메뉴 건너뛰기




Volumn 121, Issue 11-12, 2013, Pages 1253-1263

Scientific considerations for evaluating cancer bioassays conducted by the ramazzini institute

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTAME; DIISOPROPYL ETHER; DRINKING WATER; FORMALDEHYDE; MANCOZEB; METHANOL; TOLUENE; VINYLIDENE CHLORIDE;

EID: 84888424777     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1306661     Document Type: Review
Times cited : (27)

References (123)
  • 3
    • 73949135487 scopus 로고    scopus 로고
    • A review of human carcinogens- Part F: Chemical agents and related occupations
    • Baan R, Grosse Y, Straif K, Secretan B, El Ghissassi F, Bouvard V, et al. 2009. A review of human carcinogens- Part F: Chemical agents and related occupations. Lancet Oncol 10(12):1143-1144.
    • (2009) Lancet Oncol , vol.10 , Issue.12 , pp. 1143-1144
    • Baan, R.1    Grosse, Y.2    Straif, K.3    Secretan, B.4    El Ghissassi, F.5    Bouvard, V.6
  • 4
    • 84856445159 scopus 로고    scopus 로고
    • Hypothesis-based weight-of-evidence evaluation of methanol as a human carcinogen
    • Bailey LA, Prueitt RL, Rhomberg LR. 2012. Hypothesis-based weight-of-evidence evaluation of methanol as a human carcinogen. Regul Toxicol Pharmacol 62(2):278-291.
    • (2012) Regul Toxicol Pharmacol , vol.62 , Issue.2 , pp. 278-291
    • Bailey, L.A.1    Prueitt, R.L.2    Rhomberg, L.R.3
  • 5
    • 0031587498 scopus 로고    scopus 로고
    • Results of long-term experimental studies on the carcinogenicity of methyl tert-butyl ether
    • Belpoggi F, Soffritti M, Filippini F, Maltoni C. 1997. Results of long-term experimental studies on the carcinogenicity of methyl tert-butyl ether. Ann NY Acad Sci 837:77-95.
    • (1997) Ann NY Acad Sci , vol.837 , pp. 77-95
    • Belpoggi, F.1    Soffritti, M.2    Filippini, F.3    Maltoni, C.4
  • 6
    • 0036960389 scopus 로고    scopus 로고
    • Results of long-term experimental studies on the carcinogenicity of ethylene-bis-dithiocarbamate (Mancozeb) in rats
    • Belpoggi F, Soffritti M, Guarino M, Lambertini L, Cevolani D, Maltoni C. 2002a. Results of long-term experimental studies on the carcinogenicity of ethylene-bis-dithiocarbamate (Mancozeb) in rats. Ann NY Acad Sci 982:123-136.
    • (2002) Ann NY Acad Sci , vol.982 , pp. 123-136
    • Belpoggi, F.1    Soffritti, M.2    Guarino, M.3    Lambertini, L.4    Cevolani, D.5    Maltoni, C.6
  • 7
    • 0028824089 scopus 로고
    • Methyl-tertiary-butyl ether (MTBE)-a gasoline additive-causes testicular and lymphohaematopoietic cancers in rats
    • Belpoggi F, Soffritti M, Maltoni C. 1995. Methyl-tertiary-butyl ether (MTBE)-a gasoline additive-causes testicular and lymphohaematopoietic cancers in rats. Toxicol Ind Health 11(2):119-149.
    • (1995) Toxicol Ind Health , vol.11 , Issue.2 , pp. 119-149
    • Belpoggi, F.1    Soffritti, M.2    Maltoni, C.3
  • 8
    • 58549117643 scopus 로고    scopus 로고
    • Immunoblastic lymphomas in Sprague-Dawley rats following exposure to the gasoline oxygenated additives methyl-tertiary-butyl ether (MTBE) and ethyl-tertiary-butyl ether (ETBE): Early observations on their natural history
    • Belpoggi F, Soffritti M, Maltoni C. 1999. Immunoblastic lymphomas in Sprague-Dawley rats following exposure to the gasoline oxygenated additives methyl-tertiary-butyl ether (MTBE) and ethyl-tertiary-butyl ether (ETBE): early observations on their natural history. Eur J Oncol 4:563-572.
    • (1999) Eur J Oncol , vol.4 , pp. 563-572
    • Belpoggi, F.1    Soffritti, M.2    Maltoni, C.3
  • 9
    • 0036960357 scopus 로고    scopus 로고
    • Results of long-term carcinogenicity bioassays on tert-amyl-methyl-ether (TAME) and di-isopropyl-ether (DIPE) in rats
    • Belpoggi F, Soffritti M, Minardi F, Bua L, Cattin E, Maltoni C. 2002b. Results of long-term carcinogenicity bioassays on tert-amyl-methyl-ether (TAME) and di-isopropyl-ether (DIPE) in rats. Ann NY Acad Sci 982:70-86.
    • (2002) Ann NY Acad Sci , vol.982 , pp. 70-86
    • Belpoggi, F.1    Soffritti, M.2    Minardi, F.3    Bua, L.4    Cattin, E.5    Maltoni, C.6
  • 10
    • 79953034941 scopus 로고    scopus 로고
    • Chronic carcinogenicity study of gasoline vapor condensate (GVC) and GVC containing methyl tertiary-butyl ether in F344 rats
    • Benson JM, Gigliotti AP, March TH, Barr EB, Tibbetts BM, Skipper BJ, et al. 2011. Chronic carcinogenicity study of gasoline vapor condensate (GVC) and GVC containing methyl tertiary-butyl ether in F344 rats. J Toxicol Environ Health A 74(10):638-657.
    • (2011) J Toxicol Environ Health A , vol.74 , Issue.10 , pp. 638-657
    • Benson, J.M.1    Gigliotti, A.P.2    March, T.H.3    Barr, E.B.4    Tibbetts, B.M.5    Skipper, B.J.6
  • 11
    • 84864298191 scopus 로고    scopus 로고
    • Toxicity of methyl tertiary-butyl ether (MTBE) following exposure of Wistar Rats for 13 weeks or one year via drinking water
    • Bermudez E, Willson G, Parkinson H, Dodd D. 2012. Toxicity of methyl tertiary-butyl ether (MTBE) following exposure of Wistar Rats for 13 weeks or one year via drinking water. J Appl Toxicol 32(9):687-706.
    • (2012) J Appl Toxicol , vol.32 , Issue.9 , pp. 687-706
    • Bermudez, E.1    Willson, G.2    Parkinson, H.3    Dodd, D.4
  • 12
    • 0036965403 scopus 로고    scopus 로고
    • The National Toxicology Program rodent bioassay: Designs, interpretations, and scientific contributions
    • Bucher JR. 2002. The National Toxicology Program rodent bioassay: designs, interpretations, and scientific contributions. Ann NY Acad Sci 982:198-207.
    • (2002) Ann NY Acad Sci , vol.982 , pp. 198-207
    • Bucher, J.R.1
  • 15
    • 40149110675 scopus 로고    scopus 로고
    • Evaluation of evidence for infection as a mode of action for induction of rat lymphoma
    • Caldwell J, Jinot J, Devoney D, Gift JS. 2008. Evaluation of evidence for infection as a mode of action for induction of rat lymphoma. Environ Mol Mutagen 49(2):155-164.
    • (2008) Environ Mol Mutagen , vol.49 , Issue.2 , pp. 155-164
    • Caldwell, J.1    Jinot, J.2    Devoney, D.3    Gift, J.S.4
  • 17
    • 53049107066 scopus 로고    scopus 로고
    • Imaging mass spectrometry of intact proteins from alcohol-preserved tissue specimens: Bypassing formalin fixation
    • Chaurand P, Latham JC, Lane KB, Mobley JA, Polosukhin VV, Wirth PS, et al. 2008. Imaging mass spectrometry of intact proteins from alcohol-preserved tissue specimens: bypassing formalin fixation. J Proteome Res 7:3543-3555.
