Moringa Oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells

BMC Complementary and Alternative Medicine

Volumn 13, Issue , 2013, Pages

  Berkovich, Liron ^a   Earon, Gideon ^a   Ron, Ilan ^a   Rimmon, Adam ^a   Vexler, Akiva ^a   Lev Ari, Shahar ^a  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

cisplatin; Moringa Oleifera; NF kB; Pancreatic cancer

Indexed keywords

CISPLATIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MORINGA OLEIFERA EXTRACT; SYNAPTOTAGMIN I;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER RESISTANCE; CANCER SURVIVAL; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL SURVIVAL; COLORIMETRY; CONTROLLED STUDY; DNA CONTENT; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; IN VITRO STUDY; MORINGA OLEIFERA; OPTICAL DENSITY; PANCREAS CANCER; PROTEIN SUBUNIT; TREATMENT OUTCOME;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; DOWN-REGULATION; DRUG SYNERGISM; HUMANS; MORINGA OLEIFERA; NF-KAPPA B; PANCREATIC NEOPLASMS; PLANT EXTRACTS; PLANT LEAVES; PROTEIN BIOSYNTHESIS; SIGNAL TRANSDUCTION;

EID: 84883236870     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-13-212     Document Type: Article

References (22)

1. Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 2003, 66:1022-1037. 10.1021/np030096l, 12880330.
2. Hariharan D, Saied A, Kocher HM. Analysis of mortality rates for pancreatic cancer across the world. HPB (Oxford) 2008, 10:58-62.
3. Oberstein PE, Wasif Saif M. First-line treatment for advanced pancreatic cancer. J Pancreas (Online) 2011, 12:96-100.
4. Greenhalf W, Thomas A. Combination therapy for the treatment of pancreatic cancer. Anticancer Agents Med Chem 2011, 11:418-426. 10.2174/187152011795677391, 21521155.
5. Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002, 3:221-227.
6. Aggarwal BB. Nuclear factor-kappaB: the enemy within. Cancer Cell 2004, 6:203-208. 10.1016/j.ccr.2004.09.003, 15380510.
7. Van Waes C. Nuclear factor-kappaB in development, prevention, and therapy of cancer. Clin Cancer Res 2007, 13:1076-1082. 10.1158/1078-0432.CCR-06-2221, 17317814.
8. Holcomb B, Yip-Schneider M, Schmidt CM. The role of nuclear factor kappaB in pancreatic cancer and the clinical applications of targeted therapy. Pancreas 2008, 36:225-235. 10.1097/MPA.0b013e31815b3207, 18362834.
9. Shih MC, Chang CM, Kang SM, Tsai ML. Effect of different parts (leaf, stem and stalk) and seasons (summer and winter) on the chemical compositions and antioxidant activity of Moringa Oleifera. Int J Mol Sci 2011, 12:6077-6088. 10.3390/ijms12096077, 3189769, 22016645.
10. Bose CK. Possible role of Moringa Oleifera Lam. root in epithelial ovarian cancer. Med Gen Med 2007, 9:26.
11. Guevara AP, Vargas C, Sakurai H, Fujiwara Y, Hashimoto K, et al. An anti-tumor promoter from Moringa Oleifera Lam. Mutat Res 1999, 440:181-188. 10.1016/S1383-5718(99)00025-X, 10209341.
12. Sreelatha S, Jeyachitra A, Padma PR. Antiproliferation and induction of apoptosis by Moringa Oleifera leaf extract on human cancer cells. Food Chem Toxicol 2011, 49:1270-1275. 10.1016/j.fct.2011.03.006, 21385597.
13. Parvathy MVS, Umamaheshwari A. Cytotoxic effect of Moringa Oleifera leaf extracts on human multiple myeloma cultured cell lines. Trends in Medical Research 2 2007, 2(1):44-50.
14. Lev-Ari S, Vexler A, Starr A, Ashkenazy-Voghera M, Greif J, Aderka D, Ben-Yosef R. Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines. Cancer Invest 2007, 25:411-418. 10.1080/07357900701359577, 17882652.
15. Chou T-C, Talalay P. Analysis of combined drug effect: a new look at a very old problem. Trends Pharmacol Sci 1983, 4:150-154.
16. Sclabas GM, Fujioka S, Schmidt C, Fan Z, Evans DB, et al. Restoring apoptosis in pancreatic cancer cells by targeting the nuclear factor-kB signaling pathway with the anti-epidermal growth factor antibody IMC-C225. J Gastrointest Surg 2003, 7:37-43. 10.1016/S1091-255X(02)00088-4, 12559183.
17. Mabuchi S, Ohmichi M, Nishio Y, Hayasaka T, Kimura A, et al. Inhibition of NF-kappaB increases the efficacy of cis-platin in in vitro and in vivo ovarian cancer models. J Biol Chem 2004, 279:23477-23485. 10.1074/jbc.M313709200, 15026414.
18. Venkatraman M, Anto RJ, Nair A, Varghese M, Karunagaran D. Biological and chemical inhibitors of NF-kappaB sensitize SiHa cells to cisplatin-induced apoptosis. Mol Carcinog 2005, 44:51-59. 10.1002/mc.20116, 16044419.
19. Wu M, Yao B. Advances in TCM treatment of gastric cancer and studies on the apoptosis. J Tradit Chin Med 2002, 22:303-307.
20. Engdal S, Klepp O, Nilsen OG. Identification and exploration of herb-drug combinations used by cancer patients. Integr Cancer Ther 2009, 8:29-36. 10.1177/1534735408330202, 19174505.
21. Lee ER, Kang GH, Cho SG. Effect of flavonoids on human health: old subjects but new challenges. Recent Pat Biotechnol 2007, 1(2):139-150. 10.2174/187220807780809445, 19075837.
22. Awodele O, Oreagba IA, Odoma S, da Silva JA, Osunkalu VO. Toxicological evaluation of the aqueous leaf extract of Moringa oleifera Lam. (Moringaceae). J Ethnopharmacol 2012, 139(2):330-336. 10.1016/j.jep.2011.10.008, 22138517.