The clinical implications of isolated alpha1 adrenergic stimulation

Anesthesia and Analgesia

Volumn 113, Issue 2, 2011, Pages 297-304

  Thiele, Robert H ^a   Nemergut, Edward C ^a   Lynch III, Carl ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; METHOXAMINE; NORADRENALIN; PHENYLEPHRINE;

ADULT RESPIRATORY DISTRESS SYNDROME; ALPHA ADRENERGIC STIMULATION; AORTA STENOSIS; ARTICLE; BRADYCARDIA; CARCINOID; CESAREAN SECTION; DRUG EFFECT; DRUG USE; FALLOT TETRALOGY; HEART LEFT VENTRICLE OUTFLOW TRACT OBSTRUCTION; HEART OUTPUT; HUMAN; HYPOTENSION; HYPOXEMIA; LUNG VENTILATION; OXYGEN SUPPLY; PATHOPHYSIOLOGY; PREGNANCY; PRIORITY JOURNAL; SEPTIC SHOCK; SUBARACHNOID HEMORRHAGE; SYSTEMATIC REVIEW; TRAUMATIC BRAIN INJURY;

EID: 79961027720     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3182120ca5     Document Type: Review

References (89)

1. Appleton C, Olajos M, Morkin E, Goldman S. Alpha-1 adrenergic control of the venous circulation in intact dogs. J Pharmacol Exp Ther 1985;233:729-34 (Pubitemid 15024441)
2. Curiel R, Perez-Gonzalez J, Brito N, Zerpa R, Tellez D, Cabrera J, Curiel C, Cubeddu L. Positive inotropic effects mediated by alpha 1 adrenoceptors in intact human subjects. J Cardiovasc Pharmacol 1989;14:603-15 (Pubitemid 19232770)
3. Landzberg JS, Parker JD, Gauthier DF, Colucci WS. Effects of myocardial alpha 1-adrenergic receptor stimulation and blockade on contractility in humans. Circulation 1991;84:1608-14
4. Yang HT, Endoh M. Dissociation of the positive inotropic effect of methoxamine from the hydrolysis of phosphoinositide in rabbit ventricular myocardium: A comparison with the effects of phenylephrine and the subtype of the alpha-1 adrenoceptor involved. J Pharmacol Exp Ther 1994;269:732-42 (Pubitemid 24157344)
5. Zimmerman BG, Abboud FM, Eckstein JW. Comparison of the effects of sympathomimetic amines upon venous and total vascular resistance in the foreleg of the dog. J Pharmacol Exp Ther 1963;139:290-5
6. Thiele R, Nemergut E, Lynch C III. The physiologic implications of isolated alpha-1 adrenergic stimulation. Anesth Analg 2011;113:284-96
7. Heath P, Geiter CW. Use of phenylephrine hydrochloride, neo-synephrine hydrochloride, in ophthalmology. Arch Ophthal 1949;41:172-7
8. Funk DJ, Moretti EW, Gan TJ. Minimally invasive cardiac output monitoring in the perioperative setting. Anesth Analg 2009;108:887-97
9. Glantz SA. Primer of Biostatistics. 6th ed. New York: McGraw- Hill Medical, 2005
10. Antonopoulos A, Nikolopoulos D, Georgiou EK, Kyriakidis M, Proukakis C. Blood pressure elevation after phenylephrine infusion may adversely affect myocardial perfusion in patients with coronary artery disease. Int J Cardiol 2002;84:201-9 (Pubitemid 34804492)
11. Loeb HS, Saudye A, Croke RP, Talano JV, Klodnycky ML, Gunnar RM. Effects of pharmacologically-induced hypertension on myocardial ischemia and coronary hemodynamics in patients with fixed coronary obstruction. Circulation 1978;57:41-6 (Pubitemid 8254672)
12. Miller RR, Awan NA, DeMaria AN, Amsterdam EA, Mason DT. Importance of maintaining systemic blood pressure during nitroglycerin administration for reducing ischemic injury in patients with coronary disease. Effects on coronary blood flow, myocardial energetics and left ventricular function. Am J Cardiol 1977;40:504-8 (Pubitemid 8219298)
13. Crystal GJ, Kim SJ, Salem MM, Abdel-Latif M. Myocardial oxygen supply/demand relations during phenylephrine infusions in dogs. Anesth Analg 1991;73:283-8
14. Woodman OL, Vatner SF. Coronary vasoconstriction mediated by alpha 1- and alpha 2-adrenoceptors in conscious dogs. Am J Physiol 1987;253:H388-93
