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Volumn 62, Issue 2, 2012, Pages 278-291

Hypothesis-Based Weight-of-Evidence evaluation of methanol as a human carcinogen

Author keywords

Formaldehyde; Hazard identification; Human relevance; Lymphoma; Methanol; Mode of action; Risk assessment

Indexed keywords

DRINKING WATER; FORMALDEHYDE; MALONALDEHYDE; METHANOL;

EID: 84856445159     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.11.015     Document Type: Article
Times cited : (12)

References (41)
  • 1
    • 0028824089 scopus 로고
    • Methyl-tertiary-butyl ether (MTBE) - a gasoline additive - causes testicular and lympho-haematopoietic cancers in rats
    • Belpoggi F., Soffritti M., Maltoni C. Methyl-tertiary-butyl ether (MTBE) - a gasoline additive - causes testicular and lympho-haematopoietic cancers in rats. Toxicol. Ind. Health 1995, 11:119-149.
    • (1995) Toxicol. Ind. Health , vol.11 , pp. 119-149
    • Belpoggi, F.1    Soffritti, M.2    Maltoni, C.3
  • 2
    • 58549117643 scopus 로고    scopus 로고
    • Immunoblastic lymphomas in Sprague-Dawley rats following exposure to the gasoline oxygenated additives methyl-tertiary-butyl ether (MTBE) and ethyl-tertiary-butyl ether (ETBE): early observations on their natural history
    • Belpoggi F., Soffritti M., Maltoni C. Immunoblastic lymphomas in Sprague-Dawley rats following exposure to the gasoline oxygenated additives methyl-tertiary-butyl ether (MTBE) and ethyl-tertiary-butyl ether (ETBE): early observations on their natural history. Eur. J. Oncol. 1999, 4:563-572.
    • (1999) Eur. J. Oncol. , vol.4 , pp. 563-572
    • Belpoggi, F.1    Soffritti, M.2    Maltoni, C.3
  • 3
    • 0035199227 scopus 로고    scopus 로고
    • A biologically based dynamic model for predicting the disposition of methanol and its metabolites in animals and humans
    • Bouchard M., Brunet R.C., Droz P.O., Carrier G. A biologically based dynamic model for predicting the disposition of methanol and its metabolites in animals and humans. Toxicol. Sci. 2001, 64:169-184.
    • (2001) Toxicol. Sci. , vol.64 , pp. 169-184
    • Bouchard, M.1    Brunet, R.C.2    Droz, P.O.3    Carrier, G.4
  • 4
    • 40149110675 scopus 로고    scopus 로고
    • Evaluation of evidence for infection as a mode of action for induction of rat lymphoma
    • Caldwell J.C., Jinot J., DeVoney D., Gift J.S. Evaluation of evidence for infection as a mode of action for induction of rat lymphoma. Environ. Mol. Mutagen. 2008, 49:155-164.
    • (2008) Environ. Mol. Mutagen. , vol.49 , pp. 155-164
    • Caldwell, J.C.1    Jinot, J.2    DeVoney, D.3    Gift, J.S.4
  • 5
    • 0006700508 scopus 로고
    • The evaluation of six different monitors for the exposure to formaldehyde in laboratory rats
    • (in: Abstracts of the Fourteenth Annual Meeting of the Environmental Mutagen Society, March 3-6, 1983, San Antonio, Texas, abstract Bb-13.)
    • Chang L.W., McMillan L., Wynne B.R., Pereira M.A., Colley R.A., Ward J.B., Legator M.S. The evaluation of six different monitors for the exposure to formaldehyde in laboratory rats. Mol. Carcinog. 1983, 5:381. (in: Abstracts of the Fourteenth Annual Meeting of the Environmental Mutagen Society, March 3-6, 1983, San Antonio, Texas, abstract Bb-13.).
    • (1983) Mol. Carcinog. , vol.5 , pp. 381
    • Chang, L.W.1    McMillan, L.2    Wynne, B.R.3    Pereira, M.A.4    Colley, R.A.5    Ward, J.B.6    Legator, M.S.7
  • 6
    • 68849107627 scopus 로고    scopus 로고
    • Assessment of the cancer potential of methanol
    • Cruzan G. Assessment of the cancer potential of methanol. Crit. Rev. Toxicol. 2009, 39:347-363.
