The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation

Endocrinology

Volumn 154, Issue 12, 2013, Pages 4640-4649

  Mei, Yun ^a,b   Yin, Naida ^a   Jin, Xia ^a   He, Jiangyan ^a   Yin, Zhan ^a  

^a INSTITUTE OF HYDROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; HEMOGLOBIN F; ISOPRENALINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PHENYLEPHRINE; HEMOGLOBIN BETA CHAIN; HEMOGLOBIN GAMMA CHAIN; HISTONE;

ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN K 562; DRUG EFFECT; ERYTHROID CELL; ERYTHROPOIESIS; HISTONE ACETYLATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ZEBRA FISH; ANIMAL; CELL LINE; CYTOLOGY; ERYTHROLEUKEMIA; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROMOTER REGION; SIGNAL TRANSDUCTION;

ANIMALS; BETA-GLOBINS; CELL DIFFERENTIATION; CELL LINE; ERYTHROID CELLS; FETAL HEMOGLOBIN; GAMMA-GLOBINS; GENE EXPRESSION REGULATION; HISTONES; HUMANS; ISOPROTERENOL; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENYLEPHRINE; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; ZEBRAFISH;

EID: 84888272506     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1535     Document Type: Article

References (41)

1. Testa U. Fetal hemoglobin chemical inducers for treatment of hemoglobinopathies. Ann Hematol. 2009;88:505-528.
2. Sankaran VG, Xu J, Orkin SH. Advances in the understanding of haemoglobin switching. Br J Haematol. 2010;149:181-194.
3. Tiedke J, Gerlach F, Mitz SA, Hankeln T, Burmester T. Ontogeny of globin expression in zebrafish (Danio rerio). J Comp Physiol B. 2011;181:1011-1021.
4. Chan FY, Robinson J, Brownlie A, et al. Characterization of adult α- and β-globin genes in the zebrafish. Blood. 1997;89:688-700.
5. Brownlie A, Hersey C, Oates AC, et al. Characterization of embryonic globin genes of the zebrafish. Dev Biol. 2003;255:48-61.
6. Song HD, Sun XJ, Deng M, et al. Hematopoietic gene expression profile in zebrafish kidney marrow. Proc Natl Acad Sci USA. 2004;101:16240-16245.
7. Mikaelian I, Coluccio D, Morgan KT, et al. Temporal gene expression profiling indicates early up-regulation of interleukin-6 in isoproterenol- induced myocardial necrosis in rat. Toxicol Pathol. 2008;36:256-264.
8. Trivedi CM, Luo Y, Yin Z, et al. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 β activity. Nat Med. 2007;13:324-331.
9. Yin N, Jin X, He J, Yin Z. Effects of adrenergic agents on the expression of zebrafish (Danio rerio) vitellogenin Ao1. Toxicol Appl Pharmacol. 2009;238:20-26.
10. Olek A, Oswald J, Walter J. A modified and improved method for bisulphite based cytosine methylation analysis. Nucleic Acids Res. 1996;24:5064-5066.
11. Fathallah H, Portnoy G, Atweh GF. Epigenetic analysis of the human α- and β-globin gene clusters. Blood Cells Mol Dis. 2008;40:166-173.
12. Witt O, Monkemeyer S, Rönndahl G, et al. Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. Blood. 2003;101:2001-2007.
13. Pace BS, Qian XH, Sangerman J, Ofori-Acquah SF, et al. p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors. Exp Hematol. 2003;31:1089-1096.
14. Jiang J, Best S, Menzel S, et al. cMYB is involved in the regulation of fetal hemoglobin production in adults. Blood. 2006;108:1077-1083.
15. Fathallah H, Weinberg RS, Galperin Y, Sutton M, Atweh GF. Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin. Blood. 2007;110:3391-3397.
16. Sangerman J, Lee MS, Yao X, et al. Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves γ-globin activation by CREB1 and ATF-2. Blood. 2006;108:3590-3599.
17. Sevinsky JR, Whalen AM, Ahn NG. Extracellular signal-regulated kinase induces the megakaryocyte GPIIb/CD41 gene through MafB/Kreisler. Mol Cell Biol. 2004;24:4534-4545.
18. Morera D, Roher N, Ribas L, et al. RNA-Seq reveals an integrated immune response in nucleated erythrocytes. PLoS One. 2011;6:e26998.
19. Wang Z, Nishimura Y, Shimada Y, et al. Zebrafish β-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009;446:18-27.