15. Heyndrickx GR, Boettcher DH, Vatner SF. Effects of angiotensin, vasopressin, and methoxamine on cardiac function and blood flow distribution in conscious dogs. Am J Physiol 1976;231:1579-87
16. Langesaeter E, Rosseland LA, Stubhaug A. Continuous invasive blood pressure and cardiac output monitoring during cesarean delivery: A randomized, double-blind comparison of low-dose versus high-dose spinal anesthesia with intravenous phenylephrine or placebo infusion. Anesthesiology 2008;109:856-63
17. Brooker RF, Butterworth JFT, Kitzman DW, Berman JM, Kashtan HI, McKinley AC. Treatment of hypotension after hyperbaric tetracaine spinal anesthesia. A randomized, double-blind, crossover comparison of phenylephrine and epinephrine. Anesthesiology 1997;86:797-805
18. Sharrock NE, Go G, Mineo R, Harpel PC. The hemodynamic and fibrinolytic response to low dose epinephrine and phenylephrine infusions during total hip replacement under epidural anesthesia. Thromb Haemost 1992;68:436-41
19. Goertz AW, Schmidt M, Seefelder C, Lindner KH, Georgieff M. The effect of phenylephrine bolus administration on left ventricular function during isoflurane-induced hypotension. Anesth Analg 1993;77:227-31 (Pubitemid 23221418)
20. Goertz AW, Lindner KH, Seefelder C, Schirmer U, Beyer M, Georgieff M. Effect of phenylephrine bolus administration on global left ventricular function in patients with coronary artery disease and patients with valvular aortic stenosis. Anesthesiology 1993;78:834-41 (Pubitemid 23141356)
21. Lang RM, Borow KM, Neumann A, Janzen D. Systemic vascular resistance: An unreliable index of left ventricular afterload. Circulation 1986;74:1114-23 (Pubitemid 17174961)
22. Tuman KJ, McCarthy RJ, March RJ, Guynn TP, Ivankovich AD. Effects of phenylephrine or volume loading on right ventricular function in patients undergoing myocardial revascularization. J Cardiothorac Vasc Anesth 1995;9:2-8
23. Pang CC. Autonomic control of the venous system in health and disease: Effects of drugs. Pharmacol Ther 2001;90: 179-230 (Pubitemid 32926715)
24. Hirakawa S, Itoh H, Kotoo Y, Abe C, Endo T, Takada N, Fuseno H. The role of alpha and beta adrenergic receptors in constriction and dilation of the systemic capacitance vessels: A study with measurements of the mean circulatory pressure in dogs. Jpn Circ J 1984;48:620-32 (Pubitemid 14025403)
25. Eichler HG, Ford GA, Blaschke TF, Swislocki A, Hoffman BB. Responsiveness of superficial hand veins to phenylephrine in essential hypertension. Alpha adrenergic blockade during prazosin therapy. J Clin Invest 1989;83:108-12 (Pubitemid 19048412)
26. Brown BR. Selective venoconstriction by dopamine in comparison with isoproterenol and phenylephrine. Anesthesiology 1975;43:570-2
27. Flamm SD, Taki J, Moore R, Lewis SF, Keech F, Maltais F, Ahmad M, Callahan R, Dragotakes S, Alpert N, Strauss W. Redistribution of regional and organ blood volume and effect on cardiac function in relation to upright exercise intensity in healthy human subjects. Circulation 1990;81:1550-9 (Pubitemid 20158294)
28. Butterworth J. Do alpha agonists increase venous return? Anesthesiology 2004;101:1039
29. Smrcka M, Ogilvy CS, Crow RJ, Maynard KI, Kawamata T, Ames A 3rd. Induced hypertension improves regional blood flow and protects against infarction during focal ischemia: Time course of changes in blood flow measured by laser Doppler imaging. Neurosurgery 1998;42:617-24
30. O'Neill C, Fowler CJ, Winblad B. Alpha 1-adrenergic receptor binding sites in post-mortal human cerebral microvessel preparations: Preservation in multi-infarct dementia and dementia of Alzheimer type. J Neural Transm Park Dis Dement Sect 1989;1:303-10 (Pubitemid 20051709)
