Diet, obesity, and cancer progression: Are adipocytes the link?

Lipid Insights

Volumn 6, Issue , 2013, Pages 37-45

  Toren, Paul ^a   Mora, Benjamin C ^b   Venkateswaran, Vasundara ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Adipocytes; Adipokines; High fat diet; Tumour microenvironment

Indexed keywords

ADIPOCYTOKINE; FATTY ACID DERIVATIVE; INTERLEUKIN 6; LEPTIN; MACROPHAGE DERIVED CHEMOKINE; MATRIX METALLOPROTEINASE; NERVE GROWTH FACTOR BETA SUBUNIT; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OSTEOPONTIN; REACTIVE OXYGEN METABOLITE; RESISTIN; SCATTER FACTOR; TRACE ELEMENT; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ADIPOCYTE; CALORIC RESTRICTION; CANCER CELL; CANCER GROWTH; CELL INTERACTION; COCULTURE; CYTOKINE RELEASE; DIET; DISEASE ASSOCIATION; FAT INTAKE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MACRONUTRIENT; METABOLIC STRESS; NONHUMAN; OBESITY; PARACRINE SIGNALING; REVIEW; TUMOR MICROENVIRONMENT;

ANIMALIA;

EID: 84888802119     PISSN: None     EISSN: 11786353     Source Type: Journal    
DOI: 10.4137/LPI.S10871     Document Type: Review

References (83)

