Prostate cancer cell proliferation and angiogenesis in different obese mice models

International Journal of Experimental Pathology

Volumn 91, Issue 4, 2010, Pages 374-386

  Ribeiro, Andreia M ^a   Andrade, Sara ^a   Pinho, Filipa ^a   Duarte Monteiro, J ^a   Costa, Madalena ^a   Lopes, Carlos ^a   Aguas, Artur P ^a   Monteiro, Mariana P ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

leptin; morphometry; obesity; OBR; prostate cancer; RM1 cells

Indexed keywords

KI 67 ANTIGEN; LEPTIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; HORMONE BLOOD LEVEL; IN VIVO STUDY; INOCULATION; MALE; MITOSIS; MORPHOMETRICS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; SENSITIVITY ANALYSIS; TUMOR GROWTH;

ADENOCARCINOMA; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-LIKE GROWTH FACTOR I; KI-67 ANTIGEN; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MITOTIC INDEX; MUTATION; NEOVASCULARIZATION, PATHOLOGIC; OBESITY; PROSTATIC NEOPLASMS; RECEPTORS, LEPTIN; TIME FACTORS; TUMOR BURDEN;

EID: 77955079933     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2010.00726.x     Document Type: Article

References (70)

1. Ablamunits V., Cohen Y., Braazee I.B., Gaetz H.P., Vinson C., Klebanov S. (2006) Susceptibility to induced and spontaneous carcinogenesis is increased in fatless A-ZIP/F-1 but not in obese ob/ob mice. Cancer Res. 66, 8897 8902.
2. Ambrosini G., Nath A.K., Sierra-Honigmann M.R., Flores-Riveros J 2002) Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. J. Biol. Chem. 277, 34601 34609.
3. Amling C.L. (2004) The association between obesity and the progression of prostate and renal cell carcinoma. Urol. Oncol. 22, 478 484.
4. Asal N.R., Risser D.R., Kadamani S., Geyer J.R., Lee E.T., Cherng N. (1988) Risk factors in renal cell carcinoma: I. Methodology, demographics, tobacco, beverage use, and obesity. Cancer Detect. Prev. 11, 359 377.
5. Baillargeon J., Platz E.A., Rose D.P. et al. (2006) Obesity, adipokines, and prostate cancer in a prospective population-based study. Cancer Epidemiol. Biomarkers Prev. 15, 1331 1335.
6. Baley P.A., Yoshida K., Sehgal I., Thompson T.Cl. (1995) Progression to androgen insensitivity in a novel in vitro mouse model for prostate cancer. J. Steroid Biochem. Mol. Biol. 52, 403 413.
7. Baumann H., Morella K.K., White D.W. (1996) The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Natl Acad. Sci. USA 93, 8374 8378.
8. Boden G., Chen X., Mozzoli M., Ryan I. (1996) Effect of fasting on serum leptin in normal human subjects. J. Clin. Endocrinol. Metab. 81, 3419 3423.
9. Bouloumie A., Drexler H.C., Busse R. (1998) Leptin, the product of Ob gene, promotes angiogenesis. Circ. Res. 83, 1059 1066.
10. Brown L.M., Swanson C.A., Gridley G. et al. (1995) Adenocarcinoma of the esophagus: role of obesity and diet. J. Natl Cancer Inst. 87, 104 109.
11. Bruno A., Conus S., Simon H.U. (2005) Apoptotic pathways are inhibited by leptin receptor activation in neutrophils. J. Immunol. 174, 8090 8096.
12. Bub J.D., Miyazaki T., Iwamoto Y. (2006) Adiponectin as a growth inhibitor in prostate cancer cells. Biochem. Biophys. Res. Commun. 340, 1158 1166.
13. Calle E.E. Kaaks R. (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 4, 579 591.
14. Chang S., Hursting S.D., Contois J.H. (2001) Leptin and prostate cancer. Prostate 46, 62 67.
15. Chia V.M., Newcomb P.A., Trentham-Dietz A., Hampton J.M. (2007) Obesity, diabetes, and other factors in relation to survival after endometrial cancer diagnosis. Int. J. Gynecol. Cancer 17, 441 446.
16. Chua Jr. S.C., Chung W.K., Wu-Peng X.S. et al. (1996) Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271, 994 996.
17. Cohen P.G. (2001) Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection. Med. Hypotheses 56, 702 708.
18. Cox M.E., Gleave M.E., Zakikhani M. et al. (2009) Insulin receptor expression by human prostate cancers. Prostate 69, 33 40.