    • (2008) J Proteome Res , vol.7 , pp. 3543-3555
    • Chaurand, P.1    Latham, J.C.2    Lane, K.B.3    Mobley, J.A.4    Polosukhin, V.V.5    Wirth, P.S.6
  • 18
    • 0008156299 scopus 로고
    • Chemical Industry Institute of Toxicology and Battelle Memorial Institute, Research Triangle Park, NC:Chemical Industry Institute of Toxicology
    • Chemical Industry Institute of Toxicology and Battelle Memorial Institute. 1981. Final Report on a Chronic Inhalation Toxicology Study in Rats and Mice Exposed to Formaldehyde. Research Triangle Park, NC:Chemical Industry Institute of Toxicology.
    • (1981) Final Report On a Chronic Inhalation Toxicology Study In Rats and Mice Exposed to Formaldehyde
  • 20
    • 25844483804 scopus 로고    scopus 로고
    • Meeting report: Summary of IARC Monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol
    • doi:10.1289/ehp.7542
    • Cogliano VJ, Grosse Y, Baan RA, Straif K, Secretan MB, El Ghissassi F. 2005. Meeting report: summary of IARC Monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol. Environ Health Perspect 113:1205-1208; doi:10.1289/ehp.7542.
    • (2005) Environ Health Perspect , vol.113 , pp. 1205-1208
    • Cogliano, V.J.1    Grosse, Y.2    Baan, R.A.3    Straif, K.4    Secretan, M.B.5    El Ghissassi, F.6
  • 21
    • 0036566185 scopus 로고    scopus 로고
    • In situ localization of follicular lymphoma: Description and analysis by laser capture microdissection
    • Cong P, Raffeld M, Teruya-Feldstein J, Sorbara L, Pittaluga S, Jaffe ES. 2002. In situ localization of follicular lymphoma: description and analysis by laser capture microdissection. Blood 99(9):3376-3382.
    • (2002) Blood , vol.99 , Issue.9 , pp. 3376-3382
    • Cong, P.1    Raffeld, M.2    Teruya-Feldstein, J.3    Sorbara, L.4    Pittaluga, S.5    Jaffe, E.S.6
  • 22
    • 0023679021 scopus 로고
    • Long-term carcinogenicity bioassay on vinylidene chloride administered by inhalation to Sprague-Dawley rats: New results
    • Cotti G, Maltoni C, Lefemine G. 1988. Long-term carcinogenicity bioassay on vinylidene chloride administered by inhalation to Sprague-Dawley rats: new results. Ann NY Acad Sci 534:160-168.
    • (1988) Ann NY Acad Sci , vol.534 , pp. 160-168
    • Cotti, G.1    Maltoni, C.2    Lefemine, G.3
  • 23
    • 68849107627 scopus 로고    scopus 로고
    • Assessment of the cancer potential of methanol
    • Cruzan G. 2009. Assessment of the cancer potential of methanol. Crit Rev Toxicol 39(4):347-363.
    • (2009) Crit Rev Toxicol , vol.39 , Issue.4 , pp. 347-363
    • Cruzan, G.1
  • 24
    • 78049242954 scopus 로고    scopus 로고
    • A minute focus of extranodal marginal zone B-cell lymphoma arising in Hashimoto thyroiditis diagnosed with PCR after laser capture microdissection: A case report
    • doi:10.1186/1756-6614-2-9
    • D'Antonio A, Caleo A, Licci S, Addesso M, De Palma M, Boscaino A, et al. 2009. A minute focus of extranodal marginal zone B-cell lymphoma arising in Hashimoto thyroiditis diagnosed with PCR after laser capture microdissection: a case report. Thyroid Res 2(1):9; doi:10.1186/1756-6614-2-9.
    • (2009) Thyroid Res , vol.2 , Issue.1 , pp. 9
    • D'Antonio, A.1    Caleo, A.2    Licci, S.3    Addesso, M.4    de Palma, M.5    Boscaino, A.6
  • 25
    • 38049184562 scopus 로고    scopus 로고
    • Neoplastic pathology in male Sprague-Dawley rats fed AIN-93M diet ad libitum or at restricted intakes
    • Duffy PH, Lewis SM, Mayhugh MA, Trotter RW, Hass BS, Latendresse JR, et al. 2008. Neoplastic pathology in male Sprague-Dawley rats fed AIN-93M diet ad libitum or at restricted intakes. Nutr Res 28(1):36-42.
    • (2008) Nutr Res , vol.28 , Issue.1 , pp. 36-42
    • Duffy, P.H.1    Lewis, S.M.2    Mayhugh, M.A.3    Trotter, R.W.4    Hass, B.S.5    Latendresse, J.R.6
  • 26
    • 85078387559 scopus 로고    scopus 로고
    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the commission related to a new long-term carcinogenicity study on aspartame
    • EFSA (European Food Safety Authority)
    • EFSA (European Food Safety Authority). 2006. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the commission related to a new long-term carcinogenicity study on aspartame. EFSA J 4(5):1-44.
    • (2006) EFSA J , vol.4 , Issue.5 , pp. 1-44
  • 27
    • 80054700190 scopus 로고    scopus 로고
    • Scientific opinion of the Panel on Food Additives and Nutrient Sources added to Food
    • EFSA (European Food Safety Authority). 2009. Updated opinion on a request from the European Commission related to the 2nd ERF carcinogenicity study on aspartame, taking into consideration study data submitted by the Ramazzini foundation in February
    • EFSA (European Food Safety Authority). 2009. Updated opinion on a request from the European Commission related to the 2nd ERF carcinogenicity study on aspartame, taking into consideration study data submitted by the Ramazzini foundation in February 2009. Scientific opinion of the Panel on Food Additives and Nutrient Sources added to Food. EFSA J 1015:1-18.
    • (2009) EFSA J , vol.1015 , pp. 1-18
  • 28
    • 84888413657 scopus 로고    scopus 로고
    • EPL (Experimental Pathology Laboratories). 2011a. Amended Pathology Quality Assessment Review and PWG coordinator's Report for Lifetime Carcinogenicity Study of Ethyl-Tertiary-Butyl Ether (ETBE) in Sprague-Dawley Rats Conducted at the Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Chemical No./TDMS No.: C00117/00117-64. Durham, NC:Experimental Pathology Laboratories. Available, [accessed 9 September 2013]
    • EPL (Experimental Pathology Laboratories). 2011a. Amended Pathology Quality Assessment Review and PWG coordinator's Report for Lifetime Carcinogenicity Study of Ethyl-Tertiary-Butyl Ether (ETBE) in Sprague-Dawley Rats Conducted at the Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Chemical No./TDMS No.: C00117/00117-64. Durham, NC:Experimental Pathology Laboratories. Available: http://ntp.niehs.nih.gov/ntp/foia/ETBE_amended_qapwg_report_Redacted_508.pdf [accessed 9 September 2013].
  • 29
    • 84888412024 scopus 로고    scopus 로고
    • EPL (Experimental Pathology Laboratories), Amended Pathology Quality Assessment Review and PWG Coordinator's Report for Lifetime Carcinogenicity Study of Methyl Alcohol in Sprague-Dawley Rats Conducted at the Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Chemical No./TDMS No.: C00117E/00117-68. Durham, NC:Experimental Pathology Laboratories. Available, [accessed 9 September 2013]
    • EPL (Experimental Pathology Laboratories). 2011b. Amended Pathology Quality Assessment Review and PWG Coordinator's Report for Lifetime Carcinogenicity Study of Methyl Alcohol in Sprague-Dawley Rats Conducted at the Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Chemical No./TDMS No.: C00117E/00117-68. Durham, NC:Experimental Pathology Laboratories. Available: http://ntp.niehs.nih.gov/ntp/foia/pwgMethylAlcohol_508.pdf [accessed 9 September 2013].
