Assessment of the roles of P-glycoprotein and cytochrome P450 in triptolide-induced liver toxicity in sandwich-cultured rat hepatocyte model

Drug Metabolism and Disposition

Volumn 41, Issue 12, 2013, Pages 2158-2165

  Zhuang, Xiao Mei ^a   Shen, Guo Lin ^a   Xiao, Wei Bin ^a   Tan, Yan ^a   Lu, Chuang ^b   Li, Hua ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; HYDROGEN PEROXIDE; MULTIDRUG RESISTANCE PROTEIN; PHENOBARBITAL; PROTEIN BAX; PROTEIN BCL 2; QUERCETIN; RITONAVIR; TARIQUIDAR; TRIPTOLIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DETOXIFICATION; DRUG BILE LEVEL; DRUG DISPOSITION; DRUG EFFECT; ENZYME ACTIVITY; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; RAT;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BCL-2-ASSOCIATED X PROTEIN; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DITERPENES; EPOXY COMPOUNDS; HEPATOCYTES; HYDROGEN PEROXIDE; LIVER; MALE; P-GLYCOPROTEIN; PHENANTHRENES; PHENOBARBITAL; PROTO-ONCOGENE PROTEINS C-BCL-2; QUERCETIN; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RITONAVIR;

EID: 84888587343     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.054056     Document Type: Article

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