19. Crespo C.J., Smit E., Troiano R.P., Bartlett S.J., Macera C.A., Andersen R.E. (2001) Television watching, energy intake, and obesity in US children: results from the third National Health and Nutrition Examination Survey, 1988-1994. Arch. Pediatr. Adolesc. Med. 155, 360 365. (Pubitemid 32199183)
20. Deo D.D., Rao A.P., Bose S.S. et al. (2008) Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells. J. Biomed. Biotechnol. 2008, 163902.
21. Frasca F., Pandini G., Sciacca L. et al. (2008) The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch. Physiol. Biochem. 114, 23 37.
22. Frederich R.C., Hamann A., Anderson S., Lollmann B., Lowell B.B., Flier J.S. (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1, 1311 1314.
23. Frederich R.C., Lollmann B., Hamann A. et al. (1995) Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J. Clin. Invest. 96, 1658 1663.
24. Freedland S.J., Giovannucci E., Platz E.A. (2006) Are findings from studies of obesity and prostate cancer really in conflict? Cancer Causes Control 17, 5 9.
25. Freedland S.J., Wen J., Wuerstle M. (2008) Obesity is a significant risk factor for prostate cancer at the time of biopsy. Urology 72, 1102 1105.
26. Fried S.K., Bunkin D.A., Greenberg A.S. (1998) Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J. Clin. Endocrinol. Metab. 83, 847 850.
27. Fruhbeck G. (2006) Intracellular signalling pathways activated by leptin. Biochem. J. 393, 7 20.
28. Giovannucci E. Michaud D. (2007) The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology 132, 2208 2225.
29. Giovannucci E., Rimm E.B., Liu Y. et al. (2003) Body mass index and risk of prostate cancer in U.S. health professionals. J. Natl Cancer Inst. 95, 1240 1244.
30. Goktas S., Yilmaz M.I., Caglar K., Sonmez A., Kilia S., Bedir S. (2005) Prostate cancer and adiponectin. Urology 65, 1168 1172.
31. Haque W.A. Garg A. (2004) Adipocyte biology and adipocytokines. Clin. Lab. Med. 24, 217 234.
32. Hedley A.A., Ogden C.L., Johnson C.L., Carroll M.D., Curtin L.R., Flegal K.M. (2004) Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA 291, 2847 2850.
33. Hoda M.R. Popken G. (2008) Mitogenic and anti-apoptotic actions of adipocyte-derived hormone leptin in prostate cancer cells. BJU Int. 102, 383 388.
34. Hsing A.W., Chua Jr. S., Gao Y.T. et al. (2001) Prostate cancer risk and serum levels of insulin and leptin: a population-based study. J. Natl Cancer Inst. 93, 783 789.
35. James W.P. (2008) WHO recognition of the global obesity epidemic. Int. J. Obes. (Lond) 32 (Suppl 7 S120 S126.
36. Kershaw E.E. Flier J.S. (2004) Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metab. 89, 2548 2556.
37. Leitzmann M.F., Ahn J., Albanes D. et al. (2008) Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cancer Causes Control 19, 1267 1276.
38. Lihn A.S., Pedersen S.B., Richelsen B. (2005) Adiponectin: action, regulation and association to insulin sensitivity. Obes. Rev. 6, 13 21.
39. Luo J., Margolis K.L., Adami H.O., Lopez A.M., Lessin L., Ye W. (2007) Body size, weight cycling, and risk of renal cell carcinoma among postmenopausal women: the Women's Health Initiative (United States). Am. J. Epidemiol. 166, 752 759.
40. Maffei M., Halaas J., Ravussin E. et al. (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1, 1155 1161.
41. Majed B., Moreau T., Senouci K., Salmon R.J., Fourquet A., Asselain B. (2008) Is obesity an independent prognosis factor in woman breast cancer? Breast Cancer Res. Treat. 111, 329 342.
42. Malendowicz W., Rucinski M., Macchi C. et al. (2006) Leptin and leptin receptors in the prostate and seminal vesicles of the adult rat. Int. J. Mol. Med. 18, 615 618.
43. McNeal J.E. Gleason D.F. (1991) Gleason's classification of prostatic adenocarcinomas. Ann. Pathol. 11, 163 168.
44. Michalakis K., Williams C.J., Mitsiades N. et al. (2007) Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study. Cancer Epidemiol. Biomarkers Prev. 16, 308 313.