    • (2011)
  • 30
    • 84888425103 scopus 로고    scopus 로고
    • EPL (Experimental Pathology Laboratories), Amended Pathology Quality Assessment Review and PWG Coordinator's Report for Lifetime Carcinogenicity Study of Methyl-Tertiary-Butyl Ether (MTBE) in Sprague-Dawley Rats Conducted at the Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Chemical No./TDMS No.: C00117F/00117-69. Durham, NC:Experimental Pathology Laboratories. Available, [accessed 9 September 2013]
    • EPL (Experimental Pathology Laboratories). 2011c. Amended Pathology Quality Assessment Review and PWG Coordinator's Report for Lifetime Carcinogenicity Study of Methyl-Tertiary-Butyl Ether (MTBE) in Sprague-Dawley Rats Conducted at the Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Chemical No./TDMS No.: C00117F/00117-69. Durham, NC:Experimental Pathology Laboratories. Available: http://ntp.niehs.nih.gov/ntp/foia/pwgMTBE_508.pdf [accessed 9 September 2013].
    • (2011)
  • 31
    • 84888413323 scopus 로고    scopus 로고
    • EPL (Experimental Pathology Laboratories), Amended Pathology Quality Assessment Review and PWG Coordinator's Report for Lifetime Carcinogenicity Study of Vinyl Chloride in Sprague-Dawley Rats Conducted at the Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Durham, NC:Experimental Pathology Laboratories. Available, [accessed 9 September 2013]
    • EPL (Experimental Pathology Laboratories). 2011d. Amended Pathology Quality Assessment Review and PWG Coordinator's Report for Lifetime Carcinogenicity Study of Vinyl Chloride in Sprague-Dawley Rats Conducted at the Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Durham, NC:Experimental Pathology Laboratories. Available: http://ntp.niehs.nih.gov/ntp/foia/vinylchloride_amended_qapwg_report_Redacted_508BE.pdf [accessed 9 September 2013].
    • (2011)
  • 32
    • 84888401003 scopus 로고    scopus 로고
    • EPL (Experimental Pathology Laboratories), Second Amended Pathology Quality Assessment Review and PWG Coordinator's Report for Lifetime Carcinogenicity Study of Acrylonitrile in Sprague-Dawley Rats Conducted at the Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Durham, NC:Experimental Pathology Laboratories
    • EPL (Experimental Pathology Laboratories). 2012. Second Amended Pathology Quality Assessment Review and PWG Coordinator's Report for Lifetime Carcinogenicity Study of Acrylonitrile in Sprague-Dawley Rats Conducted at the Cancer Research Center, European Ramazzini Foundation for Oncology and Environmental Sciences, Bologna, Italy. Durham, NC:Experimental Pathology Laboratories.
    • (2012)
  • 34
    • 84934436484 scopus 로고    scopus 로고
    • Complementary techniques: Laser capture microdissection-increasing specificity of gene expression profiling of cancer specimens
    • Microarray Technology And Cancer Gene Profiling (Mocellin S, ed), Austin, TX:Landes Bioscience
    • Esposito G. 2007. Complementary techniques: laser capture microdissection-increasing specificity of gene expression profiling of cancer specimens. In: Microarray Technology And Cancer Gene Profiling (Mocellin S, ed). Advances in Experimental Medicine and Biology, Vol. 593. Austin, TX:Landes Bioscience, 54-65.
    • (2007) Advances In Experimental Medicine and Biology , vol.593 , pp. 54-65
    • Esposito, G.1
  • 35
    • 84888397475 scopus 로고    scopus 로고
    • FDA (Food and Drug Administration), Guidance for Industry and Other Stakeholders: Toxicological Principles for the Safety Assessment of Food Ingredients, Redbook 2000 (July 2000; Updated July 2007), Available:, [accessed 28 September 2013]
    • FDA (Food and Drug Administration). 2000. Guidance for Industry and Other Stakeholders: Toxicological Principles for the Safety Assessment of Food Ingredients, Redbook 2000 (July 2000; Updated July 2007). Available: http://www.fda.gov/downloads/Food/GuidanceRegulation/UCM222779.pdf [accessed 28 September 2013].
    • (2000)
  • 36
    • 0033816482 scopus 로고    scopus 로고
    • Laser capture microdissection in pathology
    • Fend F, Raffeld M. 2000. Laser capture microdissection in pathology. J Clin Pathol 53(9):666-672.
    • (2000) J Clin Pathol , vol.53 , Issue.9 , pp. 666-672
    • Fend, F.1    Raffeld, M.2
  • 37
    • 0024209827 scopus 로고
    • Morphologic classification and incidence of hematopoietic neoplasms in the Sprague-Dawley rat
    • Frith CH. 1988. Morphologic classification and incidence of hematopoietic neoplasms in the Sprague-Dawley rat. Toxicol Pathol 16:451-457.
    • (1988) Toxicol Pathol , vol.16 , pp. 451-457
    • Frith, C.H.1
  • 38
    • 0027185780 scopus 로고
    • The morphology, immunohistochemistry, and incidence of hematopoietic neoplasms in mice and rats
    • Frith CH, Ward JM, Chandra M. 1993. The morphology, immunohistochemistry, and incidence of hematopoietic neoplasms in mice and rats. Toxicol Pathol 21(2):206-218.
    • (1993) Toxicol Pathol , vol.21 , Issue.2 , pp. 206-218
    • Frith, C.H.1    Ward, J.M.2    Chandra, M.3
  • 39
    • 40749127139 scopus 로고    scopus 로고
    • Assessment of the carcinogenic potential of mitemcinal (GM-611): Increased incidence of malignant lymphoma in a rat carcinogenicity study
    • Fujii E, Kimura K, Mizoguchi K, Kato A, Takanashi H, Itoh Z, et al. 2008. Assessment of the carcinogenic potential of mitemcinal (GM-611): increased incidence of malignant lymphoma in a rat carcinogenicity study. Toxicol Appl Pharmacol 228(1):1-7.
    • (2008) Toxicol Appl Pharmacol , vol.228 , Issue.1 , pp. 1-7
    • Fujii, E.1    Kimura, K.2    Mizoguchi, K.3    Kato, A.4    Takanashi, H.5    Itoh, Z.6
  • 40
    • 75649133251 scopus 로고    scopus 로고
    • Applications of the poly-k statistical test to life-time cancer bioassay studies
    • Gebregziabher M, Hoel D. 2009. Applications of the poly-k statistical test to life-time cancer bioassay studies. Hum Ecol Risk Assess 15(5):858-875.
    • (2009) Hum Ecol Risk Assess , vol.15 , Issue.5 , pp. 858-875
    • Gebregziabher, M.1    Hoel, D.2
  • 42
    • 84888416582 scopus 로고    scopus 로고
    • GLP Life Test, GLP Life Test Homepage. Available, [accessed 26 September 2013]
    • GLP Life Test. 2013. GLP Life Test Homepage. Available: http:// www.glplifetest.org/ [accessed 26 September 2013].
    • (2013)
  • 45
    • 0032784783 scopus 로고    scopus 로고
    • World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997
    • Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, et al. 1999. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol 17:3835-3849.
    • (1999) J Clin Oncol , vol.17 , pp. 3835-3849
    • Harris, N.L.1    Jaffe, E.S.2    Diebold, J.3    Flandrin, G.4    Muller-Hermelink, H.K.5    Vardiman, J.6
  • 46
    • 0028064764 scopus 로고
    • A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group
    • Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, et al. 1994. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84:1361-1392.
    • (1994) Blood , vol.84 , pp. 1361-1392
    • Harris, N.L.1    Jaffe, E.S.2    Stein, H.3    Banks, P.M.4    Chan, J.K.C.5    Cleary, M.L.6
  • 47
    • 0021647477 scopus 로고
    • Statistical issues in the design, analysis and interpretation of animal carcinogenicity studies
    • Haseman JK. 1984. Statistical issues in the design, analysis and interpretation of animal carcinogenicity studies. Environ Health Perspect 58:385-392.