    • (2009) Crit. Rev. Toxicol. , vol.39 , pp. 347-363
    • Cruzan, G.1
  • 7
    • 84857369735 scopus 로고    scopus 로고
    • Evaluation of the Ramazzini Foundation Study of methanol in rats:
    • a comparison of diagnoses by the RF study pathologist and a recent NTP review team. Submitted to Methanol Institute. Available from
    • Cruzan, G., 2011. Evaluation of the Ramazzini Foundation Study of methanol in rats: a comparison of diagnoses by the RF study pathologist and a recent NTP review team. Submitted to Methanol Institute. Available from http://www.epa.gov/quality/informationguidelines/documents/10005-rel2.pdf.
    • (2011)
    • Cruzan, G.1
  • 8
    • 46649108278 scopus 로고    scopus 로고
    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to a new long-term carcinogenicity study on aspartame: question number EFSA-Q-2005-122
    • EFSA (European Food Safety Authority)
    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to a new long-term carcinogenicity study on aspartame: question number EFSA-Q-2005-122. EFSA J. 2006, 356:1-44. EFSA (European Food Safety Authority).
    • (2006) EFSA J. , vol.356 , pp. 1-44
  • 9
    • 84857360205 scopus 로고    scopus 로고
    • ERG (Eastern Research Group, Inc.), 2009. External letter peer review of reports documenting methanol studies in monkeys, rats and mice performed by the New Energy Development Organization (NEDO): peer reviewer comments. Submitted to US EPA, National Center for Environmental Assessment. Available from
    • ERG (Eastern Research Group, Inc.), 2009. External letter peer review of reports documenting methanol studies in monkeys, rats and mice performed by the New Energy Development Organization (NEDO): peer reviewer comments. Submitted to US EPA, National Center for Environmental Assessment. Available from http://www.epa.gov/ncea/pdfs/iris/meth/TO64_Methanol_Review_Deliverable_NEDO_LetterPeerReview.pdf.
  • 10
    • 33644974083 scopus 로고    scopus 로고
    • Formaldehyde as a potential human leukemogen: an assessment of biological plausibility
    • Golden R., Pyatt D., Shields P.G. Formaldehyde as a potential human leukemogen: an assessment of biological plausibility. Crit. Rev. Toxicol. 2006, 36:135-153.
    • (2006) Crit. Rev. Toxicol. , vol.36 , pp. 135-153
    • Golden, R.1    Pyatt, D.2    Shields, P.G.3
  • 11
    • 84857374012 scopus 로고    scopus 로고
    • Formaldehyde-induced hydroxymethyl DNA adducts in rats exposed to isotope labeled methanol
    • (abstract 1691)
    • Gul H., Lu K., Upton P., Swenberg J.A. Formaldehyde-induced hydroxymethyl DNA adducts in rats exposed to isotope labeled methanol. Toxicologist 2011, 120:364. (abstract 1691).
    • (2011) Toxicologist , vol.120 , pp. 364
    • Gul, H.1    Lu, K.2    Upton, P.3    Swenberg, J.A.4
  • 13
    • 31844443695 scopus 로고
    • The environment and disease: association or causation?
    • Hill A.B. The environment and disease: association or causation?. Proc. R. Soc. Med. 1965, 58:295-300.
    • (1965) Proc. R. Soc. Med. , vol.58 , pp. 295-300
    • Hill, A.B.1
  • 14
    • 0026442268 scopus 로고
    • Physiologically based pharmacokinetic model for methanol in rats, monkeys, and humans
    • Horton V.L., Higuchi M.A., Rickert D.E. Physiologically based pharmacokinetic model for methanol in rats, monkeys, and humans. Toxicol. Appl. Pharmacol. 1992, 117:26-36.
    • (1992) Toxicol. Appl. Pharmacol. , vol.117 , pp. 26-36
    • Horton, V.L.1    Higuchi, M.A.2    Rickert, D.E.3
  • 15
    • 0025128441 scopus 로고
    • The toxicity of inhaled methanol vapors
    • Kavet R., Nauss K.M. The toxicity of inhaled methanol vapors. Crit. Rev. Toxicol. 1990, 21:21-50.
    • (1990) Crit. Rev. Toxicol. , vol.21 , pp. 21-50
    • Kavet, R.1    Nauss, K.M.2
  • 16
    • 77955066854 scopus 로고    scopus 로고
    • Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia
    • Lu K., Collins L.B., Ru H., Bermudez E., Swenberg J.A. Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia. Toxicol. Sci. 2010, 116:441-451.
