메뉴 건너뛰기




Volumn 53, Issue 12, 2010, Pages 1197-1206

Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice

Author keywords

Artificial sweeteners; Aspartame; Cancers; Carcinogenicity; Hepatocarcinomas; Lung adenocarcinomas; Prenatal exposure; Rats; Swiss mice

Indexed keywords

ASPARTAME; CARCINOGEN; SWEETENING AGENT;

EID: 78649538952     PISSN: 02713586     EISSN: 10970274     Source Type: Journal    
DOI: 10.1002/ajim.20896     Document Type: Article
Times cited : (90)

References (38)
  • 2
    • 0011212735 scopus 로고
    • Attuazione della direttiva n. 86/609/CEE in materia di protezione degli animali utilizzati a fini sperimentali o ad altri fini scientifici [in Italian]
    • Decreto Legislativo 116.
    • Decreto Legislativo 116. 1992. Attuazione della direttiva n. 86/609/CEE in materia di protezione degli animali utilizzati a fini sperimentali o ad altri fini scientifici [in Italian]. Suppl Ordinario Gazz Ufficiale 40: 5-25.
    • (1992) Suppl Ordinario Gazz Ufficiale , vol.40 , pp. 5-25
  • 3
    • 48549094492 scopus 로고    scopus 로고
    • Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studies
    • Dixon D, Herbert RA, Kissling GE, Brix AE, Miller RA, Maronpot RR. 2008. Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studies. Toxicol Pathol 36: 428-439.
    • (2008) Toxicol Pathol , vol.36 , pp. 428-439
    • Dixon, D.1    Herbert, R.A.2    Kissling, G.E.3    Brix, A.E.4    Miller, R.A.5    Maronpot, R.R.6
  • 4
    • 46649108278 scopus 로고    scopus 로고
    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to a new long-term carcinogenicity study on aspartame. Question number EFSA-Q-2005-122. Adopted on 3 May 2006
    • European Food Safety Authority (EFSA).
    • European Food Safety Authority (EFSA). 2006. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to a new long-term carcinogenicity study on aspartame. Question number EFSA-Q-2005-122. Adopted on 3 May 2006. EFSA J 356: 1-44.
    • (2006) EFSA J , vol.356 , pp. 1-44
  • 5
    • 0344988510 scopus 로고
    • Aspartame: Commissioner's final decision
    • Food and Drug Administration (FDA).
    • Food and Drug Administration (FDA). 1981. Aspartame: Commissioner's final decision. Fed Reg 46: 38285-38308.
    • (1981) Fed Reg , vol.46 , pp. 38285-38308
  • 6
    • 0842263443 scopus 로고
    • Food additives permitted for direct addition to food for human consumption: Aspartame
    • Food and Drug Administration (FDA).
    • Food and Drug Administration (FDA). 1983. Food additives permitted for direct addition to food for human consumption: Aspartame. Fed Reg 48: 31376-31382.
    • (1983) Fed Reg , vol.48 , pp. 31376-31382
  • 7
    • 0842328274 scopus 로고    scopus 로고
    • Food additives permitted for direct addition to food for human consumption: Aspartame
    • Food and Drug Administration (FDA).
    • Food and Drug Administration (FDA). 1996. Food additives permitted for direct addition to food for human consumption: Aspartame. Fed Reg 61: 33654-33656.
    • (1996) Fed Reg , vol.61 , pp. 33654-33656
  • 10
    • 0004017862 scopus 로고
    • Proteins
    • New York, John Wiley & Sons, p
    • Haschemeyer RH, Haschemeyer AEV. 1973. Proteins. New York: John Wiley & Sons, p 11-30.
    • (1973) , pp. 11-30
    • Haschemeyer, R.H.1    Haschemeyer, A.E.V.2
  • 11
    • 0026556048 scopus 로고
    • Value of historical controls in the interpretation of rodent neoplasm data
    • Haseman J. 1992. Value of historical controls in the interpretation of rodent neoplasm data. Drug Inf J 26: 191-200.
    • (1992) Drug Inf J , vol.26 , pp. 191-200
    • Haseman, J.1
  • 12
    • 0028901961 scopus 로고