    • (1984) Environ Health Perspect , vol.58 , pp. 385-392
    • Haseman, J.K.1
  • 48
    • 0032619719 scopus 로고    scopus 로고
    • Chemicals associated with tumours of the kidney, urinary bladder and thyroid gland in laboratory rodents from 2000 US National Toxicology Program/ National Cancer Institute bioassays for carcinogenicity
    • Huff J, ed. 1999. Chemicals associated with tumours of the kidney, urinary bladder and thyroid gland in laboratory rodents from 2000 US National Toxicology Program/ National Cancer Institute bioassays for carcinogenicity. IARC Sci Publ 147:211-225.
    • (1999) IARC Sci Publ , vol.147 , pp. 211-225
    • Huff, J.1
  • 49
    • 0036962522 scopus 로고    scopus 로고
    • Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: In tribute to Cesare Maltoni and David Rall
    • Huff J. 2002. Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall. Ann NY Acad Sci 982:208-230.
    • (2002) Ann NY Acad Sci , vol.982 , pp. 208-230
    • Huff, J.1
  • 50
    • 58849098055 scopus 로고    scopus 로고
    • The limits of two-year bioassay exposure regimens for identifying chemical carcinogens
    • doi:10.1289/ehp.10716
    • Huff J, Jacobson MF, Davis DL. 2008. The limits of two-year bioassay exposure regimens for identifying chemical carcinogens. Environ Health Perspect 116:1439-1442; doi:10.1289/ehp.10716.
    • (2008) Environ Health Perspect , vol.116 , pp. 1439-1442
    • Huff, J.1    Jacobson, M.F.2    Davis, D.L.3
  • 51
    • 84888407263 scopus 로고    scopus 로고
    • IARC (International Agency for Research on Cancer), Preamble to the IARC Monographs. Available, [accessed 1 June 2013]
    • IARC (International Agency for Research on Cancer). 2006. Preamble to the IARC Monographs. Available: http:// monographs.iarc.fr/ENG/Preamble/ [accessed 1 June 2013].
    • (2006)
  • 52
    • 0019460728 scopus 로고
    • Incidence of brain tumors in rats fed aspartame
    • Ishii H. 1981. Incidence of brain tumors in rats fed aspartame. Toxicol Lett 7(6):433-437.
    • (1981) Toxicol Lett , vol.7 , Issue.6 , pp. 433-437
    • Ishii, H.1
  • 53
    • 0019484119 scopus 로고
    • Toxicity of aspartame and its diketopiperazine for Wistar rats by dietary administration for 104 weeks
    • Ishii H, Koshimizu T, Usami S, Fujimoto T. 1981. Toxicity of aspartame and its diketopiperazine for Wistar rats by dietary administration for 104 weeks. Toxicology 21(2):91-94.
    • (1981) Toxicology , vol.21 , Issue.2 , pp. 91-94
    • Ishii, H.1    Koshimizu, T.2    Usami, S.3    Fujimoto, T.4
  • 54
    • 84888426465 scopus 로고    scopus 로고
    • Istituto Ramazzini, Istituto Ramazzini-Cooperativa Sociale Onlus. Available, [accessed 3 June 2013]
    • Istituto Ramazzini. 2013. Istituto Ramazzini-Cooperativa Sociale Onlus. Available: http://www.ramazzini.it/ [accessed 3 June 2013].
    • (2013)
  • 55
    • 77649244055 scopus 로고    scopus 로고
    • Proteomics out of the archive: Two-dimensional electrophoresis and mass spectrometry using HOPE-fixed, paraffin-embedded tissues
    • Kähler D, Alexander C, Schultz H, Abdullah M, Branscheid D, Lindner B, et al. 2010. Proteomics out of the archive: two-dimensional electrophoresis and mass spectrometry using HOPE-fixed, paraffin-embedded tissues. J Histochem Cytochem 58(3):221-228.
    • (2010) J Histochem Cytochem , vol.58 , Issue.3 , pp. 221-228
    • Kähler, D.1    Alexander, C.2    Schultz, H.3    Abdullah, M.4    Branscheid, D.5    Lindner, B.6
  • 56
    • 0030773913 scopus 로고    scopus 로고
    • Results of a 28-month chronic inhalation toxicity study of formaldehyde in male Fisher-344 rats
    • Kamata E, Nakadate M, Uchida O, Ogawa Y, Suzuki S, Kaneko T, et al. 1997. Results of a 28-month chronic inhalation toxicity study of formaldehyde in male Fisher-344 rats. J Toxicol Sci 22(3):239-254.
    • (1997) J Toxicol Sci , vol.22 , Issue.3 , pp. 239-254
    • Kamata, E.1    Nakadate, M.2    Uchida, O.3    Ogawa, Y.4    Suzuki, S.5    Kaneko, T.6
  • 57
    • 0020602028 scopus 로고
    • Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure
    • Kerns WD, Pavkov KL, Donofrio DJ, Gralla EJ, Swenberg JA. 1983. Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res 43(9):4382-4392.
    • (1983) Cancer Res , vol.43 , Issue.9 , pp. 4382-4392
    • Kerns, W.D.1    Pavkov, K.L.2    Donofrio, D.J.3    Gralla, E.J.4    Swenberg, J.A.5
  • 58
    • 77952318264 scopus 로고    scopus 로고
    • Commentary: Update on animal models for NTP studies
    • King-Herbert AP, Sills RC, Bucher JR. 2010. Commentary: update on animal models for NTP studies. Toxicol Pathol 38(1):180-181.
    • (2010) Toxicol Pathol , vol.38 , Issue.1 , pp. 180-181
    • King-Herbert, A.P.1    Sills, R.C.2    Bucher, J.R.3
  • 59
    • 42349084141 scopus 로고    scopus 로고
    • MtBE and cancer in animals: Statistical issues with poly-3 survival adjustments for lifetime studies [Letter]
    • Kissling G, Portier C, Huff J. 2008. MtBE and cancer in animals: statistical issues with poly-3 survival adjustments for lifetime studies [Letter]. Regul Toxicol Pharmacol 50(3):428-429.
    • (2008) Regul Toxicol Pharmacol , vol.50 , Issue.3 , pp. 428-429
    • Kissling, G.1    Portier, C.2    Huff, J.3
  • 60
    • 0028513052 scopus 로고
    • Integrating QA principles with basic elements of a research program promotes quality science in a non-GLP research laboratory
    • Lilly MZ, Gold KW, Rogers RR. 1994. Integrating QA principles with basic elements of a research program promotes quality science in a non-GLP research laboratory. Qual Assur 1994; 3(3):304-311.
    • (1994) Qual Assur , vol.3 , Issue.3 , pp. 304-311
    • Lilly, M.Z.1    Gold, K.W.2    Rogers, R.R.3
  • 61
    • 27744506865 scopus 로고    scopus 로고
    • CD94 1A transcripts characterize lymphoblastic lymphoma/ leukemia of immature natural killer cell origin with distinct clinical features
    • Lin CW, Liu TY, Chen SU, Wang KT, Medeiros LJ, Hsu SM. 2005. CD94 1A transcripts characterize lymphoblastic lymphoma/ leukemia of immature natural killer cell origin with distinct clinical features. Blood 106(10):3567-3574.
    • (2005) Blood , vol.106 , Issue.10 , pp. 3567-3574
    • Lin, C.W.1    Liu, T.Y.2    Chen, S.U.3    Wang, K.T.4    Medeiros, L.J.5    Hsu, S.M.6
  • 62
    • 77956628539 scopus 로고    scopus 로고
    • Laser capture microdissection in the tissue biorepository
    • Liu A. 2010. Laser capture microdissection in the tissue biorepository. J Biomol Tech 21(3):120-125.
