cheng, A. C.; Lai, W. M.; Badmaev, V.; Ho, C. T.; Pan, M. H. Pterostilbene inhibits colorectal aberrant crypt foci (ACF) and colon carcinogenesis via suppression of multiple signal transduction pathways in azoxymethane-treated mice J. Agric. Food Chem. 2010, 58, 8833-8841
16. Yao, J.; Wang, J. Y.; Liu, L.; Li, Y. X.; Xun, A. Y.; Zeng, W. S.; Jia, C. H.; Wei, X. X.; Feng, J. L.; Zhao, L.; Wang, L. S. Anti-oxidant effects of resveratrol on mice with DSS-induced ulcerative colitis Arch. Med. Res. 2010, 41, 288-294
17. Kim, J. W.; Lim, S. C.; Lee, M. Y.; Lee, J. W.; Oh, W. K.; Kim, S. K.; Kang, K. W. Inhibition of neointimal formation by trans -resveratrol: Role of phosphatidyl inositol 3-kinase-dependent Nrf2 activation in heme oxygenase-1 induction Mol. Nutr. Food Res. 2010, 54, 1497-1505
18. Chen, C. Y.; Jang, J. H.; Li, M. H.; Surh, Y. J. Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells Biochem. Biophys. Res. Commun. 2005, 331, 993-1000
19. Bird, R. P.; Good, C. K. The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer Toxicol. Lett. 2000, 112-113, 395-402 (Pubitemid 30138150)
20. Ju, J.; Hao, X.; Lee, M. J.; Lambert, J. D.; Lu, G.; Xiao, H.; Newmark, H. L.; Yang, C. S. A γ-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice Cancer Prev. Res. 2009, 2, 143-152
21. Denkert, C.; Koch, I.; von Keyserlingk, N.; Noske, A.; Niesporek, S.; Dietel, M.; Weichert, W. Expression of the ELAV-like protein HuR in human colon cancer: Association with tumor stage and cyclooxygenase-2 Mod. Pathol. 2006, 19, 1261-1269 (Pubitemid 44268197)
22. Chen, J.; Huang, X. F. The signal pathways in azoxymethane-induced colon cancer and preventive implications Cancer Biol. Ther. 2009, 8, 1313-1317
23. Carter, J. W.; Lancaster, H. K.; Hardman, W. E.; Cameron, I. L. Distribution of intestine-associated lymphoid tissue, aberrant crypt foci, and tumors in the large bowel of 1,2-dimethylhydrazine-treated mice Cancer Res. 1994, 54, 4304-4307 (Pubitemid 24273139)
24. Hardman, W. E.; Cameron, I. L. Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas Carcinogenesis 1994, 15, 2353-2361 (Pubitemid 24317504)
25. Ashokkumar, P.; Sudhandiran, G. Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis Biomed. Pharmacother. 2008, 62, 590-597
26. Tammali, R.; Reddy, A. B.; Ramana, K. V.; Petrash, J. M.; Srivastava, S. K. Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation Carcinogenesis 2009, 30, 799-807
27. Surh, Y. J. NF-κB and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities Asia Pac. J. Clin. Nutr. 2008, 17 (Supplement 1) 269-272
28. Cui, X.; Jin, Y.; Hofseth, A. B.; Pena, E.; Habiger, J.; Chumanevich, A.; Poudyal, D.; Nagarkatti, M.; Nagarkatti, P. S.; Singh, U. P.; Hofseth, L. J. Resveratrol suppresses colitis and colon cancer associated with colitis Cancer Prev. Res. 2010, 3, 549-559
29. Fichera, A.; Little, N.; Dougherty, U.; Mustafi, R.; Cerda, S.; Li, Y. C.; Delgado, J.; Arora, A.; Campbell, L. K.; Joseph, L.; Hart, J.; Noffsinger, A.; Bissonnette, M. A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model J. Surg. Res. 2007, 142, 239-245 (Pubitemid 47418822)
30. Patel, R.; Ingle, A.; Maru, G. B. Polymeric black tea polyphenols inhibit 1,2-dimethylhydrazine induced colorectal carcinogenesis by inhibiting cell proliferation via Wnt/β-catenin pathway Toxicol. Appl. Pharmacol. 2008, 227, 136-146 (Pubitemid 351179849)
31. Cheung, K. L.; Khor, T. O.; Huang, M. T.; Kong, A. N. Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM Carcinogenesis 2010, 31, 880-885
32. Kang, E. S.; Kim, G. H.; Kim, H. J.; Woo, I. S.; Ham, S. A.; Jin, H.; Kim, M. Y.; Kim, H. J.; Lee, J. H.; Chang, K. C.; Seo, H. G.; Hwang, J. Y. Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear factor-κB Pharmacol. Res. 2008, 58, 15-21
33. Gescher, A. J.; Steward, W. P. Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: A conundrum Cancer Epidemiol., Biomarkers Prev. 2003, 12, 953-957 (Pubitemid 37310248)
34. Khor, T. O.; Huang, M. T.; Kwon, K. H.; Chan, J. Y.; Reddy, B. S.; Kong, A. N. Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis Cancer Res. 2006, 66, 11580-11584 (Pubitemid 46094166)
35. Struzynska, L.; Chalimoniuk, M.; Sulkowski, G. The role of astroglia in Pb-exposed adult rat brain with respect to glutamate toxicity Toxicology 2005, 212, 185-194 (Pubitemid 40984024)