Changes in hepatic gene expression in dogs with experimentally induced nutritional iron deficiency

Veterinary Clinical Pathology

Volumn 38, Issue 1, 2009, Pages 13-19

  Fry, Michael M ^a   Kirk, Claudia A ^b   Liggett, Jason L ^a   Daniel, Gregory B ^b   Baek, Seung Joon ^a   Gouffon, Julia S ^a   Chimakurthy, Pradeep M ^a   Rekapalli, Bhanu ^c  

^a UNIVERSITY OF TENNESSEE   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

^c University of Tennessee Knoxville   (United States)

Author keywords

Calreticulin; Canine; Hepcidin; Iron deficiency; Liver; Microarray; Transferrin receptor

Indexed keywords

CANIS FAMILIARIS;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ARTICLE; DOG; DOG DISEASE; FEMALE; GENE EXPRESSION REGULATION; IRON DEFICIENCY ANEMIA; IRON INTAKE; LIVER; MALE; METABOLISM; PHYSIOLOGY;

ANEMIA, IRON-DEFICIENCY; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION REGULATION; IRON, DIETARY; LIVER; MALE;

EID: 67549085397     PISSN: 02756382     EISSN: 1939165X     Source Type: Journal    
DOI: 10.1111/j.1939-165X.2008.00081.x     Document Type: Article

References (20)

1. Fry M, Kirk C. Reticulocyte indices in a canine model of nutritional iron deficiency. Vet Clin Pathol. 2006;35: 172-181.
2. Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr. 2006;26:323-342.
3. Krause A, Neitz S, Mägert H, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000;480:147-150.
4. Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol. 2006;290:G199-G203.
5. Ganz T. Molecular pathogenesis of anemia of chronic disease. Pediatr Blood Cancer. 2006;46:554-557.
6. Pak M, Lopez M, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood. 2006;108:3730-3735.
7. Tanno T, Bhanu N, Oneal P, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13:1096-1101.
8. Wu Z, Irizarry R, Gentleman R, Martinez-Murillo F, Spencer F. A model-based background adjustment for oligonucleotide expression arrays. J Am Stat Assoc. 2004;99:909-917.
9. University of Tennessee Microarray Database. Available at: http://genome.ws.utk.edu. Accessed August 16, 2007.
10. Sherlock G, Hernandez-Boussard T, Kasarskis A, et al. The Stanford Microarray Database. Nucleic Acids Res. 2001;29:152-155.
11. Mississippi Computational Biology Consortium. Available at: http://usm.edu/genevenn/genevenn.htm. Accessed August 16, 2007.
12. Affymetrix. Available at: http://www.affymetrix.com/ analysis/index.affx. Accessed August 16, 2007.
13. Tan Y, Fornage M, Fu Y. Ranking analysis of microarray data: a powerful method for identifying differentially expressed genes. Genomics. 2006;88:846-854.
14. Fry M, Liggett J, Baek S. Molecular cloning and expression of canine hepcidin. Vet Clin Pathol. 2004;33:223-227.
15. Ponka P, Lok C. The transferrin receptor: role in health and disease. Int J Biochem Cell Biol. 1999;31:1111-1137.
16. Daniels T, Delgado T, Rodriguez J, Helguera G, Penichet ML. The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol. 2006;121:144-158.
17. Kohgo Y, Torimoto Y, Kato J. Transferrin receptor in tissue and serum: updated clinical significance of soluble receptor. Int J Hematol. 2002;76:213-218.
18. Lee P, Gelbart T, West C, Halloran C, Beutler E. Seeking candidate mutations that affect iron homeostasis. Blood Cells Mol Dis. 2002;29:471-487.
19. Williams D. Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum. J Cell Sci. 2006;119:615-623.
20. Núñez M, Osorio A, Tapia V, Vergara A, Mura CV. Iron-induced oxidative stress up-regulates calreticulin levels in intestinal epithelial (Caco-2) cells. J Cell Biochem. 2001;82:660-665.