    • (2010) J Biomol Tech , vol.21 , Issue.3 , pp. 120-125
    • Liu, A.1
  • 63
    • 84888402708 scopus 로고    scopus 로고
    • Memorandum from D Malarkey, R Herbert, A Nyska, ME Sutphin, and K Pernika, National Toxicology Program, to J Bucher, Associate Director, National Toxicology Program. Report on visit (4/25/2010-4/30/2010) and assessment of the pathology procedures performed at the Ramazzini Institute (RI), Bentivoglio, Italy, 11 June 2010. In: Summary Report of the National Toxicology Program and Environmental Protection Agency Sponsored Review of Pathology Materials from Selected Ramazzini Institute Rodent Cancer Bioassays. Research Triangle Park, NC, 21. Available, [accessed 25 September 2013]
    • Malarkey D, Herbert R, Nyska A, Sutphin ME, Pernika K. 2010. Memorandum from D Malarkey, R Herbert, A Nyska, ME Sutphin, and K Pernika, National Toxicology Program, to J Bucher, Associate Director, National Toxicology Program. Report on visit (4/25/2010-4/30/2010) and assessment of the pathology procedures performed at the Ramazzini Institute (RI), Bentivoglio, Italy, 11 June 2010. In: Summary Report of the National Toxicology Program and Environmental Protection Agency Sponsored Review of Pathology Materials from Selected Ramazzini Institute Rodent Cancer Bioassays. Research Triangle Park, NC, 21. Available: http://ntp.niehs.nih.gov/NTP/About_NTP/ Partnerships/International/SummaryPWG_Report_RI_ Bioassays.pdf [accessed 25 September 2013].
    • (2010)
    • Malarkey, D.1    Herbert, R.2    Nyska, A.3    Sutphin, M.E.4    Pernika, K.5
  • 64
    • 0024458311 scopus 로고
    • Benzene, an experimental multipotential carcinogen: Results of the long-term bioassays performed at the Bologna Institute of Oncology
    • Maltoni C, Ciliberti A, Cotti G, Conti B, Belpoggi F. 1989. Benzene, an experimental multipotential carcinogen: Results of the long-term bioassays performed at the Bologna Institute of Oncology. Environ Health Perspect 82:109-124.
    • (1989) Environ Health Perspect , vol.82 , pp. 109-124
    • Maltoni, C.1    Ciliberti, A.2    Cotti, G.3    Conti, B.4    Belpoggi, F.5
  • 65
    • 0023740663 scopus 로고
    • Long-term carcinogenicity bioassays on acrylonitrile administered by inhalation and by ingestion to Sprague-Dawley rats
    • Maltoni C, Ciliberti A, Cotti G, Perino G. 1988a. Long-term carcinogenicity bioassays on acrylonitrile administered by inhalation and by ingestion to Sprague-Dawley rats. Ann NY Acad Sci 534(ED.):179-202.
    • (1988) Ann NY Acad Sci , vol.534 , Issue.ED , pp. 179-202
    • Maltoni, C.1    Ciliberti, A.2    Cotti, G.3    Perino, G.4
  • 66
    • 0031587527 scopus 로고    scopus 로고
    • Results of a long-term experimental study on the carcinogenicity of vinyl acetate monomer in mice
    • Maltoni C, Ciliberti A, Lefemine G, Soffritti M. 1997a. Results of a long-term experimental study on the carcinogenicity of vinyl acetate monomer in mice. Ann NY Acad Sci 837(1):209-238.
    • (1997) Ann NY Acad Sci , vol.837 , Issue.1 , pp. 209-238
    • Maltoni, C.1    Ciliberti, A.2    Lefemine, G.3    Soffritti, M.4
  • 67
    • 0031587502 scopus 로고    scopus 로고
    • Results of long-term experimental carcinogenicity studies of the effects of gasoline, correlated fuels, and major gasoline aromatics on rats
    • Maltoni C, Ciliberti A, Pinto C, Soffritti M, Belpoggi F, Menarini L. 1997b. Results of long-term experimental carcinogenicity studies of the effects of gasoline, correlated fuels, and major gasoline aromatics on rats. Ann NY Acad Sci 837(1):15-52.
    • (1997) Ann NY Acad Sci , vol.837 , Issue.1 , pp. 15-52
    • Maltoni, C.1    Ciliberti, A.2    Pinto, C.3    Soffritti, M.4    Belpoggi, F.5    Menarini, L.6
  • 68
    • 0023711738 scopus 로고
    • Carcinogenicity of vinyl chloride in Sprague-Dawley rats after prenatal and postnatal exposure
    • Maltoni C, Cotti G. 1988. Carcinogenicity of vinyl chloride in Sprague-Dawley rats after prenatal and postnatal exposure. Ann NY Acad Sci 534:145-159.
    • (1988) Ann NY Acad Sci , vol.534 , pp. 145-159
    • Maltoni, C.1    Cotti, G.2
  • 70
    • 0023690866 scopus 로고
    • Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice
    • Maltoni C, Lefemine G, Cotti G, Perino G. 1988b. Long-term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice. Ann NY Acad Sci 534:316-342.
    • (1988) Ann NY Acad Sci , vol.534 , pp. 316-342
    • Maltoni, C.1    Lefemine, G.2    Cotti, G.3    Perino, G.4
  • 71
    • 0033452010 scopus 로고    scopus 로고
    • The scientific and methodological bases of experimental studies for detecting and quantifying carcinogenic risks
    • Maltoni C, Soffritti M, Belpoggi F. 1999. The scientific and methodological bases of experimental studies for detecting and quantifying carcinogenic risks. Ann NY Acad Sci 895:10-26.
    • (1999) Ann NY Acad Sci , vol.895 , pp. 10-26
    • Maltoni, C.1    Soffritti, M.2    Belpoggi, F.3
  • 72
    • 1842458463 scopus 로고    scopus 로고
    • Relevance of animal carcinogenesis findings to human cancer predictions and prevention
    • Maronpot RR, Flake G, Huff J. 2004. Relevance of animal carcinogenesis findings to human cancer predictions and prevention. Toxicol Pathol 32(suppl 1):40-48.
    • (2004) Toxicol Pathol , vol.32 , Issue.SUPPL. 1 , pp. 40-48
    • Maronpot, R.R.1    Flake, G.2    Huff, J.3
  • 73
    • 0022573516 scopus 로고
    • Guidelines for combining neoplasms for evaluation of rodent carcinogenesis studies
    • McConnell EE, Solleveld HA, Swenberg JA, Boorman GA. 1986. Guidelines for combining neoplasms for evaluation of rodent carcinogenesis studies. J Natl Cancer Inst 76(2):283-289.
    • (1986) J Natl Cancer Inst , vol.76 , Issue.2 , pp. 283-289
    • McConnell, E.E.1    Solleveld, H.A.2    Swenberg, J.A.3    Boorman, G.A.4
  • 74
    • 40949147430 scopus 로고    scopus 로고
    • Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies
    • doi:10.1289/ehp.9989
    • Melnick RL, Thayer KA, Bucher JR. 2008. Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies. Environ Health Perspect 116:130-135; doi:10.1289/ehp.9989.
    • (2008) Environ Health Perspect , vol.116 , pp. 130-135
    • Melnick, R.L.1    Thayer, K.A.2    Bucher, J.R.3
  • 75
    • 0036965138 scopus 로고    scopus 로고
    • Results of long-term carcinogenicity bioassay on vinyl acetate monomer in Sprague-Dawley rats
    • Minardi F, Belpoggi F, Soffritti M, Ciliberti A, Lauriola M, Cattin E, et al. 2002. Results of long-term carcinogenicity bioassay on vinyl acetate monomer in Sprague-Dawley rats. Ann NY Acad Sci 982:106-122.
