Applications of the poly-K statistical test to life-time cancer bioassay studies

Human and Ecological Risk Assessment

Volumn 15, Issue 5, 2009, Pages 858-875

  Gebregziabher, Mulugeta ^a   Hoel, David ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Logistic regression score test; Logrank test; Power; Re weighted poly k test; Survival adjusted trend tests; Type I error

Indexed keywords

ANIMALIA;

EID: 75649133251     PISSN: 10807039     EISSN: 15497860     Source Type: Journal    
DOI: 10.1080/10807030903153360     Document Type: Article

References (23)

1. Armitage P. 1955. Tests for linear trends in proportions and frequencies. Biometrics 11:375-86
2. Bailer AJ and Portier CJ. 1988. Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples. Biometrics 44:417-31
3. Baker GS, Nakamura DW, and Hoel DG. 2007. Comparison of two models of cancer risk estimation: A statistical analysis. EuropeanJ Oncology 11:165-76
4. Belpoggi F, Soffritti M, and Maltoni C. 1995. Methyl-tertiary-butyl ether (MTBE)-a gasoline additive-causes testicular and lymphohaematopoietic cancers in rats. Toxicol Indust Health 11:119-49
5. Belpoggi F, Soffritti M, Filippini F, et al. 1997. Results of long-term experimental studies on the carcinogenicity of methyl tert-butyl ether. Annals NY Acad Sci 837:77-95
6. Belpoggi F, Soffritti M, and Maltoni C. 1998. Pathological characterization of testicular tumors and lymphomas-leukemias, and of their precursors observed in Spague-Dawley rats exposed to methyl-teriary-butyl-ether (MTBE). European J Oncology 3:201-6
7. Belpoggi F, Soffritti M, Padovani M, et al. 2006. Results of long-term carcinogenicity bioassay on Sprague-Dawley rats exposed to aspartame administered in feed. Annals NY Acad Sci 1076:559-77
8. Bieler G and Williams R. 1993. Ratio estimates, the delta method and quantal response tests for increased carcinogenicity. Biometrics 49:793-801
9. Cochran WG. 1954. Some methods of strengthening the common Chi-square tests. Biometrics 10:417-51
10. Dinse GE. 1994. A comparison of tumor incidence analyses applicable in single-sacrifice animal experiments. Statistics in Medicine 13:689-708
11. Dinse GE and Lagakos SW. 1983. Regression analysis of tumor prevalence data. App Statistics 32:236-48
12. Gart J, Chu K, and Tarone R. 1979. Statistical Issues in the interpretation of chronic bioassay tests for carcinigenecity. J NCI 62:957-74
13. Goodman JE, Gaylor DW, Beyer LA, et al. 2007. accepted for publication. Effects of MTBE on Leydig cell tumors in Sprague - Dawley rats: Range of possible poly-3 results. Regul Toxicol Pharmacol doi:10.1016/j.yrtph.2007.05.002
14. Hoel DG and Walburg HEJ. 1972. Statistical analysis of survival experiments. J NCI 49:361-72
15. Hollander M. and Wolfe DA. 1999. Nonparametric Statistical Methods. Wiley & Sons Inc, Weinheim, Germany
16. Kalbfliesch JD and Prentice RL. 2002. The Statistical Analysis of Failure Time Data. John Wiley and Sons, Hoboken, NJ, USA
17. Moon H, Ahn H, Kodell RL, et al. 2003. Estimation of k for the poly-k test with application to animal carcinogenicity studies. Statistics in Medicine 22:2619-36
18. Peddada DS, Dinse GE, and Haseman JK. 2005. A survival adjusted quantal response test for comparing tumor incidence rates. Appl Statistics 54:51-61
19. Peto R, Pike MC, Day NE, et al. 1980. Guidelines for Simple, Sensitive Significance Tests for Carcinogenic Effects in Long-Term Animal Experiments. IARC Monographs, Supplement 2: Long-Term and Short-Term Screening Assays for Carcinogens: A Critical Appraisal, pp 311-426. International Agency for Research on Cancer, Lyon, France
20. Piegorsch WW and Bailer AJ. 1997. Statistics for Environmental Biology and Toxicology. Chapman & Hall, New York, NY, USA
21. Portier CJ and Bailer AJ. 1989. Testing for increased carcinogenicity using a survival-adjusted quantal response test. Fundamental App Toxicol 12:731-7
22. Portier CJ, Hedges JC, and Hoel DG. 1986. Age-specific models of mortality and tumor onset for historical control animals in the National Toxicology Program's carcinogenicity experiments. Cancer Res 46:4372-8
23. STP Peto Working Group. 2002. Statistical methods for carcinogenicity studies. Toxicologic Pathology 30:403-12