Evaluation of evidence for infection as a mode of action for induction of rat lymphoma

Environmental and Molecular Mutagenesis

Volumn 49, Issue 2, 2008, Pages 155-164

  Caldwell, Jane C ^a,b   Jinot, Jennifer ^a   DeVoney, Danielle ^a   Gift, Jeff S ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Lymphoblastic leukemia; Lymphoma; Methyl tertiary butyl ether; Mode of action; Risk assessment

Indexed keywords

ASPARTAME; TERT BUTYL METHYL ETHER;

B CELL LYMPHOMA; B LYMPHOCYTE; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENICITY; CHRONIC RESPIRATORY TRACT DISEASE; CONFERENCE PAPER; ENVIRONMENTAL PROTECTION; FISCHER 344 RAT; FOOD SAFETY; IMMUNOBLASTIC LYMPHOMA; INFECTION; LYMPHATIC LEUKEMIA; LYMPHOMA; MYCOPLASMA PULMONIS; NONHUMAN; RAT STRAIN; RISK ASSESSMENT; SEX ROLE; SPRAGUE DAWLEY RAT; T LYMPHOCYTE; TOXICITY TESTING;

ANIMALS; CARCINOGENS; INFECTION; LEUKEMIA; LYMPHOMA; METHYL ETHERS; RATS;

ANIMALIA; RATTUS;

EID: 40149110675     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20356     Document Type: Conference Paper

References (62)