    • Data analysis: Statistical analysis and use of historical control data
    • Haseman J. 1995. Data analysis: Statistical analysis and use of historical control data. Regul Toxicol Pharmacol 21: 52-59.
    • (1995) Regul Toxicol Pharmacol , vol.21 , pp. 52-59
    • Haseman, J.1
  • 13
    • 0021148721 scopus 로고
    • Use of historical control data in carcinogenicity studies in rodents
    • Haseman J, Huff JE, Boorman GA. 1984. Use of historical control data in carcinogenicity studies in rodents. Toxicol Pathol 12: 126-135.
    • (1984) Toxicol Pathol , vol.12 , pp. 126-135
    • Haseman, J.1    Huff, J.E.2    Boorman, G.A.3
  • 14
    • 0034970078 scopus 로고    scopus 로고
    • Carcinogenesis bioassays: Study duration and biological relevance
    • Haseman J, Melnick R, Tomatis L, Huff J. 2001. Carcinogenesis bioassays: Study duration and biological relevance. Food Chem Toxicol 39(7): 739-744.
    • (2001) Food Chem Toxicol , vol.39 , Issue.7 , pp. 739-744
    • Haseman, J.1    Melnick, R.2    Tomatis, L.3    Huff, J.4
  • 15
    • 78649628337 scopus 로고    scopus 로고
    • Hazardous Substances Data Bank., TOXNET: Toxicological Data Network. Available: [accessed August 3, 2005].
    • Hazardous Substances Data Bank. 2005. TOXNET: Toxicological Data Network. Available: [accessed August 3, 2005].
    • (2005)
  • 16
    • 0036962522 scopus 로고    scopus 로고
    • Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program. In tribute to Cesare Maltoni and David Rall
    • Huff J. 2002. Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program. In tribute to Cesare Maltoni and David Rall. Ann N Y Acad Sci 982: 208-230.
    • (2002) Ann N Y Acad Sci , vol.982 , pp. 208-230
    • Huff, J.1
  • 17
    • 0043287924 scopus 로고    scopus 로고
    • Absence of carcinogenic activity in Fischer rats and B6C3F1 mice following 103-week inhalation exposures to toluene
    • Huff J. 2003. Absence of carcinogenic activity in Fischer rats and B6C3F1 mice following 103-week inhalation exposures to toluene. Int J Occup Environ Health 9(2): 138-146.
    • (2003) Int J Occup Environ Health , vol.9 , Issue.2 , pp. 138-146
    • Huff, J.1
  • 18
    • 58849098055 scopus 로고    scopus 로고
    • The limits of two-year bioassay exposure regimens for identifying chemical carcinogens
    • Huff J, Jacobson MF, Davis DL. 2008. The limits of two-year bioassay exposure regimens for identifying chemical carcinogens. Environ Health Perspect 116(11): 1439-1442.
    • (2008) Environ Health Perspect , vol.116 , Issue.11 , pp. 1439-1442
    • Huff, J.1    Jacobson, M.F.2    Davis, D.L.3
  • 19
  • 20
    • 0015787035 scopus 로고
    • Transplacental induction of tumors and malformations in rats treated with some chemical carcinogens
    • International Agency for Research on Cancer (IARC).
    • International Agency for Research on Cancer (IARC). 1973. Transplacental induction of tumors and malformations in rats treated with some chemical carcinogens. IARC Sci Publ 4: 100-111.
    • (1973) IARC Sci Publ , vol.4 , pp. 100-111
  • 21
    • 0031587502 scopus 로고    scopus 로고
    • Results of long-term experimental carcinogenicity studies of the effects of gasoline, correlated fuels and major gasoline aromatics on rats
    • Maltoni C, Ciliberti A, Pinto C, Soffritti M, Belpoggi F, Menarini L. 1997. Results of long-term experimental carcinogenicity studies of the effects of gasoline, correlated fuels and major gasoline aromatics on rats. Ann N Y Acad Sci 837: 15-52.
    • (1997) Ann N Y Acad Sci , vol.837 , pp. 15-52
    • Maltoni, C.1    Ciliberti, A.2    Pinto, C.3    Soffritti, M.4    Belpoggi, F.5    Menarini, L.6
  • 22
    • 70349680623 scopus 로고    scopus 로고
