Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model

Carcinogenesis

Volumn 33, Issue 3, 2012, Pages 644-651

  Adhami, Vaqar Mustafa ^a   Siddiqui, Imtiaz Ahmad ^a   Syed, Deeba N ^a   Lall, Rahul Kumar ^a   Mukhtar, Hasan ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POMEGRANATE EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER RISK; CARCINOGENESIS; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HUMAN; HUMAN CELL; LIFE EXPECTANCY; MALE; METASTASIS; MOUSE; NONHUMAN; POMEGRANATE; PRIORITY JOURNAL; PROSTATE CANCER;

EID: 84857949057     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr308     Document Type: Article

References (50)

1. Siegel, R. et al. (2011) Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J. Clin., 61, 212-236.
2. Andriole, G.L. et al. (2010) Effect of dutasteride on the risk of prostate cancer. N. Engl. J. Med., 362, 1192-1202.
3. Thompson, I.M. et al. (2003) The influence of finasteride on the development of prostate cancer. N. Engl. J. Med., 349, 215-224.
4. Syed, D.N. et al. (2008) Dietary agents for chemoprevention of prostate cancer. Cancer Lett., 265, 167-176.
5. Khan, N. et al. (2008) Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid. Redox Signal., 10, 475-510.
6. Adhami, V.M. et al. (2007) Anti-oxidants from green tea and pomegranate for chemoprevention of prostate cancer. Mol. Biotechnol., 37, 52-57.
7. Syed, D.N. et al. (2007) Pomegranate derived products for cancer chemoprevention. Semin. Cancer Biol., 17, 377-385.
8. Adhami, V.M. et al. (2009) Cancer chemoprevention by pomegranate: laboratory and clinical evidence. Nutr. Cancer, 61, 811-815.
9. Longtin, R. (2003) The pomegranate: nature's power fruit? J. Natl Cancer Inst., 95, 346-348.
10. El Kar, C. et al. (2011) Pomegranate (Punica granatum) Juices: Chemical Composition, Micronutrient Cations, and Antioxidant Capacity. J Food Sci., 76, C795-C800.
11. Gil, M.I. et al. (2000) Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J. Agric. Food Chem., 48, 4581-4589.
12. Seeram, N.P. et al. (2008) Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J. Agric. Food Chem., 56, 1415-1422.
13. Mehta, R. et al. (2004) Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture. Eur. J. Cancer Prev., 13, 345-348.
14. Adams, L.S. et al. (2010) Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev. Res., 3, 108-113.
15. Adams, L.S. et al. (2006) Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J. Agric. Food Chem., 54, 980-985.
16. Afaq, F. et al. (2009) Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin. Exp. Dermatol., 18, 553-561.
17. Saruwatari, A. et al. (2008) Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells. J. Med. Food, 11, 623-628.
18. Larrosa, M. et al. (2006) The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. J. Nutr. Biochem., 17, 611-625.
19. Rettig, M.B. et al. (2008) Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism. Mol. Cancer Ther., 7, 2662-2671.
20. Hong, M.Y. et al. (2008) Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. J. Nutr. Biochem., 19, 848-855.
21. Weisburg, J.H. et al. (2010) Pomegranate extract, a prooxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells. Anticancer Agents Med. Chem., 10, 634-644.
22. Pacheco-Palencia, L.A. et al. (2008) Protective effects of standardized pomegranate (Punica granatum) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts. J. Agric. Food Chem., 56, 8434-8441.
23. Gasmi, J. et al. (2010) Growth inhibitory, antiandrogenic, and pro-apoptotic effects of punicic acid in LNCaP human prostate cancer cells. J. Agric. Food Chem., 58, 12149-12156.
24. Koyama, S. et al. (2010) Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Growth Horm. IGF Res., 20, 55-62.
25. Kawaii, S. et al. (2004) Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells. J. Med. Food, 7, 13-18.
26. Khan, N. et al. (2007) Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res., 67, 3475-3482.
27. Khan, N. et al. (2007) Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogenesis, 28, 163-173.
28. Albrecht, M. et al. (2004) Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J. Med. Food, 7, 274-283.
29. Kim, N.D. et al. (2002) Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res. Treat., 71, 203-217.
30. Hora, J.J. et al. (2003) Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. J. Med. Food, 6, 157-161.
31. Toi, M. et al. (2003) Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo. Angiogenesis, 6, 121-128.
32. Kohno, H. et al. (2004) Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci., 95, 481-486.
33. Afaq, F. et al. (2005) Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int. J. Cancer, 113, 423-433.
34. Afaq, F. et al. (2005) Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign. Photochem. Photobiol., 81, 38-45.
35. Malik, A. et al. (2005) Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc. Natl Acad. Sci. USA, 102, 14813-14818.
36. Seeram, N.P. et al. (2007) Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J. Agric. Food Chem., 55, 7732-7737.
37. Pantuck, A.J. et al. (2006) Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin. Cancer Res., 12, 4018-4026.
38. Greenberg, N.M. et al. (1995) Prostate cancer in a transgenic mouse. Proc. Natl Acad. Sci. USA, 92, 3439-3443.
39. Rad, A.M. et al. (2008) Imaging mouse prostate gland by 3 Tesla clinical MRI system. Open Magn. Reson. Rev., 1, 60-63.
40. Hay, N. (2005) The Akt-mTOR tango and its relevance to cancer. Cancer Cell, 8, 179-183.
41. Sekulic, A. et al. (2000) A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res., 60, 3504-3513.
42. Xiang, X. et al. (2004) AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem. Biophys. Res. Commun., 321, 161-167.
43. Fryer, L.G. et al. (2002) The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J. Biol. Chem., 277, 25226-25232.
44. Gupta, S. et al. (2001) Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc. Natl Acad. Sci. USA, 98, 10350-10355.
45. Adhami, V.M. et al. (2004) Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer. Cancer Res., 64, 8715-8722.
46. Brody, H. (2011) Cancer prevention. Nature, 471, (suppl.), S1-S24.
47. Faivre, S. et al. (2006) Current development ofmTOR inhibitors as anticancer agents. Nat. Rev. Drug Discov., 5, 671-688.
48. O'Reilly, K.E. et al. (2006) mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res., 66, 1500-1508.
49. Vivanco, I. et al. (2002) The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer, 2, 489-501.
50. Hardie, D.G. et al. (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem., 67, 821-855.