1. Calle EE, Kaaks R. Overweight, obesity and cancer:epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;4:579-91.
2. Wolin KY, Carson K, Colditz GA. Obesity and cancer. Oncologist. 2010;15:556-65.
3. Thalmann GN, Rhee H, Sikes RA, et al. Human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP Cells. Eur Urol. 2010;58:162-71.
4. Mao Y, Keller ET, Garfield DH, Shen K, Wang J. Stromal cells in tumor microenvironment and breast cancer. Cancer Metastasis Rev. 2013;32(1-2):303-15.
5. Park J, Euhus DM, Scherer PE. Paracrine and endocrine effects of adipose tissue on cancer development and progression. Endocr Rev. 2011;32:550-70
6. van Kruijsdijk RC, van der Wall E, Visseren FL. Obesity and cancer: the role of dysfunctional adipose tissue. Cancer Epidemiol Biomarkers Prev. 2009;18:2569-78.
7. Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371:569-78.
8. Buschemeyer WC 3rd, Freedland SJ. Obesity and prostate cancer: epidemiology and clinical implications. Eur Urol. 2007;52:331-43.
9. Majed B, Moreau T, Senouci K, Salmon RJ, Fourquet A, Asselain B. Is obesity an independent prognosis factor in woman breast cancer? Breast Cancer Res Treat. 2008;111:329-42.
10. Zhu Y, Wang HK, Zhang HL, et al. Visceral obesity and risk of high grade disease in clinical t1a renal cell carcinoma. J Urol. 2013;189(2):447-53.
11. Ansary-Moghaddam A, Huxley R, Barzi F, et al. The effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region. Cancer Epidemiol Biomarkers Prev. 2006;15:2435-40.
12. Gilbert CA, Slingerland JM. Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression. Annu Rev Med. 2013;64:45-57.
13. Kim HJ, Kim NK, Choi JH, et al. Associations between body mass index and clinico-pathological characteristics of papillary thyroid cancer. Clin Endocrinol (Oxf). 2013;78:134-40.
14. Brandstedt J, Wangefjord S, Nodin B, Gaber A, Manjer J, Jirstrom K. Gender, anthropometric factors and risk of colorectal cancer with particular reference to tumour location and TNM stage: a cohort study. Biol Sex Differ. 2012;3:23.
15. Keto CJ, Aronson WJ, Terris MK, et al. Obesity is associated with castration- resistant disease and metastasis in men treated with androgen deprivation therapy after radical prostatectomy: results from the SEARCH database. BJU Int. 2012;110:492-8.
16. Wree A, Kahraman A, Gerken G, Canbay A. Obesity affects the liver-the link between adipocytes and hepatocytes. Digestion. 2011;83:124-33.
17. Vongsuvanh R, George J, Qiao L, van der Poorten D. Visceral adiposity in gastrointestinal and hepatic carcinogenesis. Cancer Lett. 2013;(1):1-10.
18. Yamashita AS, Lira FS, Rosa JC, et al. Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: the effect of aerobic training and energy restriction. Cytokine. 2010;52:168-74.
19. Wilson KM, Giovannucci EL, Mucci LA. Lifestyle and dietary factors in the prevention of lethal prostate cancer. Asian J Androl. 2012;14:365-74.
20. Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-54.
21. Tarhini A, Lo E, Minor DR. Releasing the brake on the immune system: ipilimumab in melanoma and other tumors. Cancer Biother Radiopharm. 2010;25:601-13.
22. Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411-22.
23. Stryjecki C, Mutch DM. Fatty acid-gene interactions, adipokines and obesity. Eur J Clin Nutr. 2011;65:285-97.
24. Wang YY, Lehuede C, Laurent V, et al. Adipose tissue and breast epithelial cells: A dangerous dynamic duo in breast cancer. Cancer Lett. 2012;324:142-51.
25. Dirat B, Bochet L, Dabek M, et al. Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res. 2011;71:2455-65.
26. Yu J, Walter K, Omura N, et al. Unlike pancreatic cancer cells pancreatic cancer associated fibroblasts display minimal gene induction after 5-aza-2'-deoxycytidine. PLoS One. 2012;7:e43456.
27. Jiang L, Gonda TA, Gamble MV, et al. Global hypomethylation of genomic DNA in cancer-associated myofibroblasts. Cancer Res. 2008;68:9900-8.
28. Ribeiro R, Monteiro C, Cunha V, et al. Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro. J Exp Clin Cancer Res. 2012;31:32.
29. Zhang Y, Daquinag AC, Amaya-Manzanares F, Sirin O, Tseng C, Kolonin MG. Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment. Cancer Res. 2012;72:5198-208.
30. Tan J, Buache E, Chenard MP, Dali-Youcef N, Rio MC. Adipocyte is a non-trivial, dynamic partner of breast cancer cells. Int J Dev Biol. 2011;55:851-9.