31. Mizuki T, Kobayashi H, Ueno S, Nakashima Y, Kuroiwa A, Izumi F. Differential changes in alpha- and betaadrenoceptors in the cerebral cortex and hippocampus of the Mongolian gerbil after unilateral brain ischemia. Stroke 1995;26:2333-7 (Pubitemid 3012723)
32. Kobayashi H, Wada A, Izumi F, Magnoni MS, Trabucchi M. Alpha-Adrenergic receptors in cerebral microvessels of normotensive and spontaneously hypertensive rats. Circ Res 1985; 56:402-9 (Pubitemid 15119516)
33. Kitaguchi K, Ohsumi H, Kuro M, Nakajima T, Hayashi Y. Effects of sevoflurane on cerebral circulation and metabolism in patients with ischemic cerebrovascular disease. Anesthesiology 1993;79:704-9 (Pubitemid 23296700)
34. Joseph M, Ziadi S, Nates J, Dannenbaum M, Malkoff M. Increases in cardiac output can reverse flow deficits from vasospasm independent of blood pressure: A study using xenon computed tomographic measurement of cerebral blood flow. Neurosurgery 2003;53:1044-51
35. Harik SI, Sharma VK, Wetherbee JR, Warren RH, Banerjee SP. Adrenergic and cholinergic receptors of cerebral microvessels. J Cereb Blood Flow Metab 1981;1:329-38 (Pubitemid 12246555)
36. Cho S, Fujigaki T, Uchiyama Y, Fukusaki M, Shibata O, Sumikawa K. Effects of sevoflurane with and without nitrous oxide on human cerebral circulation. Transcranial Doppler study. Anesthesiology 1996;85:755-60 (Pubitemid 26346714)
37. Hoffbrand BI, Forsyth RP. Regional blood flow changes during norepinephrine, tyramine and methoxamine infusions in the unanesthetized rhesus monkey. J Pharmacol Exp Ther 1973; 184:656-61
38. Grangsjo G, Persson E. Influence of some vaso-active substances on regional blood flow in the dog kidney. A study on normovolaemic and hypovolaemic dogs. Acta Anaesthesiol Scand 1971;15:71-95
39. Shinomiya K, Kajima M, Tajika H, Shiota H, Nakagawa R, Saijyou T. Renal failure caused by eyedrops containing phenylephrine in a case of retinopathy of prematurity. J Med Invest 2003;50:203-6 (Pubitemid 38019770)
40. Nygren A, Thoren A, Ricksten SE. Vasopressors and intestinal mucosal perfusion after cardiac surgery: Norepinephrine vs. phenylephrine. Crit Care Med 2006;34:722-9
41. Charlson ME, MacKenzie CR, Gold JP, Ales KL, Topkins M, Fairclough GP Jr., Shires GT. The preoperative and intraoperative hemodynamic predictors of postoperative myocardial infarction or ischemia in patients undergoing noncardiac surgery. Ann Surg 1989;210:637-48 (Pubitemid 19271942)
42. Reich DL, Bennett-Guerrero E, Bodian CA, Hossain S, Winfree W, Krol M. Intraoperative tachycardia and hypertension are independently associated with adverse outcome in noncardiac surgery of long duration. Anesth Analg 2002;95:273-7 (Pubitemid 34793082)
43. Saager L, Greenwald SD, Kelley SD, Schubert A, Sessler D. Outcomes in Anesthesia: Is There a Role for Processed EEG Monitoring? American Society of Anesthesiologists Annual Meeting, 2009. New Orleans, LA: Department of Outcomes Research and General Anesthesiology, Cleveland Clinic, 2009
44. Kaplan J. Essentials of Cardiac Anesthesia. Philadelphia: Saunders, 2008
45. Awan N, Vismara LA, Miller RR, DeMaria AN, Mason DT. Effects of isometric exercise and increased arterial impedance on left ventricular function in severe aortic valvular stenosis. Br Heart J 1977;39:651-6 (Pubitemid 8180742)
46. Snell RE, Luchsinger PC. Determination of the external work and power of the left ventricle in intact man. Am Heart J 1965;69:529-37
47. Joffe II, Riley MF, Katz SE, Ginsburg GS, Douglas PS. Acquired dynamic left ventricular outflow tract obstruction complicating acute anterior myocardial infarction: Serial echocardiographic and clinical evaluation. J Am Soc Echocardiogr 1997;10:717-21 (Pubitemid 127791222)
