Escin sodium induces apoptosis of human acute leukemia Jurkat T cells

Phytotherapy Research

Volumn 25, Issue 12, 2011, Pages 1747-1755

  Zhang, Zhenzhen ^a,c   Gao, Jian ^b   Cai, Xueting ^c   Zhao, Youlong ^a,c   Wang, Yafei ^d   Lu, Wuguang ^c   Gu, Zhenhua ^c   Zhang, Shuangquan ^a   Cao, Peng ^a,c  

^a NANJING NORMAL UNIVERSITY   (China)

^b YANCHENG INSTITUTE OF TECHNOLOGY   (China)

^c Jiangsu Province Institute of Traditional Chinese Medicine   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; escin sodium; Jurkat cells; leukemia

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; ESCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2;

ACUTE LEUKEMIA; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG INHIBITION; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TREATMENT RESPONSE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CELL PROLIFERATION; ESCIN; HUMANS; JURKAT CELLS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 82155175397     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3457     Document Type: Article

References (23)

1. Brunelle JK, Letai A,. 2009. Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci 122: 437-441.
2. Chen M, Guerrero AD, Huang L, et al,. 2007. Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members. J Biol Chem 282: 33888-33895. (Pubitemid 350159562)
3. Elmore S,. 2007. Apoptosis: a review of programmed cell death. Toxicol Pathol 35: 495-516. (Pubitemid 46911891)
4. Ferreira CG, Epping M, Kruyt FA, Giaccone G,. 2002. Apoptosis: target of cancer therapy. Clin Cancer Res 8: 2024-2034. (Pubitemid 34753570)
5. Frick RW,. 2000. Three treatments for chronic venous insufficiency: escin, hydroxyethylrutoside, and Daflon. Angiology 51: 197-205. (Pubitemid 30164933)
6. Fu F, Hou Y, Jiang W, Wang R, Liu K,. 2005. Escin: inhibiting inflammation and promoting gastrointestinal transit to attenuate formation of postoperative adhesions. World J Surg 29: 1614-1620; discussion 1621-1612. (Pubitemid 41779863)
7. Gupta S,. 2003. Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review). Int J Oncol 22: 15-20.
8. Gustafsson AB, Gottlieb RA,. 2007. Bcl-2 family members and apoptosis, taken to heart. Am J Physiol 292: C45-C51. (Pubitemid 46115120)
9. Hakem R, Hakem A, Duncan GS, et al,. 1998. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339-352. (Pubitemid 28376078)
10. Kasibhatla S, Tseng B,. 2003. Why target apoptosis in cancer treatment? Mol Cancer Ther 2: 573-580.
11. Khan N, Afaq F, Mukhtar H,. 2007. Apoptosis by dietary factors: the suicide solution for delaying cancer growth. Carcinogenesis 28: 233-239. (Pubitemid 46321838)
12. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC,. 1994. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371: 346-347. (Pubitemid 24300618)
13. Meijerink JP, Mensink EJ, Wang K, et al,. 1998. Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood 91: 2991-2997. (Pubitemid 28227551)
14. Nicholson DW, Ali A, Thornberry NA, et al,. 1995. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43.
15. Nunez G, Benedict MA, Hu Y, Inohara N,. 1998. Caspases: the proteases of the apoptotic pathway. Oncogene 17: 3237-3245. (Pubitemid 29043976)
16. Seitz SJ, Schleithoff ES, Koch A, et al,. 2009. Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Int J Cancer 126: 2049-2066.
17. Shawgo ME, Shelton SN, Robertson JD,. 2008. Caspase-mediated Bak activation and cytochrome c release during intrinsic apoptotic cell death in Jurkat cells. J Biol Chem 283: 35532-35538.
18. Sirtori CR,. 2001. Aescin: pharmacology, pharmacokinetics and therapeutic profile. Pharmacol Res 44: 183-193. (Pubitemid 32889461)
19. Sun SY, Hail N Jr, Lotan R,. 2004. Apoptosis as a novel target for cancer chemoprevention. J Nat Cancer Inst 96: 662-672. (Pubitemid 38660229)
20. Tan SM, Li F, Rajendran P, Kumar AP, Hui KM, Sethi G,. 2010. Identification of β-escin as a novel inhibitor of STAT3/JAK2 signaling. J Pharmacol Exp Ther 334: 285-293.
21. van Engeland M, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP,. 1998. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31: 1-9. (Pubitemid 28050057)
22. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C,. 1995. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 184: 39-51.
23. Zhou XY, Fu FH, Li Z, Dong QJ, He J, Wang CH,. 2009. Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma. Planta Med 75: 1580-1585.