Commentary: Update on animal models for NTP studies

Toxicologic Pathology

Volumn 38, Issue 1, 2010, Pages 180-181

  King Herbert, Angela P ^a   Sills, Robert C ^a   Bucher, John R ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Animal models; B6C3F1 N mouse; F344 N rat; NTP; Sprague dawley rat; Wistar Han rat

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON; DIOXIN;

ANIMAL MODEL; BIOASSAY; EXPOSURE; GENE MUTATION; GENETIC SUSCEPTIBILITY; LEUKEMIA; LIVER CANCER; MALIGNANT NEOPLASTIC DISEASE; MOUSE STRAIN; NONHUMAN; NOTE; PRIORITY JOURNAL; REPRODUCTION; RODENT; SPRAGUE DAWLEY RAT; TESTIS CANCER; TOXICOLOGY; ANIMAL; ARTICLE; CARCINOGEN TESTING; DISEASE MODEL; FISCHER 344 RAT; METHODOLOGY; MOUSE; RAT;

ANIMALIA; MUS; RATTUS; RODENTIA;

ANIMALS; CARCINOGENICITY TESTS; DISEASE MODELS, ANIMAL; MICE; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY;

EID: 77952318264     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623309356450     Document Type: Note

References (4)

1. Festing, M. F. (1995). Use of a multistrain assay could improve the NTP carcinogenesis bioassay. Environ Health Perspect 103, 44-52.
2. Hedrich, H. J. (2006). Taxonomy and stocks and strains. In The Laboratory Rat (M. Suckow, S. Weisbroth, and C. Franklin, eds.), pp. 71-92. Elsevier Academic, Burlington, MA.
3. King-Herbert, A., and Thayer, K. (2006). NTP workshop: Animal models for the NTP rodent cancer bioassay: stocks and strains-should we switch? Toxicol Pathol 34, 802-805
4. Pohjanvirta, R., Wong, J. M. Y., Li, W., Harper, P. A., Tuomisto, J., and Okey, A. B. (1998). Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain. Mol Pharmacol 54, 86-93.