48. Charls LM. SAM-systolic anterior motion of the anterior mitral valve leaflet post-surgical mitral valve repair. Heart Lung 2003;32:402-6 (Pubitemid 37510611)
49. Miller R. Miller's Anesthesia. 7th ed. Philadelphia: Churchill Livingstone, 2010
50. Nudel DB, Berman MA, Talner NS. Effects of acutely increasing systemic vascular resistance on oxygen tension in tetralogy of Fallot. Pediatrics 1976;58:248-51
51. Oba Y, Salzman GA. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury. N Engl J Med 2000;343:813
52. Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 1988;138:720-3
53. Doering EB, Hanson CW 3rd, Reily DJ, Marshall C, Marshall BE. Improvement in oxygenation by phenylephrine and nitric oxide in patients with adult respiratory distress syndrome. Anesthesiology 1997;87:18-25 (Pubitemid 27438619)
54. Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 1993;328:399-405 (Pubitemid 23042288)
55. Puybasset L, Rouby JJ, Mourgeon E, Stewart TE, Cluzel P, Arthaud M, Poete P, Bodin L, Korinek AM, Viars P. Inhaled nitric oxide in acute respiratory failure: Dose-response curves. Intensive Care Med 1994;20:319-27 (Pubitemid 24190957)
56. Bigatello LM, Hurford WE, Kacmarek RM, Roberts JD Jr., Zapol WM. Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Effects on pulmonary hemodynamics and oxygenation. Anesthesiology 1994;80:761-70 (Pubitemid 24128938)
57. Prost JF, Desche P, Jardin F, Margairaz A. Comparison of the effects of intravenous almitrine and positive end-expiratory pressure on pulmonary gas exchange in adult respiratory distress syndrome. Eur Respir J 1991;4:683-7
58. Rossaint R, Gerlach H, Schmidt-Ruhnke H, Pappert D, Lewandowski K, Steudel W, Falke K. Efficacy of inhaled nitric oxide in patients with severe ARDS. Chest 1995;107:1107-15
59. Kosnik EJ, Hunt WE. Postoperative hypertension in the management of patients with intracranial arterial aneurysms. J Neurosurg 1976;45:148-54
60. Stevens RD, Naval NS, Mirski MA, Citerio G, Andrews PJ. Intensive care of aneurysmal subarachnoid hemorrhage: An international survey. Intensive Care Med 2009;35:1556-66
61. Greenberg MS. Handbook of Neurosurgery. 6th ed. New York: Thieme, 2005
62. Treggiari MM, Deem S. Which H is the most important in triple-H therapy for cerebral vasospasm? Curr Opin Crit Care 2009;15:83-6
63. Muench E, Horn P, Bauhuf C, Roth H, Philipps M, Hermann P, Quintel M, Schmiedek P, Vajkoczy P. Effects of hypervolemia and hypertension on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation after subarachnoid hemorrhage. Crit Care Med 2007;35:1844-51 (Pubitemid 47220357)
64. MacDonald RL. Evidence-based treatment of subarachnoid hemorrhage: Current status and future possibilities. Clin Neurosurg 2006;53:257-66
65. Egge A, Waterloo K, Sjoholm H, Solberg T, Ingebrigtsen T, Romner B. Prophylactic hyperdynamic postoperative fluid therapy after aneurysmal subarachnoid hemorrhage: A clinical, prospective, randomized, controlled study. Neurosurgery 2001;49:593-605
66. Lennihan L, Mayer SA, Fink ME, Beckford A, Paik MC, Zhang H, Wu YC, Klebanoff LM, Raps EC, Solomon RA. Effect of hypervolemic therapy on cerebral blood flow after subarachnoid hemorrhage: A randomized controlled trial. Stroke 2000;31:383-91 (Pubitemid 30078170)
67. Muizelaar JP, Becker DP. Induced hypertension for the treatment of cerebral ischemia after subarachnoid hemorrhage. Direct effect on cerebral blood flow. Surg Neurol 1986; 25:317-25 (Pubitemid 16152723)
68. Buckland MR, Batjer HH, Giesecke AH. Anesthesia for cerebral aneurysm surgery: Use of induced hypertension in patients with symptomatic vasospasm. Anesthesiology 1988;69:116-9