    • (2002) Ann NY Acad Sci , vol.982 , pp. 106-122
    • Minardi, F.1    Belpoggi, F.2    Soffritti, M.3    Ciliberti, A.4    Lauriola, M.5    Cattin, E.6
  • 76
    • 0008108286 scopus 로고
    • Preclinical studies of aspartame in nonprimate animals
    • Stegink LD, Filer LJ Jr, eds). New York:Marcel Dekker
    • Molinary VS. 1984. Preclinical studies of aspartame in nonprimate animals. In: Aspartame: Physiology and Biochemistry (Stegink LD, Filer LJ Jr, eds). New York:Marcel Dekker, 289-306.
    • (1984) Aspartame: Physiology and Biochemistry , pp. 289-306
    • Molinary, V.S.1
  • 77
    • 84888398797 scopus 로고
    • New Energy Development Organization, Test Report: 18-Month Inhalation Carcinogenicity Study on Methanol in B6C3F1 Mice (Test No. 4A-223). Available:, [accessed 18 October 2013]
    • New Energy Development Organization. 1985. Test Report: 18-Month Inhalation Carcinogenicity Study on Methanol in B6C3F1 Mice (Test No. 4A-223). Available: http://www.epa.gov/ncea/pdfs/iris/meth/18MonthmouseVolume1.pdf [accessed 18 October 2013].
    • (1985)
  • 78
    • 84888411821 scopus 로고
    • New Energy Development Organization, Test Report: 24-Month Inhalation Carcinogenicity Study on Methanol in Fischer Rats (Test No.: 5A-268). Available:, [accessed 18 October 2013]
    • New Energy Development Organization. 1985. Test Report: 24-Month Inhalation Carcinogenicity Study on Methanol in Fischer Rats (Test No.: 5A-268). Available: http://www. epa.gov/ncea/pdfs/iris/meth/24MonthRatVolume1.pdf [accessed 18 October 2013].
    • (1985)
  • 79
    • 84888400937 scopus 로고
    • New Energy Development Organization, Toxicological Research of Methanol as a Fuel for Power Station: Summary Report on Tests with Monkeys, Rats and Mice. Available:, [accessed 20 September 2013]
    • New Energy Development Organization. 1987. Toxicological Research of Methanol as a Fuel for Power Station: Summary Report on Tests with Monkeys, Rats and Mice. Available: http://www.epa.gov/ncea/pdfs/iris/meth/NEDO1987.pdf [accessed 20 September 2013].
    • (1987)
  • 80
    • 84888406233 scopus 로고
    • NTP (National Toxicology Program), Carcinogenesis Bioassay of Vinylidene Chloride (CAS No. 75-35-4) in F344/N Rats and B6C3F1/N Mice (Gavage Study). TR 228. Research Triangle Park, NC:NTP, Available:, [accessed 1 June 2013]
    • NTP (National Toxicology Program). 1982. Carcinogenesis Bioassay of Vinylidene Chloride (CAS No. 75-35-4) in F344/N Rats and B6C3F1/N Mice (Gavage Study). TR 228. Research Triangle Park, NC:NTP. Available: http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr228.pdf [accessed 1 June 2013].
    • (1982)
  • 81
    • 84888412188 scopus 로고
    • NTP (National Toxicology Program), Toxicology and Carcinogenesis Studies of Toluene (CAS No. 108-88-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). TR 371. Research Triangle Park, NC:NTP, Available, [accessed 24 September 2013]
    • NTP (National Toxicology Program). 1990. Toxicology and Carcinogenesis Studies of Toluene (CAS No. 108-88-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). TR 371. Research Triangle Park, NC:NTP. Available: http://ntp. niehs.nih.gov/ntp/htdocs/LT_rpts/tr371.pdf [accessed 24 September 2013].
    • (1990)
  • 82
    • 84888395948 scopus 로고
    • NTP (National Toxicology Program), Toxicology and Carcinogenesis Studies of Chlorinated Water (CAS Nos. 7782-50-5 and 7681-52-9) and Chloraminated Water (CAS No. 10599-90-3) (Deionized and Charcoal-Filtered) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). TR 392. Research Triangle Park, NC:NTP, Available, [accessed 1 June 2013]
    • NTP (National Toxicology Program). 1992. Toxicology and Carcinogenesis Studies of Chlorinated Water (CAS Nos. 7782-50-5 and 7681-52-9) and Chloraminated Water (CAS No. 10599-90-3) (Deionized and Charcoal-Filtered) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). TR 392. Research Triangle Park, NC:NTP. Available: http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr392.pdf [accessed 1 June 2013].
    • (1992)
  • 83
    • 84888407024 scopus 로고    scopus 로고
    • NTP (National Toxicology Program)., NTP Historical Control Information for the NIH-07 Diet. Available, [accessed 1 June 2013]
    • NTP (National Toxicology Program). 1999. NTP Historical Control Information for the NIH-07 Diet. Available: http://ntp.niehs.nih.gov/?objectid=92E6AAA5-F1F6-975E-71C88528A3E7B315 [accessed 1 June 2013].
    • (1999)
  • 84
    • 84888401677 scopus 로고    scopus 로고
    • NTP (National Toxicology Program), Toxicology Studies of Aspartame (CAS No. 22839-47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2atm1Rdp (N2) Deficient Mice and Carcinogenicity Studies of Aspartame in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Feed Studies). NTP GMM 1; NIH Publication No. 06-4459. Research Triangle Park, NC:NTP, [accessed 26 September 2013]
    • NTP (National Toxicology Program). 2005. Toxicology Studies of Aspartame (CAS No. 22839-47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2atm1Rdp (N2) Deficient Mice and Carcinogenicity Studies of Aspartame in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Feed Studies). NTP GMM 1; NIH Publication No. 06-4459. Research Triangle Park, NC:NTP. http://ntp.niehs.nih.gov/ntp/htdocs/GMM_rpts/GMM1.pdf [accessed 26 September 2013].
    • (2005)
  • 85
    • 84888424918 scopus 로고    scopus 로고
    • NTP (National Toxicology Program), Specifications for the Conduct of Studies to Evaluate the Toxic and Carcinogenic Potential of Chemical, Biological and Physical Agents In Laboratory Animals for the National Toxicology Program (NTP). Research Triangle Park, NC:NTP. Available, [accessed 26 September 2013]
    • NTP (National Toxicology Program). 2011. Specifications for the Conduct of Studies to Evaluate the Toxic and Carcinogenic Potential of Chemical, Biological and Physical Agents In Laboratory Animals for the National Toxicology Program (NTP). Research Triangle Park, NC:NTP. Available: http://ntp.niehs.nih.gov/ntp/Test_Info/FinalNTP_ ToxCarSpecsJan2011.pdf [accessed 26 September 2013].
    • (2011)
  • 86
    • 84888404799 scopus 로고    scopus 로고
    • NTP (National Toxicology Program)., Summary Report of the National Toxicology Program and Environmental Protection Agency Sponsored Review of Pathology Materials from Selected Ramazzini Institute Rodent Cancer Bioassays. Research Triangle Park, NC:NTP, Available:, [accessed 1 June 2013]
    • NTP (National Toxicology Program). 2011. Summary Report of the National Toxicology Program and Environmental Protection Agency Sponsored Review of Pathology Materials from Selected Ramazzini Institute Rodent Cancer Bioassays. Research Triangle Park, NC:NTP. Available: http://ntp.niehs.nih.gov/NTP/About_NTP/Partnerships/International/SummaryPWG_Report_RI_Bioassays.pdf [accessed 1 June 2013].
    • (2011)
  • 87
    • 84888404278 scopus 로고    scopus 로고
    • NTP (National Toxicology Program), NTP Historical Controls for NTP-2000 Diet. Available:, [accessed 1 June 2013]
    • NTP (National Toxicology Program). 2013. NTP Historical Controls for NTP-2000 Diet. Available: http://ntp.niehs.nih. gov/?objectid=92E705C7-F1F6-975E-72D23026B1645EB9 [accessed 1 June 2013].
