Delivery of basic fibroblast growth factor with a pH-responsive, injectable hydrogel to improve angiogenesis in infarcted myocardium

Biomaterials

Volumn 32, Issue 9, 2011, Pages 2407-2416

  Garbern, Jessica C ^a   Minami, Elina ^b   Stayton, Patrick S ^a   Murry, Charles E ^a,b,c  

^a University of Washington   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Angiogenesis; Controlled drug release; Copolymer; Fibroblast growth factor; Hydrogel; Thermally responsive material

Indexed keywords

ACIDIC MICROENVIRONMENT; ANGIOGENESIS; ANGIOGENIC GROWTH FACTORS; ANIMAL MODEL; BASIC FIBROBLAST GROWTH FACTOR; BLOOD FLOW; BUTYL ACRYLATES; CARDIAC FUNCTIONS; CONTROLLED DRUG RELEASE; FIBROBLAST GROWTH FACTOR; HYDROGEL SYSTEM; IN-VIVO; INJECTABLE HYDROGELS; LOCAL DELIVERY; N-ISOPROPYLACRYLAMIDES; PH-RESPONSIVE; PHYSICAL GEL; RANDOM COPOLYMER; REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER POLYMERIZATION; SPATIO-TEMPORAL; TEMPERATURE-RESPONSIVE; THERAPEUTIC ANGIOGENESIS; THERAPEUTIC EFFECTS; THERMALLY-RESPONSIVE MATERIAL;

ACRYLIC MONOMERS; AMIDES; BLOOD; CELL CULTURE; COPOLYMERIZATION; COPOLYMERS; ECHOCARDIOGRAPHY; FIBROBLASTS; FREE RADICAL POLYMERIZATION; HEMODYNAMICS; PEPTIDES; PH EFFECTS; POLYMERS;

HYDROGELS;

BASIC FIBROBLAST GROWTH FACTOR; BIOTIN; HEPARIN; POLY(N ISOPROPYLACRYLAMIDE CO PROPYLACRYLIC ACID CO BUTYL ACRYLATE); POLY(N ISOPROPYLACRYLAMIDE); SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLAR DENSITY; ARTERY BLOOD FLOW; ARTICLE; BIOTINYLATION; CAPILLARY DENSITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ECHOCARDIOGRAPHY; FRAGMENTATION REACTION; HEART FUNCTION; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HYDROGEL; MALE; NONHUMAN; PH; POLYMERIZATION; PRIORITY JOURNAL; RAT; TEMPERATURE;

ACRYLAMIDES; ANIMALS; BIOTIN; CORONARY CIRCULATION; DISEASE MODELS, ANIMAL; FIBROBLAST GROWTH FACTOR 2; HYDROGEL; HYDROGEN-ION CONCENTRATION; INFLAMMATION; INJECTIONS; MALE; MYOCARDIAL INFARCTION; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, INBRED F344; SYSTOLE;

ANIMALIA; RATTUS;

EID: 78751700969     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.11.075     Document Type: Article

References (35)