69. Awad IA, Carter LP, Spetzler RF, Medina M, Williams FC Jr. Clinical vasospasm after subarachnoid hemorrhage: Response to hypervolemic hemodilution and arterial hypertension. Stroke 1987;18:365-72 (Pubitemid 17059661)
70. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenation. J Neurotrauma 2007;24(Suppl 1):S7-13
71. Dudkiewicz M, Proctor KG. Tissue oxygenation during management of cerebral perfusion pressure with phenylephrine or vasopressin. Crit Care Med 2008;36:2641-50
72. Pfister D, Strebel SP, Steiner LA. Effects of catecholamines on cerebral blood vessels in patients with traumatic brain injury. Eur J Anaesthesiol Suppl 2008;42:98-103 (Pubitemid 351643066)
73. Myburgh JA. Driving cerebral perfusion pressure with pressors: How, which, when? Crit Care Resusc 2005;7:200-5
74. Alspaugh DM, Sartorelli K, Shackford SR, Okum EJ, Buckingham S, Osler T. Prehospital resuscitation with phenylephrine in uncontrolled hemorrhagic shock and brain injury. J Trauma 2000;48:851-63
75. Rosner MJ, Rosner SD, Johnson AH. Cerebral perfusion pressure: Management protocol and clinical results. J Neurosurg 1995;83:949-62 (Pubitemid 26048132)
76. Robertson CS, Valadka AB, Hannay HJ, Contant CF, Gopinath SP, Cormio M, Uzura M, Grossman RG. Prevention of secondary ischemic insults after severe head injury. Crit Care Med 1999;27:2086-95 (Pubitemid 29508318)
77. Morelli A, Lange M, Ertmer C, Dunser M, Rehberg S, Bachetoni A, D'Alessandro M, Van Aken H, Guarracino F, Pietropaoli P, Traber DL, Westphal M. Short-term effects of phenylephrine on systemic and regional hemodynamics in patients with septic shock: A crossover pilot study. Shock 2008;29:446-51 (Pubitemid 351416797)
78. Morelli A, Ertmer C, Rehberg S, Lange M, Orecchioni A, Laderchi A, Bachetoni A, D'Alessandro M, Van Aken H, Pietropaoli P, Westphal M. Phenylephrine versus norepinephrine for initial hemodynamic support of patients with septic shock: A randomized, controlled trial. Crit Care 2008;12:R143
79. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296-327
80. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77
81. Varpula M, Tallgren M, Saukkonen K, Voipio-Pulkki LM, Pettila V. Hemodynamic variables related to outcome in septic shock. Intensive Care Med 2005;31:1066-71 (Pubitemid 41125337)
82. Townsend CM, Beauchamp RD, Evers, BM, Mattox K. Sabiston Textbook of Surgery. Maryland Heights, MO: Saunders, 2007
83. Hamid SK, Harris DN. Hypotension following valve replacement surgery in carcinoid heart disease. Anaesthesia 1992;47:490-2
84. Holdcroft A. Hormones and the gut. Br J Anaesth 2000;85:58-68 (Pubitemid 30417222)
85. Ralston DH, Shnider SM, DeLorimier AA. Effects of equipotent ephedrine, metaraminol, mephentermine, and methoxamine on uterine blood flow in the pregnant ewe. Anesthesiology 1974;40:354-70
86. Lee A, Ngan Kee WD, Gin T. A quantitative, systematic review of randomized controlled trials of ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean delivery. Anesth Analg 2002;94:920-6 (Pubitemid 34263741)
87. Khaw KS. Hypotension during spinal anaesthesia for caesarean section: Implications, detection, prevention, and treatment. Fetal Maternal Med Rev 2006;17:157-83 (Pubitemid 44147653)
88. Cooper DW, Carpenter M, Mowbray P, Desira WR, Ryall DM, Kokri MS. Fetal and maternal effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Anesthesiology 2002;97:1582-90 (Pubitemid 35417460)
89. Ngan Kee WD, Lee A, Khaw KS, Ng FF, Karmakar MK, Gin T. A randomized double-blinded comparison of phenylephrine and ephedrine infusion combinations to maintain blood pressure during spinal anesthesia for cesarean delivery: The effects on fetal acid-base status and hemodynamic control. Anesth Analg 2008;107:1295-302