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Volumn 80, Issue 3, 2008, Pages 392-398

Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects

Author keywords

Diabetes mellitus; Metabolic syndrome; Pre diabetes; Single nucleotide polymorphisms; Transcription factor 7 like 2 gene; United Arab Emirates

Indexed keywords

TRANSCRIPTION FACTOR 7 LIKE 2;

EID: 43049165958     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2008.01.008     Document Type: Article
Times cited : (74)

References (41)
  • 1
    • 21744461617 scopus 로고    scopus 로고
    • Glucose intolerance and associated factors in the multi-ethnic population of the United Arab Emirates: results of a national survey
    • Malik M., Bakir A., Abi Saab B., and King H. Glucose intolerance and associated factors in the multi-ethnic population of the United Arab Emirates: results of a national survey. Diabetes Res. Clin. Pract. 69 (2005) 188-195
    • (2005) Diabetes Res. Clin. Pract. , vol.69 , pp. 188-195
    • Malik, M.1    Bakir, A.2    Abi Saab, B.3    King, H.4
  • 2
    • 35649009385 scopus 로고    scopus 로고
    • Prevalence of diabetes mellitus and its complications in a population-based sample in Al Ain, United Arab Emirates
    • (Epub ahead of print)
    • Saadi H., Carruthers S.G., Nagelkerke N., Al-Maskari F., Afandi B., Reed R., et al. Prevalence of diabetes mellitus and its complications in a population-based sample in Al Ain, United Arab Emirates. Diabetes Res. Clin. Pract. May (2007) (Epub ahead of print)
    • (2007) Diabetes Res. Clin. Pract. , Issue.May
    • Saadi, H.1    Carruthers, S.G.2    Nagelkerke, N.3    Al-Maskari, F.4    Afandi, B.5    Reed, R.6
  • 3
    • 43049177093 scopus 로고    scopus 로고
    • International Diabetes Federation, Diabetes Atlas, third ed., 2006.
    • International Diabetes Federation, Diabetes Atlas, third ed., 2006.
  • 5
    • 0029586736 scopus 로고
    • Diabetes, obesity and hypertension in urban and rural people of bedouin origin in the United Arab Emirates
    • el Mugamer I.T., Ali Zayat A.S., Hossain M.M., and Pugh R.N. Diabetes, obesity and hypertension in urban and rural people of bedouin origin in the United Arab Emirates. J. Trop. Med. Hyg. 98 (1995) 407-415
    • (1995) J. Trop. Med. Hyg. , vol.98 , pp. 407-415
    • el Mugamer, I.T.1    Ali Zayat, A.S.2    Hossain, M.M.3    Pugh, R.N.4
  • 6
    • 2942632847 scopus 로고    scopus 로고
    • Obesity, lifestyle and reproductive health in a representative sample of women citizens of Al Ain, United Arab Emirates
    • Carter A., Saadi H., Reed R.L., and Dunn E.V. Obesity, lifestyle and reproductive health in a representative sample of women citizens of Al Ain, United Arab Emirates. J. Health Popul. Nutr. 22 (2004) 75-83
    • (2004) J. Health Popul. Nutr. , vol.22 , pp. 75-83
    • Carter, A.1    Saadi, H.2    Reed, R.L.3    Dunn, E.V.4
  • 8
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R., Rocheleau G., Rung J., Dina C., Shen L., Serre D., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445 (2007) 881-885
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3    Dina, C.4    Shen, L.5    Serre, D.6
  • 9
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D., Hirschhorn J.N., Klannemark M., Lindgren C.M., Vohl M.C., Nemesh J., et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26 (2000) 76-80
    • (2000) Nat. Genet. , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3    Lindgren, C.M.4    Vohl, M.C.5    Nemesh, J.6
  • 10
    • 0037317981 scopus 로고    scopus 로고
    • Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 ABCC8) confirm that the KCNJ11 E23K variant is associated with Type 2 diabetes