45. Mistry T., Digby J.E., Chen J., Desai K.M., Randeva H.S. (2006) The regulation of adiponectin receptors in human prostate cancer cell lines. Biochem. Biophys. Res. Commun. 348, 832 838.
46. Mistry T., Digby J.E., Desai K.M., Randeva H.S. (2007) Obesity and prostate cancer: a role for adipokines. Eur. Urol. 52, 46 53.
47. Mistry T., Digby J.E., Desai K.M., Randeva H.S. (2008) Leptin and adiponectin interact in the regulation of prostate cancer cell growth via modulation of p53 and bcl-2 expression. BJU Int. 101, 1317 1322.
48. Monteiro M.P., Monteiro J.D., Aguas A.P., Cardoso M.H. (2006) Rats submitted to gastric banding are leaner and show distinctive feeding patterns. Obes. Surg. 16, 597 602.
49. Nakashima K., Narazaki M., Taga T. (1997) Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130. FEBS Lett. 401, 49 52. (Pubitemid 27051256)
50. Nandeesha H. (2009) Insulin: a novel agent in the pathogenesis of prostate cancer. Int. Urol. Nephrol. 41, 267 272.
51. Nunez N.P., Oh W.J., Rosenberg J. et al. (2006) Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation. Cancer Res. 66, 5469 5476.
52. Ogden C.L., Carroll M.D., Curtin L.R., McDowell M.A., Tabak C.J., Flegal K.M. (2006) Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 295, 1549 1555.
53. Onuma M., Bub J.D., Rummel T.L., Iwamoto Y. (2003) Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase. J. Biol. Chem. 278, 42660 42667.
54. O'Rourke L., Yeaman S.J., Shepherd P.R. et al. (2001) Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways. Diabetes 50, 955 961.
55. Pischon T., Lahmann P.H., Boeing H. et al. (2006) Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). J. Natl Cancer Inst. 98, 920 931. (Pubitemid 44018922)
56. Ribeiro R., Lopes C., Medeiros R. (2006) The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives. Prostate Cancer Prostatic. Dis. 9, 19 24.
57. Ronti T., Lupattelli G., Mannarino E. (2006) The endocrine function of adipose tissue: an update. Clin. Endocrinol. (Oxf) 64, 355 365.
58. Schoen R.E., Tangen C.M., Kuller L.H. et al. (1999) Increased blood glucose and insulin, body size, and incident colorectal cancer. J. Natl Cancer Inst. 91, 1147 1154.
59. Sierra-Honigmann M.R., Nath A.K., Murakami C. et al. (1998) Biological action of leptin as an angiogenic factor. Science 281, 1683 1686.
60. Somasundar P., Yu A.K., Vona-Davis L., McFadden D.W. (2003) Differential effects of leptin on cancer in vitro. J. Surg. Res. 113, 50 55.
61. Somasundar P., Frankenberry K.A., Skinner H. et al. (2004) Prostate cancer cell proliferation is influenced by leptin. J. Surg. Res. 118, 71 82.
62. Stattin P., Kaaks R., Johansson R. et al. (2003) Plasma leptin is not associated with prostate cancer risk. Cancer Epidemiol. Biomarkers Prev. 12, 474 475.
63. Stienstra R., Duval C., Muller M., Kersten S. (2007) PPARs, Obesity, and Inflammation. PPAR Res. 2007, 95974.
64. Stubbs C.O. Lee A.J. (2004) The obesity epidemic: both energy intake and physical activity contribute. Med. J. Aust. 181, 489 491.
65. Tartaglia L.A., Dembski M., Weng X. et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263 1271.
66. Trayhurn P. Beattie J.H. (2001) Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc. Nutr. Soc. 60, 329 339.
67. Vaughan T.L., Davis S., Kristal A., Thomas D.B. (1995) Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev. 4, 85 92.
68. Veugelers P.J., Porter G.A., Guernsey D.L., Casson A.G. (2006) Obesity and lifestyle risk factors for gastroesophageal reflux disease, Barrett esophagus and esophageal adenocarcinoma. Dis. Esophagus 19, 321 328.
69. Voeks D.J., Martiniello-Wilks R., Russel P.J. (2002) Derivation of MPR and TRAMP models of prostate cancer and prostate cancer metastasis for evaluation of therapeutic strategies. Urol. Oncol. 7, 111 118.
70. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425 432.