Thiolated hyaluronan-based hydrogels crosslinked using oxidized glutathione: An injectable matrix designed for ophthalmic applications

Acta Biomaterialia

Volumn 10, Issue 1, 2014, Pages 94-103

  Zarembinski, Thomas I ^a   Doty, Nathaniel J ^a   Erickson, Isaac E ^a   Srinivas, Ramya ^a   Wirostko, Barbara M ^b   Tew, William P ^a  

^a BIOTIME INC   (United States)

^b Jade Therapeutics Inc   (United States)

Author keywords

Hyaluronic acid; In situ crosslinking; Oxidized glutathione; Synthetic extracellular matrix; Thiol disulfide exchange

Indexed keywords

BIOCOMPATIBILITY; ENZYME ACTIVITY; GELATION; HYDROGELS; NUCLEIC ACIDS; OXIDATION; PEPTIDES; STEM CELLS; SULFUR COMPOUNDS;

CROSSLINKED; GLUTHATHIONE; HYALURONAN; IN SITU CROSSLINKING; INJECTABLES; OXIDIZED GLUTATHIONE; SITU CROSS-LINKING; SYNTHETIC EXTRACELLULAR MATRIX; THIOL DISULFIDE EXCHANGE; THIOL-DISULFIDE EXCHANGE REACTION;

HYALURONIC ACID;

DISULFIDE; GELATIN; GELIN S; GLUTATHIONE DISULFIDE; GLYCOSIL; HYALURONIC ACID; HYSTEM C; NUCLEIC ACID; PROTEIN DERIVATIVE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; HYDROGEL; NONHUMAN; PRIORITY JOURNAL; RABBIT; STEM CELL TRANSPLANTATION;

HYALURONIC ACID; IN SITU CROSSLINKING; OXIDIZED GLUTATHIONE; SYNTHETIC EXTRACELLULAR MATRIX; THIOL-DISULFIDE EXCHANGE;

ADIPOSE TISSUE; ANIMALS; CROSS-LINKING REAGENTS; EYE; GLUTATHIONE DISULFIDE; HUMANS; HYALURONIC ACID; HYDROGEL; INJECTIONS; OLIGOPEPTIDES; OPHTHALMOLOGY; RABBITS; SKIN; STEM CELLS; SULFHYDRYL COMPOUNDS;

EID: 84888645890     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.09.029     Document Type: Article

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