    • Gloyn A.L., Weedon M.N., Owen K.R., Turner M.J., Knight B.A., Hitman G., et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 ABCC8) confirm that the KCNJ11 E23K variant is associated with Type 2 diabetes. Diabetes 52 (2003) 568-572
    • (2003) Diabetes , vol.52 , pp. 568-572
    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3    Turner, M.J.4    Knight, B.A.5    Hitman, G.6
  • 12
    • 33750587754 scopus 로고    scopus 로고
    • Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample
    • Scott L.J., Bonnycastle L.L., Willer C.J., Sprau A.G., Jackson A.U., Narisu N., et al. Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes 55 (2006) 2649-2653
    • (2006) Diabetes , vol.55 , pp. 2649-2653
    • Scott, L.J.1    Bonnycastle, L.L.2    Willer, C.J.3    Sprau, A.G.4    Jackson, A.U.5    Narisu, N.6
  • 13
    • 33750892139 scopus 로고    scopus 로고
    • Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
    • Saxena R., Gianniny L., Burtt N.P., Lyssenko V., Giuducci C., Sjogren M., et al. Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes 55 (2006) 2890-2895
    • (2006) Diabetes , vol.55 , pp. 2890-2895
    • Saxena, R.1    Gianniny, L.2    Burtt, N.P.3    Lyssenko, V.4    Giuducci, C.5    Sjogren, M.6
  • 15
    • 34547664593 scopus 로고    scopus 로고
    • Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men
    • Dahlgren A., Zethelius B., Jensevik K., Syvanen A.C., and Berne C. Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men. Diabetologia 50 (2007) 1852-1857
    • (2007) Diabetologia , vol.50 , pp. 1852-1857
    • Dahlgren, A.1    Zethelius, B.2    Jensevik, K.3    Syvanen, A.C.4    Berne, C.5
  • 16
    • 33750584981 scopus 로고    scopus 로고
    • Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance
    • Damcott C.M., Pollin T.I., Reinhart L.J., Ott S.H., Shen H., Silver K.D., et al. Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 55 (2006) 2654-2659
    • (2006) Diabetes , vol.55 , pp. 2654-2659
    • Damcott, C.M.1    Pollin, T.I.2    Reinhart, L.J.3    Ott, S.H.4    Shen, H.5    Silver, K.D.6
  • 17
    • 34447340935 scopus 로고    scopus 로고
    • TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis
    • Cauchi S., El Achhab Y., Choquet H., Dina C., Krempler F., Weitgasser R., et al. TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J. Mol. Med. 85 (2007) 777-782
    • (2007) J. Mol. Med. , vol.85 , pp. 777-782
    • Cauchi, S.1    El Achhab, Y.2    Choquet, H.3    Dina, C.4    Krempler, F.5    Weitgasser, R.6
  • 18
    • 33845936147 scopus 로고    scopus 로고
    • Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population
    • Chandak G.R., Janipalli C.S., Bhaskar S., Kulkami S.R., Mohankrishna P., Hattersley A.T., et al. Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia 50 (2007) 63-67
    • (2007) Diabetologia , vol.50 , pp. 63-67
    • Chandak, G.R.1    Janipalli, C.S.2    Bhaskar, S.3    Kulkami, S.R.4    Mohankrishna, P.5    Hattersley, A.T.6
  • 19
    • 33847618213 scopus 로고    scopus 로고
    • A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population
    • Horikoshi M., Hara K., Ito C., Nagai R., Froguel P., and Kadowaki T. A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population. Diabetologia 50 (2007) 747-751
    • (2007) Diabetologia , vol.50 , pp. 747-751
    • Horikoshi, M.1    Hara, K.2    Ito, C.3    Nagai, R.4    Froguel, P.5    Kadowaki, T.6
  • 20
    • 36849038409 scopus 로고    scopus 로고
    • TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: an analysis of 3501 individuals
    • (Epub ahead of print)
    • Guo T., Hanson R.L., Traurig M., Muller Y.L., Ma L., Mack J., et al. TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: an analysis of 3501 individuals. Diabetes October (2007) (Epub ahead of print)