    • Biological basis of differential susceptibility to hepatocarcinogenesis among mouse strains
    • Maronpot RR. 2009. Biological basis of differential susceptibility to hepatocarcinogenesis among mouse strains. J Toxicol Pathol 22: 11-33.
    • (2009) J Toxicol Pathol , vol.22 , pp. 11-33
    • Maronpot, R.R.1
  • 24
    • 0003532399 scopus 로고
    • Aspartame physiology and biochemistry
    • In, Stegink LD, Filer LJ, Jr., editors., New York, Dekker, p
    • Mazur RH. 1984. Discovery of aspartame. In: Stegink LD, Filer LJ, Jr., editors. Aspartame physiology and biochemistry. New York: Dekker, p 3-9.
    • (1984) Discovery of aspartame , pp. 3-9
    • Mazur, R.H.1
  • 25
    • 0003627588 scopus 로고
    • Biochemistry
    • New York, Academic Press, p
    • Metzler DE. 1977. Biochemistry. New York: Academic Press, p 90-107.
    • (1977) , pp. 90-107
    • Metzler, D.E.1
  • 26
    • 78649579762 scopus 로고
    • Aspartame physiology and biochemistry
    • In, Stegink LD, Filer LJ, Jr., editors., New York, Dekker, p
    • Molinary SV. 1984. Preclinical studies of aspartame in nonprimate animals. In: Stegink LD, Filer LJ, Jr., editors. Aspartame physiology and biochemistry. New York: Dekker, p 289-306.
    • (1984) Preclinical studies of aspartame in nonprimate animals , pp. 289-306
    • Molinary, S.V.1
  • 27
    • 78649591105 scopus 로고    scopus 로고
    • National Toxicology Program (NTP)., Genetically Modified Model Report. Toxicology Studies of Aspartame (CAS NO. 22839-47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2atm1Rdp (N2) Deficient Mice and Carcinogenicity Studies of Aspartame in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Feed Studies). NTP GMM1. National Toxicology Program, Research Triangle Park. Available at: .
    • National Toxicology Program (NTP). 2005. Genetically Modified Model Report. Toxicology Studies of Aspartame (CAS NO. 22839-47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2atm1Rdp (N2) Deficient Mice and Carcinogenicity Studies of Aspartame in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Feed Studies). NTP GMM1. National Toxicology Program, Research Triangle Park. Available at.
    • (2005)
  • 32
    • 0036960610 scopus 로고    scopus 로고
    • Ramazzini Foundation cancer program: History and major projects, life-span carcinogenicity bioassay design, chemicals studied, and results
    • Soffritti M, Belpoggi F, Minardi F, Maltoni C. 2002. Ramazzini Foundation cancer program: History and major projects, life-span carcinogenicity bioassay design, chemicals studied, and results. Ann N Y Acad Sci 982: 26-45.
    • (2002) Ann N Y Acad Sci , vol.982 , pp. 26-45
    • Soffritti, M.1    Belpoggi, F.2    Minardi, F.3    Maltoni, C.4
  • 35
    • 33644771206 scopus 로고    scopus 로고
    • First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats
    • Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L, Tibaldi E, Rigano A. 2006. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environ Health Perspect 114: 379-385.
    • (2006) Environ Health Perspect , vol.114 , pp. 379-385
    • Soffritti, M.1    Belpoggi, F.2    Degli Esposti, D.3    Lambertini, L.4    Tibaldi, E.5    Rigano, A.6
  • 36
    • 34748884376 scopus 로고    scopus 로고
    • Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats
    • Soffritti M, Belpoggi F, Tibaldi E, Esposti DD, Lauriola M. 2007. Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats. Environ Health Perspect 115: 1293-1297.
    • (2007) Environ Health Perspect , vol.115 , pp. 1293-1297
    • Soffritti, M.1    Belpoggi, F.2    Tibaldi, E.3    Esposti, D.D.4    Lauriola, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.