Change in serum ferritin concentration in experimentally induced anemia of chronic inflammation in dogs

Journal of Veterinary Medical Science

Volumn 75, Issue 11, 2013, Pages 1419-1426

  Chikazawa, Seishiro ^a   Nakazawa, Takafumi ^a   Hori, Yasutomo ^a   Hoshi, Fumio ^a   Kanai, Kazutaka ^a   Ito, Naoyuki ^a   Orino, Koichi ^a   Watanabe, Kiyotaka ^a   Higuchi, Seiichi ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

ACD; Canine; Chronic inflammation; Ferritin; Hepcidin

Indexed keywords

C REACTIVE PROTEIN; FERRITIN; HEPCIDIN; RNA;

ANEMIA; ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; BLOOD CELL COUNT; CHEMISTRY; DOG; DOG DISEASE; FEMALE; GENETICS; IMMUNOLOGY; INFLAMMATION; LIVER; MALE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANEMIA; ANIMALS; BLOOD CELL COUNT; C-REACTIVE PROTEIN; DOG DISEASES; DOGS; FEMALE; FERRITINS; HEPCIDINS; INFLAMMATION; LIVER; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 84888804665     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.13-0149     Document Type: Article

References (46)

1. Andrews, N. C. 1999. The iron transporter DMT1. Int. J. Biochem. Cell Biol. 31: 991-994. [Medline] [CrossRef]
2. Angelucci, E., Brittenham, G. M., Mclaren, D. E., Ripalta, M., Baronciani, D., Giardino, C., Galimberti, M., Polichi, P. and Lucarelli, G. 2000. Hepatic iron concentration and total body iron stores in thalassemia major. N. Engl. J. Med. 343: 327-331. [Medline] [CrossRef]
3. Barger, A. M. 2003. The complete blood cell count: a powerful diagnostic tool. Vet. Clin. North Am. Small Anim. Pract. 33: 1207-1222. [Medline] [CrossRef]
4. Bergman, P. J. 2007. Paraneoplastic syndromes. pp. 77-94. In: Small Animal Clinical Oncology, 4th ed. (Withrow, S. J. and Vail, D. M. eds.), Saunders, Philadelphia.
5. Cerón, J. J., Eckersall, P. D. and Subiela, S. M. 2005. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet. Clin. Pathol. 34: 85-99. [Medline] [CrossRef]
6. Chikazawa, S., Hori, Y., Hoshi, F., Kanai, K., Ito, N., Sato, J., Orino, K., Watanabe, K. and Higuchi, S. 2013. Development of a sandwich enzyme-linked immunosorbent assay to detect and measure serum levels of canine ferritin. J. Vet. Med. Sci. 75: 515-517. [Medline] [CrossRef]
7. Cowgill, E. S., Neel, J. A. and Grindem, C. B. 2003. Clinical application of reticulocyte counts in dogs and cats. Vet. Clin. North Am. Small Anim. Pract. 33: 1223-1244. [Medline] [CrossRef]
8. de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G. and Vries, J. E. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174: 1209-1220. [Medline] [CrossRef]
9. Delaby, C., Pilard, N., Gonçalves, A. S., Beaumont, C. and Hergaux, F. C. 2005. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood 106: 3979-3984. [Medline] [CrossRef]
10. Delaby, C., Pilard, N., Hetet, G., Driss, F., Grandchamp, B., Beaumont, C. and Canonne-Hergaux, C. 2005. A physiological model to study iron recycling in macrophages. Exp. Cell Res. 310: 43-53. [Medline] [CrossRef]
11. Feldman, B. F., Kaneko, J. J. and Farver, T. B. 1981. Anemia of inflammatory disease in the dog: clinical characterization. Am. J. Vet. Res. 42: 1109-1113. [Medline]
12. Friedrichs, K. R., Thomas, C., Piler, M., Andrews, G. A., Chavey, P. S. and Young, K. M. 2010. Evaluation of serum ferritin as a marker for canine histiocytic sarcoma. J. Vet. Intern. Med. 24: 904-911. [Medline] [CrossRef]
13. Fry, M. M., Liggett, J. L. and Beak, S. J. 2004. Molecular cloning and expression of canine hepcidin. Vet. Clin. Pathol. 33: 223-227. [Medline] [CrossRef]
14. Fry, M. M., Kirk, C. A., Liggett, J. L., Daniel, G. B., Baek, S. J., Gouffon, J. S., Chimakurthy, P. M. and Rekapalli, B. 2009. Change in hepatic gene expression in dogs with experimentally induced nutritional iron deficiency. Vet. Clin. Pathol. 38: 13-19. [Medline] [CrossRef]
15. Gallimore, B., Gagnon, R. F., Subang, R. and Richards, G. K. 1991. Natural history of chronic Staphylococcus epidermidis foreign body infection in a mouse model. J. Infect. Dis. 164: 1220-1223. [Medline] [CrossRef]
16. Ganz, T. 2011. Hepcidin and iron regulation, 10 years later. Blood 117: 4425-4433. [Medline] [CrossRef]
17. Harrison, P. M. and Arosio, P. 1996. The ferritins: molecular properties, iron storage function and cellular regulation. Biochem. Biophys. Acta 1275: 161-203. [Medline] [CrossRef]
18. Hintze, K. J. and Theli, E. C. 2006. Cellular regulation and molecular interactions of the ferritins. Cell Mol. Life Sci. 63: 591-600. [Medline] [CrossRef]
19. Jacobs, A. and Worwood, M. 1975. Ferritin in serum: Clinical and biochemical implications. N. Engl. J. Med. 292: 951-956. [Medline] [CrossRef]
20. Kakuta, K., Orino, K., Yamamoto, S. and Watanabe, K. 1997. High levels of ferritin and its iron in fetal bovine serum. Comp. Biochem. Physiol. A Physiol. 118: 165-169. [Medline] [Cross-Ref]
