Murine models of anaemia of inflammation: Extramedullary haematopoiesis represents a species specific difference to human anaemia of inflammation that can be eliminated by splenectomy

International Journal of Immunopathology and Pharmacology

Volumn 21, Issue 3, 2008, Pages 577-584

  Schubert, Thomas E O ^a,b   Obermaier, F ^a   Ogucsai, P ^a   Mannel D N ^a   Echtenacher, B ^a   Hofstadter F ^a   Haerle, P ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b Laboratory of Pathology   (Germany)

Author keywords

Anaemic; Extramedullary haematopoiesis; Inflammation; Mouse; Spleen

Indexed keywords

ANEMIA; ANEMIA OF INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; COLITIS; CONTROLLED STUDY; DISEASE MODEL; ERYTHROCYTE; ERYTHROCYTE COUNT; ERYTHROPOIESIS; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; HUMAN VERSUS ANIMAL COMPARISON; IRON DEFICIENCY ANEMIA; IRON METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETICULOCYTE COUNT; SPECIES DIFFERENCE; SPLEEN WEIGHT; SPLENECTOMY;

EID: 53849101071     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200802100310     Document Type: Article

References (20)

1. Weiss G. Pathogenesis and treatment of anaemia of chronic disease. Blood Rev 2002; 16:87-96.
2. Cartwright GE. The anemia of chronic disorders. Semin Hematol 1966; 3:351-75.
3. Gubler CJ, Cartwright GE, Wintrobe MM. The anemia of infection. XI. The effect of turpentine and cobalt on the absorption of iron by the rat. J Biol Chem 1950; 184:575-78.
4. Edwards CQ, Deiss A, Cole BC et al. Hematologic changes in chronic arthritis of mice induced by Mycoplasma arthritidis. Proc Soc Exp Biol Med 1975; 150:664-668.
5. Carbonell MT, Saiz MP, Marti MT et al. Iron mobilization in three animal models of inflammation. Rev Esp Fisiol 1989; 45:163-70.
6. Muntane J, Puig-Parellada P, Mitjavila MT. Iron metabolism and oxidative stress during acute and chronic phases of experimental inflammation: effect of iron-dextran and deferoxamine. J Lab Clin Med 1995; 126:435-43.
7. Sartor RB, Anderle SK, Rifai N et al. Protracted anemia associated with chronic, relapsing systemic inflammation induced by arthropathic peptidoglycanpolysaccharide polymers in rats. Infect Immun 1989; 57:1177-85.
8. Zacharia LA, Rigby PG. The anemia of chronic disorders: experimental abscess, spleen transplantation, and red cell iron reutilization. J Surg Oncol 1971; 3:67-72.
9. Maronpot RR, Boorman GA, Gaul BW. Pathology of the mouse. 1 ed. Vienna: Cache River Press, 1999, p. 1.
10. Bozzini CE, Barrio Rendo ME, Devoto FC et al. Studies on medullary and extramedullary erythropoiesis in the adult mouse. Am J Physiol 1970; 219:724-8.
11. Schubert T, Echtenacher B, Hofstadter F et al. TNF-independent development of transient anemia of chronic disease in a mouse model of protracted septic peritonitis. Lab Invest 2003; 83:1743-50.
12. Resnick M, Fibach E, Lebastard M et al. Response of the murine hematopoietic system to chronic infection with Mycobacterium lepraemurium. Infect Immun 1988; 56:3145-51.
13. Reissmann KR, Udupa KB. Effect of inflammation on erythroid precursors (BFU-E and CFU-E) in bone marrow and spleen of mice. J Lab Clin Med 1978; 92:22-9.
14. Schubert TE, Echtenacher B, Hofstadter F et al. Failure of interferon-gamma and tumor necrosis factor in mediating anemia of chronic disease in a mouse model of protracted septic peritonitis. Int J Mol Med 2005; 16:753-8.
15. Obermeier F, Kojouharoff G, Hans W et al. Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice. Clin Exp Immunol 1999; 116:238-45.
16. Okayasu I, Hatakeyama S, Yamada M et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990; 98:694-702.
17. Ganz T. The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic disease. Isr Med Assoc J 2002; 4:1043-5.
18. Jensen WN, Gubler CJ, Cartwright GE et al. Anemia of infection. XVIII. Effects of turpentine and colloidal thorium dioxide on rat plasma iron levels. Proc Soc Exp Biol Med 1952; 80:33-6.
19. Anogianaki A, Negrev NN, Shaik YB et al. Capsaicin an irritant anti-inflammatory compound. J Biol Regul Homeost Agents 2007; 21:1-4.
20. Borrione P, Parisi A, Salvo RA et al. Apeculiar pattern of expression of the transferrin receptor (CD71) by reticulocytes in patients given recombinant human erythropoietin (rHuEPO): a novel marker for abuse in sport? J Biol Regul Homeost Agents 2007; 21:79-88.