    • (2007) Diabetes , Issue.October
    • Guo, T.1    Hanson, R.L.2    Traurig, M.3    Muller, Y.L.4    Ma, L.5    Mack, J.6
  • 21
    • 0034745185 scopus 로고    scopus 로고
    • Brief genetics report the Pro12 → Ala substitution in PPAR γ is associated with resistance to development of diabetes in the general population possible involvement in impairment of insulin secretion in individuals with type 2 diabetes
    • Mori H., Ikegami H., Kawaguchi Y., Seino S., Yokoi N., Takeda J., et al. Brief genetics report the Pro12 → Ala substitution in PPAR γ is associated with resistance to development of diabetes in the general population possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. Diabetes 50 (2001) 891-894
    • (2001) Diabetes , vol.50 , pp. 891-894
    • Mori, H.1    Ikegami, H.2    Kawaguchi, Y.3    Seino, S.4    Yokoi, N.5    Takeda, J.6
  • 22
    • 4243353569 scopus 로고    scopus 로고
    • Comment: studies of the Pro12Ala polymorphism of the PPAR gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome
    • Frederiksen L., Broadbaek K., Fenger M., Jorgensen T., Borch-Johnsen K., Madsbad S., et al. Comment: studies of the Pro12Ala polymorphism of the PPAR gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. J. Clin. Endocrinol. Metab. 87 (2002) 3989-3992
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3989-3992
    • Frederiksen, L.1    Broadbaek, K.2    Fenger, M.3    Jorgensen, T.4    Borch-Johnsen, K.5    Madsbad, S.6
  • 23
    • 39049159123 scopus 로고    scopus 로고
    • Lack of association between the Pro(12)Ala polymorphism of the PPAR-gamma2 gene and type 2 diabetes mellitus in the Qatari consanguineous population
    • (Epub ahead of print)
    • Badii R., Bener A., Zirie M., Al-Rikabi A., Simsek M., Al-Hamaq A.O., et al. Lack of association between the Pro(12)Ala polymorphism of the PPAR-gamma2 gene and type 2 diabetes mellitus in the Qatari consanguineous population. Acta Diabetol. September (2007) (Epub ahead of print)
    • (2007) Acta Diabetol. , Issue.September
    • Badii, R.1    Bener, A.2    Zirie, M.3    Al-Rikabi, A.4    Simsek, M.5    Al-Hamaq, A.O.6
  • 24
    • 17744398695 scopus 로고    scopus 로고
    • The peroxisome proliferator activated receptorgamma2 (PPARgamma2) Pro12Ala variant: lack of association with type 2 diabetes in obese and non-obese Tunisian patients
    • Zouari Bouassida K., Chouchane L., Jellouli K., Cherif S., Haddad S., Gabbouj S., et al. The peroxisome proliferator activated receptorgamma2 (PPARgamma2) Pro12Ala variant: lack of association with type 2 diabetes in obese and non-obese Tunisian patients. Diabetes Metab. 31 (2005) 119-123
    • (2005) Diabetes Metab. , vol.31 , pp. 119-123
    • Zouari Bouassida, K.1    Chouchane, L.2    Jellouli, K.3    Cherif, S.4    Haddad, S.5    Gabbouj, S.6
  • 25
    • 43049172596 scopus 로고    scopus 로고
    • World Health Organization, Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications, Report of a WHO Consultation, WHO/NCD/NCS/99.2, Geneva, 1999.
    • World Health Organization, Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications, Report of a WHO Consultation, WHO/NCD/NCS/99.2, Geneva, 1999.
  • 26
    • 25144459980 scopus 로고    scopus 로고
    • Metabolic syndrome-a new world-wide definition: a consensus statement from the International Diabetes Federation
    • Alberti K.G., Zimmet P., and Shaw J. Metabolic syndrome-a new world-wide definition: a consensus statement from the International Diabetes Federation. Lancet 366 (2005) 1059-1062
    • (2005) Lancet , vol.366 , pp. 1059-1062
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 27
    • 43049163183 scopus 로고    scopus 로고