21. Kazmierski, K. J., Ogilvie, G. K., Fettman, M. J., Lana, S. E., Walton, J. A., Hansen, R. A., Richardson, K. L., Harmar, D. W., Bedwell, C. L., Andrews, G. and Chavey, S. 2001. Serum zinc, chromium, and iron concentrations in dogs with lymphoma and osteosarcoma. J. Vet. Intern. Med. 15: 585-588. [Medline] [CrossRef]
22. Kemna, E., Pickkers, P., Nemeth, E., Hoeven, H. and Swinkels, D. 2005. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in human injected with LPS. Blood 106: 1864-1866. [Medline] [CrossRef]
23. Krause, A., Neitz, S., Mägert, H. J., Schultz, A., Forssmann, W. G., Knappe, P. S. and Adermann, K. 2000. LEAP-1 a novel highly disulfide-bounded human peptide, exhibits antimicrobial activity. FEBS. Lett. 480: 147-150. [Medline] [CrossRef]
24. Krause, J. R. and Stolc, V. 1979. Serum ferritin and bone marrow iron stores: I. Correlation with absence of iron in biopsy specimens. Am. J. Clin. Pathol. 72: 817-820. [Medline]
25. Lassen, E. D. and Weiser, G. 2004. Laboratory technology for veterinary medicine. pp. 18-20. In: Veterinary Hematology and Clinical Chemistry (Thrall, M. A., Baker, D. C., Campbell, T. W., DeNicola, D., Fettman, M. J., Lassen, E. D., Rebar, A. and Weiser, G. eds.), Lippincott Williams and Wilkins, Philadelphia.
26. Ludwiczek, S., Aigner, E., Theurl, I. and Weiss, G. 2003. Cytokine-mediated regulation of iron transport in human monocytic cells. Blood 101: 4148-4154. [Medline] [CrossRef]
27. Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K. and Ganz, T. 2004. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 113: 1271-1276. [Medline]
28. Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Gueux, E., Ruivard, M., Coudray, C. and Rayssiguier, Y. 2004. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093. [Medline] [CrossRef]
29. Newlands, C. E., Houston, D. M. and Vasconcelos, D. Y. 1994. Hyperferritinemia associated with malignant histiocytosis in a dog. J. Am. Vet. Med. Assoc. 205: 849-851. [Medline]
30. Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A. and Vaulont, S. 2002. The gene expression the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110: 1037-1044. [Medline]
31. Onishi, T., Inokuma, H., Ohno, H., Soeda, K., Noguchi, S. and Sasaki, K. 2000. C-reactive protein concentrations in normal and diseased dogs-measured by laser nephelometric immunoassay. J. Jpn. Vet. Med. Assoc. 53: 595-601.
32. Orino, K. and Watanabe, K. 2008. Molecular, physiological and clinical aspects of the iron storage protein ferritin. Vet. J. 178: 191-201. [Medline] [CrossRef]
33. Piek, C. J., Brinkhof, B., Rothuizen, J., Dekker, A. and Penning, L. C. 2011. Leukocyte count affects expression of reference genes in canine whole blood samples. BMC. Res. Notes 4: 36. [CrossRef]
34. Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P. and Loreal, O. 2001. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276: 7811-7819. [Medline] [CrossRef]
35. Rebouche, C. J., Wilcox, C. L. and Widness, J. A. 2004. Microanalysis of non-heme iron in animal tissues. J. Biochem. Biophys. Methods 58: 239-251. [Medline] [CrossRef]
36. Rivera, S. and Ganz, T. 2009. Animal models of anemia of inflammation. Semin. Hematol. 46: 351-357. [Medline] [Cross-Ref]
37. Schubert, T. E., Obermaier, F., Ugocsai, P., Männel, D. N., Echtenacher, B., Hofstädter, F. and Haerle, P. 2008. Murine models of anaemia of inflammation: extramedullary haematopoiesis represents a species specific difference to human anaemia of inflammation that can be eliminated by splenectomy. Int. J. Immunopathol. Pharmacol. 21: 577-584. [Medline]
38. Stookey, L. L. 1970. Ferrozine-a new spectrophotometric reagent for iron. Anal. Chem. 42: 779-781. [CrossRef]
39. Sun, X. F. 2006. An iron regulator hepcidin is affected by EPO. Zhonqquo Shi Yan Xue Ye Xue Za Zhi 14: 778-782. [Medline]
40. Theurl, I., Mattle, V., Seifert, M., Mariani, M., Marth, C. and Weiss, G. 2006. Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood 107: 4142-4148. [Medline] [CrossRef]
41. Torti, F. M. and Torti, S. V. 2002. Regulation of ferritin genes and protein. Blood 99: 3505-3516. [Medline] [CrossRef]
42. Vokurka, M. 2011. Hepcidin expression in the liver of mice with implanted tumour reacts to iron deficiency, inflammation and erythropoietin administration. Folia Biologica 57: 248-254. [Medline]
43. Watanabe, K., Muranishi, N., Murata, Y., Orino, K., Okano, S. and Yamamoto, S. 2000. Biochemical properties of canine serum ferritin: iron content and nonbinding to concanavalin A. BioMetals 13: 319-324. [Medline] [CrossRef]
44. Weiss, G. 1999. Iron and anemia of chronic disease. Kidney Int. Suppl. 69: S12-S17. [Medline] [CrossRef]
45. Williams, R. O. 2004. Collagen-induced arthritis as a model for rheumatoid arthritis. Methods Mol. Med. 98: 207-216. [Medline]
46. Worwood, M. 1990. Ferritin. Blood Rev. 4: 259-269. [Medline] [CrossRef]