    • (2010) Toxicol. Sci. , vol.116 , pp. 441-451
    • Lu, K.1    Collins, L.B.2    Ru, H.3    Bermudez, E.4    Swenberg, J.A.5
  • 17
    • 79951835425 scopus 로고    scopus 로고
    • Molecular dosimetry of N(2)-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde
    • Lu K., Moeller B., Doyle-Eisele M., McDonald J., Swenberg J.A. Molecular dosimetry of N(2)-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde. Chem. Res. Toxicol. 2011, 24:159-161.
    • (2011) Chem. Res. Toxicol. , vol.24 , pp. 159-161
    • Lu, K.1    Moeller, B.2    Doyle-Eisele, M.3    McDonald, J.4    Swenberg, J.A.5
  • 18
    • 84857374013 scopus 로고    scopus 로고
    • report on visit (4/25/2010-4/30/2010) and assessment of the pathology procedures performed at the Ramazzini Institute (RI), Bentivoglio, Italy.
    • National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC.
    • Malarkey, D., Herbert, R., 2010. Unpublished internal memo to J. Bucher re: report on visit (4/25/2010-4/30/2010) and assessment of the pathology procedures performed at the Ramazzini Institute (RI), Bentivoglio, Italy. National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC.
    • (2010) Unpublished internal memo to J. Bucher re:
    • Malarkey, D.1    Herbert, R.2
  • 19
    • 79951839276 scopus 로고    scopus 로고
    • Methanol exposure does not lead to accumulation of oxidative DNA damage in bone marrow and spleen of mice, rabbits or primates
    • McCallum G.P., Sui M., Ondovcik S.L., Sweeting J.N., Wells P.G. Methanol exposure does not lead to accumulation of oxidative DNA damage in bone marrow and spleen of mice, rabbits or primates. Mol. Carcinog. 2011, 50:163-172.
    • (2011) Mol. Carcinog. , vol.50 , pp. 163-172
    • McCallum, G.P.1    Sui, M.2    Ondovcik, S.L.3    Sweeting, J.N.4    Wells, P.G.5
  • 20
    • 78650566572 scopus 로고    scopus 로고
    • Methanol exposure does not produce oxidatively damaged DNA in lung, liver or kidney of adult mice, rabbits or primates
    • McCallum G.P., Siu M., Sweeting J.N., Wells P.G. Methanol exposure does not produce oxidatively damaged DNA in lung, liver or kidney of adult mice, rabbits or primates. Toxicol. Appl. Pharmacol. 2011, 250:147-153.
    • (2011) Toxicol. Appl. Pharmacol. , vol.250 , pp. 147-153
    • McCallum, G.P.1    Siu, M.2    Sweeting, J.N.3    Wells, P.G.4
  • 21
    • 84857369734 scopus 로고    scopus 로고
    • MI (Methanol Institute), 2010. Comments on the U.S. EPA Draft Toxicological Review of Methanol (IRIS).
    • Submitted to US EPA Docket, EPA-HQ-ORD-2009-0398-0019.1.
    • MI (Methanol Institute), 2010. Comments on the U.S. EPA Draft Toxicological Review of Methanol (IRIS). Submitted to US EPA Docket, EPA-HQ-ORD-2009-0398-0019.1.
  • 22
    • 79951815592 scopus 로고    scopus 로고
    • Determination of N(2)-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following (13)CD(2)-formaldehyde inhalation exposure
    • Moeller B.C., Lu K., Doyle-Eisele M., McDonald J., Gigliotti A., Swenberg J.A. Determination of N(2)-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following (13)CD(2)-formaldehyde inhalation exposure. Chem. Res. Toxicol. 2011, 24:162-164.
    • (2011) Chem. Res. Toxicol. , vol.24 , pp. 162-164
    • Moeller, B.C.1    Lu, K.2    Doyle-Eisele, M.3    McDonald, J.4    Gigliotti, A.5    Swenberg, J.A.6
  • 23
    • 84942242906 scopus 로고    scopus 로고
    • NIOSH (National Institute for Occupational Safety and Health), 2007. NIOSH pocket guide to chemical hazards.
    • DHHS (NIOSH) publication no. 2005-149. Available from
    • NIOSH (National Institute for Occupational Safety and Health), 2007. NIOSH pocket guide to chemical hazards. DHHS (NIOSH) publication no. 2005-149. Available from http://www.cdc.gov/niosh/npg/.