31. Yamaguchi J, Ohtani H, Nakamura K, Shimokawa I, Kanematsu T. Prognostic impact of marginal adipose tissue invasion in ductal carcinoma of the breast. Am J Clin Pathol. 2008;130:382-8.
32. Novakovic K, Fitchev P, Brendler C, et al. 314 Active triacylglycerol metabolism and increased infiltrating adipocyte density in high grade prostate cancer. J Urology. 2012;187:e127.
33. Vona-Davis L, Gibson LF. Adipocytes as a critical component of the tumor microenvironment. Leuk Res. 2013;37(5):483-4.
34. Castells M, Thibault B, Delord JP, Couderc B. Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death. Int J Mol Sci. 2012;13:9545-71.
35. Sacca PA, Creydt VP, Choi H, et al. Human periprostatic adipose tissue: its influence on prostate cancer cells. Cell Physiol Biochem. 2012;30:113-22.
36. Ribeiro R, Monteiro C, Catalan V, et al. Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue. BMC Med. 2012;10:108.
37. Jotzu C, Alt E, Welte G, et al. Adipose tissue-derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor-derived factors. Anal Cell Pathol (Amst). 2010;33:61-79.
38. Nieman KM, Kenny HA, Penicka CV, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 2011;17:1498-503.
39. Skelhorne-Gross G, Reid AL, Apostoli AJ, et al. Stromal adipocyte PPARgamma protects against breast tumorigenesis. Carcinogenesis. 2012;33:1412-20.
40. Dalamaga M, Diakopoulos KN, Mantzoros CS. The role of adiponectin in cancer: a review of current evidence. Endocr Rev. 2012;33:547-94.
41. Park J, Scherer PE. Adipocyte-derived endotrophin promotes malignant tumor progression. J Clin Invest. 2012;122:4243-56.
42. Takaoka M, Nagata D, Kihara S, et al. Periadventitial adipose tissue plays a critical role in vascular remodeling. Circ Res. 2009;105:906-11.
43. Hermsdorff HH, Zulet MA, Abete I, Martinez JA. Discriminated benefits of a Mediterranean dietary pattern within a hypocaloric diet program on plasma RBP4 concentrations and other inflammatory markers in obese subjects. Endocrine. 2009;36:445-51.
44. D'Esposito V, Passaretti F, Hammarstedt A, et al. Adipocyte-released insulin- like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro. Diabetologia. 2012;55:2811-22.
45. Klimcakova E, Kovacikova M, Stich V, Langin D. Adipokines and dietary interventions in human obesity. Obes Rev. 2010;11:446-56.
46. Chaldakov GN, Beltowsky J, Ghenev PI, et al. Adipoparacrinology-vascular periadventitial adipose tissue (tunica adiposa) as an example. Cell Biol Int. 2012;36:327-30.
47. Fernandez-Quintela A, Churruca I, Portillo MP. The role of dietary fat in adipose tissue metabolism. Public Health Nutr. 2007;10:1126-31.
48. Wang Z, Yang L, Jiang Y, et al. High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin 22. PLoS One. 2011;6:e23737.
49. Davis PA, Vasu VT, Gohil K, et al. A high-fat diet containing whole walnuts (Juglans regia) reduces tumour size and growth along with plasma insulin-like growth factor 1 in the transgenic adenocarcinoma of the mouse prostate model. Br J Nutr. 2012;108(10):1764-72.
50. Llaverias G, Danilo C, Wang Y, et al. A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer. Am J Pathol. 2010;177:3180-91.
51. Lloyd JC, Antonelli JA, Phillips TE, et al. Effect of isocaloric low fat diet on prostate cancer xenograft progression in a hormone deprivation model. J Urol. 2010;183:1619-24.
52. Mavropoulos JC, Buschemeyer WC 3rd, Tewari AK, et al. The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model. Cancer Prev Res (Phila). 2009;2:557-65.
53. Garaulet M, Perez-Llamas F, Perez-Ayala M, et al. Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity. Am J Clin Nutr. 2001;74:585-91.
54. Karki S, Chakrabarti P, Huang G, Wang H, Farmer SR, Kandror KV. The multi-level action of fatty acids on adiponectin production by fat cells. PLoS One. 2011;6:e28146.
55. Lamers D, Schlich R, Greulich S, Sasson S, Sell H, Eckel J. Oleic acid and adipokines synergize in inducing proliferation and inflammatory signalling in human vascular smooth muscle cells. J Cell Mol Med. 2011;15:1177-88.
56. Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring). 2008;16:1248-55.
57. Perez-Matute P, Perez-Echarri N, Martinez JA, Marti A, Moreno-Aliaga MJ. Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha. Br J Nutr. 2007;97:389-98.
58. Flachs P, Mohamed-Ali V, Horakova O, et al. Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. Diabetologia. 2006;49:394-7.
59. Pierotti MA, Berrino F, Gariboldi M, et al. Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects. Oncogene. 2013;32(12):1475-87.