20. Bianchi N, Zuccato C, Lampronti I, Borgatti M, Gambari R. Fetal hemoglobin inducers from the natural world: a novel approach for identification of drugs for the treatment of β-thalassemia and sickle-cell anemia. Evid Based Complement Alternat Med. 2009;6:141-151.
21. Liu K, Xing H, Zhang S, Liu S, Fung Mc. Cucurbitacin D induces fetal hemoglobin synthesis in K562 cells and human hematopoietic progenitors through activation of p38 pathway and stabilization of the γ-globin mRNA. Blood Cells Mol Dis. 2010;45:269-275.
22. Lampronti I, Bianchi N, Borgatti M, Fibach E, Prus E, Gambari R. Accumulation of γ-globin mRNA in human erythroid cells treated with angelicin. Eur J Haematol. 2003;71:189-195.
23. Sawafuji K, Miyakawa Y, Kizaki M, Ikeda Y. Cyclosporin A induces erythroid differentiation of K562 cells through p38 MAPK and ERK pathways. Am J Hematol. 2003;72:67-69.
24. Aggeli IK, Gaitanaki C, Lazou A, Beis I. α(1)- And β-adrenoceptor stimulation differentially activate p38-MAPK and atrial natriuretic peptide production in the perfused amphibian heart. J Exp Biol. 2002;205:2387-2397.
25. Shelly C, Petruzzelli L, Herrera R. PMA-induced phenotypic changes in K562 cells: MAPK-dependent and -independent events. Leukemia. 1998;12:1951-1961.
26. McElveen RL, Lou TF, Reese K, Xia S, Baliga BS, Pace BS. Erk pathway inhibitor U0126 induces γ-globin expression in erythroid cells. Cell Mol Biol (Noisy-le-grand). 2005;51:215-227.
27. De Cesare D, Fimia GM, Sassone-Corsi P. Signaling routes to CREM and CREB: plasticity in transcriptional activation. Trends Biochem Sci. 1999;24:281-285.
28. Kuroyanagi Y, Kaneko Y, Muta K, et al. cAMP differentially regulates gamma-globin gene expression in erythroleukemic cells and primary erythroblasts through c-Myb expression. Biochem Biophys Res Commun. 2006;344:1038-1047.
29. Olivieri NF, Weatherall DJ. The therapeutic reactivation of fetal haemoglobin. Hum Mol Genet. 1998;7:1655-1658.
30. Fonseca RB, Mohr AM, Wang L, et al. Adrenergic modulation of erythropoiesis following severe injury is mediated through bone marrow stroma. Surg Infect (Larchmt). 2004;5:385-393.
31. Oneal PA, Gantt NM, Schwartz JD, et al. Fetal hemoglobin silencing in humans. Blood. 2006;108:2081-2086.
32. Gauwerky C, Golde DW. Hormonal effects on cell proliferation in a human erythroleukemia cell line (K562). Blood. 1980;56:886-891.
33. Fuchs R, Stelzer I, Haas HS, Leitinger G, Schauenstein K, Sadjak A. The α1-adrenergic receptor antagonists, benoxathian and prazosin, induce apoptosis and a switch towards megakaryocytic differentiation in human erythroleukemia cells. Ann Hematol. 2009;88:989-997.
34. Fuchs R, Schraml E, Leitinger G, et al. α1-Adrenergic drugs exhibit affinity to a thapsigargin-sensitive binding site and interfere with the intracellular Ca2+ homeostasis in human erythroleukemia cells. Exp Cell Res. 2011;317:2969-2980.
35. Thiele RH, Nemergut EC, Lynch C 3rd. The clinical implications of isolated α(1) adrenergic stimulation. Anesth Analg. 2011;113:297-304.
36. Pearce N, Hensley MJ. Epidemiologic studies of β agonists and asthma deaths. Epidemiol Rev. 1998;20:173-186.
37. Dar MS, Al-Rejaie S. Tonic modulatory role of mouse cerebellar α- and β-adrenergic receptors in the expression of ethanol-induced ataxia: role of AC-cAMP. Behav Brain Res. 2013;241:154-160.
38. Markou T, Hadzopoulou-Cladaras M, Lazou A. Phenylephrine induces activation of CREB in adult rat cardiac myocytes through MSK1 and PKA signaling pathways. J Mol Cell Cardiol. 2004;37:1001-1011.
39. Fathallah H, Atweh GF. Induction of fetal hemoglobin in the treatment of sickle cell disease. Hematology Am Soc Hematol Educ Program. 2006;2006:58-62.
40. Sripichai O, Kiefer CM, Bhanu NV, et al. Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming. Blood. 2009;114:2299-2306.
41. Chan SW, Hu M, Tomlinson B. The pharmacogenetics of β-adrenergic receptor antagonists in the treatment of hypertension and heart failure. Expert Opin Drug Metab Toxicol. 2012;8:767-790.