Animal Models of Anemia of Inflammation

Seminars in Hematology

Volumn 46, Issue 4, 2009, Pages 351-357

  Rivera, Seth ^a   Ganz, Tomas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN;

ANEMIA; ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; BACTERIAL INFECTION; BACTERIAL STRAIN; CELL SURVIVAL; CHRONIC INFLAMMATION; COLITIS; DISEASE COURSE; DISEASE MODEL; DISEASE SEVERITY; ERYTHROCYTE LIFESPAN; ERYTHROPOIESIS; HEMATOPOIESIS; HEMOLYSIS; HEMOLYTIC ANEMIA; IMMUNE RESPONSE; INFLAMMATION; INFLAMMATORY DISEASE; INTESTINE PERFORATION; IRON DEFICIENCY ANEMIA; MAMMAL; MORTALITY; NONHUMAN; PARASITE; PARASITOSIS; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PSEUDOINFECTION; REPRODUCIBILITY; SYSTEMIC DISEASE; TRANSGENIC MOUSE;

ANEMIA; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIAL INFECTIONS; DISEASE MODELS, ANIMAL; INFLAMMATION; IRON; MICE; MICE, TRANSGENIC; MYCOBACTERIUM INFECTIONS; PARASITIC DISEASES; REPRODUCIBILITY OF RESULTS;

EID: 70349319807     PISSN: 00371963     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2009.06.003     Document Type: Article

References (59)