1. Freedman S.B., Isner J.M. Therapeutic angiogenesis for ischemic cardiovascular disease. J Mol Cell Cardiol 2001, 33:379-393.
2. Simons M., Annex B.H., Laham R.J., Kleiman N., Henry T., Dauerman H., et al. Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial. Circulation 2002, 105:788-793.
3. Henry T.D., Annex B.H., McKendall G.R., Azrin M.A., Lopez J.J., Giordano F.J., et al. The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis. Circulation 2003, 107:1359-1365.
4. Iwakura A., Fujita M., Kataoka K., Tambara K., Sakakibara Y., Komeda M., et al. Intramyocardial sustained delivery of basic fibroblast growth factor improves angiogenesis and ventricular function in a rat infarct model. Heart Vessels 2003, 18:93-99.
5. Silva E.A., Mooney D.J. Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis. J Thromb Haemost 2007, 5:590-598.
6. Pike D.B., Cai S., Pomraning K.R., Firpo M.A., Fisher R.J., Shu X.Z., et al. Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF. Biomaterials 2006, 27:5242-5251.
7. Shao Z.Q., Takaji K., Katayama Y., Kunitomo R., Sakaguchi H., Lai Z.F., et al. Effects of intramyocardial administration of slow-release basic fibroblast growth factor on angiogenesis and ventricular remodeling in a rat infarct model. Circ J 2006, 70:471-477.
8. Fujita M., Ishihara M., Morimoto Y., Simizu M., Saito Y., Yura H., et al. Efficacy of photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 in a rabbit model of chronic myocardial infarction. J Surg Res 2005, 126:27-33.
9. Wang H., Zhang X., Li Y., Ma Y., Zhang Y., Liu Z., et al. Improved myocardial performance in infarcted rat heart by co-injection of basic fibroblast growth factor with temperature-responsive chitosan hydrogel. J Heart Lung Transplant 2010, 29:881-887.
10. Hao X., Silva E.A., Mansson-Broberg A., Grinnemo K.H., Siddiqui A.J., Dellgren G., et al. Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc Res 2007, 75:178-185.
11. Matsusaki M., Akashi M. Novel functional biodegradable polymer IV: pH-sensitive controlled release of fibroblast growth factor-2 from a poly(gamma-glutamic acid)-sulfonate matrix for tissue engineering. Biomacromolecules 2005, 6:3351-3356.
12. Shim W.S., Kim J.-H., Park H., Kim W., Kwon I.C., Lee D.S. Biodegradability and biocompatibility of a pH- and thermo-sensitive hydrogel formed from a sulfonamide-modified poly(e-caprolactone-co-oactinde)-poly(ethylene glycol)-poly(e-caprolactone-co-lactide) block copolymer. Biomaterials 2006, 27:5178-5185.
13. Khabbaz K.R., Zankoul F., Warner K.G. Intraoperative metabolic monitoring of the heart: II. Online measurement of myocardial tissue pH. Ann Thorac Surg 2001, 72:S2227-S2233. [discussion S33-4, S67-70].
14. Kumbhani D.J., Healey N.A., Birjiniuk V., Crittenden M.D., Josa M., Treanor P.R., et al. Determinants of regional myocardial acidosis during cardiac surgery. Surgery 2004, 136:190-198.
15. Chen G., Hoffman A.S. Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH. Nature 1995, 373:49-52.
16. Brazel C.S., Peppas N.A. Synthesis and characterization of thermo- and chemomechanically responsive poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels. Macromolecules 1995, 28:8016-8020.
17. Lackey C.A., Murthy N., Press O.W., Tirrell D.A., Hoffman A.S., Stayton P.S. Hemolytic activity of pH-responsive polymer-streptavidin bioconjugates. Bioconjug Chem 1999, 10:401-405.
18. Yin X., Hoffman A.S., Stayton P.S. Poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers that respond sharply to temperature and pH. Biomacromolecules 2006, 7:1381-1385.
19. Alexandridis P., Hatton T.A. Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. Colloids Surf A Physicochem Eng Asp 1995, 96:1-46.
20. Han C.K., Bae Y.H. Inverse thermally-reversible gelation of aqueous N-isopropylacrylamide copolymer solutions. Polymer 1998, 39:2809-2812.
21. Garbern J.C., Hoffman A.S., Stayton P.S. Injectable pH- and temperature-responsive poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for delivery of angiogenic growth factors. Biomacromolecules 2010, 11:1833-1839.
22. Ferrito M., Tirrell D.A. Poly(2-ethylacrylic acid). Macromol Synth 1992, 11:59-62.
23. Anderl J.N., Robey T.E., Stayton P.S., Murry C.E. Retention and biodistribution of microspheres injected into ischemic myocardium. J Biomed Mater Res A 2009, 88:704-710.
24. Laflamme M.A., Chen K.Y., Naumova A.V., Muskheli V., Fugate J.A., Dupras S.K., et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 2007, 25:1015-1024.
25. Hale S.L., Vivaldi M.T., Kloner R.A. Fluorescent microspheres: a new tool for visualization of ischemic myocardium in rats. Am J Physiol 1986, 251:H863-H868.
26. Van Oosterhout M.F., Willigers H.M., Reneman R.S., Prinzen F.W. Fluorescent microspheres to measure organ perfusion: validation of a simplified sample processing technique. Am J Physiol 1995, 269:H725-H733.
27. Glenny R.W., Bernard S., Brinkley M. Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion. J Appl Physiol 1993, 74:2585-2597.
28. Schor A.M., Pendleton N., Pazouki S., Smither R.L., Morris J., Lessan K., et al. Assessment of vascularity in histological sections: effects of methodology and value as an index of angiogenesis in breast tumours. Histochem J 1998, 30:849-856.
29. Christman K.L., Vardanian A.J., Fang Q., Sievers R.E., Fok H.H., Lee R.J. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium. J Am Coll Cardiol 2004, 44:654-660.
30. Virag J.A., Rolle M.L., Reece J., Hardouin S., Feigl E.O., Murry C.E. Fibroblast growth factor-2 regulates myocardial infarct repair: effects on cell proliferation, scar contraction, and ventricular function. Am J Pathol 2007, 171:1431-1440.
31. Weisman H.F., Bush D.E., Mannisi J.A., Weisfeldt M.L., Healy B. Cellular mechanisms of myocardial infarct expansion. Circulation 1988, 78:186-201.
32. Dai W., Wold L.E., Dow J.S., Kloner R.A. Thickening of the infarcted wall by collagen injection improves left ventricular function in rats: a novel approach to preserve cardiac function after myocardial infarction. J Am Coll Cardiol 2005, 46:714-719.
33. Fujimoto K.L., Ma Z., Nelson D.M., Hashizume R., Guan J., Tobita K., et al. Synthesis, characterization and therapeutic efficacy of a biodegradable, thermoresponsive hydrogel designed for application in chronic infarcted myocardium. Biomaterials 2009, 30:4357-4368.
34. Nahrendorf M., Swirski F.K., Aikawa E., Stangenberg L., Wurdinger T., Figueiredo J.L., et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 2007, 204:3037-3047.
35. Polverini P.J., Cotran P.S., Gimbrone M.A., Unanue E.R. Activated macrophages induce vascular proliferation. Nature 1977, 269:804-806.