60. Wheatley KE, Williams EA, Smith NC, et al. Low-carbohydrate diet versus caloric restriction: effects on weight loss, hormones, and colon tumor growth in obese mice. Nutr Cancer. 2008;60:61-8.
61. Harvey AE, Lashinger LM, Otto G, Nunez NP, Hursting SD. Decreased systemic IGF-1 in response to calorie restriction modulates murine tumor cell growth, nuclear factor-kappaB activation, and inflammation-related gene expression. Mol Carcinog. 2012. [Epub ahead of print.]
62. Kaplan-Lefko PJ, Chen TM, Ittmann MM, et al. Pathobiology of autochthonous prostate cancer in a pre-clinical transgenic mouse model. Prostate. 2003;55:219-37.
63. Bonorden MJ, Rogozina OP, Kluczny CM, et al. Intermittent calorie restriction delays prostate tumor detection and increases survival time in TRAMP mice. Nutr Cancer. 2009;61:265-75.
64. Chen CT, Du Y, Yamaguchi H, et al. Targeting the IKKbeta/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer. Mol Cancer Ther. 2012;11:2212-21.
65. Nogueira LM, Dunlap SM, Ford NA, Hursting SD. Calorie restriction and rapamycin inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity. Endocr Relat Cancer. 2012;19:57-68.
66. Chartoumpekis DV, Zaravinos A, Ziros PG, et al. Differential expression of microRNAs in adipose tissue after long-term high-fat diet-induced obesity in mice. PLoS One. 2012;7:e34872.
67. Blando J, Moore T, Hursting S, et al. Dietary energy balance modulates prostate cancer progression in Hi-Myc mice. Cancer Prev Res (Phila). 2011;4:2002-14.
68. Sung MK, Yeon JY, Park SY, Park JH, Choi MS. Obesity-induced metabolic stresses in breast and colon cancer. Ann N Y Acad Sci. 2011;1229:61-8.
69. Ford NA, Nunez NP, Holcomb VB, Hursting SD. IGF1 dependence of dietary energy balance effects on murine Met1 mammary tumor progression, epithelial-to-mesenchymal transition, and chemokine expression. Endocr Relat Cancer. 2013;20:39-51.
70. Flores MB, Rocha GZ, Damas-Souza DM, et al. Obesity-induced increase in tumor necrosis factor-alpha leads to development of colon cancer in mice. Gastroenterology. 2012;143:741-53, e1-4.
71. Rondini EA, Harvey AE, Steibel JP, Hursting SD, Fenton JI. Energy balance modulates colon tumor growth: Interactive roles of insulin and estrogen. Mol Carcinog. 2011;50:370-82.
72. Huffman DM, Johnson MS, Watts A, Elgavish A, Eltoum IA, Nagy TR. Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake. Cancer Res. 2007;67:417-24.
73. Thompson KJ, Swan RZ, Iannitti DA, McKillop IH, Sindram D. Diet-induced obesity and ethanol impair progression of hepatocellular carcinoma in a mouse mesenteric vein injection model. Surg Endosc. 2013;27:246-55.
74. James BR, Tomanek-Chalkley A, Askeland EJ, Kucaba T, Griffith TS, Norian LA. Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth. J Immunol. 2012;189:1311-21.
75. White PB, Ziegler KM, Swartz-Basile DA, et al. Obesity, but not high-fat diet, promotes murine pancreatic cancer growth. J Gastrointest Surg. 2012;16:1680-5.
76. Dunlap SM, Chiao LJ, Nogueira L, et al. Dietary Energy Balance Modulates Epithelial-to-Mesenchymal Transition and Tumor Progression in Murine Claudin-Low and Basal-like Mammary Tumor Models. Cancer Prev Res (Phila). 2012;5:930-42.
77. Iatropoulos MJ, Duan JD, Jeffrey AM, et al. Hepatocellular proliferation and hepatocarcinogen bioactivation in mice with diet-induced fatty liver and obesity. Exp Toxicol Pathol. 2013;65(4):451-6.
78. Price RS, Cavazos DA, De Angel RE, Hursting SD, deGraffenried LA. Obesity-related systemic factors promote an invasive phenotype in prostate cancer cells. Prostate Cancer Prostatic Dis. 2012;15:135-43.
79. De Angel RE, Conti CJ, Wheatley KE, et al. The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001. Mol Carcinog. 2013;52(6):446-58.
80. Liu Z, Brooks RS, Ciappio ED, et al. Diet-induced obesity elevates colonic TNF-alpha in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. J Nutr Biochem. 2012;23:1207-13.
81. Yun JP, Behan JW, Heisterkamp N, et al. Diet-induced obesity accelerates acute lymphoblastic leukemia progression in two murine models. Cancer Prev Res (Phila). 2010;3:1259-64.
82. Ribeiro AM, Andrade S, Pinho F, et al. Prostate cancer cell proliferation and angiogenesis in different obese mice models. Int J Exp Pathol. 2010;91:374-86.
83. Nunez NP, Perkins SN, Smith NC, et al. Obesity accelerates mouse mammary tumor growth in the absence of ovarian hormones. Nutr Cancer. 2008;60:534-41.