1. Weinstein D.A., Roy C.N., Fleming M.D., Loda M.F., Wolfsdorf J.I., and Andrews N.C. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 100 (2002) 3776-3781
2. Roy C.N., Mak H.H., Akpan I., Losyev G., Zurakowski D., and Andrews N.C. Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Blood 109 (2007) 4038-4044
3. Rivera S., Liu L., Nemeth E., Gabayan V., Sorensen O.E., and Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood 105 (2005) 1797-1802
4. Nguyen B.V., Bota D.P., Melot C., and Vincent J.L. Time course of hemoglobin concentrations in nonbleeding intensive care unit patients. Crit Care Med 31 (2003) 406-410
5. Vincent J.L., Baron J.F., Reinhart K., Gattinoni L., Thijs L., Webb A., et al. Anemia and blood transfusion in critically ill patients. JAMA 288 (2002) 1499-1507
6. Weiss G., and Goodnough L.T. Anemia of chronic disease. N Engl J Med 352 (2005) 1011-1023
7. Weiss G. Pathogenesis and treatment of anaemia of chronic disease. Blood Rev 16 (2002) 87-96
8. Anosa V.O. Postsplenectomy blood values, marrow cytology, erythrocyte life-span, and sequestration in mice. Am J Physiol 231 (1976) 1254-1257
9. Wallner S.F., Vautrin R., and Katz J. The haematopoietic response to burning: studies in a splenectomized animal model. Burns Incl Therm Inj 13 (1987) 15-21
10. Schubert T.E., Obermaier F., Ugocsai P., Mannel D.N., Echtenacher B., Hofstadter F., et al. Murine models of anaemia of inflammation: extramedullary haematopoiesis represents a species specific difference to human anaemia of inflammation that can be eliminated by splenectomy. Int J Immunopathol Pharmacol 21 (2008) 577-584
11. Jurado R.L. Iron, infections, and anemia of inflammation. Clin Infect Dis 25 (1997) 888-895
12. Poli-de-Figueiredo L.F., Garrido A.G., Nakagawa N., and Sannomiya P. Experimental models of sepsis and their clinical relevance. Shock 30 Suppl 1 (2008) 53-59
13. Freise H., Bruckner U.B., and Spiegel H.U. Animal models of sepsis. J Invest Surg 14 (2001) 195-212
14. Schubert T., Echtenacher B., Hofstadter F., and Mannel D.N. TNF-independent development of transient anemia of chronic disease in a mouse model of protracted septic peritonitis. Lab Invest 83 (2003) 1743-1750
15. Schubert T.E., Echtenacher B., Hofstadter F., and Mannel D.N. Failure of interferon-gamma and tumor necrosis factor in mediating anemia of chronic disease in a mouse model of protracted septic peritonitis. Int J Mol Med 16 (2005) 753-758
16. Gallimore B., Gagnon R.F., Subang R., and Richards G.K. Natural history of chronic Staphylococcus epidermidis foreign body infection in a mouse model. J Infect Dis 164 (1991) 1220-1223
17. Bunce C., Wheeler L., Reed G., Musser J., and Barg N. Murine model of cutaneous infection with gram-positive cocci. Infect Immun 60 (1992) 2636-2640
18. Lee S.W., Kang Y.A., Yoon Y.S., Um S.W., Lee S.M., Yoo C.G., et al. The prevalence and evolution of anemia associated with tuberculosis. J Korean Med Sci 21 (2006) 1028-1032
19. Boelaert J.R., Vandecasteele S.J., Appelberg R., and Gordeuk V.R. The effect of the host's iron status on tuberculosis. J Infect Dis 195 (2007) 1745-1753
20. Lounis N., Truffot-Pernot C., Grosset J., Gordeuk V.R., and Boelaert J.R. Iron and Mycobacterium tuberculosis infection. J Clin Virol 20 (2001) 123-126
21. Marquis J.F., Lacourse R., Ryan L., North R.J., and Gros P. Genetic and functional characterization of the mouse Trl3 locus in defense against tuberculosis. J Immunol 182 (2009) 3757-3767
22. Ihedioha J.I., Ochiogu I.S., and Ihedioha T.E. Co-administration of Na-EDTA and diminazene aceturate (DA) to mice infected with DA-resistant Trypanosoma brucei. J Comp Pathol 136 (2007) 206-211
23. Amole B.O., Clarkson Jr. A.B., and Shear H.L. Pathogenesis of anemia in Trypanosoma brucei-infected mice. Infect Immun 36 (1982) 1060-1068
24. Emeribe A.O., and Anosa V.O. Haematology of experimental Trypanosoma brucei gambiense infection. II. Erythrocyte and leucocyte changes. Rev Elev Med Vet Pays Trop 44 (1991) 53-57
25. Stijlemans B., Vankrunkelsven A., Brys L., Magez S., and De B.P. Role of iron homeostasis in trypanosomiasis-associated anemia. Immunobiology 213 (2008) 823-835
26. de MQ. Nadjm B., Reyburn H., Kemna E.H., Amos B., Laarakkers C.M., et al. Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection. J Infect Dis 199 (2009) 253-262
27. Howard C.T., McKakpo U.S., Quakyi I.A., Bosompem K.M., Addison E.A., Sun K., et al. Relationship of hepcidin with parasitemia and anemia among patients with uncomplicated Plasmodium falciparum malaria in Ghana. Am J Trop Med Hyg 77 (2007) 623-626
28. Nicolas G., Chauvet C., Viatte L., Danan J.L., Bigard X., Devaux I., et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110 (2002) 1037-1044
29. Pak M., Lopez M.A., Gabayan V., Ganz T., and Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 108 (2006) 3730-3735
30. Vokurka M., Krijt J., Sulc K., and Necas E. Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res 55 (2006) 667-674
31. Thawani N., Tam M., and Stevenson M.M. STAT6-mediated suppression of erythropoiesis in an experimental model of malarial anemia. Haematologica 94 (2009) 195-204
