Simultaneous determination of triptolide and its prodrug MC002 in dog blood by LC-MS/MS and its application in pharmacokinetic studies

Journal of Ethnopharmacology

Volumn 150, Issue 1, 2013, Pages 131-137

  Zhuang, Xiao Mei ^a   Liu, Ping Xia ^b   Zhang, Yu Jie ^c,d   Li, Chang Kun ^a   Li, Ying ^a   Wang, Juan ^a   Zhou, Lei ^a   Zhang, Zhen Qing ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b LuShan Sanitarium of PLA ^*  (China)

^c Beijing Medicass Biotechnology Co Ltd   (China)

^d BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

LC MS MS; Pharmacokinetics; Prodrug; Triptolide

Indexed keywords

ACETIC ACID ETHYL ESTER; FLUORIDE SODIUM; MC 002; PRODRUG; TRIPTOLIDE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG CLEARANCE; DRUG DECOMPOSITION; DRUG DEGRADATION; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STABILITY; ELECTROSPRAY; EXPERIMENTAL DOG; FEMALE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; QUANTITATIVE ASSAY; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

CANIS FAMILIARIS; TRIPTERYGIUM WILFORDII;

LC-MS/MS; PHARMACOKINETICS; PRODRUG; TRIPTOLIDE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, LIQUID; DITERPENES; DOGS; EPOXY COMPOUNDS; FEMALE; GLYCINE; MALE; PHENANTHRENES; PRODRUGS; TANDEM MASS SPECTROMETRY;

EID: 84885418201     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.08.018     Document Type: Article

References (19)

1. S. Bansal, and A. DeStefano Key elements of the bioanalytical method validation for small molecules The APPS Journal 9 2007 E109 E114
2. B. Davies, and T. Morris Physiological parameters in laboratory animals and humans Pharmaceutical Research 10 1993 1093 1095
3. L. Dhooghe, S. Van Miert, H. Jansen, A. Vlietinck, and L. Pieters A new decomposition product of dihydroartemisinin Pharmazie 62 2007 900 901
4. Y.H. Jin, Y.Z. Wang, D. Su, G.D. Yuan, Y. Zhang, S.S. Guo, Y.J. Zhang, and X.L. Cui Anti-tumor activity of MC002 on mice with transplanted human A549 and HT-1080 Chinese Pharmacological Bulletin 24 2008 1196 1199
5. J.J.E.M. Kitzen, M.J.A. de Jonge, C.H.J. Lamers, F.A.L.M. Eskens, D. van der Biessen, L. van Doorn, J. ter Steeg, M. Brandely, C. Puozzo, and J. Verweij Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumors European Journal of Cancer 45 2009 1764 1772
6. P.E. Lipsky, and X.L. Tao A potential new treatment for rheumatoid arthritis: thunder god vine Seminars in Arthritis and Rheumatism 26 1997 713 723
7. F. Liu, Y. Xu, S. Gao, and Q. Guo Determination of hydrochlorothiazide in human plasma by liquid chromatography/tandem mass spectrometry Journal of Pharmaceutical and Biomedical Analysis 44 2007 1187 1191
8. J. Liu, Q.L. Wu, Y.H. Feng, Y.F. Wang, X.Y. Li, and J.P. Zuo Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells Acta Pharmacologica Sinica 26 2005 223 227
9. M.X. Liu, J. Dong, Y.J. Yang, X.L. Yang, and H.B. Xu Effect of poly (D, L-lactic acid) nanoparticles as triptolide carrier on abating rats renal toxicity by NMR-based metabolic analysis Journal of Nanoscience and Nanotechnology 8 2008 3493 3499
10. Q.Y. Liu Triptolide and its expanding multiple pharmacological functions International Immunopharmacology 11 2011 377 383
11. S.Y. Liu, K.S. Liu, C.H. KueiJann-Inn Tzeng, S.T. Ho, and J.J. Wang Simultaneous determination of buprenorphine and its prodrug, buprenorphine propionate, by high-performance liquid chromatography with fluorescence detection: application to pharmacokinetic studies in rabbits Journal of Chromatography B 818 2005 233 239
12. F. Shao, G.J. Wang, J.G. Sun, H.T. Xie, H. Li, Y. Liang, R. Zhang, and X.Y. Zhu Liquid chromatographic/mass spectrometry assay of triptolide in dog plasma and its application to pharmacokinetic study Journal of Pharmaceutical and Biomedical Analysis 41 2006 341 346
13. X.L. Tao, Y. Sun, Y. Dong, Y.L. Xiao, D.W. Hu, Y.P. Shi, Q.L. Zhu, H. Dai, and N.Z. Zhang A prospective, controlled, double-blind, cross-over study of tripterygium wilfodii hook F in treatment of rheumatoid arthritis Chinese Medical Journal 102 1989 327 332
14. Vandercruyssen, K.; D'Hondt, M.; Vergote, V.; Jansen, H.; Burvenich, C.; Spiegeleer, B.D. LC-UV/MS quality analytics of paediatric artemether formulations. Journal of Pharmaceutical Analysis 24, 10.1016/j.jpha.2013.03.006, in press
15. Z. Wang, J. Wen, J. Xing, and D. Guo Determination of triptolide and triptonide in human plasma by high-performance liquid chromatography Biomedical Chromatography 19 2005 60 62
16. F. Yang, X.G. Dong, Z.M. An, G.Q. Wu, L.J. Zhang, N.B. Gong, and T.N. Gu Retrospect and prospect of studies on Tripterygium wilfordii Hook f Chinese Journal of Integrative Medicine 11 2005 89 96
17. S. Yang, J. Chen, Z. Guo, X.M. Xu, L. Wang, X.F. Pei, J. Yang, C.B. Underhill, and L. Zhang Triptolide inhibits the growth and metastasis of solid tumors Molecular Cancer Therapeutics 2 2003 65 72
18. X. Ye, W. Li, Y. Yan, C. Mao, R. Cai, H. Xu, and X. Yang Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in rat Toxicology Letters 192 2010 212 220
19. Z.R. Zhang, Q. Zheng, J. Han, G.P. Gao, J. Liu, T. Gong, Z.W. Gu, Y. Huang, X. Sun, and Q. He The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cells Biomaterials 7 2009 1372 1381