    • O.B. Ahmad, C. Boschi-Pinto, A.D. Lopez, C.J.L. Murray, R. Lozano, M. Inoue, Age standardization of rates: a new WHO standard, World Health Organization (GPE Discussion Paper Series: No. 31), Geneva, 2000.
    • O.B. Ahmad, C. Boschi-Pinto, A.D. Lopez, C.J.L. Murray, R. Lozano, M. Inoue, Age standardization of rates: a new WHO standard, World Health Organization (GPE Discussion Paper Series: No. 31), Geneva, 2000.
  • 30
    • 18944381751 scopus 로고    scopus 로고
    • SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci
    • Shi Y.Y., and He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 15 (2005) 97-98
    • (2005) Cell Res. , vol.15 , pp. 97-98
    • Shi, Y.Y.1    He, L.2
  • 31
    • 34948845069 scopus 로고    scopus 로고
    • Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population
    • Chang Y.C., Chang T.J., Jiang Y.D., Kuo S.S., Lee K.C., Lee K.C., et al. Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes 56 (2007) 2631-2637
    • (2007) Diabetes , vol.56 , pp. 2631-2637
    • Chang, Y.C.1    Chang, T.J.2    Jiang, Y.D.3    Kuo, S.S.4    Lee, K.C.5    Lee, K.C.6
  • 32
    • 34247855851 scopus 로고    scopus 로고
    • Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion
    • Wang J., Kuusisto J., Vänttinen M., Kuulasmaa T., Lindstrom J., Tuomilehto J., et al. Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia 50 (2007) 1192-1200
    • (2007) Diabetologia , vol.50 , pp. 1192-1200
    • Wang, J.1    Kuusisto, J.2    Vänttinen, M.3    Kuulasmaa, T.4    Lindstrom, J.5    Tuomilehto, J.6
  • 33
    • 34548727370 scopus 로고    scopus 로고
    • The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies
    • De Silva N.M., Steele A., Shields B., Knight B., Parnell K., Weedon M.N., et al. The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies. Diabet. Med. 24 (2007) 1067-1072
    • (2007) Diabet. Med. , vol.24 , pp. 1067-1072
    • De Silva, N.M.1    Steele, A.2    Shields, B.3    Knight, B.4    Parnell, K.5    Weedon, M.N.6
  • 34
    • 33846666328 scopus 로고    scopus 로고
    • Effects of the diabetes linked TCF7L2 polymorphism in a representative older population
    • Melzer D., Murray A., Hurst A.J., Weedon M.N., Bandinelli S., Corsi A.M., et al. Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med. 4 (2006) 34
    • (2006) BMC Med. , vol.4 , pp. 34
    • Melzer, D.1    Murray, A.2    Hurst, A.J.3    Weedon, M.N.4    Bandinelli, S.5    Corsi, A.M.6
  • 35
    • 33845939675 scopus 로고    scopus 로고
    • TCF7L2: the biggest story in diabetes genetics since HLA?
    • Zeggini E., and McCarthy M.I. TCF7L2: the biggest story in diabetes genetics since HLA?. Diabetologia 50 (2007) 1-4
    • (2007) Diabetologia , vol.50 , pp. 1-4
    • Zeggini, E.1    McCarthy, M.I.2
  • 39
    • 1042280184 scopus 로고    scopus 로고
    • The prevalence of the metabolic syndrome among Arab Americans
    • Jaber L.A., Brown M.B., Hammad A., Zhu Q., and Herman W.H. The prevalence of the metabolic syndrome among Arab Americans. Diabetes Care 27 (2004) 234-238
    • (2004) Diabetes Care , vol.27 , pp. 234-238
    • Jaber, L.A.1    Brown, M.B.2    Hammad, A.3    Zhu, Q.4    Herman, W.H.5
  • 40
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey
    • Ford E.S., Giles W.H., and Dietz W.H. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287 (2002) 356-359
    • (2002) JAMA , vol.287 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 41
    • 34548790660 scopus 로고    scopus 로고
    • The importance of TCF7L2
    • Weedon M.N. The importance of TCF7L2. Diabet. Med. 24 (2007) 1062-1066
    • (2007) Diabet. Med. , vol.24 , pp. 1062-1066
    • Weedon, M.N.1


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