32. Lamb T.J., and Langhorne J. The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites. Malar J 7 (2008) 68
33. Nunes J.K., Starnbach M.N., and Wirth D.F. Secreted antibody is required for immunity to Plasmodium berghei. Infect Immun 77 (2009) 414-418
34. Vigario A.M., Belnoue E., Gruner A.C., Mauduit M., Kayibanda M., Deschemin J.C., et al. Recombinant human IFN-alpha inhibits cerebral malaria and reduces parasite burden in mice. J Immunol 178 (2007) 6416-6425
35. Hargreaves J., Yoeli M., and Nussenzweig R.S. Immunological studies in rodent malaria. I: Protective immunity induced in mice by mild strains of Plasmodium berghei yoelii against a virulent and fatal line of this plasmodium. Ann Trop Med Parasitol 69 (1975) 289-299
36. Frazer D.M., Wilkins S.J., Millard K.N., McKie A.T., Vulpe C.D., and Anderson G.J. Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE. Br J Haematol 126 (2004) 434-436
37. Mikolajew M., Stachurska J., Kalczak M., Lewicka S., and Kossakowska M. [Hematologic changes in rats with adjuvant-induced disease. Intravascular clotting and fibrinolysis as a possible factor in the pathogenesis of anemia]. Reumatologia 13 (1975) 47-56
38. Wang Q., and Liao Q.K. [Effect of nitric oxide on iron metabolism in rats with anemia of chronic disease]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 11 (2003) 385-389
39. Asai F., and Oshima T. Recombinant human erythropoietin, but not iron supplementation, improves anemia in rats with adjuvant-induced arthritis. Jpn J Pharmacol 57 (1991) 291-298
40. Feldman B.F., Kaneko J.J., and Farver T.B. Anemia of inflammatory disease in the dog: ferrokinetics of adjuvant-induced anemia. Am J Vet Res 42 (1981) 583-585
41. Sasu B, Hainu M, Boone TC, Bi X-J, Lee KJ, Arvedson T, et al. Hepcidin, hepcidin antagonists and methods of use. US Patent and Trade Office Application no. 20080213277; filed January 30, 2008.
42. Kemna E.H., Kartikasari A.E., van Tits L.J., Pickkers P., Tjalsma H., and Swinkels D.W. Regulation of hepcidin: insights from biochemical analyses on human serum samples. Blood Cells Mol Dis 40 (2008) 339-346
43. Montosi G., Corradini E., Garuti C., Barelli S., Recalcati S., Cairo G., et al. Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload. Hepatology 41 (2005) 545-552
44. Lasocki S., Millot S., Andrieu V., Letteron P., Pilard N., Muzeau F., et al. Phlebotomies or erythropoietin injections allow mobilization of iron stores in a mouse model mimicking intensive care anemia. Crit Care Med 36 (2008) 2388-2394
45. Sun X.F., Zhou D.B., and Zhao Y.Q. [An iron regulator hepcidin is affected by EPO]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 14 (2006) 778-782
46. Nemeth E., Rivera S., Gabayan V., Keller C., Taudorf S., Pedersen B.K., et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113 (2004) 1271-1276
47. Raja K.B., Duane P., and Peters T.J. Effects of turpentine-induced inflammation on the hypoxic stimulation of intestinal Fe3+ absorption in mice. Int J Exp Pathol 71 (1990) 785-789
48. Williams R.O. Collagen-induced arthritis as a model for rheumatoid arthritis. Methods Mol Med 98 (2004) 207-216
49. Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., and Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101 (2003) 2461-2463
50. Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-2093
51. Katsume A., Saito H., Yamada Y., Yorozu K., Ueda O., Akamatsu K., et al. Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice. Cytokine 20 (2002) 304-311
52. Sartor R.B., Anderle S.K., Rifai N., Goo D.A., Cromartie W.J., and Schwab J.H. Protracted anemia associated with chronic, relapsing systemic inflammation induced by arthropathic peptidoglycan-polysaccharide polymers in rats. Infect Immun 57 (1989) 1177-1185
53. Theurl I., Aigner E., Theurl M., Nairz M., Seifert M., Schroll A., et al. Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood 113 (2009) 5277-5286
54. Coccia M.A., Cooke K., Stoney G., Pistillo J., Del C.J., Duryea D., et al. Novel erythropoiesis stimulating protein (darbepoetin alfa) alleviates anemia associated with chronic inflammatory disease in a rodent model. Exp Hematol 29 (2001) 1201-1209
55. Foller M., Biswas R., Mahmud H., Akel A., Shumilina E., Wieder T., et al. Effect of peptidoglycans on erythrocyte survival. Int J Med Microbiol 299 (2009) 75-85
56. Uchiyama Y., Koike N., and Mihara M. Anemia in monkey collagen-induced arthritis is correlated with serum IL-6, but not TNFalpha. Rheumatol Int 28 (2008) 879-883
57. Hu X., Camus A.C., Aono S., Morrison E.E., Dennis J., Nusbaum K.E., et al. Channel catfish hepcidin expression in infection and anemia. Comp Immunol Microbiol Infect Dis 30 (2007) 55-69
58. Shike H., Lauth X., Westerman M.E., Ostland V.E., Carlberg J.M., Van Olst J.C., et al. Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge. Eur J Biochem 269 (2002) 2232-2237
59. Shike H., Shimizu C., Lauth X., and Burns J.C. Organization and expression analysis of the zebrafish hepcidin gene, an antimicrobial peptide gene conserved among vertebrates. Dev Comp Immunol 28 (2004) 747-754