  • 24
    • 84857362705 scopus 로고    scopus 로고
    • NRC (National Research Council), 2011. Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde.
    • National Academies Press, Washington, DC. Available from
    • NRC (National Research Council), 2011. Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde. National Academies Press, Washington, DC. Available from http://www.nap.edu/catalog/13142.html.
  • 25
    • 84857360203 scopus 로고    scopus 로고
    • NTP (National Toxicology Program), 2010. 2-Year study protocol. Available from
    • NTP (National Toxicology Program), 2010. 2-Year study protocol. Available from http://ntp.niehs.nih.gov/.
  • 26
    • 84857360204 scopus 로고    scopus 로고
    • OECD (Organisation for Economic Co-operation and Development), 2009. OECD test guideline 453: combined chronic toxicity/carcinogenicity studies. OECD 453. Available from
    • OECD (Organisation for Economic Co-operation and Development), 2009. OECD test guideline 453: combined chronic toxicity/carcinogenicity studies. OECD 453. Available from http://www.oecdilibrary.org/oecd/content/book/9789264071223-en.
  • 28
    • 0001516733 scopus 로고
    • Battery of short-term tests in laboratory animals to corroborate the detection of human population exposures to genotoxic chemicals
    • (in: Abstracts of the Thirteenth Annual Meeting of the Environmental Mutagen Society, February 26-March 1, 1982, Boston, Massachusetts)
    • Pereira M.A., Chang L.W., McMillan L., Ward J.B., Legator M.S. Battery of short-term tests in laboratory animals to corroborate the detection of human population exposures to genotoxic chemicals. Mol. Carcinog. 1982, 4:317. (in: Abstracts of the Thirteenth Annual Meeting of the Environmental Mutagen Society, February 26-March 1, 1982, Boston, Massachusetts).
    • (1982) Mol. Carcinog. , vol.4 , pp. 317
    • Pereira, M.A.1    Chang, L.W.2    McMillan, L.3    Ward, J.B.4    Legator, M.S.5
  • 29
    • 81255211976 scopus 로고    scopus 로고
    • Hypothesis-Based Weight-of-Evidence evaluation of the neurodevelopmental effects of chlorpyrifos
    • Prueitt R.L., Goodman J.E., Bailey L.A., Rhomberg L.R. Hypothesis-Based Weight-of-Evidence evaluation of the neurodevelopmental effects of chlorpyrifos. Crit. Rev. Toxicol. 2011, 41:822-897.
    • (2011) Crit. Rev. Toxicol. , vol.41 , pp. 822-897
    • Prueitt, R.L.1    Goodman, J.E.2    Bailey, L.A.3    Rhomberg, L.R.4
  • 30
    • 43449115362 scopus 로고    scopus 로고
    • Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies?
    • Pyatt D., Natelson E., Golden R. Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies?. Regul. Toxicol. Pharmacol. 2008, 51:119-133.
    • (2008) Regul. Toxicol. Pharmacol. , vol.51 , pp. 119-133
    • Pyatt, D.1    Natelson, E.2    Golden, R.3
  • 31
    • 77955906183 scopus 로고    scopus 로고
    • Hypothesis-Based Weight-of-Evidence: a tool for evaluating and communicating uncertainties and inconsistencies in the large body of evidence in proposing a carcinogenic mode of action - Naphthalene as an example
    • Rhomberg L.R., Bailey L.A., Goodman J.E. Hypothesis-Based Weight-of-Evidence: a tool for evaluating and communicating uncertainties and inconsistencies in the large body of evidence in proposing a carcinogenic mode of action - Naphthalene as an example. Crit. Rev. Toxicol. 2010, 40:671-696.
    • (2010) Crit. Rev. Toxicol. , vol.40 , pp. 671-696
    • Rhomberg, L.R.1    Bailey, L.A.2    Goodman, J.E.3
  • 32
    • 79960790215 scopus 로고    scopus 로고
    • Is exposure to formaldehyde in air causally associated with leukemia? - A Hypothesis-Based Weight-of-Evidence analysis
    • Rhomberg L.R., Bailey L.A., Goodman J.E., Hamade A., Mayfield D. Is exposure to formaldehyde in air causally associated with leukemia? - A Hypothesis-Based Weight-of-Evidence analysis. Crit. Rev. Toxicol. 2011, 41:555-621.