1. Ames BN, Gold LS. 1990. Chemical carcinogenesis: Too many rodent carcinogens. Proc Natl Acad Sci 87:7772-7776.
2. Attems J, Konig C, Huber M, Lintner F, Jellinger KA. 2005. Cause of death in demented and non-demented elderly inpatients: An autopsy study of 308 cases. J Alzheimers Dis 8:57-62.
3. Belpoggi F, Soffritti M, Maltoni C. 1995. Methyl tertiary-butyl ether (MtBE) - A gasoline additive-causes testicular and lymphohaematopoietic cancers in rats. Toxicol lnd Health 11:119-149.
4. Belpoggi F, Soffritti M, Maltoni C. 1998. Pathological characterization of testicular tumors and lymphoma-leukaemias and their precursors observed in Sprague-Dawley rats exposed to methyl tertiary-butyl ether (MTBE). Eur J Oncol 3:201-206.
5. Belpoggi F, Soffritti M, Minardi F, Bua L, Cattin E, Maltoni C. 2002. Results of long-term carcinogenicity bioassays on tert-amyl-methyl-ether (TAME) and di-idopropyl-ether (DIPE) in rats. Ann N Y Acad Sci 982:70-86.
6. Beral V, Peterman T, Berkelman R, Jaffe H. 1991. AIDS-associated non-Hodgkin lymphoma. Lancet 337:805-809.
7. Besson C, Goubar A, Gabarre J, Rozenbaum W, Pialoux G, Chatelet FP, Ktlama C, Charlotte F, Dupont B, Brousse N, Huerre M, Mikol J, Camparo P, Mokhtari K, Tulliez M, Salmon-Ceron D, Boue F, Costagliola D, Raphael M. 2001. Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy. Blood 98:2339-2344.
8. Bodey GP. 1975. Infections in cancer patients. Cancer Treat Rev 2:89-128.
9. Bucher J. 2002. The National Toxicology Program rodent bioassay; designs, interpretations, and scientific contributions. Ann NY Acad Sci 982:198-207.
10. Casazza AR, Duval CP, Carbone PP. 1966. Infection in lymphoma. Histology, treatment, and duration in relation to incidence and survival. JAMA 197:710-716.
11. Chamandy N, Wolfson C. 2005. Underlying cause of death in demented and non-demented elderly Canadians. Neuroepidemiology 25:75-84.
12. Chandra M, Riley MG, Johnson DE. 1992. Spontaneous neoplasms in aged Sprague-Dawley rats. Arch Toxicol 66:496-502.
13. Chun JS, Burleigh-Flayer HD, Kintigh WJ. 1992. Methyl tertiary-butyl ether: Vapor inhalation oncogenicity study in Fischer 344 rats. Report No. 91N0013B. Submitted to U.S. EPA under TSCA Section 4 Testing Consent Order 40 CFR 799.500. EPA/OPTS #42098. Bushy Run Research Center, Union Carbide Chemicals and Plastics Co. Export, PA.
14. Columbano A, Ledda-Columbano GM. 2003. Mitogenesis by ligands of nuclear receptors: An attractive model for the study of the molecular mechanisms implicated in liver growth. Cell Death Differ 10 (Suppl 1):S19-S21.
15. Covelli V, Di Majo V, Bassani B, Mancini C, Adorini L, Doria G. 1985. Spontaneous lymphomas in mice genetically selected for high or low phytohemagglutinin responsiveness. J Natl Cancer Inst 75:1083-1090.
16. Cuninngham-Rundles C, Bodian C. 1999. Common variable immunodeficiency: Clinical and immunological features of 248 patients. Clin Immunol 92:34-48.
17. Dekant W, Bernauer U, Rosner E, Amberg A. 2001. Biotransformation of MTBE, ETBE, and TAME after inhalation or ingestion in rats and humans Health Effects Institute research report: Metabolism of ether oxygenates added to gasoline, Number 102 Cambridge, MA. Res Rep Health Eff Inst 102:29-71; discussion 95-109.
18. Du HF, Xu LH, Wang HF, Liu YF, Tsang XY, Liu KX, Peng SX. 2005. Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry. Environ Toxicol 20:397-401.
19. Engels EA. 2007. Infectious agents as causes of non-hodgkins lymphoma. Cancer Epidemiol Biomarkers Prev 16:401-404.
20. Esaki Y, Sawabe M, Arai T, Matsushita S, Takubo K. 1999. Pathologic evaluation of the main cause of death in Japanese centarians. Nippon Ronen Igakkai Zasshi 36:116-21.
21. European Food Safety Authority (EFSA). 2006. Opinion of the scientific panel AFC related to a new long-term carcinogenicity study on aspartame. Available online May 11, 2006: http://www.efsa.eu.int/science/afc/afc_opinions/ 1471_en.html
22. Everitt JI, Richter CB. 1990. Infectious diseases of the upper respiratory tract: Implication for toxicology studies. Environ Health Perspect 85:239-247.
23. Frith CH. 1988. Morphological classification and incidence of hematopoietic neoplasms in the Sprague-Dawley rat. Toxicol Pathol 16:451-457.
24. Futamura A, Matsumura T, Yoshida W, Wakasa S, Miyamoto. 2005. Examination of acute disease in the long-term geriatric ward. Gan To Kagaku Ryoho 32:56-58.
25. Gelderblom WC, Galendo D, Abel S, Swanevelder S, Marasas WFO, Wild CP. 2001. Cancer initiation by fumonisin B(1) in rat liver - Role of cell proliferation. Cancer Lett 169:127-137.
26. Goormachtigh G, Ouk TS, Mougel A, Tranchand-Bunel D, Masy E, Le Clorennec C, Feuillard J, Bornkamm GW, Auriault C, Manet E, Fafeur V, Adrianenssens E, Coll J. 2006. Autoactivation of the Epstein-Barr Virus oncogenic protein LMP1 during type II latency through opposite roles of the NF-κB and JNK signaling pathways. J Virol 80:7382-7393.
27. Greaves MF. 2004. Biological models for leukaemia and lymphoma. IARC Sci Publ 157:351-372.
28. Harris NL, Jaffe ES, Stein H, Banks PM, Chan J, Cleary ML, Delsol G, De Wolf-Peters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Muller-Hermelink HK, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA. 1994. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 84:1361-1392.
29. Harris NL, Jaffe ES, Diebold J, Flandrin G, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD. 1999. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November, 1997. J Clin Oncol 17:3835-3849.
30. Haseman JK, Hailey JR, Morris RW. 1998. Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: A National Toxicology Program update. Toxicol Pathol 26:428-441.
31. Hiscott J, Kwon H, Génin P. 2001. Hostile takeovers: Viral appropriation of the NF-κB pathway. J Clin Investig 107:143-151.