    • (2013)
  • 88
    • 84888408584 scopus 로고    scopus 로고
    • OECD (Organization for Economic Co-operation and Development), Establishment and Control of Archives that Operate in Compliance with the Principles of GLP
    • OECD (Organization for Economic Co-operation and Development). 2007. Establishment and Control of Archives that Operate in Compliance with the Principles of GLP.
    • (2007)
  • 89
    • 84888393298 scopus 로고    scopus 로고
    • OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring No. 15. Paris:OECD. Available:, [accessed 1 June 2013]
    • OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring No. 15. Paris:OECD. Available: http://www.ilnas.public.lu/fr/publications/acreditation/ bonnes-pratiques-laboratoire/rapports-application/bpl-15-en.pdf [accessed 1 June 2013].
  • 91
    • 0042472988 scopus 로고    scopus 로고
    • Application of laser capture microdissection to cytologic specimens for the detection of immunoglobulin heavy chain gene rearrangement in patients with malignant lymphoma
    • Orba Y, Tanaka S, Nishihara H, Kawamura N, Itoh T, Shimizu M, et al. 2003. Application of laser capture microdissection to cytologic specimens for the detection of immunoglobulin heavy chain gene rearrangement in patients with malignant lymphoma. Cancer 99(4):198-204.
    • (2003) Cancer , vol.99 , Issue.4 , pp. 198-204
    • Orba, Y.1    Tanaka, S.2    Nishihara, H.3    Kawamura, N.4    Itoh, T.5    Shimizu, M.6
  • 92
    • 0036919522 scopus 로고    scopus 로고
    • Relevant animal model of human lymphoblastic leukaemia/lymphoma-spontaneous T-cell lymphomas in an inbred Sprague-Dawley rat strain (SD/Cub)
    • Otová B, Sladká M, Damoiseaux J, Panczak A, Mandys V, Marinov I. 2002. Relevant animal model of human lymphoblastic leukaemia/lymphoma-spontaneous T-cell lymphomas in an inbred Sprague-Dawley rat strain (SD/Cub). Folia Biol (Praha) 48(6):213-226.
    • (2002) Folia Biol (Praha) , vol.48 , Issue.6 , pp. 213-226
    • Otová, B.1    Sladká, M.2    Damoiseaux, J.3    Panczak, A.4    Mandys, V.5    Marinov, I.6
  • 93
    • 77957177350 scopus 로고
    • Testing for increased carcinogenicity using a survival-adjusted quantal response test
    • Portier CJ, Bailer AJ. 1989. Testing for increased carcinogenicity using a survival-adjusted quantal response test. Toxicol Sci 12(4):731-737.
    • (1989) Toxicol Sci , vol.12 , Issue.4 , pp. 731-737
    • Portier, C.J.1    Bailer, A.J.2
  • 94
    • 79953787237 scopus 로고    scopus 로고
    • Commentary: Further comments on Mycoplasma pulmonis and lymphoma in bioassays of rats
    • Schoeb TR, McConnell EE. 2011. Commentary: further comments on Mycoplasma pulmonis and lymphoma in bioassays of rats. Vet Pathol 48(2):420-426.
    • (2011) Vet Pathol , vol.48 , Issue.2 , pp. 420-426
    • Schoeb, T.R.1    McConnell, E.E.2
  • 95
    • 79959777710 scopus 로고    scopus 로고
    • Mycoplasma pulmonis and lymphoma in a methanol bioassay
    • Schoeb TR, McConnell EE. 2011. Mycoplasma pulmonis and lymphoma in a methanol bioassay. Vet Pathol 48(4):903-905.
    • (2011) Vet Pathol , vol.48 , Issue.4 , pp. 903-905
    • Schoeb, T.R.1    McConnell, E.E.2
  • 97
    • 22544444917 scopus 로고    scopus 로고
    • A note on variance estimation in random effects meta-regression
    • Sidik K, Jonkman JN. 2005. A note on variance estimation in random effects meta-regression. J Biopharm Stat 15(5):823-838.
    • (2005) J Biopharm Stat , vol.15 , Issue.5 , pp. 823-838
    • Sidik, K.1    Jonkman, J.N.2
  • 98
    • 0031262894 scopus 로고    scopus 로고
    • Documentation of pathology peer review: Position of the Society of Toxicologic Pathologists
    • Society of Toxicologic Pathologists
    • Society of Toxicologic Pathologists. 1997. Documentation of pathology peer review: position of the Society of Toxicologic Pathologists. Toxicol Pathol 25(6):655.
    • (1997) Toxicol Pathol , vol.25 , Issue.6 , pp. 655
  • 99
    • 0036965323 scopus 로고    scopus 로고
    • Results of long-term experimental studies on the carcinogenicity of methyl alcohol and ethyl alcohol in rats
    • Soffritti M, Belpoggi F, Cevolani D, Guarino M, Padovani M, Maltoni C, eds. 2002. Results of long-term experimental studies on the carcinogenicity of methyl alcohol and ethyl alcohol in rats. Ann NY Acad Sci 982:46-69.
    • (2002) Ann NY Acad Sci , vol.982 , pp. 46-69
    • Soffritti, M.1    Belpoggi, F.2    Cevolani, D.3    Guarino, M.4    Padovani, M.5    Maltoni, C.6
  • 100
    • 76649110468 scopus 로고    scopus 로고
    • Cancer prevention: The lesson from the lab
    • (Biasco G, Tanneberger S, eds). Bologna, Italy:Bononia University Press, Available, [accessed 18 October 2013]
    • Soffritti M, Belpoggi F, Degli Esposti D. 2006. Cancer prevention: the lesson from the lab. In: Cancer Medicine at the Dawn of the 21st Century: The View from Bologna (Biasco G, Tanneberger S, eds). Bologna, Italy:Bononia University Press, 49-64. Available: http://www.ramazzini. org/wp-content/uploads/2008/03/Cancer-Prevention_the-lesson-from-the-lab_2006.pdf [accessed 18 October 2013].
    • (2006) Cancer Medicine At the Dawn of the 21st Century: The View From Bologna , pp. 49-64
    • Soffritti, M.1    Belpoggi, F.2    Degli, E.D.3
  • 103
    • 33644771206 scopus 로고    scopus 로고
    • First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats
    • doi:10.1289/ehp.8711
    • Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L, Tibaldi T, Rigano A. 2006. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environ Health Perspect 114:379-385; doi:10.1289/ehp.8711.
    • (2006) Environ Health Perspect , vol.114 , pp. 379-385
    • Soffritti, M.1    Belpoggi, F.2    Degli, E.D.3    Lambertini, L.4    Tibaldi, T.5    Rigano, A.6
  • 104
    • 0036965158 scopus 로고    scopus 로고
    • Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats
    • Soffritti M, Belpoggi F, Lambertini L, Lauriola M, Padovani M, Maltoni C. 2002. Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats. Ann NY Acad Sci 982:87-105.
    • (2002) Ann NY Acad Sci , vol.982 , pp. 87-105
    • Soffritti, M.1    Belpoggi, F.2    Lambertini, L.3    Lauriola, M.4    Padovani, M.5    Maltoni, C.6
  • 105
    • 0031587507 scopus 로고    scopus 로고
    • Results of long-term carcinogenicity studies of chlorine in rats
    • Soffritti M, Belpoggi F, Lenzi A, Maltoni C. 1997. Results of long-term carcinogenicity studies of chlorine in rats. Ann N Y Acad Sci 837:189-208.
    • (1997) Ann N Y Acad Sci , vol.837 , pp. 189-208
    • Soffritti, M.1    Belpoggi, F.2    Lenzi, A.3    Maltoni, C.4
  • 106
    • 78649538952 scopus 로고    scopus 로고
    • Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice
    • Soffritti M, Belpoggi F, Manservigi M, Tibaldi E, Lauriola M, Falcioni L, et al. 2010. Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice. Am J Ind Med 53(12):1197-1206.