    • (2011) Crit. Rev. Toxicol. , vol.41 , pp. 555-621
    • Rhomberg, L.R.1    Bailey, L.A.2    Goodman, J.E.3    Hamade, A.4    Mayfield, D.5
  • 33
    • 79953787237 scopus 로고    scopus 로고
    • Commentary: further comments on Mycoplasma pulmonis and lymphoma in bioassays of rats
    • Schoeb T.R., McConnell E.E. Commentary: further comments on Mycoplasma pulmonis and lymphoma in bioassays of rats. Vet. Pathol. 2011, 48:420-426.
    • (2011) Vet. Pathol. , vol.48 , pp. 420-426
    • Schoeb, T.R.1    McConnell, E.E.2
  • 34
    • 79959777710 scopus 로고    scopus 로고
    • Mycoplasma pulmonis and lymphoma in a methanol bioassay
    • Schoeb T.R., McConnell E.E. Mycoplasma pulmonis and lymphoma in a methanol bioassay. Vet. Pathol. 2011, 48:903-905.
    • (2011) Vet. Pathol. , vol.48 , pp. 903-905
    • Schoeb, T.R.1    McConnell, E.E.2
  • 37
    • 0036965323 scopus 로고    scopus 로고
    • Results of long-term experimental studies on the carcinogenicity of methyl alcohol and ethyl alcohol in rats
    • Soffritti M., Belpoggi F., Cevolani D., Guarino M., Padovani M., Maltoni C. Results of long-term experimental studies on the carcinogenicity of methyl alcohol and ethyl alcohol in rats. Ann. N. Y. Acad. Sci. 2002, 982:46-69.
    • (2002) Ann. N. Y. Acad. Sci. , vol.982 , pp. 46-69
    • Soffritti, M.1    Belpoggi, F.2    Cevolani, D.3    Guarino, M.4    Padovani, M.5    Maltoni, C.6
  • 38
    • 84857369736 scopus 로고    scopus 로고
    • TERA (Toxicology Excellence for Risk Assessment), 2010. Report on the peer review of the methanol bioassays: Soffritti et al. (2002) and Apaja (1980). Report to Methanol Institute. Available from
    • TERA (Toxicology Excellence for Risk Assessment), 2010. Report on the peer review of the methanol bioassays: Soffritti et al. (2002) and Apaja (1980). Report to Methanol Institute. Available from http://www.tera.org/peer/MeetingReports/MethanolFinalReportRevised.pdf.
  • 39
    • 84857370010 scopus 로고    scopus 로고
    • US EPA, 2009. Toxicological review of methanol in support of summary information on the Integrated Risk Information System (IRIS) (external peer review draft). EPA/635/R-09/013. Available from.
    • US EPA, 2009. Toxicological review of methanol in support of summary information on the Integrated Risk Information System (IRIS) (external peer review draft). EPA/635/R-09/013. Available from. http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=56521.
  • 40
    • 84857369733 scopus 로고    scopus 로고
    • US EPA, 2010. Toxicological review of formaldehyde - inhalation assessment (CAS No. 50-00-0) in support of summary information on the Integrated Risk Information System (IRIS), (draft). EPA/635/R-10/002A.
    • US EPA, 2010. Toxicological review of formaldehyde - inhalation assessment (CAS No. 50-00-0) in support of summary information on the Integrated Risk Information System (IRIS), vol. I-IV (draft). EPA/635/R-10/002A.
    • , vol.1-4
  • 41
    • 84857374011 scopus 로고    scopus 로고
    • Analysis of formaldehyde-DNA adducts in leukocyte DNA by liquid chromatography-electrospray ionization-tandem mass spectrometry: application to rats treated with aspartame [abstract].
    • Abstract No. 2250, in 99th AACR Annual Meeting, April 12-16, 2008, San Diego, CA. Available from
    • Wang, M., Cheng, G., Villalta, P., Kassie, F., Hecht, S., 2008. Analysis of formaldehyde-DNA adducts in leukocyte DNA by liquid chromatography-electrospray ionization-tandem mass spectrometry: application to rats treated with aspartame [abstract]. Abstract No. 2250, in 99th AACR Annual Meeting, April 12-16, 2008, San Diego, CA. Available from http://www.aacrmeetingabstracts.org.
    • (2008)
    • Wang, M.1    Cheng, G.2    Villalta, P.3    Kassie, F.4    Hecht, S.5


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