MTBE: Recent carcinogenicity studies

International Journal of Occupational and Environmental Health

Volumn 18, Issue 1, 2012, Pages 66-69

  Burns, Kathleen M ^a   Melnick, Ronald L ^b  

^a Sciencecorps   (United States)

^b Consulting LLC ^*  (United States)

Author keywords

Brain tumors; Carcinogenicity; Gasoline oxygenate; MTBE; Water contaminant

Indexed keywords

CARCINOGEN; DRINKING WATER; ETHER DERIVATIVE; TERT BUTYL METHYL ETHER;

ANIMAL; ARTICLE; BRAIN TUMOR; CHEMICALLY INDUCED DISORDER; FEMALE; FISCHER 344 RAT; HEALTH SURVEY; HUMAN; MALE; RAT; STANDARD; WATER POLLUTANT; WISTAR RAT;

ANIMALS; BRAIN NEOPLASMS; CARCINOGENS; DRINKING WATER; FEMALE; HEALTH STATUS INDICATORS; HUMANS; MALE; METHYL ETHERS; RATS; RATS, INBRED F344; RATS, WISTAR; WATER POLLUTANTS, CHEMICAL;

EID: 84861735448     PISSN: 10773525     EISSN: None     Source Type: Journal    
DOI: 10.1179/107735212X13293200778947     Document Type: Article

References (25)

1. Bird MG, Burleigh-Flayer HD, Chun JS, Douglas JF, Kneiss JJ, Andrews LS. Oncogenicity studies of inhaled methyl tertiary-butyl ether (MTBE) in CD-1 mice and F-344 rats. J Appl Toxicol 1997;17:S45-55.
2. Belpoggi F, Soffritti M, Maltoni C. Pathological characterization of testicular tumors and lymphomas-leukaemias, and of their precursors observed in Sprague-Dawley rats exposed to methyl-tertiary-butyl-ether (MTBE). Eur J Oncol 1998;3:201-6.
3. Dodd DE, Layko DK, Bermudez E. Methyl tertiary-butyl ether (MTBE): two-year combined chronic toxicity/carcinogenicity drinking water study in Wistar rats. Protocol Number 07001. Research Triangle Park, NC: Hamner Institute for Health Sciences; 2010. Available from the following: http://hero.epa.gov/ index.cfm?action=search.view&reference_id=835572 http://hero. epa.gov/index.cfm?action=search.view&reference_id=835686 http:// hero.epa.gov/index.cfm?action=search.view&reference_id=835697 http://hero.epa.gov/index.cfm?action=search.view&reference_id=835726 http://hero.epa.gov/index.cfm?action=search.view&reference_id=835761
4. Benson JM, Gigliotti AP, March TH, Barr EB, Tibbetts BM, Skipper BJ, et al. Chronic carcinogenicity study of gasoline vapor condensate (GVC) and GVC containing methyl tertiarybutyl ether in F344 rats. J Toxicol Environ Health A2011;74:638-57
5. US Environmental Protection Agency. Methyl tertiary butyl ether (MTBE) overview; 2008. [cited 2011] Available from: http://www. epa.gov/mtbe/faq.htm
6. Haseman JK, Huff J, Boorman GA. Use of historical control data in carcinogenicity studies in rodents. Toxicol Pathol 1984;12:126-35.
7. Haseman JK, Boorman GA, Huff J. Value of historical control data and other issues related to the evaluation of long-term rodent carcinogenicity studies. Toxicol Pathol 1997;25:524-7.
8. Keenan C, Elmore S, Francke-Carroll S, Kemp R, Kerlin R, Peddada S, et al. Best practices for use of historical control data of proliferative rodent lesions. Toxicol Pathol 2009;37:679-3
9. Walsh KM, Poteracki J. Spontaneous neoplasms in control Wistar rats. Fundam Appl Toxicol 1994;22:65-72.
10. Poteracki J, Walsh KM. Spontaneous neoplasms in control Wistar rats: a comparison of reviews. Toxicol Sci 1998;45:1-8.
11. Weber K, Garman RH, Germann PG, Hardisty JF, Krinke G, Millar P, et al. Classification of neural tumors in laboratory rodents, emphasizing the rat. Toxicol Pathol 2011;39:129-51.
12. Boorman GA, Montgomery CA, Jr, Eustis SL, Wolfe MJ, McConnell EE, Hardisty JF. Quality assurance in pathology for rodent carcinogenicity studies. In: Milman HA, Weisburger EK, editors. Handbook of carcinogen testing. Park Ridge, NJ: Noyes Publications; 1985. p. 345-67.
13. Prescott-Mathews JS, Poet TS, Borghoff SJ. Evaluation of the in vivo interaction of methyl tert-butyl ether with alpha2uglobulin nephropathy in male F-344 rats. Toxicol Appl Pharmacol 1999;157:60-7.
14. Prescott-Mathews JS, Wolf DC, Wong BA, Borghoff SJ. Methyl tert-butyl ether causes alpha2u-globulin nephropathy and enhanced renal cell proliferation in male Fischer-344 rats. Toxicol Appl Pharmacol 1997;143:301-14.
15. Capen CC, Dybing E, Rice JM, Wilbourn JD, editors. Species differences in thyroid, kidney and urinary bladder carcinogenesis. IARC Scientific Publication No. 147. Lyon: International Agency for Research on Cancer; 1999.
16. US Environmental Protection Agency (US EPA). Alpha 2uglobulin association with chemically induced renal toxicity and neoplasia in the male rat. Risk Assessment Forum. EPA/625/3-91/019F. Washington, DC: US Environmental Protection Agency; 1991.
17. Swenberg JA, Dietrich DR. Immunohistochemical localization of a2u-globulin in kidneys of treated and control rats of a 13-week vapor inhalation study undertaken with methyl tertiary butyl ether (MTBE). Report to the MTBE Health Effects Testing Task Force. 1991.
18. Melnick RL, Kohn MC. Possible mechanisms of induction of renal tubular cell neoplasms in rats associated with a2uglobulin: role of protein accumulation versus ligand delivery to the kidney. In: Capen CC, Dybing E, Rice JM, Wilbourn JD, editors. Species differences in thyroid, kidney and urinary bladder carcinogenesis. IARC Scientific Publication No. 147. Lyon: International Agency for Research on Cancer; 1999. p. 119-37.
19. Melnick RL, White MC, Davis JM, Hartle RW, Ghanayem B, Ashley DL, et al. Potential health effects of oxygenated gasoline. In: Interagency assessment of oxygenated fuels. Washington, DC: National Science and Technology Council; 1997. p. 4.1-4.38
20. Brady JF, Xiao F, Ning SM, Yang CS. Metabolism of methyl tertiary-butyl ether by rat hepatic microsomes. Arch Toxicol 1990;64:157-60.
21. International Agency for Research on Cancer (IARC). Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropan-2-ol. Vol. 88. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Lyon: IARC; 2006.
22. Baan R, Grosse Y, Straif K, Secretan B, El Ghissassi F, Bouvard V et al. A review of human carcinogens-Part F: Chemical agents and related occupations. Lancet Oncol 2009;10:1143-4.
23. International Agency for Research on Cancer (IARC). [cited 2011] Available from: http://monographs.iarc.fr/ENG/ Preamble/index.php
24. National Toxicology Program. [cited 2011] Available from: http:// ntp.niehs.nih.gov/?objectid=47B37760-F1F6-975E-7C15022B9C93B5A6
25. US Environmental Protection Agency. Guidelines for carcinogen risk assessment. EPA/630/P-03/001F. Washington, DC: US Environmental Protection Agency; 2005.