    • (2010) Am J Ind Med , vol.53 , Issue.12 , pp. 1197-1206
    • Soffritti, M.1    Belpoggi, F.2    Manservigi, M.3    Tibaldi, E.4    Lauriola, M.5    Falcioni, L.6
  • 107
    • 0036960610 scopus 로고    scopus 로고
    • Ramazzini Foundation cancer program: History and major projects, life-span carcinogenicity bioassay design, chemicals studied, and results
    • Soffritti M, Belpoggi F, Minardi F, Maltoni C. 2002c. Ramazzini Foundation cancer program: history and major projects, life-span carcinogenicity bioassay design, chemicals studied, and results. Ann NY Acad Sci 982:26-45.
    • (2002) Ann NY Acad Sci , vol.982 , pp. 26-45
    • Soffritti, M.1    Belpoggi, F.2    Minardi, F.3    Maltoni, C.4
  • 108
    • 34748884376 scopus 로고    scopus 로고
    • Life span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats
    • doi:10.1289/ehp.10271
    • Soffritti M, Belpoggi F, Tibaldi E, Degli Esposti D, Lauriola M. 2007. Life span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats. Environ Health Perspect 115:1293-1297; doi:10.1289/ehp.10271.
    • (2007) Environ Health Perspect , vol.115 , pp. 1293-1297
    • Soffritti, M.1    Belpoggi, F.2    Tibaldi, E.3    Degli, E.D.4    Lauriola, M.5
  • 112
    • 0024564662 scopus 로고
    • Chronic toxicity study on formaldehyde administered orally to rats
    • Tobe M, Naito K, Kurokawa Y. 1989. Chronic toxicity study on formaldehyde administered orally to rats. Toxicology 56(1):79-86.
    • (1989) Toxicology , vol.56 , Issue.1 , pp. 79-86
    • Tobe, M.1    Naito, K.2    Kurokawa, Y.3
  • 113
    • 84888406360 scopus 로고
    • U.S. EPA (U.S. Environmental Protection Agency), Pesticide Regulation (PR) Notice 94-5: Requests for Re-considerations of Carcinogenicity Peer Review Decisions Based on Changes in Pathology Diagnoses. Available, [accessed 1 June 2013]
    • U.S. EPA (U.S. Environmental Protection Agency). 1994. Pesticide Regulation (PR) Notice 94-5: Requests for Re-considerations of Carcinogenicity Peer Review Decisions Based on Changes in Pathology Diagnoses. Available: http://www.epa.gov/PR_Notices/pr94-5.html [accessed 1 June 2013].
    • (1994)
  • 114
    • 84888424183 scopus 로고    scopus 로고
    • U.S. EPA (U.S. Environmental Protection Agency), Health Effects Test Guidelines: OPPTS 870.4200 Carcinogenicity. EPA/712/C-98/211. Washington, DC:U.S. EPA. Available, [accessed 1 June 2013]
    • U.S. EPA (U.S. Environmental Protection Agency). 1998. Health Effects Test Guidelines: OPPTS 870.4200 Carcinogenicity. EPA/712/C-98/211. Washington, DC:U.S. EPA. Available: http://www.epa.gov/ocspp/pubs/frs/publications/Test_Guidelines/series870.htm [accessed 1 June 2013].
    • (1998)
  • 115
    • 84888402269 scopus 로고    scopus 로고
    • U.S. EPA (U.S. Environmental Protection Agency), Guidelines, for Carcinogen Risk Assessment. EPA/630/P- 03/001F. Washington, DC:U.S EPA. Available, [accessed 25 September 2013]
    • U.S. EPA (U.S. Environmental Protection Agency). 2005a. Guidelines for Carcinogen Risk Assessment. EPA/630/P- 03/001F. Washington, DC:U.S EPA. Available: http://www.epa.gov/raf/publications/pdfs/CANCER_GUIDELINES_ FINAL_3-25-05.PDF [accessed 25 September 2013].
    • (2005)
  • 116
    • 84888404720 scopus 로고    scopus 로고
    • U.S. EPA (U.S. Environmental Protection Agency), Supplemental Guidance for Assessing Susceptibility from Early-life Exposure to Carcinogens. EPA/630/R-03/003F. Washington, DC:U.S. EPA. Available, [accessed 26 September 2013]
    • U.S. EPA (U.S. Environmental Protection Agency). 2005b. Supplemental Guidance for Assessing Susceptibility from Early-life Exposure to Carcinogens. EPA/630/R-03/003F. Washington, DC:U.S. EPA. Available: http://www.epa.gov/raf/publications/pdfs/childrens_supplement_final.pdf [accessed 26 September 2013].
    • (2005)
  • 117
    • 84888413708 scopus 로고    scopus 로고
    • U.S. EPA (U.S. Environmental Protection Agency), U.S. Environmental Protection Agency Peer Review Handbook. 3rd ed. Available, [accessed 1 June 2013]
    • U.S. EPA (U.S. Environmental Protection Agency). 2006. U.S. Environmental Protection Agency Peer Review Handbook. 3rd ed. Available: http://nepis.epa.gov/exe/ZyPURL.cgi?Dockey=P1001XCG.txt [accessed 1 June 2013].
    • (2006)
  • 118
    • 84888413018 scopus 로고    scopus 로고
    • U.S. EPA (U.S. Environmental Protection Agency), Benchmark Dose Technical Guidance. EPA/100/R-12/001. Washington, DC:U.S. EPA. Available, [accessed 1 June 2013]
    • U.S. EPA (U.S. Environmental Protection Agency). 2012. Benchmark Dose Technical Guidance. EPA/100/R-12/001. Washington, DC:U.S. EPA. Available: http://www.epa.gov/raf/publications/pdfs/benchmark_dose_guidance.pdf [accessed 1 June 2013].
    • (2012)
  • 119
    • 84888420266 scopus 로고    scopus 로고
    • U.S. EPA (U.S. Environmental Protection Agency), Update on Ramazzini Institute Data in IRIS Assessments. Washington, DC:U.S. EPA. Available, [accessed 1 June 2013]
    • U.S. EPA (U.S. Environmental Protection Agency). 2012. Update on Ramazzini Institute Data in IRIS Assessments. Washington, DC:U.S. EPA. Available: http://epa.gov/iris/ramazzini.htm [accessed 1 June 2013].
    • (2012)
  • 120
    • 9144265458 scopus 로고    scopus 로고
    • Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936
    • van Dongen JJ, Langerak AW, Brüggemann M, Evans PA, Hummel M, Lavender FL, et al. 2003. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17(12):2257-2317.
    • (2003) Leukemia , vol.17 , Issue.12 , pp. 2257-2317
    • van Dongen, J.J.1    Langerak, A.W.2    Brüggemann, M.3    Evans, P.A.4    Hummel, M.5    Lavender, F.L.6
  • 122
    • 34548706494 scopus 로고    scopus 로고
    • Analysis of T-cell clonality using laser capture microdissection and high-resolution microcapillary electrophoresis
    • Yakirevich E, Jackson CL, Meitner PA, MacKenzie D, Tavares R, Robinson-Bostom L, et al. 2007. Analysis of T-cell clonality using laser capture microdissection and high-resolution microcapillary electrophoresis. J Mol Diagn 9(4):490-497.
    • (2007) J Mol Diagn , vol.9 , Issue.4 , pp. 490-497
    • Yakirevich, E.1    Jackson, C.L.2    Meitner, P.A.3    Mackenzie, D.4    Tavares, R.5    Robinson-Bostom, L.6
  • 123
    • 59349084923 scopus 로고    scopus 로고
    • Formaldehyde exposure and leukemia: A new meta-analysis and potential mechanisms
    • Zhang L, Steinmaus C, Eastmond DA, Xin XK, Smith MT. 2009. Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms. Mutat Res 681(2-3):150-168.
    • (2009) Mutat Res , vol.681 , Issue.2-3 , pp. 150-168
    • Zhang, L.1    Steinmaus, C.2    Eastmond, D.A.3    Xin, X.K.4    Smith, M.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.