32. Huff J. 2002. Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: In tribute to Cesare Maltoni and David Rall. Ann N Y Acad Sci 982:208-229.
33. Jeong SJ, Radonovich M, Brady JN, Pise-Masison CA. 2004. HTLV-1 Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 trancriptional activity. Blood 104:1490-1497.
34. Koss MN. 1995. Pulmonary lymphoid disorders. Semin Diagn Pathol 12:158-171.
35. Kruse RL, Mehr DR, van der Steen JT, Ooms ME, Madsen RW, Shermans AK, D'Agostino RB, van der Wal G, Ribbe MW. 2005. Antibiotic treatment and survival of nursing home patients with lower respiratory tract infection: A cross-national analysis. Ann Fam Med 3:422-429.
36. Küppers R, Klein U, Leo-Hansmann M, Rajewsky K. 1999. Cellular origin of human B-cell lymphoma. N Engl J Med 341:1520-1529.
37. Ledda-Columbano GM, Perra A, Loi R, Shinozuka H, Columbano A. 2000. Cell proliferation induced by triidothyronine in rat liver is associated with nodule regression and reduction of hepatocellular carcinomas. Cancer Res 60:603-609.
38. Levine AM. 2006. AIDS-related lymphoma. Semin Oncol Nurs 22:80-89.
39. Lindsey JR, Baker HJ, Overcash RG, Cassell GH, Hunt CE. 1971. Murine chronic respiratory disease. Significance as a research complication and experimental production with Mycoplasma pulmonis. Am J Pathol 64:675-708.
40. Lindsey JR, Davidson MK, Schoeb TR, Cassell GH. 1985. Mycoplasma pulmonis-host relationships in a breeding colony of Sprague-Dawley rats with enzootic murine respiratory mycoplasmosis. Lab Anim Sci 35:597-608.
41. Lynch DW, Lewis TR, Moorman WJ, Burg JR, Groth DH, Khan A, Ackerman LJ, Cockrell BY. 1984. Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats. Toxicol Appl Pharmacol 76:69-84.
42. Marik PE, Kaplan D. 2003. Aspiration pneumonia and dysphagia in the elderly. Chest 124:328-336.
43. Maronpot RR, Flake G, Huff J. 2004. Relevance of animal carcinogenesis findings to human cancer predictions and prevention. Toxicol Pathol 32 (Suppl 1):40-48.
44. Morse HC, Anver MR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Jaffe ES, Kogan SC, MacLennan CM, Pattengale PK, Ward JM. 2002. Bethesda proposals for classification of lymphoid neoplasms in mice. Blood 100:246-258.
45. National Toxicology Program (NTP). 2006. Last accessed 06/16/06. NIH07 and NTP-2000 Historical control data. Available at http://ntp-server.niehs.nih. gov/ntpweb/index.cfm?objectid=92E61F1B-F1F6-975E-7D3BED551F07DC0A
46. Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RSK, Küppers R, Dalla-Favera R. 2001. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 412:341-346.
47. Pathology Working Group (PWG) Chairperson's Report: Lifetime study in rats conducted by the Ramazzini Foundation. Prepared by JR Hailey (Pathology Working Group Chair) NIEHS and submitted to F. Belpoggi November 30, 2004.
48. Priola AM, Priola SM, Cardinale L, Cataldi A, Fava C. 2006. The anterior mediastinum: Diseases. Radiol Med (Torino) 111:312-342.
49. Ramazzini Foundation. 2006. European Ramazzini Foundation stands behind aspartame study results, announces ongoing research on artificial sweeteners. Available at http://www.ramzzini/it/eng/fondazione/eventidettagli.asp?id=292
50. Razin S, Yogev D, Naot Y. 1998. Molecular biology and pathology of mycoplasmas. Microbiol Mol Biol Rev 62:1094-1156.
51. Rosell M, Lacorte S, Forner C, Rohns HP, Irmscher R, Barcelo D. 2005. Fate of gasoline oxygenates in conventional and multilevel wells of a contaminated groundwater table in Dusseldorf, Germany. Environ Toxicol Chem 24:2785-2795.
52. Sedman RM, Beaumont J, McDonald TA, Reynolds S, Krowech G, Howd R. 2006. Review of the evidence regarding the carcinogenicity of hexavalent chromium in drinking water. J Environ Sci Health C: Environ Carcinog Ecotoxicol Rev 24:155-182.
53. Smith MT, Skibola CF, Allan JM, Morgan GJ. 2004. Causal models of leukemia and lymphoma. IARC Sci Publ 157:373-392.
54. Soffritti M, Belpoggi F, Minardi F, Maltoni C. 2002a. Ramazzini Foundation Cancer Program: History and major projects, life-span carcinogenicity bioassay design, chemicals studies, and results. Ann NY Acad Sci 982:26-45.
55. Soffritti M, Belpoggi F, Cevolani D, Guarino M, Padovani M, Maltoni C. 2002b. Results of the long-term experimental studies on the carcinogenicity of methyl alcohol and ethyl alcohol in rats. Ann N Y Acad Sci 982:46-69.
56. Soffritti M, Belpoggi F, Eposti DD, Lambertini L, Tibaldi E, Rigano A. 2006a. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered to the feed to Sprague-Dawley rats. Environ Health Perspect 114:379-385.
57. Soffritti M. 2006b.On the basis of individual animal data from the Belpoggi et al. (1998) study and general information regarding ERF studies provided in a personal communication from Kathryn Knowles, European Foundation of Oncology and Environmental Sciences "B Ramazzini", to Jane Caldwell, US EPA, May 4 and July 6.
58. Soffritti M, Belpoggi F, Tibaldi E, Degli Esposti D, Lauriole M. 2007. Life-span exposure to low doses of aspartame beginning during the prenatal life increases cancer effects in rats. Environ Health Perspect 115:1293-1297.
59. Swaen GJ, van Heerde P. 1973. Tumours of the haematopoietic system. IARC Sci Publ 5:185-214.
60. Thornburg NJ, Kulwichit W, Edwards RH, Shair KHY, Bendt KM, Raab-Traub N. 2006. LMP1 signaling and activation of NF-κB in LMP1 transgenic mice. Oncogene 25:288-297.
61. U.S. EPA (Environmental Protection Agency). 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001F. Washington DC: Risk Assessment Forum, U.S. Environmental Protection Agency. Available: http://oaspub.epa.gov/ eims/eimscomm.getfile7p_download_id=439797[Accessed 8/05].
62. Zein MM, Suidan MT, Venosa AD. 2006. Bioremediation of groundwater contaminated with gasoline hydrocarbons and oxygenates using a membrane-based reactor. Environ Sci Technol 40:1997-2003.